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The number of studies on work breaks and the importance of this subject is growing rapidly, with research showing that work breaks increase employees’ wellbeing and performance and workplace safety. However, comparing the results of work break research is difficult since the study designs and methods are heterogeneous and there is no standard theoretical model for work breaks. Based on a systematic literature search, this scoping review included a total of 93 studies on experimental work break research conducted over the last 30 years. This scoping review provides a first structured evaluation regarding the underlying theoretical framework, the variables investigated, and the measurement methods applied. Studies using a combination of measurement methods from the categories “self-report measures,” “performance measures,” and “physiological measures” are most common and to be preferred in work break research. This overview supplies important information for ergonomics researchers allowing them to design work break studies with a more structured and stronger theory-based approach. A standard theoretical model for work breaks is needed in order to further increase the comparability of studies in the field of experimental work break research in the future.
Die Nachfrage nach nachhaltigen und ökologischen Bau- und Dämmstoffen wächst, besonders im Hinblick auf den fortschreitenden Klimawandel und die knapper werdenden fossilen Ressourcen. Eine mögliche Alternative zu traditionellen Baustoffen stellen dabei nachwachsende Rohstoffe dar, denn diese sind im Vergleich zu fossilen Ressourcen CO2-neutral. [1,2]
Dysregulation of IL12 Signaling As a Novel Cause of an Autoimmune Lymphoproliferative like Syndrome
(2014)
Although work events can be regarded as pivotal elements of organizational life, only a few studies have examined how positive and negative events relate to and combine to affect work engagement over time. Theory suggests that to better understand how current events affect work engagement (WE), we have to account for recent events that have preceded these current events. We present competing theoretical views on how recent and current work events may affect employees (e.g., getting used to a high frequency of negative events or becoming more sensitive to negative events). Although the occurrence of events implies discrete changes in the experience of work, prior research has not considered whether work events actually accumulate to sustained mid-term changes in WE. To address these gaps in the literature, we conducted a week-level longitudinal study across a period of 15 consecutive weeks among 135 employees, which yielded 849 weekly observations. While positive events were associated with higher levels of WE within the same week, negative events were not. Our results support neither satiation nor sensitization processes. However, high frequencies of negative events in the preceding week amplified the beneficial effects of positive events on WE in the current week. Growth curve analyses show that the benefits of positive events accumulate to sustain high levels of WE. WE dissipates in the absence of continuous experience of positive events. Our study adds a temporal component and informs research that has taken a feature-oriented perspective on the dynamic interplay of job demands and resources.
BACKGROUND/AIM
Cytokine-induced killer (CIK) cells are ex vivo expanded major histocompatibility complex (MHC)-unrestricted cytotoxic cells with promising effects against a variety of cancer types. Regulatory T-cells (T-reg) have been shown to reduce the effectiveness of CIK cells against tumor cells. Peptide P60 has been shown to inhibit the immunosuppressive functions of T-regs. This study aimed at examining the effect of p60 on CIK cells efficacy against renal and pancreatic cancer cells.
MATERIALS AND METHODS
The effect of P60 on CIK cytotoxicity was examined using flow cytometry, WST-8-based cell viability assay and interferon γ (IFNγ) ELISA.
RESULTS
P60 treatment resulted in a significant decrease in the viability of renal and pancreatic cancer cell lines co-cultured with CIK cells. No increase in IFNγ secretion from CIK cells was detected following treatment with P60. P60 caused no changes in the distribution of major effector cell populations in CIK cell cultures.
CONCLUSION
P60 may potentiate CIK cell cytotoxicity against tumor cells.
The Concept of Purpose, Travelling, and Connectivity: Three Pillars of Organization and Leadership
(2020)
The three pillars of organization and leadership are discussed as being fundamental because they enable organizations to continuously synchronize with business needs and opportunities and enable their employees to interact flexibly and successfully. The building blocks or pillars are interconnected with agile practices such as iterative procedures and minimum viable solutions. They also challenge our learning abilities beyond enriching our inner maps, i.e., adapting them and even managing their adaption.
Application developers constitute an important part of a digital platform’s ecosystem. Knowledge about psychological processes that drive developer behavior in platform ecosystems is scarce. We build on the lead userness construct which comprises two dimensions, trend leadership and high expected benefits from a solution, to explain how developers’ innovative work behavior (IWB) is stimulated. We employ an efficiencyoriented and a social-political perspective to investigate the relationship between lead userness and IWB. The efficiency-oriented view resonates well with the expected benefit dimension of lead userness, while the social-political view might be interpreted as a reflection of trend leadership. Using structural equation modeling, we test our model with a sample of over 400 developers from three platform ecosystems. We find that lead userness is indirectly associated with IWB and the performance-enhancing view to be the stronger predictor of IWB. Finally, we unravel differences between paid and unpaid app developers in platform ecosystems.
High-precision, multidimensional holes are required in many technical applications. Due to its undercut shape, these kind of holes are usually manufactured from two sides of the work piece including a time-consuming co-axial alignment. Compared to current state of the art, a one-sided drilling strategy has numerous advantages regarding flexibility, precision and process efficiency. In this work, a helical drilling optic and an ultrashort pulse laser are utilized to fabricate a rotationally symmetric multidimensional-shaped hole in one single process step. The influences of single pulse energy, pulse repetition rate, rotation speed of laser beam as well as the drilling time on ablation depth are investigated. By varying the pulse energy and pulse density, the deposited energy per unit length on the single helical path can be adapted and thus the ablation depth can be scaled. With the adapted laser energy deposition, a T-shaped hole with a uniformed depth of about 80 mu m inlet is fabricated. Morphological analysis on the hole wall show excellent drilling quality without recast layers or heat-affected zones and roughness Rq < 0.35 mu m.
Data-Driven Robot Fault Detection and Diagnosis Using Generative Models: A Modified SFDD Algorithm
(2019)
This paper presents a modification of the data-driven sensor-based fault detection and diagnosis (SFDD) algorithm for online robot monitoring. Our version of the algorithm uses a collection of generative models, in particular restricted Boltzmann machines, each of which represents the distribution of sliding window correlations between a pair of correlated measurements. We use such models in a residual generation scheme, where high residuals generate conflict sets that are then used in a subsequent diagnosis step. As a proof of concept, the framework is evaluated on a mobile logistics robot for the problem of recognising disconnected wheels, such that the evaluation demonstrates the feasibility of the framework (on the faulty data set, the models obtained 88.6% precision and 75.6% recall rates), but also shows that the monitoring results are influenced by the choice of distribution model and the model parameters as a whole.
Atmospheric aerosols affect the power production of solar energy systems. Their impact depends on both the atmospheric conditions and the solar technology employed. By being a region with a lack in power production and prone to high solar insolation, West Africa shows high potential for the application of solar power systems. However, dust outbreaks, containing high aerosol loads, occur especially in the Sahel, located between the Saharan desert in the north and the Sudanian Savanna in the south. They might affect the whole region for several days with significant effects on power generation. This study investigates the impact of atmospheric aerosols on solar energy production for the example year 2006 making use of six well instrumented sites in West Africa. Two different solar power technologies, a photovoltaic (PV) and a parabolic through (PT) power plant, are considered. The daily reduction of solar power due to aerosols is determined over mostly clear-sky days in 2006 with a model chain combining radiative transfer and technology specific power generation. For mostly clear days the local daily reduction of PV power (at alternating current) (PVAC) and PT power (PTP) due to the presence of aerosols lies between 13 % and 22 % and between 22 % and 37 %, respectively. In March 2006 a major dust outbreak occurred, which serves as an example to investigate the impact of an aerosol extreme event on solar power. During the dust outbreak, daily reduction of PVAC and PTP of up to 79 % and 100 % occur with a mean reduction of 20 % to 40 % for PVAC and of 32 % to 71 % for PTP during the 12 days of the event.
„Auf uns hört ja keiner“
(2019)
Background: We evaluated the Wellion Galileo GLU/KET blood and ketone (ß-Hydroxybutyrate, ß-OHB) meter to demonstrate that it meets ISO15107:2015 regulatory approval criteria. Research Design and Methods: A total of 100 subjects (52 female, age: 30 to 84 years, diabetes: 10 type 1/90 type 2) with blood glucose levels distributed over the entire measurement range as required by the ISO15197 protocol were tested (double determinations with 3 strip lots and two devices). A similar test protocol was followed to test ß-OHB strip performance (reference devices: YSI 2300plus for glucose and STANBIO ß-HOB LiquiColor TestKit for ß-OHB). Precision was tested for glucose with 3 blood glucose concentrations (ß-OHB: 2 control solutions). Results: All glucose test-strip lots met the strict ISO acceptance criteria. Mean absolute relative difference (MARD) was 4.9% and all data pairs were in zone A of the consensus error grid. The ß-OHB test-strips also met the pre-defined acceptance criteria. Within-run and between-run precision was calculated to be 2.3% and 0.7% for the glucose strips (3.7%/0.8% for the ketone strips). Conclusions: When tested according to the ISO15197:2015 guideline, the device showed very accurate measurement performance for glucose and ß-OHB testing and fully met regulatory accuracy approval criteria.
