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3D tracking using multiple Nintendo Wii Remotes: a simple consumer hardware tracking approach
(2009)
An easy to build and cost-effective 3D tracking solution is presented, using Nintendo Wii Remotes acting as cameras. As the hardware differs from usual tracking cameras, the calibration and tracking process has to be adapted accordingly. The tracking approach described could be used for tracking the user's motions in video games based upon physical activity (sports, fighting or dancing games), allowing the player to interact with the game in a more intuitive way than by just pressing buttons.
3D-Imaging
(2009)
In the last 5 years a close co-operation between the Bonn-Rhein-Sieg University of Applied Sciences and the Philips Research Laboratories in Aachen has been established. In this article I want to report on the co-operation of the Department of Electrical Engineering, Mechanical Engineering and Technical Journalism with Philips. Besides a number of diploma theses on the field of water treatment with new discharge lamps, power electronics and modelling of electromagnetic field configurations, there is running also an activity on a new generation of highly efficient light sources based on molecular discharges.
Timely recognition of threats can be significantly supported by security assistance systems that work continuously in time and call the security personnel in case of anomalous events in the surveillance area. We describe the concept and the realization of an indoor security assistance system for real-time decision support. The system consists of a computer vision module and a person classification module. The computer vision module provides a video event analysis of the entrance region in front of the demonstrator. After entering the control corridor, the persons are tracked, classified, and potential threats are localized inside the demonstrator. Data for the person classification are provided by chemical sensors detecting hazardous materials. Due to their limited spatio-temporal resolution, a single chemical sensor cannot localize this material and associate it with a person. We compensate this deficiency by fusing the output of multiple, distributed chemical sensors with kinematical data from laser-range scanners. Considering both the computer vision formation and the results of the person classification affords the localization of threats and a timely reaction of the security personnel.
This report presents the implementation and evaluation of a computer vision task on a Field Programmable Gate Array (FPGA). As an experimental approach for an application-specific image-processing problem it provides reliable results to measure gained performance and precision compared with similar solutions on General Purpose Processor (GPP) architectures.
The project addresses the problem of detecting Binary Large OBjects (BLOBs) in a continuous video stream. For this problem a number of different solutions exist. But most of these are realized on GPP platforms, where resolution and processing speed define the performance barrier. With the opportunity of parallelization and performance abilities like in hardware, the application of FPGAs become interesting. This work belongs to the MI6 project from the Computer Vision research group of the University of Applied Sciences Bonn-Rhein-Sieg. It address the detection of the users position and orientation in relation to the virtual environment in an Immersion Square.
The goal is to develop a light emitting device, that points from the user towards the point of interest on the projection screen. The projected light dots are used to represent the user in the virtual environment. By detecting the light dots with video cameras, the idea is to interface the position and orientation of the relative position of the user interface. Fort that the laser dots need to be arranged in a unique pattern, which requires at least five points.[29] For a reliable estimation a robust computation of the BLOB's center-points is necessary.
This project has covered the development of a BLOB detection system on a FPGA platform. It detects binary spatially extended objects in a continuous video stream and computes their center points. The results are displayed to the user and where validated for their ground truth. The evaluation compares precision and performance gain against similar approaches on GPP platforms.
Embryonic stem cells (ES) have the potential of long-term viability, selfrenewal and pluripotency which makes them interesting candidates for tissue engineering and gene therapy applications. On the other hand ethical and political issues arise while using theses cells and severe problems such as their tumorgenicity have not been solved yet. In the last couple of month a new source of cells with stem cell character was developed, the induced pluripotent stem cells (iPS). These cells are derived from differentiated adult cells via transduction of three transcription factors and show features similar to embryonic stem cells. Unfortunately, this includes the tumorgenicity which is even higher in those cells since the transcription factor transduction needed until now, is performed with retrovial vectors, which have a tumor potential on their own. Thus, adult stem cells are investigated extensively as alternative source of self-renewing cells. Human mesenchymal stem cells (HMSCs), which have in addition the advantage of potential autologous transplantation, can be found in various differentiated tissues since they are needed for maintenance and repair. They can be differentiated in chondrogenic, osteogenic, adipogenic and myogenic lineages which makes them an excellent tool for future tissue replacement strategies.
The invention relates to compounds that include peptide and peptidomimetics that inhibit estrogen receptor dependent cell proliferation. The compounds of the invention are useful for treating cell proliferative disorders or physiological conditions characterized by undesirable or unwanted estrogen induced cell proliferation, including breast cancer.
Dihydropyrimidine dehydrogenase (DPD) deficiency is an infrequently described autosomal recessive disorder of the pyrimidine degradation pathway and can lead to mental and motor retardation and convulsions. DPD deficiency is also known to cause a potentially lethal toxicity following administration of the antineoplastic agent 5-fluorouracil. In an ongoing study of 72 DPD deficient patients, we analysed the molecular background of 5 patients in more detail in whom initial sequence analysis did not reveal pathogenic mutations. In three patients, a 13.8 kb deletion of exon 12 was found and in one patient a 122 kb deletion of exon 14–16 of DPYD. In the fifth patient, a c.299_302delTCAT mutation in exon 4 was found and also loss of heterozygosity of the entire DPD gene. Further analysis demonstrated a de novo deletion of approximately 14 Mb of chromosome 1p13.3–1p21.3, which includes DPYD. Haploinsufficiency of NTNG1, LPPR4, GPSM2, COL11A1 and VAV3 might have contributed to the severe psychomotor retardation and unusual craniofacial features in this patient. Our study showed for the first time the presence of genomic deletions affecting DPYD in 7% (5/72) of all DPD deficient patients. Therefore, screening of DPD deficient patients for genomic deletions should be considered.
Die Wiederverwertung von Kunststoffen (Kunststoffrecycling) kann in die werkstoffliche (materielle), die rohstoffliche (chemische) und die energetische Verwertung unterteilt werden. Beim werkstofflichen Kunststoffrecycling werden sortenreine Kunststoffreste gewaschen, gemahlen und von der Kunststoff verarbeitenden Industrie als Rohmaterial eingesetzt. Der chemische Aufbau des erhaltenen Werkstoffs (Re-Granulats) bleibt erhalten. Bei der rohstofflichen Verwertung werden Kunststoffreste zu Monomeren zurückgeführt. Die erhaltenen Monomere werden dann bei der Herstellung neuer Kunststoffe verwendet. Bei der energetischen Verwertung werden die Kunststoffreste der Zement- oder Stahlindustrie als Energieträger zugeführt.
A soluble form of the complement receptor CD21 (sCD21) is shed from the lymphocyte surface. The sCD21 is able to bind all known ligands such as CD23, sCD23, Epstein-Barr virus and C3d in immune complexes. Here, we show the serum levels of sCD21 in sera the of antiphospholipid syndrome (APS) patients. Antiphospholipid syndrome is an autoimmune disorder in which autoantibodies cause heart attack, stroke and miscarriage. Antiphospholipid syndrome may appear as primary or in association with systemic lupus erythromatosus (SLE) and other autoimmune diseases. Here, we ask whether APS patients have different sCD21 titers compared to healthy persons and whether sCD21 levels correlate with the presence of anti-β2-GPI autoantibodies. We show that autoimmune APS patients have significantly reduced amounts of sCD21 in their sera, irrespective of the presence of anti-β2-GPI autoantibodies. In our APS patients cohort additional SLE, vasculities, DVT (deep vein thrombosis), fetal loss or thrombosis did not correlate to the reduced level of sCD21.
BACKGROUND
Neuronal migration is a crucial process that allows neurons to reach their correct target location to allow the nervous system to function properly. AP-2alpha is a transcription factor essential for neural crest cell migration and its mutation results in apoptosis within this cell population, as demonstrated by genetic models.
RESULTS
We down-modulated AP-2alpha expression in GN-11 neurons by RNA interference and observe reduced neuron migration following the activation of a specific genetic programme including the Adhesion Related Kinase (Axl) gene. We prove that Axl is able to coordinate migration per se and by ChIP and promoter analysis we observe that its transcription is directly driven by AP-2alpha via the binding to one or more functional AP-2alpha binding sites present in its regulatory region. Analysis of migration in AP-2alpha null mouse embryo fibroblasts also reveals an essential role for AP-2alpha in cell movement via the activation of a distinct genetic programme.
CONCLUSION
We show that AP-2alpha plays an essential role in cell movement via the activation of cell-specific genetic programmes. Moreover, we demonstrate that the AP-2alpha regulated gene Axl is an essential player in GN-11 neuron migration.
Heutzutage ist die Entwicklung von Luft- und Raumfahrzeugen ein komplexer und standardisierter Prozess, der verschiedene Disziplinen der Wissenschaft und des Ingenieurwesens vereint. Die Kenntnis flugphysikalischer Eigenschaften, insbesondere Aerodynamik und Strömung, ist für den Entwurf von Luft- und Raumfahrzeugen unerlässlich. Um den Aufwand zur Berechnung dieser Eigenschaften zu verringern, wurden Methoden und Werkzeuge zur computergestützten Simulation entworfen. Diese werden in integrierten simulationsbasierten Entwicklungsprozessen zusammengefasst. Dadurch ist es beispielsweise möglich, Zeitersparnisse von bis zu mehreren Jahren, gegenüber physikalischen Tests in Windkanälen, zu erzielen [Bec08].
Ein wichtiges Themengebiet der Forschung ist die Beschleunigung von Berechnungen mittels Parallelisierung von Algorithmen. Grafikprozessoren, die für den General Purpose Computation on GPU’s (GPGPU) Betrieb geeignet sind, bieten eine aktuelle Möglichkeit der Parallelisierung. Anhand dieser Grafikkarten ist es möglich, die hohe Leistung der Grafikprozessoren zur Berechnung wissenschaftlicher Aufgabenstellungen zu nutzen. In dieser Arbeit wird ein Algorithmus zur Ausrichtung von Belichtungsreihen, die bei der High-Dynamic-Range (HDR) Fotografie genutzt werden, ausgewählt und auf der Grafikkartenarchitektur von NVIDIA parallelisiert.