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Due to regionalization and global competition, many companies have turned their attention to other markets outside the domestic ones in anticipation of securing profitable market(s) for their products. Cormart (Nigeria) Limited is one of such companies, seeking to expand beyond its domestic borders. Cormart is a Nigerian trading company specializing in Industrial Raw Materials and Chemicals. It represents the business interests of top Multinational Companies that wish to do business in Nigeria. In line with its expansion strategy, Cormart seeks to introduce its newly developed spray starch product (RENEW) into the Ghanaian market.
This case study is based on Azuri Health Ltd, a small company in Kenya that specializes mainly in the manufacture of dried fruit and flours. The company was started in 2010 and currently has 15 employees. It buys fruits, especially mangoes from farmers, processes them and markets them in- and outside of Kenya as dried fruits. This value addition enhances the shelf life of the products which would otherwise spoil within a few days after ripening.
Here, we present a miR mechanism which is active in the nucleus and is essential for the production of intron included, C-terminal truncated and biologically active proteins, like e.g. Vim3. We exemplified this mechanism by miRs, miR-15a and miR-498, which are overexpressed in clear cell renal carcinoma or oncocytoma. Both miRs directly interact with DNA in an intronic region, leading to transcriptional stop, and therefore repress the full length version of the pre-mRNA, resulting in intron included truncated proteins (Mxi-2 and Vim3). A computational survey shows that this miR:DNA interactions mechanism may be generally involved in regulating the human transcriptome, with putative interaction sites in intronic regions for over 1000 genes. In this work, an entirely new mechanism is revealed how miRs can repress full length protein translation, resulting in C-terminal truncated proteins.
TREE Jahresbericht 2017
(2018)
Knapp fünf Jahre nach Gründung als Fachbereichsinstitut und zwei Jahre nach Verankerung als zentrale wissenschaftliche Einrichtung der Hochschule präsentieren wir - nicht ganz ohne Stolz - den ersten Jahresbericht des Instituts TREE. Er soll in seiner Breite als auch in seiner Tiefe die Stärken unserer gemeinschaftlichen Anstrengungen im Forschungsfeld der nachhaltigen Technologien aufzeigen: interdisziplinär, forschungsstark, nachwuchsfördernd und gesellschaftszugewandt. TREE ist weiterhin ein im Aufbruch begriffenes Institut, aber gerade das Jahr 2017 zeigt auch, dass wir uns schon in der Wissenschaftslandkarte einen Namen machen konnten: nach NaWETec konnte mit dem Themenkomplex "Effiziente Transportalternativen" ein zweiter Forschungsschwerpunkt drittmittelgefördert etabliert werden. Erste Promotionen im Rahmen des TREE konnten erfolgreich abgeschlossen und interessante Nachwuchswissenschaftler für "FHKarrierewege" gewonnen werden.
This paper introduces a random number generator (RNG) based on the avalanche noise of two diodes. A true random number generator (TRNG) generates true random numbers with the use of the electronic noise produced by two avalanche diodes. The amplified outputs of the diodes are sampled and digitized. The difference between the two concurrently sampled and digitized outputs is calculated and used to select a seed and to drive a pseudo-random number generator (PRNG). The PRNG is an xorshift generator that generates 1024 bits in each cycle. Every sequence of 1024 bits is moderately modified and output. The TRNG delivers the next seed and the next cycle begins. The statistical behavior of the generator is analyzed and presented.
Die vergangene Forschung zeigte, dass Werte und Persönlichkeitseigenschaften von (potentiellen) Arbeitnehmern die wahrgenommene Attraktivität bestimmter Arbeitgebermerkmale wie der Corporate Social Responsibility (CSR) beeinflussen. Weitere Forschung wird hingegen benötigt, um die in diesem Zusammenhang relevanten Persönlichkeitsmerkmale zu identifizieren. Diese Studie zielt darauf ab, die Werte und Persönlichkeitseigenschaften zu ermitteln, welche die unterschiedliche Attraktivität von CSR und weiteren Arbeitgebermerkmalen, die sich nicht auf die CSR beziehen, erklären können. Dazu bewerteten (potentielle) Arbeitnehmer (N = 145) auf zwei eigenentwickelten Skalen sowohl CSR-basierte Faktoren der Arbeitgeberattraktivität (z.B. Wassersparen) als auch Nicht-CSR-basierte Faktoren der Arbeitgeberattraktivität (z.B. erwünschte Unternehmenslage) hinsichtlich ihrer Wichtigkeit. Für die CSR-basierte Arbeitgeberattraktivität konnten unter Kontrolle der Big-Five hypothesenkonform die Wertedimension Selbst-Überwindung, die Persönlichkeitsdimension Communion und die prosoziale Persönlichkeit als Prädiktoren identifiziert werden. Die Wertedimensionen Selbst-Erhöhung und Selbst-Überwindung sowie die Persönlichkeitsdimensionen Agency und Communion leisten – ebenfalls über die Big-Five hinaus – einen bedeutenden Beitrag zur Vorhersage der Nicht-CSR-basierten Arbeitgeberattraktivität.
Um das digitale Storytelling für Medienunternehmen lukrativ nutzbar zu machen, existiert eine zunehmende Zahl von Tools, Software also, die das deutlich weniger zeitaufwendige Produzieren mithilfe zur Verfügung stehender Seitenvorlagen möglich machen. Drei oftmals verwendete Tools zur Produktion als auch zur Veröffentlichung von Beiträgen im digitalen Storytelling sind Atavist, Pageflow und Shorthand. Statt eigenem Programmieren können verschiedene multimediale Elemente in der Regel mit wenigen Mausklicks integriert werden. Nicolas Kaufmann beschäftigt sich in seiner Abschlussarbeit zum Bachelor of Science mit dem Thema "Digitales Storytelling - Eine Untersuchung zu Darstellungsformen, Nutzen und Tools".
In 2018, in the US alone, it is estimated that 268,670 people will be diagnosed with breast cancer, and that 41,400 will die from it. Since breast cancers often become resistant to therapies, and certain breast cancers lack therapeutic targets, new approaches are urgently required. A cell-stress response pathway, the unfolded protein response (UPR), has emerged as a promising target for the development of novel breast cancer treatments. This pathway is activated in response to a disturbance in endoplasmic reticulum (ER) homeostasis but has diverse physiological and disease-specific functions. In breast cancer, UPR signalling promotes a malignant phenotype and can confer tumours with resistance to widely used therapies. Here, we review several roles for UPR signalling in breast cancer, highlighting UPR-mediated therapy resistance and the potential for targeting the UPR alone or in combination with existing therapies.
Triple-negative breast cancer (TNBC) lacks targeted therapies and has a worse prognosis than other breast cancer subtypes, underscoring an urgent need for new therapeutic targets and strategies. IRE1 is an endoplasmic reticulum (ER) stress sensor, whose activation is predominantly linked to the resolution of ER stress and, in the case of severe stress, to cell death. Here we demonstrate that constitutive IRE1 RNase activity contributes to basal production of pro-tumorigenic factors IL-6, IL-8, CXCL1, GM-CSF, and TGFβ2 in TNBC cells. We further show that the chemotherapeutic drug, paclitaxel, enhances IRE1 RNase activity and this contributes to paclitaxel-mediated expansion of tumor-initiating cells. In a xenograft mouse model of TNBC, inhibition of IRE1 RNase activity increases paclitaxel-mediated tumor suppression and delays tumor relapse post therapy. We therefore conclude that inclusion of IRE1 RNase inhibition in therapeutic strategies can enhance the effectiveness of current chemotherapeutics.
A Method for the Sustainable Documentation of Operations Processes in Parcel Distribution Centers
(2018)
There is often no common understanding on operational processes in logistics companies as they are not properly documented. Hence, people execute the same process differently and training is conducted by experienced operators on an ad-hoc basis. Furthermore, continuous process improvement is hampered as neither the ideal process nor current issues in as-is processes are visible. A major reason for the missing documentation is the complexity of existing business process modelling languages. Modelling experts are required for initially describing the processes and also for updating the models after process changes. Furthermore, operations people are usually not used to read complex process models in EPCs or BPMN diagrams. In order to overcome these limitations, a domain-specific modelling language which facilitates maintaining up-to-date process models has been designed with a large logistics company in Germany. The paper at hand briefly describes this language and illustrates the method on how to apply it in operations environments.
Through the “Act to Strengthen the Non-financial Reporting by Corporations in their Management and Group Management Reports” (Gesetz zur Stärkung der nichtfinanziellen Berichterstattung der Unternehmen in ihren Lage- und Konzernlageberichten) (CSR Directive Transposition Act, „CSR-RUG“) of 11 April 2017[1], the German Bundestag implemented Directive 2014/95/EU (“CSR Directive”)[2] into German law. Following the European impetus, the CSR-RUG enriches the traditional repertoire of forms of action under environmental law by a further instrument. Already the regulatory context gives an idea of its atypical nature: The centrepiece of the CSR-RUG is the amendment of and addition to the Third Book of the German Commercial Code (Handelsgesetzbuch, “HGB”), which deals with the “trading books” of undertakings, i.e., accounting and reporting requirements. Since the reporting year 2017, large capital market-oriented corporations must report extensively within the framework of their annual management reports on their activities and effects in certain areas of “Corporate Social Responsibility”. This also includes environmental matters. The transparency and publicity this entails is intended to generate positive stimuli for more responsible, sustained and not least of all environmentally friendly entrepreneurial action.
Following a brief presentation of the European legal bases and their implementation in Germany (I.), we will classify the provisions within the underlying concept of Corporate Social Responsibility (II.) and analyse and systemise the governance effects of non-financial reporting (III.). A few remarks on selected aspects of the chosen approach and its implementation (IV.) as well as an outlook summarising our conclusions (V.) will complete this article. By detailing the German approach to transposing the CSR Directive, this paper intends to provide an example of the challenges member state legislators face when complying with modern governance concepts such as Corporate Social Responsibility by way of non-financial reporting obligations.
[1] Federal Law Gazette, Part I 2017, 802 et seq.
[2] Directive 2014/95/EU of the European Parliament and of the Council 22 October 2014 amending Directive 2013/34/EU as regards disclosure of non-financial and diversity information by certain large undertakings and groups, OJ EU No. L 330, p. 1.
Social Assistance
(2018)
If the first Sustainable Development Goal (SDG) to “End poverty in all its forms everywhere” is to be taken seriously, most low- and middle-income countries face a huge challenge. An estimated 1 billion people have indeed escaped extreme poverty since the early 1990s, and the global poverty rate fell from 35% in 1990 to 10.7% in 2013, but the absolute number of people living below the international poverty line of $1.90 at purchasing power parity has hardly changed. Countries in Asia contributed greatly to the overall decline in poverty rates: from 2012 to 2013, over 100 million people in Asia left extreme poverty behind, notably in India, Indonesia, and the People’s Republic of China (PRC) (World Bank 2016). Yet the living standards of those still below that line have hardly improved (Ravallion 2016). The achievement of the first SDG requires additional efforts at global and national levels, particularly on policies that address chronic poverty traps and that improve the outcomes of poor and vulnerable populations.
The main objective of this chapter is to give insights into how H-BRS as a German University of Applied Sciences supports small and medium-sized enterprises (SMEs) in exploring African markets. The university achieves this objective by engaging its Bachelor and Master level students in applied market research. Students engage in this research as part of their final thesis writing. This chapter lays out a process for successful marketing research projects for German SMEs in nine steps.
Internships and professional experience are becoming more and more important requisites for students and graduates and are almost taken for granted by many HR officials. In opposition to this, many newly created Bachelor and Master programmes make it difficult for students to integrate internships into their studies without having to add another semester and thereby "losing" valuable time. This becomes all the more relevant with private universities or universities generally that charge considerable tuition fees.
Bei Thymian (Thymus vulgaris) handelt es sich um eine sehr varietätenreiche Art, die aufgrund ihres Gehaltes an therapeutisch wirksamen Inhaltsstoffen als Arzneipflanze monographiert ist. Insbesondere das ätherische Öl mit dem Hauptbestandteil Thymol (ca. 50%) hat eine hohe antioxidative Wirkung. Ziel ist es, dieses Potential als nachhaltig produzierte Additive zu nutzen. Hierfür eignen sich antioxidativ bzw. antimikrobiell wirksame sowie UV-absorbierende Substanzen, die das Produkt bei Zusatz vor oxidativem Stress, mikrobiellem Abbau und Qualitätsverlust schützen.
Hierzu werden zunächst sechs Varianten auf verschiedene Parameter analysiert, um die potenteste Variante auszuwählen. Auf diese Variante wird sich die weitere Forschung konzentrieren.
Daher wird das ätherische Öl durch azeotrope Destillation extrahiert und mittels GCMS analysiert. In Extrakten werden zudem das AP und Absorptionsverhalten bestimmt. Auch die chemische Zusammensetzung des Extrakts sowie die flüchtigen Stoffe des Thymians werden untersucht. Generell gibt es wenig qualitative, teilweise jedoch quantitative Unterschiede: Eine Variante weist u.a. einen deutlich höheren Thymolgehalt im Öl (ca. 65 %) und ein hohes hydrophiles AP auf. Somit ist eine vielversprechende Variante für die weitere Entwicklung und Optimierung bioaktiver Additive gefunden.
Serine/threonine kinase 4 (STK4) deficiency is an autosomal recessive genetic condition that leads to primary immunodeficiency (PID) typically characterized by lymphopenia, recurrent infections and Epstein Barr Virus (EBV) induced lymphoproliferation and -lymphoma. State-of-the-art treatment regimens consist of prevention or treatment of infections, immunoglobulin substitution (IVIG) and restoration of the immune system by hematopoietic stem cell transplantation. Here, we report on two patients from two consanguineous families of Turkish (patient P1) and Moroccan (patient P2) decent, with PID due to homozygous STK4 mutations. P1 harbored a previously reported frameshift (c.1103 delT, p.M368RfsX2) and P2 a novel splice donor site mutation (P2; c.525+2 T>G). Both patients presented in childhood with recurrent infections, CD4 lymphopenia and dysregulated immunoglobulin levels. Patient P1 developed a highly malignant B cell lymphoma at the age of 10 years and a second, independent Hodgkin lymphoma 5 years later. To our knowledge she is the first STK4 deficient case reported who developed lymphoma in the absence of detectable EBV or other common viruses. Lymphoma development may be due to the lacking tumor suppressive function of STK4 or the perturbed immune surveillance due to the lack of CD4+ T cells. Our data should raise physicians' awareness of [1] lymphoma proneness of STK4 deficient patients even in the absence of EBV infection and [2] possibly underlying STK4 deficiency in pediatric patients with a history of recurrent infections, CD4 lymphopenia and lymphoma and unknown genetic make-up. Patient P2 experienced recurrent otitis in childhood, but when she presented at the age of 14, she showed clinical and immunological characteristics similar to patients suffering from Autoimmune Lymphoproliferative Syndrome (ALPS): elevated DNT cell number, non-malignant lymphadenopathy and hepatosplenomegaly, hematolytic anemia, hypergammaglobulinemia. Also patient P1 presented with ALPS-like features (lymphadenopathy, elevated DNT cell number and increased Vitamin B12 levels) and both were initially clinically diagnosed as ALPS-like. Closer examination of P2, however, revealed active EBV infection and genetic testing identified a novel STK4 mutation. None of the patients harbored typically ALPS-associated mutations of the Fas receptor mediated apoptotic pathway and Fas-mediated apoptosis was not affected. The presented case reports extend the clinical spectrum of STK4 deficiency.
This work discusses how to use OSM for robotic applications and aims at starting a discussion between the OSM and the robotics community. OSM contains much topological and semantic information that can be directly used in robotics and offers various advantages: 1) Standardized format with existing tooling. 2) The graph structure allows to compose the OSM models with domain-specific semantics by adding custom nodes, relations, and key-value pairs. 3) Information about many places is already available and can be used by robots since it is driven by a community effort.
Friction effects impose a requirement for the supplementary amount of torque to be produced in actuators for a robot to move, which in turn increases energy consumption. We cannot eliminate friction, but we can optimize motions to make them more energy efficient, by considering friction effects in motion computations. Optimizing motions means computing efficient joint torques/accelerations based on different friction torques imposed in each joint. Existing friction forces can be used for supporting certain types of arm motions, e.g standing still.
Reducing energy consumption of robot's arms will provide many benefits, such as longer battery life of mobile robots, reducing heat in motor systems, etc.
The aim of this project is extending an already available constrained hybrid dynamic solver, by including static friction effects in the computations of energy optimal motions. When the algorithm is extended to account for static friction factors, a convex optimization (maximization) problem must be solved.
The author of this hybrid dynamic solver has briefly outlined the approach for including static friction forces in computations of motions, but without providing a detailed derivation of the approach and elaboration that will show its correctness. Additionally, the author has outlined the idea for improving the computational efficiency of the approach, but without providing its derivation.
In this project, the proposed approach for extending the originally formulated algorithm has been completely derived and evaluated in order to show its feasibility. The evaluation is conducted in simulation environment with one DOF robot arm, and it shows correct results from the computation of motions. Furthermore, this project presents the derivation of the outlined method for improving the computational efficiency of the extended solver.
This Handbook of Applied Marketing and Personnel Services is part of the project "German-African University Partnership Platform for the Development of Entrepreneurship and SMEs", financed by the German Federal Ministry of Economic Cooperation and Development (BMZ) and the German Academic Exchange Service (DAAD), and jointly conducted by Bonn-Rhein-Sieg University of Applied Sciences, University of Cape Coast in Ghana and University of Nairobi in Kenya.
According to the International Union of Pure and Applied Chemistry (IUPAC) recommendation, analytical pyrolysis (Py) is defined as the characterization in an inert atmosphere of a material or a chemical process by a chemical degradation reaction(s) induced by thermal energy [1]. Thermal degradation under controlled conditions is often used as a part of an analytical procedure, either to render a sample into a suitable form for subsequent analysis by gas chromatography (GC), mass spectrometry (MS), gas chromatography coupled with the mass spectrometry (GC/MS), with the Fourier-transform infrared spectroscopy (GC/FTIR), or by direct monitoring as an analytical technique in its own right [2].
While Anglo-Saxon HEIs focus on a strong educational background and personal development of students, the German system, in particular Universities of Applied Sciences, emphasize employability through the transfer of job-related professional and soft skills. In this context, learning by practical application of skills has become an important instrument. Concepts for linking theory and application include research-based learning, practical internships or service learning – methods, which also maintain high standards of academic education.