Refine
Departments, institutes and facilities
- Fachbereich Angewandte Naturwissenschaften (23)
- Fachbereich Wirtschaftswissenschaften (21)
- Fachbereich Informatik (17)
- Fachbereich Ingenieurwissenschaften und Kommunikation (12)
- Institut für funktionale Gen-Analytik (IFGA) (12)
- Institut für Technik, Ressourcenschonung und Energieeffizienz (TREE) (9)
- Fachbereich Sozialpolitik und Soziale Sicherung (7)
- Institute of Visual Computing (IVC) (5)
- Institut für Cyber Security & Privacy (ICSP) (4)
- Institut für Sicherheitsforschung (ISF) (2)
Document Type
- Article (105) (remove)
Year of publication
- 2015 (105) (remove)
Keywords
- Prozessmanagement (3)
- ENaC (2)
- Sortimentspolitik (2)
- simulation (2)
- 3D activity landscapes (1)
- AMBER (1)
- Absatzkanal (1)
- Acute lymphoblastic leukemia (1)
- Adipose tissue-derived stem cells (1)
- Affordances (1)
Competitions for Benchmarking: Task and Functionality Scoring Complete Performance Assessment
(2015)
The human MPV17-related mitochondrial DNA depletion syndrome is an inherited autosomal recessive disease caused by mutations in the inner mitochondrial membrane protein MPV17. Although more than 30 MPV17 gene mutations were shown to be associated with mitochondrial DNA depletion syndrome, the function of MPV17 is still unknown. Mice deficient in Mpv17 show signs of premature aging. In the present study, we used electrophysiological measurements with recombinant MPV17 to reveal that this protein forms a non-selective channel with a pore diameter of 1.8 nm and located the channel's selectivity filter. The channel was weakly cation-selective and showed several subconductance states. Voltage-dependent gating of the channel was regulated by redox conditions and pH and was affected also in mutants mimicking a phosphorylated state. Likewise, the mitochondrial membrane potential (Δψm) and the cellular production of reactive oxygen species were higher in embryonic fibroblasts from Mpv17−/− mice. However, despite the elevated Δψm, the Mpv17-deficient mitochondria showed signs of accelerated fission. Together, these observations uncover the role of MPV17 as a Δψm-modulating channel that apparently contributes to mitochondrial homeostasis under different conditions.
Industrie 4.0: Digitale Wirtschaft – Herausforderung und Chance für Unternehmen und Arbeitswelt
(2015)
Seit Mitte der 1990er Jahre werden neue Informations- und Kommunikationstechnologien in der Arbeitswelt genutzt, in wachsendem Ausmaß und mit wachsender Bedeutung. Die verstärkte Digitalisierung verändert sowohl die Wirtschaft als auch die Gesellschaft. Es wird sogar von der "vierten industriellen Revolution" gesprochen, denn traditionelle Geschäftsmodelle geraten unter Druck.
Viele Controller verzeichnen steigende IT-Kosten, die zum Teil durch Lizenzkosten verursacht werden. Oft werden Kosteneinsparungen durch ineffizientes oder fehlendes Lizenzmanagement nicht realisiert, zudem sehen sich zahlreiche Unternehmen zusehends mit dem Problem nicht budgetierter Nachlizenzierungen, aufgrund steigender Aktivitäten der Softwarehersteller im Bereich der Lizenzierungsüberprüfung, konfrontiert. Der Beitrag zeigt die Problematik des IT-Lizenzmanagements und grundsätzliche Lösungsmöglichkeiten auf. Ein Referenzmodell demonstriert, wie im praktischen Anwendungsfall eine Kostensenkung und Prozessverbesserung realisiert werden kann.
Digitales Geld
(2015)
Unternehmen agieren in einem dynamischen Umfeld mit hoher Komplexität und Unsicherheit. Um dabei langfristig wettbewerbsfähig zu bleiben, ist eine kontinuierliche Optimierung der Prozesse erforderlich. Eine konsequente Prozessorientierung wird daher seit langem angestrebt. Zur Ermittlung des aktuellen Standes der Prozessorganisation in deutschen Unternehmen hat die Gesellschaft für Organisation e. V. (gfo) eine Studie durchführen lassen, deren erste Ergebnisse hier vorgestellt werden.
Big Data und aktuelle Trends
(2015)
Web of Services Security
(2015)
Background: Falls and fall-related injuries are a serious public health issue. Exercise programs can effectively reduce fall risk in older people. The iStoppFalls project developed an Information and Communication Technology-based system to deliver an unsupervised exercise program in older people’s homes. The primary aims of the iStoppFalls randomized controlled trial were to assess the feasibility (exercise adherence, acceptability and safety) of the intervention program and its effectiveness on common fall risk factors.
Methods: A total of 153 community-dwelling people aged 65+ years took part in this international, multicentre, randomized controlled trial. Intervention group participants conducted the exercise program for 16 weeks, with a recommended duration of 120 min/week for balance exergames and 60 min/week for strength exercises. All intervention and control participants received educational material including advice on a healthy lifestyle and fall prevention. Assessments included physical and cognitive tests, and questionnaires for health, fear of falling, number of falls, quality of life and psychosocial outcomes.
Results: The median total exercise duration was 11.7 h (IQR = 22.0) over the 16-week intervention period. There were no adverse events. Physiological fall risk (Physiological Profile Assessment, PPA) reduced significantly more in the intervention group compared to the control group (F1,127 = 4.54, p = 0.035). There was a significant three-way interaction for fall risk assessed by the PPA between the high-adherence (>90 min/week; n = 18, 25.4 %), low-adherence (<90 min/week; n = 53, 74.6 %) and control group (F2,125 = 3.12, n = 75, p = 0.044). Post hoc analysis revealed a significantly larger effect in favour of the high-adherence group compared to the control group for fall risk (p = 0.031), postural sway (p = 0.046), stepping reaction time (p = 0.041), executive functioning (p = 0.044), and quality of life (p for trend = 0.052).
Conclusions: The iStoppFalls exercise program reduced physiological fall risk in the study sample. Additional subgroup analyses revealed that intervention participants with better adherence also improved in postural sway, stepping reaction, and executive function.