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Solar energy is one option to serve the rising global energy demand with low environmental impact. Building an energy system with a considerable share of solar power requires long-term investment and a careful investigation of potential sites. Therefore, understanding the impacts from varying regionally and locally determined meteorological conditions on solar energy production will influence energy yield projections.
Reliable and regional differentiated power forecasts are required to guarantee an efficient and economic energy transition towards renewable energies. Amongst other renewable energy technologies, e.g. wind mills, photovoltaic (PV) systems are an essential component of this transition being cost-efficient and simply to install. Reliable power forecasts are however required for a grid integration of photovoltaic systems, which among other data requires high-resolution spatio-temporal global irradiance data.
In silico Epitope Mapping of Glucose-6-Phosphate Isomerase: A Rheumatoid Arthritis Autoantigen
(2017)
Rheumatoid arthritis-like symptoms can be initiated experimentally in naive K/BxN mice by simultaneously administering the two monoclonal antibodies 11H3 and 46H9. Both antibodies specifically recognize Glucose-6-Phosphate Isomerase (GPI), a known auto antigen in RA patients. Amino acid sequences of the Fv parts of the antibodies were determined by translating the respective hybridoma DNA sequences and served for threedimensional structure modeling of the paratope regions. In silico docking of both Fv antibody structure models to the X-ray structures of the homodimeric murine GPI as well as to the homodimeric human GPI predicted the murine epitope of the 11H3 antibodies to comprise partial amino acid sequences QRVRSGDWKGYTGKS (aa134-148) and AAKDPSAVAK (aa232-241), generating an assembled (conformational) epitope. The 11H3 epitope on human GPI encompasses the matching partial amino acid sequences QRVRSGDWKGYTGKT (aa134-148) and AAKDPSAVAK (aa232-241). The epitope of the 46H9 antibody was determined to consist of the partial murine GPI amino acid sequence RKELQAAGKSPEDLEK (aa446-461) and the human GPI amino acid sequence RKELQAAGKSPEDLER (aa446-461), respectively, resembling consecutive (linear) epitopes. The predicted epitopes were verified by mass spectrometric epitope mapping using synthetic epitope peptides. Peptide QRVRSGDWKGYTGKS[GSMSGS] AAKDPSAAK included a small spacer sequence in between the epitope sequences, mimicking the assembled epitope for the 11H3 antibody. The peptide RKELQAAGKSPEDLEK represented the consecutive epitope for the 46H9 antibody. The determined B-cell epitopes of GPI and their interactions with the monoclonal antibodies provide a detailed structural understanding of immunological disease onset mechanisms in a mouse model of rheumatoid arthritis.
The technological development of the digital computer and new options to collect, store and transfer mass data have changed the world in the last 40 years. Moreover, due to the ongoing progress of computer power, the establishment of the Internet as critical infrastructure and the options of ubiquitous sensor systems will have a dramatic impact on economies and societies in the future. We give a brief overview about the technological basics especially with regard to the exponential growth of big data and current turn towards sensor-based data collection. From this stance, we reconsider the various dimensions of personal data and and market mechanisms that have an impact of data usage and protection.
Do remittances and social assistance transfers have different impacts on household’s expenditure patterns? While two separate strands of literature have looked at how social assistance or remittances have been spent, few studies have compared them directly. Using data from a household survey conducted in Moldova in 2011, this paper assesses the impact both types of transfers have on household expenditure patterns. Contrary to the common assumption that money is fungible, we find that social assistance and remittances have different impacts on expenditure patterns (having controlled for potential endogeneity). In other words, where the income comes from can determine how it is spent. As such, different sources of income may have different poverty impacts. In our sample, the two types of transfers are received by different, but slightly overlapping population groups. The fact that the two transfers are spent in different ways means that, to some extent, social assistance and remittances are complements rather than substitutes.
Background and Objectives: In advanced β-cell dysfunction, proinsulin is increasingly replacing insulin as major component of the secretion product. It has been speculated that proinsulin has at least the same adipogenic potency than insulin, leading to an increased tendency of lipid tissue formation in patients with late stage β-cell dysfunction. Methods and Results: Mesenchymal stem cells obtained from liposuction material were grown in differentiation media containing insulin (0.01 μmol), proinsulin (0.01 μmol) or insulin+proinsulin (each 0.005 μmol). Cell culture supernatants were taken from these experiments and an untreated control at weeks 1, 2, and 3, and were stored at -80°C until analysis. Cell differentiation was microscopically supervised and adiponectin concentrations were measured as marker for differentiation into mature lipid cells. This experiment was repeated three times. No growth of lipid cells and no change in adiponectin values was observed in the negative control group (after 7/14/12 days: 3.2±0.5/3.3±0.1/4.4±0.5 ng/ml/12 h). A continuous differentiation into mature adipocytes (also confirmed by Red-Oil-staining) and a corresponding increase in adiponectin values was observed in the experiments with insulin (3.6±1.9/5.1±1.4/13.3±1.5 ng/ml/12 h; p<0.05 week 1 vs. week 3) and proinsulin (3.3±1.2/3.5±0.3/12.2±1.2 ng/ml/12 h; p<0.05). Comparable effects were seen with the insulin/proinsulin combination. Conclusions: Proinsulin has the same adipogenic potential than insulin in vitro. Proinsulin has only 10∼20% of the glucose-lowering effect of insulin. It can be speculated that the adipogenic potential of proinsulin may be a large contributor to the increased body weight problems in patients with type 2 diabetes and advanced β-cell dysfunction.
Human butyrylcholinesterase (BChE) is a glycoprotein capable of bioscavenging toxic compounds such as organophosphorus (OP) nerve agents. For commercial production of BChE, it is practical to synthesize BChE in non-human expression systems, such as plants or animals. However, the glycosylation profile in these systems is significantly different from the human glycosylation profile, which could result in changes in BChE's structure and function. From our investigation, we found that the glycan attached to ASN241 is both structurally and functionally important due to its close proximity to the BChE tetramerization domain and the active site gorge. To investigate the effects of populating glycosylation site ASN241, monomeric human BChE glycoforms were simulated with and without site ASN241 glycosylated. Our simulations indicate that the structure and function of human BChE are significantly affected by the absence of glycan 241.
“Building Bridges Across Continents” (BBAC) is an intercultural and student-centered project that seeks to promote international communication and helps students develop competencies in entrepreneurship, international trade and global cultural awareness. The project, which is in its fourth phase of implementation, connects students from the United States, Germany, Ghana and Kenya with the help of Information Communication Technologies (ICT) in order to work on a common research assignment for a period of ten calendar weeks. The main ICTs used in the project are Skype, Facebook, wiki, email and WhatsApp. This paper describes and analyzes the background, structure, and results of the project.
Higher Education Institutions (HEIs) should, on the one hand, provide theoretical and practical knowledge to students and, on the other hand, make valuable contributions to theoretical knowledge and provide new insights by means of research. However, HEIs have to face changing and increasing demands with respect to what they are expected to achieve. Education and research issues are no longer enough, what matters today is the so called “third mission”. A specific example for implementing a third mission is the cooperation between HEIs and business incubators. With this in mind, a local consortium consisting of regional HEIs, e.g. Bonn-Rhein-Sieg University of Applied Sciences, as well as public and private institutions and partners initiated and established an incubator hub for the region Bonn/Rhein-Sieg in 2016, called “Digital Hub Region Bonn”. This conference contribution reports on our experience with regards to this cooperation approach resulting from the above- mentioned case. Furthermore the pros and cons as well as some issues of this kind of cooperation will be discussed. Last but not least this paper initiates the opportunity to share and compare the experiences of other university business incubators in Africa as well as in Germany. As we will describe, the financial investment of HEIs in a joint-incubator with other public as well as private partners offers substantial benefits, such as mutual know-how transfer from HEIs to the economy and vice versa. This strengthens entrepreneurial mindsets and activities and contributes to the development and growth of the local economy. Consequently, this cooperation sometimes creates challenges at various levels, for example due to differing interests between HEIs and business partners. This conference contribution offers approaches to solve these issues and to support private public partnership in business incubation.
Forschung@H-BRS
(2017)
Die Hochschule präsentiert mit ihrer neuen Broschüre "Forschung@H-BRS" ausgewählte Projekte von Wissenschaftlerinnen und Wissenschaftlern aus den Instituten und Fachbereichen in einem ansprechenden Format. Hochschulpräsident Harmtut Ihne blickt zu Anfang der Broschüre auf den Stand der anwendungsorientierten Forschung an der Hochschule und in Deutschland.
Als weltweit anspruchsvollstes Umweltmanagementsystem trägt EMAS auf Unternehmensebene als Baustein zur Nachhaltigen Entwicklung bei. EMAS ist ein Instrument der Europäischen Union, an dem Organisationen, unabhängig von ihrer Größe und Branche, weltweit auf freiwilliger Basis teilnehmen können. Die geplante EMAS-Validierung der UN-Klimakonferenz (COP 23) in Bonn (06. – 17.11.2017), hat das Interesse der Projektkoordination von „Sustainable Bonn – Konferenzort der Nachhaltigkeit“ geweckt, die EMAS-Einführung bei deren Projektteilnehmern untersuchen zu lassen. Daher liegt der Branchenfokus auf dem Gastgewerbe, aus denen die derzeitigen Teilnehmer des Bonner Projekts überwiegend stammen. Um Branchenspezifika bei EMAS besser zu berücksichtigen hat die Europäische Kommission im April 2016 hat ein Referenzdokument über bewährte Umweltmanagementpraktiken zur Steigerung der Öko-Effektivität mit einschlägigen Indikatoren zur Messung der Umweltleistung mit Richtwerten für die Tourismusbranche veröffentlicht, die im Rahmen einer EMAS-Einführung unter anderem von Gastgewerbebetrieben berücksichtigt werden müssen.
Today, more than 70 million tons of lignin are produced by the pulp and paper industry every year. However, the utilization of lignin as a source for chemical synthesis is still limited due to the complex and heterogeneous lignin structure. The purpose of this study was a selective photodegradation of industrially available kraft lignin in order to obtain appropriate fragments and building block chemicals for further utilization, e.g. polymerization. Thus, kraft lignin obtained from soft wood black liquor by acidification was dissolved in sodium hydroxide and irradiated at a wavelength of 254 nm with and without the presence of titanium dioxide in various concentrations. Analyses of the irradiated products via SEC showed decreasing molar masses and decreasing polydispersity indices over time. At the end of the irradiation period the lignin was depolymerised to form fragments as small as the lignin monomers. TOC analyses showed minimal mineralisation due to the depolymerisation process.
This work presents the analysis of data recorded by an eye tracking device in the course of evaluating a foveated rendering approach for head-mounted displays (HMDs). Foveated rendering methods adapt the image synthesis process to the user’s gaze and exploiting the human visual system’s limitations to increase rendering performance. Especially, foveated rendering has great potential when certain requirements have to be fulfilled, like low-latency rendering to cope with high display refresh rates. This is crucial for virtual reality (VR), as a high level of immersion, which can only be achieved with high rendering performance and also helps to reduce nausea, is an important factor in this field. We put things in context by first providing basic information about our rendering system, followed by a description of the user study and the collected data. This data stems from fixation tasks that subjects had to perform while being shown fly-through sequences of virtual scenes on an HMD. These fixation tasks consisted of a combination of various scenes and fixation modes. Besides static fixation targets, moving tar- gets on randomized paths as well as a free focus mode were tested. Using this data, we estimate the precision of the utilized eye tracker and analyze the participants’ accuracy in focusing the displayed fixation targets. Here, we also take a look at eccentricity-dependent quality ratings. Comparing this information with the users’ quality ratings given for the displayed sequences then reveals an interesting connection between fixation modes, fixation accuracy and quality ratings.
Studienverläufe von Studenten weichen nicht selten vom offiziell geplanten Curriculum ab. Für eine den Studienerfolg verbessernde Planung und Weiterentwicklung von Studiengängen und Curricula fehlen den Verantwortlichen häufig Erkenntnisse über tatsächliche sowie typischerweise erfolgreiche und weniger erfolgreiche Studienverlaufsmuster. Process-Mining-Techniken können helfen, mehr Transparenz bei der Auswertung von Studienverläufen zu schaffen und so die Erkennung typischer Studienverlaufsmuster, die Überprüfung der Übereinstimmung der konkreten Studienverläufe mit dem vorgegebenen Curriculum sowie eine zielgerechte Verbesserung des Curriculums zu unterstützen.
Real-World Performance of current Mesh Protocols in a small-scale Dual-Radio Multi-Link Environment
(2017)
Two key questions motivated the work in this paper: What is the impact of different usage schemes for multiple channels in a dual-radio Wireless Mesh Network (WMN), and what is the impact of some popular WMN routing protocols on its performance. These two questions were evaluated in a small and simple real-world scenario. A major concern was reproducibility of the results. We show that it is beneficial to use both radios on different frequencies in a fully meshed environment with four routers. The routing protocols Babel, B.A.T.M.A.N. V, BMX7 and OLSRv2 recognize a saturated channel and prefer the other one. We show that in our scenario all of the protocols perform equally well since the protocol overhead is comparably low not influencing the overall performance of the network.
Comparación de perfiles de ansiedad matemática entre estudiantes mexicanos y estudiantes alemanes
(2017)
Se determinan los perfiles de ansiedad matemática de estudiantes mexicanos y estudiantes alemanes por medio de la aplicación de un cuestionario desarrollado ex profeso. La ansiedad matemática se define en términos de tres descriptores: creencias, actitudes y emociones. Los autores definen un Índice de Ansiedad Matemática, al aplicarlo encuentran que los estudiantes alemanes presentan un valor mayor de dicho Índice, lo que significa que tienen una mayor nivel de ansiedad matemática. Las diferencias en los valores del Índice de Ansiedad Matemática se interpretan en términos de diferencias culturales. La interpretación parece ser consistente con las diferencias culturales y se ajusta a los resultados obtenidos.
Political economic analyses of recent social protection reforms in Asian, African or Latin American countries have increased throughout the last few years. Yet, most contributions focus on one social protection mechanism only and do not provide a comparative approach across policy areas. In addition, most studies are empirical studies, with no or very limited theoretical linkages. The paper aims to explain multiple trajectories of social protection reform processes looking at cash transfers and social health protection policies in Kenya. It develops a taxonomy and suggest a conceptual framework to assess and explain reform dynamics across different social protection pillars. In order to allow for a more differentiated typology and enable us to understand different reform dynamics, the article uses the approach on gradual institutional change. While existing approaches to institutional change mostly focus on institutional change prompted by exogenous shocks or environmental shifts, this approach takes account of both, exogenous and endogenous sources of change.
In recent years, there has been a growing interest in the start-up scene in sub-Saharan Africa. "Silicon Savannah" is today widely used to describe the thriving IT industry in and around Nairobi. Kenya's geographical advantage, its favorable economic reforms, and mature start-up ecosystem makes it stands out positively. Since a lot of hype exists around the start-up scene many investors are drawn to it, but in reality very few start-ups are investment-ready. The increasing start-up requirements and needs force incubators to diversify their offer. In contrast, to traditional incubators, an Innovation Hub (Hub) is characterized based on the concept of open innovation and collaboration. A Hub nurtures an enabling environment where a community of entrepreneurs can grow. At the same time, it serves as a nexus point for the local start-up community, investors, academia, technology companies and the wider private sector. It aims to create a structure where people serendipitously interact with others that they would not typically meet. Considering the great interest for and the large amounts of money invested in Hubs by governments, universities, private companies and other interested parties, not only researchers have been raising the question of the actual benefit of Hubs. This research study aims to investigate to what extent the support offered by the Hubs is tackling the challenges faced by start-ups in Nairobi, Kenya. The analysis can serve as a basis for identifying strength and weaknesses in the Hub models.
Impact of atmospheric aerosols on photovoltaic energy production - Scenario for the Sahel zone
(2017)
Photovoltaic (PV) energy is one option to serve the rising global energy need with low environmental impact. PV is of particular interest for local energy solutions in developing countries prone to high solar insolation. In order to assess the PV potential of prospective sites, combining knowledge of the atmospheric state modulating solar radiation and the PV performance is necessary. The present study discusses the PV power as function of atmospheric aerosols in the Sahel zone for clear-sky-days. Daily yields for a polycrystalline silicon PV module are reduced by up to 48 % depending on the climatologically-relevant aerosol abundances.
Service robots performing complex tasks involving people in houses or public environments are becoming more and more common, and there is a huge interest from both the research and the industrial point of view. The RoCKIn@Home challenge has been designed to compare and evaluate different approaches and solutions to tasks related to the development of domestic and service robots. RoCKIn@Home competitions have been designed and executed according to the benchmarking methodology developed during the project and received very positive feedbacks from the participating teams. Tasks and functionality benchmarks are explained in detail.
RoCKIn@Work was focused on benchmarks in the domain of industrial robots. Both task and functionality benchmarks were derived from real world applications. All of them were part of a bigger user story painting the picture of a scaled down real world factory scenario. Elements used to build the testbed were chosen from common materials in modern manufacturing environments. Networked devices, machines controllable through a central software component, were also part of the testbed and introduced a dynamic component to the task benchmarks. Strict guidelines on data logging were imposed on participating teams to ensure gathered data could be automatically evaluated. This also had the positive effect that teams were made aware of the importance of data logging, not only during a competition but also during research as useful utility in their own laboratory. Tasks and functionality benchmarks are explained in detail, starting with their use case in industry, further detailing their execution and providing information on scoring and ranking mechanisms for the specific benchmark.
Universities, Entrepreneurship and Enterprise Development in Africa – Conference Proceedings 2016
(2017)
These proceedings are the outcome of the 5th annual joint conference on “Universities Entrepreneurship and Enterprise Development in Africa” between the University of Nairobi, Kenya, the University of Cape Coast, Ghana, and Bonn-Rhein-Sieg University of Applied Sciences, Germany, held on 10-11 November 2016 on Campus Sankt Augustin, Bonn-Rhein-Sieg University of Applied Sciences.
Dare – Democracy and Science
(2017)
Das Cutting sticks-Problem ist in seiner allgemeinen Formulierung ein NP-vollständiges Problem mit Anwendungspotenzialen im Bereich der Logistik. Unter der Annahme, dass P ungleich NP (P != NP) ist, existieren keine effizienten, d.h. polynomiellen Algorithmen zur Lösung des allgemeinen Problems.
In diesem Papier werden für eine Reihe von Instanzen effiziente Lösungen angegeben.