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Anne Dreller shows that data sharing offers great opportunities and huge value creation potential for the business world. Despite many opportunities that data sharing promises, the business world has not fully operationalized this fact yet, due to various existing challenges. Thus, an exemplary, future-oriented, and platform-based data sharing business model is developed for the startup Quemey. This business model is also equipped with prioritized implementation advice, including measures like focusing on strong values for all platform participants, growing their business into a powerful monopolist position, and eliminating barriers of technological, contractual and legal or data privacy uncertainties.
Der globalisierte Kapitalismus, Umweltkatastrophen, Überbevölkerung sowie zunehmende politisch und religiös motivierte Konflikte fordern ein Umdenken ökonomischer Konzepte. Allein mit den herkömmlichen Sozial- und Wirtschaftssystemen lassen sich existenzbedrohende Probleme wie Armut, Hunger, Krankheit, mangelnde Bildung und Betreuung nicht lösen. Es gilt dringend, neue, zukunftsweisende unternehmerische Konzepte zu entwickeln und zu fördern. Seit geraumer Zeit hat sich unter dem Begriff „Social Entrepreneurship“ eine Bewegung etabliert, die versucht, unter Beachtung klassischer Ökonomiegrundsätze gesellschaftliche Herausforderungen nachhaltig zu lösen.
Scientific or statistical research has long been the domain of dedicated programming languages such as R, SPSS or SAS. A few years other competitors entered the arena, among them Python with its powerful SciPy package. The following article introduces SciPy by applying a small subset of its functionality to a well-known dataset.
ドイツで学んだ研究の方法と働き方
(2018)
Auf den Kunden fixiert
(2018)
Variable Sterne sind Sterne, welche in bestimmten Messparametern variabel sind. In unserem Fall ist dies die Helligkeit der Sterne. Grundsätzlich gibt es hier zwei Arten der Variabilität, intrinsiche und extrinsische Prozesse. Unter intrinischen Prozessen versteht man Variabilität, deren Ursache im Stern selbst liegt.
Beim Entwurf eines effizienten und sicheren Luftfahrzeugs müssen viele fachliche Aspekte berücksichtigt werden. Die Bereiche Aerodynamik, Strukturmechanik als auch Flugmechanik spielen eine wichtige Rolle und hängen voneinander ab. Daher ist ein iterativer Entwurfsprozess erforderlich, um einen an die Anforderungen bestmöglich angepassten Kompromiss zu finden. In der Forschung am Deutschen Zentrum für Luft- und Raumfahrt e.V. (DLR) werden dafür automatisierte Prozessketten entwickelt, die zur Bewertung und Entwicklung von neuen Flugzeugkonzepten dienen.
Text is one of the key sources of information for social sciences and humanities which, with the rise and development of computational technologies, has been mostly available via digital libraries, archives and websites. It enables researchers to increasingly deal with large scale text corpora that require the use of advanced software tools to process them and extract information. Computational linguistics - a discipline that has emerged on the border of computer science, linguistics and statistics - has achieved certain results in automated text analysis and information extraction, e.g., tools for part-of-speech tagging, grammar parsing, semantic role labelling, sentiment analysis and anaphora resolution have been developed and successfully used in many scientific projects. However, there still exists a gap between technology available and the needs of social sciences: named entity recognizers are incapable of identifying actors, sentiment analysis just provides the overall mood of an expression but is not able to identify the evaluation of information by the utterer, topic modeling tools can only assign a topic to a document, but fall short of measuring its frame.
Kontemporäre Service-orientierte Systeme sind hochgradig vernetzt und haben zudem die Eigenschaft massiv-skalierbar zu sein. Diese Charakteristiken stellen im besonderen Maße Anforderungen an die Datensicherheit der Anwender solcher Systeme und damit primär an alle Stakeholder der Softwareentwicklung, die in der Verantwortung sind, passgenaue Sicherheitsmechanismen effektiv in die Softwareprodukte zu bringen. Die Effektivität von Sicherheitsarchitekturen in service-orientierten Systemen hängt maßgeblich von der richtigen Nutzung und Integration von Security-APIs durch eine heterogene Gruppe von Softwareentwicklern ab, bei der nicht per se ein fundiertes Hintergrundwissen über komplexe digitale Sicherheitsmechanismen vorausgesetzt werden kann. Die Diskrepanz zwischen komplexen und in der Anwendung fehleranfälligen APIs und einem fehlenden Verständnis für die zugrundeliegenden Sicherheitskonzepte auf Seiten der Nutzer begünstigt in der Praxis unsichere Softwaresysteme. Aus diesem Grund ist die Gebrauchstauglichkeit von Security-APIs besonders relevant, damit Programmierer den benötigten Funktionsumfang effektiv, effizient und zufriedenstellend verwenden können. Abgeleitet von dieser Problemstellung, konzentriert sich das Dissertationsvorhaben auf die gebrauchstaugliche Ausgestaltung von Security-APIs und den Herausforderungen die sich aus den Methoden zur Evaluation der Usability in typischen Umgebungen der Softwareentwicklung ergeben.
The epithelial sodium channel (ENaC) is a critical regulator of vertebrate electrolyte homeostasis. ENaC is the only constitutively open ion channel in the degenerin/ENaC protein family, and its expression, membrane abundance, and open probability therefore are tightly controlled. The canonical ENaC is composed of three subunits (, , and ), but a fourth -subunit may replace and form atypical -ENaCs. Using Xenopus laevis as a model, here we found that mRNAs of the - and -subunits are differentially expressed in different tissues and that -ENaC predominantly is present in the urogenital tract. Using whole-cell and single-channel electrophysiology of oocytes expressing Xenopus - or -ENaC, we demonstrate that the presence of the -subunit enhances the amount of current generated by ENaC due to an increased open probability, but also changes current into a transient form. Activity of canonical ENaCs is critically dependent on proteolytic processing of the - and -subunits, and immunoblotting with epitope-tagged ENaC subunits indicated that, unlike -ENaC, the -subunit does not undergo proteolytic maturation by the endogenous protease furin. Furthermore, currents generated by -ENaC were insensitive to activation by extracellular chymotrypsin, and presence of the -subunit prevented cleavage of -ENaC at the cell surface. Our findings suggest that subunit composition constitutes an additional level of ENaC regulation, and we propose that the Xenopus -ENaC subunit represents a functional example that demonstrates the importance of proteolytic maturation during ENaC evolution.
Evolutionary conservation of the antimicrobial function of mucus: a first defence against infection
(2018)
Mucus layers often provide a unique and multi-functional hydrogel interface between the epithelial cells of organisms and their external environment. Mucus has exceptional properties including elasticity, changeable rheology and an ability to self-repair by reannealing, and is therefore an ideal medium for trapping and immobilising pathogens and serving as a barrier to microbial infection. The ability to produce a functional surface mucosa was an important evolutionary step, which evolved first in the Cnidaria, which includes corals, and the Ctenophora. This allowed the exclusion of non-commensal microbes and the subsequent development of the mucus-lined digestive cavity seen in higher metazoans. The fundamental architecture of the constituent glycoprotein mucins is also evolutionarily conserved. Although an understanding of the biochemical interactions between bacteria and the mucus layer are important to the goal of developing new antimicrobial strategies, they remain relatively poorly understood. This review summarises the physicochemical properties and evolutionary importance of mucus, which make it so successful in the prevention of bacterial infection. In addition, the strategies developed by bacteria to counteract the mucus layer are also explored.
This paper describes a dynamic, model-based approach for estimating intensities of 22 out of 44 different basic facial muscle movements. These movements are defined as Action Units (AU) in the Facial Action Coding System (FACS) [1]. The maximum facial shape deformations that can be caused by the 22 AUs are represented as vectors in an anatomically based, deformable, point-based face model. The amount of deformation along these vectors represent the AU intensities, and its valid range is [0, 1]. An Extended Kalman Filter (EKF) with state constraints is used to estimate the AU intensities. The focus of this paper is on the modeling of constraints in order to impose the anatomically valid AU intensity range of [0, 1]. Two process models are considered, namely constant velocity and driven mass-spring-damper. The results show the temporal smoothing and disambiguation effect of the constrained EKF approach, when compared to the frame-by-frame model fitting approach ‘Regularized Landmark Mean-Shift (RLMS)’ [2]. This effect led to more than 35% increase in performance on a database of posed facial expressions.