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Chain models as a tool to quantify the relation between soil, crop quality and human exposure
(2008)
„from stable to table“
(2008)
Durch natürliche und anthropogene Säureeinträge sind vor
allem auf naturnahen Standorten Mineleuropas, insbeson-
dere bei Waldböden, schwerwiegende und langfristig wirk-
same negative Veränderungen der Bodeneigenschaften, der
Bodenvegetation und teilweise auch der Qualität des Si-
ckerwassers und der Oberflächengewässer eingetreten
(Veerhoff et al. 1996). Die weitere Bodenentwicklung auf
solchen Standorten wird ganz wesentlich von der SNK und
den H'-Pufferraten der (noch) vorhandenen Bodenminerale
bestimmt. Um Prognosen über die zukünftige Entwicklung
machen zu können, wurden neun für Böden typische Mine-
rale auf ihr Pufferverhalten untersucht.
Chloritesare found in igneous rocks, and more commonly
in sediments and low grade metamorphic rocks (BrinJiey &
Brown 1980). Because chlorites are less stable than most of
the other clay minerals when placed into an acidic
environment (Barnhisel & Bertsch 1989), they play
significant roles in the solution chemistry and may be an
important source of magnesium and micronutrients in soils
(Ross 1975). The objective of the present study was to
compare the weathering behavior of different chlorites in
different chemical environments.
Mobilität und Bindungsformen von Cd, Cr, As und V in urbanen Böden unterschiedlicher Belastung
(1995)
Striated muscle contraction is regulated by the translocation of troponin-tropomyosin strands over the thin filament surface. Relaxation relies partly on highly-favorable, conformation-dependent electrostatic contacts between actin and tropomyosin, which position tropomyosin such that it impedes actomyosin associations. Impaired relaxation and hypercontractile properties are hallmarks of various muscle disorders. The α-cardiac actin M305L hypertrophic cardiomyopathy-causing mutation lies near residues that help confine tropomyosin to an inhibitory position along thin filaments. Here, we investigate M305L actin in vivo, in vitro, and in silico to resolve emergent pathological properties and disease mechanisms. Our data suggest the mutation reduces actin flexibility and distorts the actin-tropomyosin electrostatic energy landscape that, in muscle, result in aberrant contractile inhibition and excessive force. Thus, actin flexibility may be required to establish and maintain interfacial contacts with tropomyosin as well as facilitate its movement over distinct actin surface features and is, therefore, likely necessary for proper regulation of contraction.
RELA haploinsufficiency is a recently described autoinflammatory condition presenting with intermittent fevers and mucocutaneous ulcerations. The RELA gene encodes the p65 protein, one of five NF-κB family transcription factors. As RELA is an essential regulator of mucosal homeostasis, haploinsufficiency leads to decreased NF-κB signaling which promotes TNF-driven mucosal apoptosis with impaired epithelial recovery. Thus far, only eight cases have been reported in the literature. Here, we report four families with three novel and one previously described pathogenic variant in RELA. These four families included 23 affected individuals for which genetic testing was available in 16. Almost half of these patients had been previously diagnosed with more common rheumatologic entities (such as Behcet's Disease; BD) prior to the discovery of their pathogenic RELA variants. The most common clinical features were orogenital ulcers, rash, joint inflammation, and fever. The least common were conjunctivitis and recurrent infections. Clinical variability was remarkable even among familial cases, and incomplete penetrance was observed. Patients in our series were treated with a variety of medications, and benefit was observed with glucocorticoids, colchicine, and TNF inhibitors. Altogether, our work adds to the current literature and doubles the number of reported cases with RELA-Associated Inflammatory Disease (RAID). It reaffirms the central importance of the NF-κB pathway in immunity and inflammation, as well as the important regulatory role of RELA in mucosal homeostasis. RELA associated inflammatory disease should be considered in all patients with BD, particularly those with early onset and/or with a strong family history.
The deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessively inherited disease that has undergone extensive phenotypic expansion since being first described in patients with fevers, recurrent strokes, livedo racemosa, and polyarteritis nodosa in 2014. It is now recognized that patients may develop multisystem disease that spans multiple medical subspecialties. Here, we describe the findings from a large single center longitudinal cohort of 60 patients, the broad phenotypic presentation, as well as highlight the cohort's experience with hematopoietic cell transplantation and COVID-19. Disease manifestations could be separated into three major phenotypes: inflammatory/vascular, immune dysregulatory, and hematologic, however, most patients presented with significant overlap between these three phenotype groups. The cardinal features of the inflammatory/vascular group included cutaneous manifestations and stroke. Evidence of immune dysregulation was commonly observed, including hypogammaglobulinemia, absent to low class-switched memory B cells, and inadequate response to vaccination. Despite these findings, infectious complications were exceedingly rare in this cohort. Hematologic findings including pure red cell aplasia (PRCA), immune-mediated neutropenia, and pancytopenia were observed in half of patients. We significantly extended our experience using anti-TNF agents, with no strokes observed in 2026 patient months on TNF inhibitors. Meanwhile, hematologic and immune features had a more varied response to anti-TNF therapy. Six patients received a total of 10 allogeneic hematopoietic cell transplant (HCT) procedures, with secondary graft failure necessitating repeat HCTs in three patients, as well as unplanned donor cell infusions to avoid graft rejection. All transplanted patients had been on anti-TNF agents prior to HCT and received varying degrees of reduced-intensity or non-myeloablative conditioning. All transplanted patients are still alive and have discontinued anti-TNF therapy. The long-term follow up afforded by this large single-center study underscores the clinical heterogeneity of DADA2 and the potential for phenotypes to evolve in any individual patient.
Somatic Mutations in UBA1 Define a Distinct Subset of Relapsing Polychondritis Patients With VEXAS
(2021)
BACKGROUND
Biallelic loss-of-function variants in NCF1 lead to reactive oxygen species deficiency and chronic granulomatous disease (CGD). Heterozygosity for the p.Arg90His variant in NCF1 has been associated with susceptibility to systemic lupus erythematosus, rheumatoid arthritis, and Sjögren's syndrome in adult patients. This study demonstrates the association of the homozygous p.Arg90His variant with interferonopathy with features of autoinflammation and autoimmunity in a pediatric patient.
CASE PRESENTATION
A 5-year old female of Indian ancestry with early-onset recurrent fever and headache, and persistently elevated antinuclear, anti-Ro, and anti-La antibodies was found to carry the homozygous p.Arg90His variant in NCF1 through exome sequencing. Her unaffected parents and three other siblings were carriers for the mutant allele. Because the presence of two NCF1 pseudogenes, this variant was confirmed by independent genotyping methods. Her intracellular neutrophil oxidative burst and NCF1 expression levels were normal, and no clinical features of CGD were apparent. Gene expression analysis in peripheral blood detected an interferon gene expression signature, which was further supported by cytokine analyses of supernatants of cultured patient's cells. These findings suggested that her inflammatory disease is at least in part mediated by type I interferons. While her fever episodes responded well to systemic steroids, treatment with the JAK inhibitor tofacitinib resulted in decreased serum ferritin levels and reduced frequency of fevers.
CONCLUSION
Homozygosity for p.Arg90His in NCF1 should be considered contributory in young patients with an atypical systemic inflammatory antecedent phenotype that may evolve into autoimmunity later in life. The complex genomic organization of NCF1 poses a difficulty for high-throughput genotyping techniques and variants in this gene should be carefully evaluated when using the next generation and Sanger sequencing technologies. The p.Arg90His variant is found at a variable allele frequency in different populations, and is higher in people of South East Asian ancestry. In complex genetic diseases such as SLE, other rare and common susceptibility alleles might be necessary for the full disease expressivity.
Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies (NEDDFL), defined primarily by developmental delay/intellectual disability, speech delay, postnatal microcephaly, and dysmorphic features, is a syndrome resulting from heterozygous variants in the dosage-sensitive bromodomain PHD finger chromatin remodeler transcription factor BPTF gene. To date, only 11 individuals with NEDDFL due to de novo BPTF variants have been described. To expand the NEDDFL phenotypic spectrum, we describe the clinical features in 25 novel individuals with 20 distinct, clinically relevant variants in BPTF, including four individuals with inherited changes in BPTF. In addition to the previously described features, individuals in this cohort exhibited mild brain abnormalities, seizures, scoliosis, and a variety of ophthalmologic complications. These results further support the broad and multi-faceted complications due to haploinsufficiency of BPTF.
Mendelian diseases of dysregulated canonical NF-κB signaling: From immunodeficiency to inflammation
(2020)
Systemic autoinflammatory diseases (SAIDs) are a group of inflammatory disorders caused by dysregulation in the innate immune system that leads to enhanced immune responses. The clinical diagnosis of SAIDs can be difficult since individually these are rare diseases with considerable phenotypic overlap. Most SAIDs have a strong genetic background, but environmental and epigenetic influences can modulate the clinical phenotype. Molecular diagnosis has become essential for confirmation of clinical diagnosis. To date there are over 30 genes and a variety of modes of inheritance that have been associated with monogenic SAIDs. Mutations in the same gene can lead to very distinct phenotypes and can have different inheritance patterns. In addition, somatic mutations have been reported in several of these conditions. New genetic testing methods and databases are being developed to facilitate the molecular diagnosis of SAIDs, which is of major importance for treatment, prognosis and genetic counselling. The aim of this review is to summarize the latest advances in genetic testing for SAIDs and discuss potential obstacles that might arise during the molecular diagnosis of SAIDs.
The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar to the "guard" mechanism in plants. Rho GTPases act as molecular switches to regulate a variety of signal transduction pathways including cytoskeletal organization. Pathogens can modulate Rho GTPase activity to suppress host immune responses such as phagocytosis. Pyrin is encoded by MEFV, the gene that is mutated in patients with familial Mediterranean fever (FMF). FMF is the prototypic autoinflammatory disease characterized by recurring short episodes of systemic inflammation and is a common disorder in many populations in the Mediterranean basin. Pyrin specifically senses modifications in the activity of the small GTPase RhoA, which binds to many effector proteins including the serine/threonine-protein kinases PKN1 and PKN2 and actin-binding proteins. RhoA activation leads to PKN-mediated phosphorylation-dependent pyrin inhibition. Conversely, pathogen virulence factors downregulate RhoA activity in a variety of ways, and these changes are detected by the pyrin inflammasome irrespective of the type of modifications. MEFV pathogenic variants favor the active state of pyrin and elicit proinflammatory cytokine release and pyroptosis. They can be inherited either as a dominant or recessive trait depending on the variant's location and effect on the protein function. Mutations in the C-terminal B30.2 domain are usually considered recessive, although heterozygotes may manifest a biochemical or even a clinical phenotype. These variants are hypomorphic in regard to their effect on intramolecular interactions, but ultimately accentuate pyrin activity. Heterozygous mutations in other domains of pyrin affect residues critical for inhibition or protein oligomerization, and lead to constitutively active inflammasome. In healthy carriers of FMF mutations who have the subclinical inflammatory phenotype, the increased activity of pyrin might have been protective against endemic infections over human history. This finding is supported by the observation of high carrier frequencies of FMF-mutations in multiple populations. The pyrin inflammasome also plays a role in mediating inflammation in other autoinflammatory diseases linked to dysregulation in the actin polymerization pathway. Therefore, the assembly of the pyrin inflammasome is initiated in response to fluctuations in cytoplasmic homeostasis and perturbations in cytoskeletal dynamics.
The generation and maintenance of intricate spatiotemporal patterns of gene expression in multicellular organisms requires the establishment of complex mechanisms of transcriptional regulation. Estimations that up to one million enhancers exist in the human genome accentuates the utmost importance of this type of cis-regulatory element for gene regulation. However, surprisingly little is known about the mechanisms used to temporarily or permanently activate or inactivate enhancers during cellular differentiation. The current work addresses the question how enhancer regulation can be achieved.
Using the chemokine (C-C motif) ligand gene Ccl22 as a model, the first example is based on the question how the activation of an enhancer can be prevented in a physiological context. Ccl22 is expressed by myeloid cells, such as dendritic cells, upon exposure to inflammatory stimuli. The expression in other cell types, such as fibroblasts, is prevented by the strong accumulation of H3K9me3 at the enhancer's proximal region. This accumulation is attenuated in myeloid cells through activity of the stimulus-induced demethylase Jmjd2d. To tease out which genomic fragment or fragments in the Ccl22 locus could be responsible for the maintenance of enhancer inactivity, potentially through the recruitment of H3K9 methyltransferases, the enhancer repressing capacity of 1 kb fragments of the gene locus was analysed in retroviral reporter assays. It was found that a fragment adjacent to the Ccl22 enhancer that overlaps with a member of a subfamily of long interspersed nuclear elements (LINEs) showed strong repressive potential on a model enhancer. Subsequent retroviral reporter assays with LINEs from loci of other stimulus-dependent genes identified additional LINE fragments that exhibit strong enhancer repressive capacity. These findings suggest a mechanism for enhancer silencing involving LINEs.
The second example concentrates on the inactivation of an enhancer during colorectal cancer (CRC) progression. The adenoma to carcinoma transition during CRC progression often is accompanied by a downregulation of the tumour suppressor gene EPHB2. The EMT inducing factor SNAIL1 strongly downregulated EPHB2 expression in a CRC cell model. To gain insights into the transcriptional regulation of EPHB2, potential cis-regulatory elements in the EPHB2 upstream region were analysed using reporter assays. A cell-type-specific enhancer was identified and subsequent chromatin analyses revealed a correlation between enhancer chromatin conformation and EPHB2 expression in different CRC cell lines. Additionally, the overexpression of the murine Snail1 induced chromatin changes at the EPHB2 enhancer towards a poised, transcriptionally silent chromatin conformation. Mutational analyses of the minimal enhancer region pinpointed three transcription factor binding motifs to be essential for full enhancer activity. Different binding patterns between CRC cell lines at the TCF/LEF motif were subsequently identified. Furthermore, a switch from TCF7L2 to LEF1 occupancy was found upon overexpression of Snail1 in vitro and in vivo. The generation of LS174T CRC cells overexpressing LEF1 confirmed the involvement of LEF1 in the downregulation of EPHB2 and the competitive displacement of TCF7L2. This part of the work demonstrated that the SNAIL1 induced downregulation of EPHB2 is dependent on the decommissioning of a transcriptional enhancer and led to a hypothetical model involving LEF1 and ZEB1.
In summary, this work highlighted two distinct mechanisms for enhancer regulation. One mechanism is based on enhancer repressive LINE fragments that might prevent stimulus-dependent enhancer activation. In the second, enhancer silencing was shown to be based on a competitive transcription factor binding mechanism.
The access to electricity and water in rural areas in Côte d’Ivoire as well as in large parts of Africa is limited. According to Ivorian government sources, the national coverage rate of drinkable water and electricity was about 80% in 2020, whereas there are differences between rural and urban regions. The coverages are lower in rural areas that are situated far from the governmental infrastructures. The poor supply of electricity also hinders education, since petroleum lamps are often the only source of light for learning after sunset. Besides, increasing demand for electricity is predicted in Côte d’Ivoire due to economic growth. The economic power is also affected by the poor supply of electricity, so only a limited production of goods is possible. A further big concern in Côte d’Ivoire is the employability of graduate students, as the educational system has a strong theoretic character, not yet taking enough into account practice orientation. Scientific public universities in Côte d'Ivoire often offer only subjects such as mathematics, physics, or chemistry but hardly any engineering.
The paper investigates the nature of Kenya's entrepreneurship education ecosystem (EEE) through a comparative analysis of three entrepreneurship education programs and an examination of how the institutions foster a favourable entrepreneurial environment. This study looks at the entrepreneurship education ecosystem through the lens of universities, NGO's and private institutes in Kenya.
A systemic analysis of EEE is provided by utilizing the Actiotope Model as a conceptual framework. The exploratory research adopts a pragmatic mixed-method methodological approach best suited to understand the research problem.
The results reveal that entrepreneurship education at higher education institutions was primarily theoretical and relied on traditional forms of entrepreneurship education. Recurring rigid patterns show minimal personalization of content and learning styles within the University, with more personalization reported in the Mully Model of education and the more specialized entrepreneurship program of the Identity Projects.
The adaptation of the Actiotope Model provided a new and unique approach to analyzing entrepreneurship ecosystems. The person-centred approach of the model provides valuable insights to learners and to entrepreneurship education institutions and researchers.
Enhanced collaboration between the different entrepreneurial education stakeholders could be a more effective short to medium-term solution to addressing the gaps in entrepreneurial education at tertiary institutions.
In the long term, the study recommends adopting practical-based and goal-oriented entrepreneurship teaching models.
Social businesses have a great positive impact on communities and are a sustainable way to do business today and in the future. This impact can be amplified through the means of digitalization. In the past, traditional for-profit business models have been used to understand the structures of business operations. However, the underlying business model of digital social businesses has not yet been explored. This study presents a building block analysis of business models and a subsequent typology. Digital and social business models are identified via a literature review. The building block analysis encompasses an assessment of the individual business activities contained in the business models. The typology is developed from existing literature utilizing a matrix for the evaluation of digital social businesses. Additionally, five semi-structured expert interviews are conducted to inform, extend, or content the findings of this study. To this end, an inductive coding procedure is applied to the transcribed interviews for the detection of themes within the text. This study contributes to social business model research by providing a first insight into the unique building blocks of digital social business models. It also creates a typology tool based on two parameters, which enables the comparison of digital social businesses.
Mobile technologies have evolved into the means of gaining access to information for learning. Its application in higher education is still a novel concept, particularly in underdeveloped countries. This study is aimed at exploring the views of doctoral students regarding their learning experiences with mobile technologies. Student focus group interviews of 24 doctoral students from 3 different academic institutions were interviewed. The participants’ responses were recorded, transcribed, and analyzed to make conclusions. According to the findings of this study, mobile devices play an important part in the learning experiences of doctoral students. The participating students engaged in collaborative learning using mobile technologies. Given the benefits of adopting mobile technologies for learning activities, academic institutions should focus on teaching faculty members to use this to involve students in their learning process. The implications of this study call for the continued advancement of mobile technologies to facilitate effective learning experience for the multitude of mobile learners in developing countries. Another implication is that academic institutions with collaboration with libraries should see the need to develop user friendly mobile app that is linked to the library management system. Such an application would allow the students to optimally use their smartphones and tablets to search the library’s resources from their mobile devices. Training should be offered to the teaching faculty members to come to terms with the benefits of mobile technologies for learning activities.
The differentiation of the higher education sector in Ethiopia has created a new sector of Higher Education Institutions: Universities of Applied Sciences (UAS). Its focus is on educating academically trained experts for regional industries. Close cooperation between industries and UAS is set as a key requirement. However, Ethiopian industries in many regions are not developed enough that those could be considered as active partners for UASs and able to accommodate interns or to provide expert teachers to UAS classes. European UAS structures serve as benchmarks for the Ethiopian Ministry of Education (MoE). Therefore, UAS curricula of study programmes in building-construction, electro-engineering and economic/business/tourism from different European countries build a common ground for Ethiopian UASs. But, due to the lack of industries in the regions, Ethiopian UAS are not able to mirror the European counterparts, where study programmes at bachelor level comprise 70 credits out or 210 credits as practical works, internships and bachelor thesis. - The question is, how can Ethiopian UASs in the absence of companies offer practice-oriented education in their study programmes? This paper refers to the ongoing research, on how to integrate UAS (academic and non-academic) departments at UAS campuses to create internship placements for students in the absence of internship placements in the private sector. Kotebe University of Education (KUE) - as one of the newly founded UAS in Ethiopia - has agreed to act as subject of this try-out.
Rapid and sustained innovation in developed markets triggers the generation of innovative start-ups, some with disruptive innovations. However, when their offering faces a saturated market with satisfactory and widely available established traditional solutions, many innovative start-ups from these markets may fail. The literature on some start-ups that successfully brought their innovation to emerging markets shows how using leapfrogging traditional solutions to innovative solutions can offer survival and growth opportunities to these start-ups. However, a wide exploitation of leapfrogging processes in emerging markets for survival or business growth of innovative start-ups from developed markets is not yet theorized. To contribute to closing this gap, we propose a conceptual framework to assess the readiness of an emerging market to leapfrog to innovative solutions.
The design of the conceptual framework uses a scenario-planning like approach with two key factors, namely Context Readiness and Value Network Integration. To test and refine the proposed framework and show its relevance for coming to an informed expansion decision making, we used PAR (Participatory Action Research). For the illustration of the application of the proposed conceptual framework, the case of telehealth in Morocco is used.
Tourism in Rwanda is challenging. Since the country is small and hilly, it is difficult to tap the potential. As the country is blessed with diverse nature, the Rwandan government decided to combine ecotourism with high-end tourism, to exploit the full potential. This study aims to assess the extent to which these two types of tourism fit together, as well as if sustainability is a decisive argument in this upscale segment. In this context, ecotourism is characterized by its 3 core criteria: education, nature and sustainability. To evaluate the main question: to what extent can ecotourism projects help to promote the perception of Rwanda as a high-end tourist destination on the German market? As well as if sustainability is a decisive argument, interviews with stakeholder from the Rwandan tourism industry as well as German tour operators were conducted, to gain an understanding of both sites and then evaluate them according to the 3 ecotourism core criteria and the demands of high-end tourists. The results showed that there is a difference in the perception of the needs of high-end tourists. While the 3 core criteria seem to be too relevant while they are in booking decision with the tour operator. The high-end lodges in Rwanda state an interest in these three criteria. It is evident from the results that there is a limited active demand for sustainable tourist products, while nature and education are more relevant, but not yet fully exploited. However, all interviewees indicated that ecotourism, and in particular sustainability, is experiencing an increase in demand and will continue to grow in importance in the future. Accordingly, the results suggest the driving markets approach is relevant to further drive demand in that segment.
As a developing economy, Rwanda has been exploring transitioning to being a technologically driven and sustainable economy. Moreover, research on economic growth have focused on the need to improve human capacity potential within increasing demands of climate change activists but there remains a theoretic and practical lacuna in including renewable energy resources in economic growth and expansion of electricity access. Therefore, it is necessary to study the impact of competent skill acquisition and graduate employment market on the interaction mix between economic growth and the expansion of energy access in Rwanda, particularly finding out the problems advancing the non-inclusiveness of engineering graduates, which result to high rate of unemployment and diversions, especially for the graduates specializing in energy fields. As a result, the following open questions were raised with variations 1; how did employees penetrate energy-sector labour market opportunity in Rwanda? 2; what influenced employee’s decision in pursuing a career in Rwanda’s labour market, 3; what were the specific employee competent skills that enabled smooth transition in energy-sector employment after graduation and the ones required to maintain their current positions? 4; what specific competent skills are required for inclusivity of today's engineering graduates in energy sector employment market? The study is qualitative and it uses the exploratory research design. It is based on the growth pole theory employing snowball/chain purposeful sampling technique, whereby key informants in Rwanda energy sector were located. Data was specifically collected from these primary sources through semi-structured interviews and documentary method. Interview data and text from documents were inductively analysed. The study generally recommended institution or program for connecting learning institutions, industry and employment market in the distributed and renewable energy resources to promote competent skills acquisition, competition and improve graduates’ inclusiveness in the expansion of electricity access, thereby leading to economic growth in Rwanda.
While 14 % of the world's working-age population currently lives in sub-Saharan Africa (SSA), this figure will predictably be higher than the rest of the world combined by 2036. If this demographic group finds meaningful employment, Africa experiences an economic and social upswing. To tap this potential, the paper intends to answer the research question, "What are the prerequisites and how are they defined for the successful implementation of sustainable business model ideas in SSA?", by developing a top ten ranking consisting of previously identified sustainable business model ideas best suited for productive use. This achieves a novel approach to implementing future-oriented business models and contributes to current research on sustainable models. Since the geographical scope of SSA is pervasive, this paper focuses on Namibia, Rwanda, Senegal, and Uganda. An extensive literature review on these countries was conducted to gain a broader understanding of the situation in SSA. Additionally, research was carried out on the agricultural, energy, and information and communications technology (ICT) sectors to identify the most promising ideas. To contribute to current knowledge, experts were interviewed, and panel discussions were analyzed. Furthermore, the Business Model Canvas (BMC) was combined with the circular economy concept, which served as a framework for the business model ideas. Experts evaluated these ideas, which were subsequently ranked using fuzzy logic with artificial intelligence, based on the system for exploring country risks (CRISK-Explorer). The paper shows that skipping individual development processes opens up promising opportunities, such as the ICT-based business model e-crowd logistics or the renewable energy-based model e-Boda-Boda. Seven prerequisites for the successful implementation of these ideas were identified and defined: value delivery, promising customers, sufficient capital, presence of key resources, possibility to perform the key activities, sustainability, and profitability. The paper concludes by identifying limitations and suggesting avenues for future research.
Channels of distribution are important factors in the connection between goods and services produced for the final consumer and, therefore, determine the effectiveness with which they are delivered and ultimately availed to the final consumers. Globally, studies show that channels of distribution and sales play an essential role in building bonds between manufacturers, retailers, wholesalers and their consumers. The main purpose of this study is to examine the influence of distribution channels and networks on customer choice of fast-moving consumer goods (FCMG) in the Upper East Region of Ghana. The study adopted a quantitative approach and questionnaires were used to collect primary data from 110 customers of Unilever Ghana Limited in the Upper East Region of Ghana. The findings reveal that product-related factors, such as the price of products, perishability of products, size and weight of products, promote the effective distribution of Unilever goods and services, whilst consumer-related factors, such as the number of customers and increased consumer base, promote effective distribution channels. The study also established a positive influence of factors, such as incentives, receiving feedback and sales performance, on customer choice of fast-moving consumer goods (FMCG). Managers and producers in the FMCGs industry should implement reward and incentive programmes and policies to boost the sale and distribution of fast-moving consumer goods and services in the retail industry in Ghana.
Entrepreneurship is labelled as the panacea for graduate unemployment in Ghana. In the training process, students are mandatorily required to read a course in entrepreneurship, so as to be able to start their own businesses in the face of job adversities caused by the inadequacy of job opportunities created by government and lack of government drive to diversify the economy for more jobs to be created. This study, therefore aimed at investigating the critical precursors of entrepreneurial intentions among higher education students in Ghana. Using the analytical cross-sectional survey design, 250 respondents were recruited from public universities using probability sampling techniques (stratified-disproportionate and simple random) to participate in the survey. Respondents were required to respond to three constructs (entrepreneurial scaffolding, psychological capital, and entrepreneurial intentions). The data analyses were performed using multivariate regression. The study findings showed that entrepreneurial scaffolding and psychological capital were significant predictors of entrepreneurial intentions. The researchers concluded that students' convictions in succeeding or otherwise and planning to engage in entrepreneurial behaviours depended on proper entrepreneurial guidance and a positive mind-set. Therefore, it was recommended that higher education institutions in Ghana strengthened and included practical guides to entrepreneurial training. This will encourage higher education students to consider entrepreneurship, hence, reducing graduate unemployment in Ghana.
The dawn of the 21st Century has witnessed a tremendous increase in trade pacts among nations, resulting in renewed hopes for sustainable enterprise development in emerging economies worldwide. Ghana and other sub- Saharan African (SSA) countries have signed onto several North-South and South-South free trade agreements with the hope of strengthening their presence in the international trade arena, and to promote economic growth in SSA. For over two decades, however, very little has changed, and many have dashed their high hopes as enterprises continue to struggle in SSA. Not even the African Continental Free Trade Agreement (AfCFTA) could renew the hopes of sceptics. Several studies opined that enterprises in SSA could improve their domestic and international competitiveness by establishing mutually beneficial partnerships with their counterparts from the Global North and South. This study delved into the issues that affect North-South and South-South business collaborations and recommends key success factors that could help promote mutually beneficial cross-border business partnerships. The research includes both literature and empirical information on the key success factors of business partnerships between African enterprises as well as between African enterprises and firms from the Global North. We approached the study qualitatively using a phenomenological research design. Research participants included important stakeholders in Africa and Europe's international trade and sustainable enterprise development ecosystem. The study identified several challenges with the current business collaborations and recommended new ways of making such partnerships more beneficial.
Introduction: Antimicrobial resistance (AMR) has emerged as one of the leading threats to public health. AMR possesses a multidimensional challenge that has social, economic, and environmental dimensions that encompass the food production system, influencing human and animal health. The One Health approach highlights the inextricable linkage and interdependence between the health of people, animals, agriculture, and the environment. Antibiotic use in any of these One Health areas can potentially impact the health of other areas. There is a dearth of evidence on AMR from the natural environment, such as the plant-based agriculture sector. Antibiotics, antibiotic-resistant bacteria (ARB), and related AMR genes (ARGs) are assumed to present in the natural environment and disseminate resistance to fresh produce/vegetables and thus to human health upon consumption. Therefore, this study aims to investigate the role of vegetables in the spread of AMR through an agroecosystem exploration from a One Health perspective in Ahmedabad, India.
Protocol: The present study will be executed in Ahmedabad, located in Gujarat state in the Western part of India, by adopting a mixed-method approach. First, a systematic review will be conducted to document the prevalence of ARB and ARGs on fresh produce in South Asia. Second, agriculture farmland surveys will be used to collect the general farming practices and the data on common vegetables consumed raw by the households in Ahmedabad. Third, vegetable and soil samples will be collected from the selected agriculture farms and analyzed for the presence or absence of ARB and ARGs using standard microbiological and molecular methods.
Discussion: The analysis will help to understand the spread of ARB/ARGs through the agroecosystem. This is anticipated to provide an insight into the current state of ARB/ARGs contamination of fresh produce/vegetables and will assist in identifying the relevant strategies for effectively controlling and preventing the spread of AMR.
In recent years, the ability of intelligent systems to be understood by developers and users has received growing attention. This holds in particular for social robots, which are supposed to act autonomously in the vicinity of human users and are known to raise peculiar, often unrealistic attributions and expectations. However, explainable models that, on the one hand, allow a robot to generate lively and autonomous behavior and, on the other, enable it to provide human-compatible explanations for this behavior are missing. In order to develop such a self-explaining autonomous social robot, we have equipped a robot with own needs that autonomously trigger intentions and proactive behavior, and form the basis for understandable self-explanations. Previous research has shown that undesirable robot behavior is rated more positively after receiving an explanation. We thus aim to equip a social robot with the capability to automatically generate verbal explanations of its own behavior, by tracing its internal decision-making routes. The goal is to generate social robot behavior in a way that is generally interpretable, and therefore explainable on a socio-behavioral level increasing users' understanding of the robot's behavior. In this article, we present a social robot interaction architecture, designed to autonomously generate social behavior and self-explanations. We set out requirements for explainable behavior generation architectures and propose a socio-interactive framework for behavior explanations in social human-robot interactions that enables explaining and elaborating according to users' needs for explanation that emerge within an interaction. Consequently, we introduce an interactive explanation dialog flow concept that incorporates empirically validated explanation types. These concepts are realized within the interaction architecture of a social robot, and integrated with its dialog processing modules. We present the components of this interaction architecture and explain their integration to autonomously generate social behaviors as well as verbal self-explanations. Lastly, we report results from a qualitative evaluation of a working prototype in a laboratory setting, showing that (1) the robot is able to autonomously generate naturalistic social behavior, and (2) the robot is able to verbally self-explain its behavior to the user in line with users' requests.
Introduction. The experience of pain is regularly accompanied by facial expressions. The gold standard for analyzing these facial expressions is the Facial Action Coding System (FACS), which provides so-called action units (AUs) as parametrical indicators of facial muscular activity. Particular combinations of AUs have appeared to be pain-indicative. The manual coding of AUs is, however, too time- and labor-intensive in clinical practice. New developments in automatic facial expression analysis have promised to enable automatic detection of AUs, which might be used for pain detection. Objective. Our aim is to compare manual with automatic AU coding of facial expressions of pain. Methods. FaceReader7 was used for automatic AU detection. We compared the performance of FaceReader7 using videos of 40 participants (20 younger with a mean age of 25.7 years and 20 older with a mean age of 52.1 years) undergoing experimentally induced heat pain to manually coded AUs as gold standard labeling. Percentages of correctly and falsely classified AUs were calculated, and we computed as indicators of congruency, "sensitivity/recall," "precision," and "overall agreement (F1)." Results. The automatic coding of AUs only showed poor to moderate outcomes regarding sensitivity/recall, precision, and F1. The congruency was better for younger compared to older faces and was better for pain-indicative AUs compared to other AUs. Conclusion. At the moment, automatic analyses of genuine facial expressions of pain may qualify at best as semiautomatic systems, which require further validation by human observers before they can be used to validly assess facial expressions of pain.