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- 2010 (248) (remove)
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Gebührenordnung der Hochschul- und Kreisbibliothek der Hochschule Bonn-Rhein-Sieg vom 18.02.2010
(2010)
Wesch D, Miranda P, Afonso-Oramas D, Althaus M, Castro-Hernandez J, Dominguez J, Morty RE, Clauss W, Gonzalez-Hernandez T, Alvarez de la Rosa D, Giraldez T. The neuronalspecific SGK1.1 kinase regulates delta-epithelial Na+ channel independently of PY motifs and couples it to phospholipase C signaling. Am J Physiol Cell Physiol 299: C779-C790, 2010. First published July 14, 2010; doi:10.1152/ajpcell.00184.2010.-The delta-subunit of the epithelial Na+ channel (ENaC) is expressed in neurons of the human and monkey central nervous system and forms voltage-independent, amiloride-sensitive Na+ channels when expressed in heterologous systems. It has been proposed that delta-ENaC could affect neuronal excitability and participate in the transduction of ischemic signals during hypoxia or inflammation. The regulation of delta-ENaC activity is poorly understood. ENaC channels in kidney epithelial cells are regulated by the serum-and glucocorticoid-induced kinase 1 (SGK1). Recently, a new isoform of this kinase (SGK1.1) has been described in the central nervous system. Here we show that delta-ENaC isoforms and SGK1.1 are coexpressed in pyramidal neurons of the human and monkey (Macaca fascicularis) cerebral cortex. Coexpression of delta beta gamma-ENaC and SGK1.1 in Xenopus oocytes increases amiloride-sensitive current and channel plasma membrane abundance. The kinase also exerts its effect when delta-subunits are expressed alone, indicating that the process is not dependent on accessory subunits or the presence of PY motifs in the channel. Furthermore, SGK1.1 action depends on its enzymatic activity and binding to phosphatidylinositol(4,5)-bisphosphate. Physiological or pharmacological activation of phospholipase C abrogates SGK1.1 interaction with the plasma membrane and modulation of delta-ENaC. Our data support a physiological role for SGK1.1 in the regulation of delta-ENaC through a pathway that differs from the classical one and suggest that the kinase could serve as an integrator of different signaling pathways converging on the channel.
Die Erfindung befasst sich mit einer Sicherheitsvorrichtung zur Verhinderung von Unfällen mit Personenschäden durch Maschinen, die ein Flächenelement enthält, welches auf der Oberfläche des Bereichs des Roboters, innerhalb dessen ein Unfall verhindert werden soll, durch ein Gelenk beweglich angeordnet ist. Des Weiteren weist die Sicherheitsvorrichtung Sensoren auf, die unter dem Flächenelement angeordnet sind und die Verkippung des Flächenelements erfassen.
Die Debatte um muslimische Einwandernde in Deutschland, die in jüngster Zeit neuen Auftrieb erhalten hat (1), offenbart immer wieder simplifizierende Sichtweisen vom Islam als einer homogenen Religion. Dabei beweist bereits ein Blick auf die vielfältige muslimische Organisationslandschaft in Deutschland: Es gibt nicht den Islam, sondern stattdessen eine Vielzahl unterschiedlicher islamischer Strömungen, welche mitunter in Konkurrenz zu einander stehen und sich mal mehr, mal weniger deutlich voneinander abgrenzen. Diese Vielfalt der MuslimInnen in Deutschland sowie ihr eher geringer Organisationsgrad erschwert die Bildung eines zentralen islamischen Ansprechpartners, der für sich in Anspruch nehmen könnte, für die Mehrheit der MuslimInnen in Deutschland zu sprechen.
Usable Security und Privacy
(2010)
When entering a password (or other secrets) the typed input is most commonly masked, i.e. the characters are hidden behind bullets or asterisks. This, however, complicates the input and highly decreases the user's confident causing several issues such as login failure attempts. On the other hand, password masking is an important security requirement for a lot of applications and contexts to prevent a third person to read the password. Thus, simply dropping password masking is not feasible in general. A common solution provides the user with the choice of toggling password masking on and off, but due to distinct defaults (in dependency of the application and context) this is rather complex and confusing. Enhanced password visualization technologies beyond the simple masking of passwords can provide more sophisticated solutions from both a usability and security perspective. In this paper, available password visualization technologies are presented and discussed. Furthermore a novel password visualization approach is introduced, the TransparentMask, which provides unique properties in comparison to the existing schemes. Amongst these are the ability to detect mistakes while typing and being able to localize and correct the typo within a certain range. Finally, a security analysis of the TransparentMask shows that the protection level given by a certain password length is slightly decreased in comparison to the fully masked approach.
Publikation von Umweltdaten
(2010)
Workflow Management
(2010)
Standard Software
(2010)
Sourcing
(2010)