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The European General Data Protection Regulation requires the implementation of Technical and Organizational Measures (TOMs) to reduce the risk of illegitimate processing of personal data. For these measures to be effective, they must be applied correctly by employees who process personal data under the authority of their organization. However, even data processing employees often have limited knowledge of data protection policies and regulations, which increases the likelihood of misconduct and privacy breaches. To lower the likelihood of unintentional privacy breaches, TOMs must be developed with employees’ needs, capabilities, and usability requirements in mind. To reduce implementation costs and help organizations and IT engineers with the implementation, privacy patterns have proven to be effective for this purpose. In this chapter, we introduce the privacy pattern Data Cart, which specifically helps to develop TOMs for data processing employees. Based on a user-centered design approach with employees from two public organizations in Germany, we present a concept that illustrates how Privacy by Design can be effectively implemented. Organizations, IT engineers, and researchers will gain insight on how to improve the usability of privacy-compliant tools for managing personal data.
Users should always play a central role in the development of (software) solutions. The human-centered design (HCD) process in the ISO 9241-210 standard proposes a procedure for systematically involving users. However, due to its abstraction level, the HCD process provides little guidance for how it should be implemented in practice. In this chapter, we propose three concrete practical methods that enable the reader to develop usable security and privacy (USP) solutions using the HCD process. This chapter equips the reader with the procedural knowledge and recommendations to: (1) derive mental models with regard to security and privacy, (2) analyze USP needs and privacy-related requirements, and (3) collect user characteristics on privacy and structure them by user group profiles and into privacy personas. Together, these approaches help to design measures for a user-friendly implementation of security and privacy measures based on a firm understanding of the key stakeholders.
Selection Performance and Reliability of Eye and Head Gaze Tracking Under Varying Light Conditions
(2024)
Is It Really You Who Forgot the Password? When Account Recovery Meets Risk-Based Authentication
(2024)
Introduction: A multitude of findings from cell cultures and animal studies are available to support the anti-cancer properties of cannabidiol (CBD). Since CBD acts on multiple molecular targets, its clinical adaptation, especially in combination with cancer immunotherapy regimen remains a serious concern.
Methods: Considering this, we extensively studied the effect of CBD on the cytokine-induced killer (CIK) cell immunotherapy approach using multiple non-small cell lung cancer (NSCLC) cells harboring diverse genotypes.
Results: Our analysis showed that, a) The Transient Receptor Potential Cation Channel Subfamily V Member 2 (TRPV2) channel was intracellularly expressed both in NSCLC cells and CIK cells. b) A synergistic effect of CIK combined with CBD, resulted in a significant increase in tumor lysis and Interferon gamma (IFN-g) production. c) CBD had a preference to elevate the CD25+CD69+ population and the CD62L_CD45RA+terminal effector memory (EMRA) population in NKT-CIK cells, suggesting early-stage activation and effector memory differentiation in CD3+CD56+ CIK cells. Of interest, we observed that CBD enhanced the calcium influx, which was mediated by the TRPV2 channel and elevated phosphor-Extracellular signal-Regulated Kinase (p-ERK) expression directly in CIK cells, whereas ERK selective inhibitor FR180204 inhibited the increasing cytotoxic CIK ability induced by CBD. Further examinations revealed that CBD induced DNA double-strand breaks via upregulation of histone H2AX phosphorylation in NSCLC cells and the migration and invasion ability of NSCLC cells suppressed by CBD were rescued using the TRPV2 antagonist (Tranilast) in the absence of CIK cells. We further investigated the epigenetic effects of this synergy and found that adding CBD to CIK cells decreased the Long Interspersed Nuclear Element-1 (LINE-1) mRNA expression and the global DNA methylation level in NSCLC cells carrying KRAS mutation. We further investigated the epigenetic effects of this synergy and found that adding CBD to CIK cells decreased the Long Interspersed Nuclear Element-1 (LINE-1) mRNA expression and the global DNA methylation level in NSCLC cells carrying KRAS mutation.
Conclusions: Taken together, CBD holds a great potential for treating NSCLC with CIK cell immunotherapy. In addition, we utilized NSCLC with different driver mutations to investigate the efficacy of CBD. Our findings might provide evidence for CBD-personized treatment with NSCLC patients.
Self-motion perception is a multi-sensory process that involves visual, vestibular, and other cues. When perception of self-motion is induced using only visual motion, vestibular cues indicate that the body remains stationary, which may bias an observer’s perception. When lowering the precision of the vestibular cue by for example, lying down or by adapting to microgravity, these biases may decrease, accompanied by a decrease in precision. To test this hypothesis, we used a move-to-target task in virtual reality. Astronauts and Earth-based controls were shown a target at a range of simulated distances. After the target disappeared, forward self-motion was induced by optic flow. Participants indicated when they thought they had arrived at the target’s previously seen location. Astronauts completed the task on Earth (supine and sitting upright) prior to space travel, early and late in space, and early and late after landing. Controls completed the experiment on Earth using a similar regime with a supine posture used to simulate being in space. While variability was similar across all conditions, the supine posture led to significantly higher gains (target distance/perceived travel distance) than the sitting posture for the astronauts pre-flight and early post-flight but not late post-flight. No difference was detected between the astronauts’ performance on Earth and onboard the ISS, indicating that judgments of traveled distance were largely unaffected by long-term exposure to microgravity. Overall, this constitutes mixed evidence as to whether non-visual cues to travel distance are integrated with relevant visual cues when self-motion is simulated using optic flow alone.
Protocol for conducting advanced cyclic tests in lithium-ion batteries to estimate capacity fade
(2024)
Using advanced cyclic testing techniques improves accuracy in estimating capacity fade and incorporates real-world scenarios in battery cycle aging assessment. Here, we present a protocol for conducting cyclic tests in lithium-ion batteries to estimate capacity fade. We describe steps for implementing strategies for accounting for variations in rest periods, charge-discharge rates, and temperatures. We also detail procedures for validating tests experimentally within a climate-controlled chamber and for developing an empirical model to estimate capacity fading under various testing objectives. For complete details on the use and execution of this protocol, please refer to Mulpuri et al.1.
Sustainable urban soil management is becoming increasingly crucial due to its vital role in climate and water regulation and its significant potential for storing soil organic carbon (SOC). This significance is emphasized considering the ongoing urbanization and climate change issues. Although SOC is influenced by many factors, such as soil type and climate fluctuations (temperature, precipitation patterns), on a regional scale, land use and management practices (e.g., fertilization, irrigation) can have a more significant impact on SOC storage and the balance of soil-atmosphere carbon fluxes. However, there is still a limited understanding of the amount of humus content in urban soils and the effects of urban development and management practices on soil health and carbon storage. We investigated how management practices in urban green spaces influence soil carbon storage as the primary indicator of soil health.
The present study was carried out in the Bonn-Rhein-Sieg area, as the region is vital in terms of sustainable urban and regional development with a high population density (Rhein-Sieg district: 338.4, Bonn: 520.9 inhabitants/km2) in Germany. A survey was conducted with owners and managers of urban private (e.g., allotment and backyard garden) and public green spaces on the practices for the most common vegetation types (e.g., lawn, vegetable, ornamental). In the autumn and winter of 2022, 248 soil samples (0–20 cm depth) were collected from 95 private and public green spaces in the study area and analyzed for physiochemical and biological properties. Multivariate Analysis of Variance (MANOVA) was performed to assess the effects of different management practices on soil properties.
Our results indicate that the average SOC stock in public green areas (94.67 Mg ha-1) is substantially higher than in private ones (house garden 67.72 Mg ha-1, allotment garden 73.15 Mg ha-1). Moreover, urban green spaces with vegetables (91.66 Mg ha-1) and ornamentals (85.05 mg ha-1) show greater SOC stock levels when comparing vegetation types (lawn 62.48 Mg ha-1). Significant differences in SOC are also found for various management practices. Specifically, the monthly fertilization schedule resulted in higher SOC levels (127.37 Mg ha⁻¹) compared to the yearly fertilization schedule (76.88 Mg ha⁻¹). Additionally, the use of organic fertilizers contributed to increased SOC levels (84.40 Mg ha⁻¹) in contrast to mineral fertilizer applications (65.31 Mg ha⁻¹). The average SOC stock in all the studied urban green spaces (85 mg ha-1) was higher than the average SOC stock in arable soils in Germany (47.30 Mg ha-1). The higher SOC in the region could be due to vegetation types and fertilization frequencies, which show statistically significant effects (p-value <0.001). Other management practices (e.g., irrigation type and frequency) did not show a significant effect. Our findings highlight the significance of soil management practices, particularly in selecting vegetation types and determining fertilization frequency, as essential factors influencing urban SOC.
Process-induced changes in thermo-mechanical viscoelastic properties and the corresponding morphology of biodegradable polybutylene adipate terephthalate (PBAT) and polylactic acid (PLA) blown film blends modified with four multifunctional chain-extending cross-linkers (CECL) were investigated. The introduction of CECL modified the properties of the reference PBAT/PLA blend significantly. The thermal analysis showed that the chemical reactions were incomplete after compounding, and that film blowing extended them. SEM investigations of the fracture surfaces of blown extrusion films reveal the significant effect of CECL on the morphology formed during the processing. The anisotropic morphology introduced during film blowing proved to affect the degradation processes as well. Furthermore, the reactions of CECL with PBAT/PLA induced by the processing depend on the deformation directions. The blow-up ratio parameter was altered to investigate further process-induced changes proving synergy with mechanical and morphological features. Using blown film extrusion, the elongational behavior represents a very important characteristic. However, its evaluation may be quite often problematic, but with the SER Universal Testing Platform it was possible to determine changes in the duration of time intervals corresponding to the rupture of elongated samples.