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Low-frequency vibrational excitations in zeolite ZSM-5 and its partially crystalline derivatives
(2004)
Although p27 plays a central role in cell cycle regulation, its role in breast cancer prognosis is controversial. Furthermore, the p27 gene CDKN1B carries a polymorphism with unknown functional relevance. This study was designed to evaluate p27 expression and p27 genotyping with respect to early breast cancer prognosis. 279 patients with infiltrating metastasis-free breast cancer were included in this study. p27 expression was determined in tumor tissue specimens from 261 patients by immunohistochemistry. From 108 patients, the CDKN1B genotype was examined by PCR and subsequent direct sequencing. 55.2% of the tumors were considered p27 positive. p27 expression did not correlate with any of the established parameters except for nodal involvement but significantly correlated to prolonged disease-free survival. In 35% of the tumors analyzed, the CDKN1B gene showed a polymorphism at codon 109 (V109G). The V109G polymorphism correlated with greater nodal involvement. In the node-negative subgroup, V109G correlated significantly with a shortened disease-free survival. In conclusion, the determination of the CDKN1B genotype might be a powerful tool for the prognosis of patients with early breast cancer.
Improvement of Cardiovascular Risk Markers by Pioglitazone Is Independent From Glycemic Control
(2005)
Defect evolution in thermal barrier coating systems under multi-axial thermomechanical loading
(2005)
Autoantibodies in sera from patients with autoimmune diseases have long been known and have become diagnostic tools. Analysis of their functional role again became popular with the availability of mice mutant for several genes of the complement and Fcγ receptor (FcγR) systems. Evidence from different inflammatory models suggests that both systems are interconnected in a hierarchical way. The complement system mediators such as complement component 5a (C5a) might be crucial in the communication between the complement system and FcγR-expressing cells. The split complement protein C5a is known to inactivate cells by its G-protein-coupled receptor and to be involved in the transcriptional regulation of FcγRs, thereby contributing to the complex regulation of autoimmune disease.
Analysis of Synthetic Polymers and Copolymers by Pyrolysis- Gas Chromatography/Mass Spectrometry
(2005)
Structural analysis and the study of degradation properties are important in order to understand and improve performance characteristics of synthetic polymers and copolymers in many industrial applications. Polymers/copolymers are inherently difficult to analyze because of their high molecular weight and lack of volatility. Traditionally, various analytical techniques are used to characterize polymers/copolymers including physical testing (rheological testing), thermogravimetric analysis (TGA), electron microscopy, Fourier transform infrared (FTIR) spectroscopy, size-exclusion chromatography (SEC)/gel permeation chromatography (GPC), and mass spectrometry (MS). Often, time consuming sample preparation, including hydrolysis, dissolution, or derivatization is needed before analysis.
We present herein a new class of resin formulations for stereolithography, named FlexSL, with a broad bandwidth of tunable mechanical properties. The novel polyether(meth)acrylate based material class has outstanding material characteristics in combination with the advantages of being a biocompatible (meth)acrylate based processing material. FlexSL shows very promising results in several initial biocompatibility tests. This emphasizes its non-toxic behavior in a biomedical environment, caused mainly by the (meth)acrylate based core components. A short overview of mechanical and processing properties will be given in the end. The herein presented novel FlexSL materials show a significant lower cytotoxicity in contrast to commercial applied acrylic stereolithography resins. Further biocompatibility tests according to ISO 10993 protocols are planned. On the one hand, there are technical applications for this material (e.g. flaps, tubes, hoses, cables, sealing parts, connectors and other technical rubber-like applications), and on the other hand, broad fields of potential biomedical applications in which the FlexSL materials can be beneficial are obvious. Especially these could be small series production of medical products with special flexible material requirements. In addition, the usage for individual soft hearing aid shells, intra-operative planning services and tools like intra-op cutting templates and sawing guides is very attractive. The possibility to modify the FlexSL resins also for high-resolution applications makes it possible to manufacture now very flexible micro-prototypes with outstanding material characteristics and very fine structures with a minimum resolution of 20 mym and a layer thickness of minimal 5 myrn. These resin formulations are applicable and adjustable to other stereolithographic equipment available on the market.