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Demografischer Wandel: Auswirkungen auf den Arbeitsmarkt und die Erwerbsbeteiligung von Frauen
(2007)
Cancer is a complex disease where resistance to therapies and relapses often pose a serious clinical challenge. The scenario is even more complicated when the cancer type itself is heterogeneous in nature, e.g., lymphoma, a cancer of the lymphocytes which constitutes more than 70 different subtypes. Indeed, the treatment options continue to expand in lymphomas. Herein, we provide insights into lymphoma-specific clinical trials based on cytokine-induced killer (CIK) cell therapy and other pre-clinical lymphoma models where CIK cells have been used along with other synergetic tumor-targeting immune modules to improve their therapeutic potential. From a broader perspective, we will highlight that CIK cell therapy has potential, and in this rapidly evolving landscape of cancer therapies its optimization (as a personalized therapeutic approach) will be beneficial in lymphomas.
Intention: Within the research project EnerSHelF (Energy-Self-Sufficiency for Health Facilities in Ghana), i. a. energy-meteorological and load-related measurement data are collected, for which an overview of the availability is to be presented on a poster.
Context: In Ghana, the total electricity consumed has almost doubled between 2008 and 2018 according to the Energy Commission of Ghana. This goes along with an unstable power grid, resulting in power outages whenever electricity consumption peaks. The blackouts called "dumsor" in Ghana, pose a severe burden to the healthcare sector. Innovative solutions are needed to reduce greenhouse gas emissions and improve energy and health access.
Das autonome Fahren wird die Mobilität revolutionieren. Um die Auswirkung der Vollautomation auf dieEigenschaften der Verkehrsmittel und die Präferenzen der Nutzer besser zu verstehen, haben wir dieNutzenwerte neuen Verkehrsmodi im Vergleich zu den bestehenden Verkehrsmodi analysiert und imRahmen einer Online-Umfrage von potentiellen Nutzern in Form eines vollständigen Paarvergleichsbewerten lassen. Die Studie zeigt, dass der Privat-PKW, unabhängig davon ob traditionell odervollautomatisiert, zwar nach wie vor das präferierte Verkehrsmittel ist, im direkten Vergleich das Carsharingjedoch viel stärker von der Vollautomation profitiert. Darüber hinaus gibt es Hinweise darauf, dass dasvollautomatisierte Carsharing verstärkt in Konkurrenz zum ÖPNV tritt.
The clear-sky radiative effect of aerosol–radiation interactions is of relevance for our understanding of the climate system. The influence of aerosol on the surface energy budget is of high interest for the renewable energy sector. In this study, the radiative effect is investigated in particular with respect to seasonal and regional variations for the region of Germany and the year 2015 at the surface and top of atmosphere using two complementary approaches.
First, an ensemble of clear-sky models which explicitly consider aerosols is utilized to retrieve the aerosol optical depth and the surface direct radiative effect of aerosols by means of a clear-sky fitting technique. For this, short-wave broadband irradiance measurements in the absence of clouds are used as a basis. A clear-sky detection algorithm is used to identify cloud-free observations. Considered are measurements of the short-wave broadband global and diffuse horizontal irradiance with shaded and unshaded pyranometers at 25 stations across Germany within the observational network of the German Weather Service (DWD). The clear-sky models used are the Modified MAC model (MMAC), the Meteorological Radiation Model (MRM) v6.1, the Meteorological–Statistical solar radiation model (METSTAT), the European Solar Radiation Atlas (ESRA), Heliosat-1, the Center for Environment and Man solar radiation model (CEM), and the simplified Solis model. The definition of aerosol and atmospheric characteristics of the models are examined in detail for their suitability for this approach.
Second, the radiative effect is estimated using explicit radiative transfer simulations with inputs on the meteorological state of the atmosphere, trace gases and aerosol from the Copernicus Atmosphere Monitoring Service (CAMS) reanalysis. The aerosol optical properties (aerosol optical depth, Ångström exponent, single scattering albedo and asymmetry parameter) are first evaluated with AERONET direct sun and inversion products. The largest inconsistency is found for the aerosol absorption, which is overestimated by about 0.03 or about 30 % by the CAMS reanalysis. Compared to the DWD observational network, the simulated global, direct and diffuse irradiances show reasonable agreement within the measurement uncertainty. The radiative kernel method is used to estimate the resulting uncertainty and bias of the simulated direct radiative effect. The uncertainty is estimated to −1.5 ± 7.7 and 0.6 ± 3.5 W m−2 at the surface and top of atmosphere, respectively, while the annual-mean biases at the surface, top of atmosphere and total atmosphere are −10.6, −6.5 and 4.1 W m−2, respectively.
The retrieval of the aerosol radiative effect with the clear-sky models shows a high level of agreement with the radiative transfer simulations, with an RMSE of 5.8 W m−2 and a correlation of 0.75. The annual mean of the REari at the surface for the 25 DWD stations shows a value of −12.8 ± 5 W m−2 as the average over the clear-sky models, compared to −11 W m−2 from the radiative transfer simulations. Since all models assume a fixed aerosol characterization, the annual cycle of the aerosol radiation effect cannot be reproduced. Out of this set of clear-sky models, the largest level of agreement is shown by the ESRA and MRM v6.1 models.
Organisationen wollen Produkte mit guter User Experience herstellen. Durch die Evaluation der organisationalen UX-Gestaltungskompetenz können Organisationen erkennen, wie stark ihre momentane UX-Gestaltungskompetenz ausgeprägt ist und wie die Kompetenz gezielt gesteigert werden kann. Für die Abbildung der aktuellen Kompetenz werden ein Fragebogen zur theoretischen Kompetenz und ein Fragebogen für die Produktevaluation kombiniert. Durch diese Kombination wird die Kompetenz der Organisation aus der Handlungs- und der Ergebnisperspektive betrachtet. Für die Erarbeitung von Handlungsfeldern zur Verbesserung der Kompetenz werden qualitative Interviews durchgeführt und mit den Ergebnissen der quantitativen Erhebungen verknüpft. Durch einen anschließenden Ergebnisworkshop erarbeiten sich die Mitglieder der Organisation einen effizienten Weg zur Steigerung der organisationalen UX-Kompetenz.