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Die Prognose über den Studienerfolg von Studierenden in MINT-Fächern wird häufig an ihre Prüfungsleistungen in mathematischen und naturwissenschaftlichen Veranstaltungen geknüpft. Die Relevanz von sprachlichen Kompetenzen, insbesondere der Textrezeption und -produktion, für Studium und Berufstätigkeit, gerade auch in ingenieurwissenschaftlichen Betätigungsfeldern, wird sowohl von den Studierenden als auch von Dozent*innen nicht erkannt oder zurückgestellt.
Wireless sensor networks are widely used in a variety of fields including industrial environments. In case of a clustered network the location of cluster head affects the reliability of the network operation. Finding of the optimum location of the cluster head, therefore, is critical for the design of a network. This paper discusses the optimisation approach, based on the brute force algorithm, in the context of topology optimisation of a cluster structure centralised wireless sensor network. Two examples are given to verify the approach that demonstrate the implementation of the brute force algorithm to find an optimum location of the cluster head.
Tierexperimentell konnte nachgewiesen werden, dass spezifische Ionenkanäle (vor allem TRPA1) des nozizeptiven Systems nachhaltig durch die Exposition mit blauem Licht moduliert werden können. Durch Nachweis der Wirksamkeit von nicht-visuellen Effekten einer Lichtexposition auf Somatosensorik und Nozizeption beim Menschen könnte der Einsatz einer Lichttherapie bei Patienten mit Erkrankungen des somatosensorischen Systems, insbesondere neuropathischen Schmerzen, von großer Bedeutung sein.
Reliable and regional differentiated power forecasts are required to guarantee an efficient and economic energy transition towards renewable energies. Amongst other renewable energy technologies, e.g. wind mills, photovoltaic systems are an essential component of this transition being cost-efficient and simply to install. Reliable power forecasts are however required for a grid integration of photovoltaic systems, which among other data requires high-resolution spatio-temporal global irradiance data. Hence the generation of robust reviewed global irradiance data is an essential contribution for the energy transition.
Salts and proteins comprise two of the basic molecular components of biological materials. Kosmotropic/chaotropic co-solvation and matching ion water affinities explain basic ionic effects on protein aggregation observed in simple solutions. However, it is unclear how these theories apply to proteins in complex biological environments and what the underlying ionic binding patterns are. Using the positive ion Ca2+ and the negatively charged membrane protein SNAP25, we studied ion effects on protein oligomerization in solution, in native membranes and in molecular dynamics (MD) simulations. We find that concentration-dependent ion-induced protein oligomerization is a fundamental chemico-physical principle applying not only to soluble but also to membrane-anchored proteins in their native environment. Oligomerization is driven by the interaction of Ca2+ ions with the carboxylate groups of aspartate and glutamate. From low up to middle concentrations, salt bridges between Ca2+ ions and two or more protein residues lead to increasingly larger oligomers, while at high concentrations oligomers disperse due to overcharging effects. The insights provide a conceptual framework at the interface of physics, chemistry and biology to explain binding of ions to charged protein surfaces on an atomistic scale, as occurring during protein solubilisation, aggregation and oligomerization both in simple solutions and membrane systems.