The role of the complement and the FcγR system in the pathogenesis of arthritis
- Autoantibodies in sera from patients with autoimmune diseases have long been known and have become diagnostic tools. Analysis of their functional role again became popular with the availability of mice mutant for several genes of the complement and Fcγ receptor (FcγR) systems. Evidence from different inflammatory models suggests that both systems are interconnected in a hierarchical way. The complement system mediators such as complement component 5a (C5a) might be crucial in the communication between the complement system and FcγR-expressing cells. The split complement protein C5a is known to inactivate cells by its G-protein-coupled receptor and to be involved in the transcriptional regulation of FcγRs, thereby contributing to the complex regulation of autoimmune disease.
Document Type: | Article |
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Language: | English |
Author: | Samuel Solomon, Daniela Kassahn, Harald Illges |
Parent Title (English): | Arthritis Research & Therapy |
Volume: | 7 |
Issue: | 4 |
First Page: | 129 |
Last Page: | 135 |
ISSN: | 1478-6354 |
DOI: | https://doi.org/10.1186/ar1761 |
PMID: | https://pubmed.ncbi.nlm.nih.gov/15987494 |
Publisher: | BioMed Central |
Date of first publication: | 2005/05/16 |
Copyright: | © 2005 BioMed Central Ltd |
Departments, institutes and facilities: | Fachbereich Angewandte Naturwissenschaften |
Institut für funktionale Gen-Analytik (IFGA) | |
Dewey Decimal Classification (DDC): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Entry in this database: | 2015/04/02 |