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Efficacy of a proapoptotic peptide towards cancer cells

  • BACKGROUND: Conventional cancer therapies are associated with severe side-effects and the development of drug resistance. Therefore, new strategies to specifically target tumor cells leaving healthy tissue unaffected are of great interest. MATERIALS AND METHODS: On this respect, we tested the antimicrobial peptide (KLAKLAK)(2). RESULTS: This peptide exhibits cytotoxicity against human breast cancer and other tumor cells, while healthy cells remain unaffected. Moreover, treatment with this cationic amphipathic peptide results in slower tumor growth and longer overall survival in vivo. CONCLUSION: Our data suggest a potential use of (KLAKLAK)(2) peptide for patients with breast and other types of cancer.

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Document Type:Article
Author:Clara E. Jäkel, Karoline Meschenmoser, Young Kim, Hans Weiher, Ingo G. H. Schmidt-Wolf
Parent Title (English):In Vivo
First Page:419
Last Page:426
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=22523294
Publisher:The International Institute of Anticancer Research
Publication year:2012
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für funktionale Gen-Analytik (IFGA)
Dewey Decimal Classification (DDC):6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Entry in this database:2015/04/02