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In the field of automatic music generation, one of the greatest challenges is the consistent generation of pieces continuously perceived positively by the majority of the audience since there is no objective method to determine the quality of a musical composition. However, composing principles, which have been refined for millennia, have shaped the core characteristics of today's music. A hybrid music generation system, mlmusic, that incorporates various static, music-theory-based methods, as well as data-driven, subsystems, is implemented to automatically generate pieces considered acceptable by the average listener. Initially, a MIDI dataset, consisting of over 100 hand-picked pieces of various styles and complexities, is analysed using basic music theory principles, and the abstracted information is fed into explicitly constrained LSTM networks. For chord progressions, each individual network is specifically trained on a given sequence length, while phrases are created by consecutively predicting the notes' offset, pitch and duration. Using these outputs as a composition's foundation, additional musical elements, along with constrained recurrent rhythmic and tonal patterns, are statically generated. Although no survey regarding the pieces' reception could be carried out, the successful generation of numerous compositions of varying complexities suggests that the integration of these fundamentally distinctive approaches might lead to success in other branches.
Recent advances in Natural Language Processing have substantially improved contextualized representations of language. However, the inclusion of factual knowledge, particularly in the biomedical domain, remains challenging. Hence, many Language Models (LMs) are extended by Knowledge Graphs (KGs), but most approaches require entity linking (i.e., explicit alignment between text and KG entities). Inspired by single-stream multimodal Transformers operating on text, image and video data, this thesis proposes the Sophisticated Transformer trained on biomedical text and Knowledge Graphs (STonKGs). STonKGs incorporates a novel multimodal architecture based on a cross encoder that uses the attention mechanism on a concatenation of input sequences derived from text and KG triples, respectively. Over 13 million so-called text-triple pairs, coming from PubMed and assembled using the Integrated Network and Dynamical Reasoning Assembler (INDRA), were used in an unsupervised pre-training procedure to learn representations of biomedical knowledge in STonKGs. By comparing STonKGs to an NLP- and a KG-baseline (operating on either text or KG data) on a benchmark consisting of eight fine-tuning tasks, the proposed knowledge integration method applied in STonKGs was empirically validated. Specifically, on tasks with a comparatively small dataset size and a larger number of classes, STonKGs resulted in considerable performance gains, beating the F1-score of the best baseline by up to 0.083. Both the source code as well as the code used to implement STonKGs are made publicly available so that the proposed method of this thesis can be extended to many other biomedical applications.