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Abschlussarbeiten FAQ/FGA
(2006)
Background: Type 2 diabetes mellitus is associated with increased cardiovascular risk. One laboratory marker for cardiovascular risk assessment is high-sensitivity C-reactive protein (hsCRP).
Methods: This cross-sectional study attempted to analyze the association of hsCRP levels with insulin resistance, β-cell dysfunction and macrovascular disease in 4270 non-insulin-treated patients with type 2 diabetes [2146 male, 2124 female; mean age ±SD, 63.9±11.1years; body mass index (BMI) 30.1±5.5kg/m2; disease duration 5.4±5.6years; hemoglobin A1c (HbA1c) 6.8±1.3%]. It consisted of a single morning visit with collection of a fasting blood sample. Observational parameters included several clinical scores and laboratory biomarkers.
Results: Stratification into cardiovascular risk groups according to hsCRP levels revealed that 934 patients had low risk (hsCRP <1mg/L), 1369 patients had intermediate risk (hsCRP 1–3mg/L), 1352 patients had high risk (hsCRP >3–10mg/L), and 610 patients had unspecific hsCRP elevation (>10mg/L). Increased hsCRP levels were associated with other indicators of diabetes-related cardiovascular risk (homeostatic model assessment, intact proinsulin, insulin, BMI, β-cell dysfunction, all p<0.001), but showed no correlation with disease duration or glucose control. The majority of the patients were treated with diet (34.1%; hsCRP levels 2.85±2.39mg/L) or metformin monotherapy (21.1%; 2.95±2.50mg/L hsCRP). The highest hsCRP levels were observed in patients treated with sulfonylurea (17.0%; 3.00±2.43mg/L).
Conclusions: Our results indicate that hsCRP may be used as a cardiovascular risk marker in patients with type 2 diabetes mellitus and should be evaluated in further prospective studies.
BGML - a novel XML format for the exchange and the reuse of bond graph models of engineering systems
(2006)
Bond graph modelling
(2006)
Bei der Wertschöpfung in den entwickelten Volkswirtschaften spielen digitale Güter eine wichtige Rolle. Sie haben Eigenschaften, die oft unter dem Stichwort „Marktversagen“ diskutiert werden. Ungeachtet davon gibt es viele Unternehmen wie Microsoft, Apple, Google oder Ebay, die beachtliche Markterfolge erzielen, da sie die Besonderheiten ihrer digitalen Güter in geeignete Marktstrategien umsetzen. Einige Grundregeln der ökonomischen Theorie, die bei materiellen Gütern zum Marktversagen führen, gelten nicht für digitale Güter.
With the rapid advances in multimedia content delivery technologies, there is an increasing challenge for efficient Quality of Service (QoS) based multicast transport in mobile Internet environment. This paper discusses architectural approach for provision of multicast services in heterogeneous mobile IPv6 environment using context transfer. Following issues of QoS based mobile multicast transport are addressed: - Application of context transfer between access routers for seamless handover of active multicast services; - Adaptation of multicast group management and routing designed for wired IPv6 infrastructures to heterogeneous mobile environment; - Candidate access router discovery and context aware user interfaces for optimised handover; - Reliable mobile multicast for content delivery supported by context transfer at access routers; - Distributed QoS management of multicast services in heterogeneous mobile environment. The work is part of the mobile architecture developed in the EU IST project DAIDALOS.
Eine Suite für den Patienten
(2006)