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Human butyrylcholinesterase (BChE) is a glycoprotein capable of bioscavenging toxic compounds such as organophosphorus (OP) nerve agents. For commercial production of BChE, it is practical to synthesize BChE in non-human expression systems, such as plants or animals. However, the glycosylation profile in these systems is significantly different from the human glycosylation profile, which could result in changes in BChE's structure and function. From our investigation, we found that the glycan attached to ASN241 is both structurally and functionally important due to its close proximity to the BChE tetramerization domain and the active site gorge. To investigate the effects of populating glycosylation site ASN241, monomeric human BChE glycoforms were simulated with and without site ASN241 glycosylated. Our simulations indicate that the structure and function of human BChE are significantly affected by the absence of glycan 241.
This work presents the analysis of data recorded by an eye tracking device in the course of evaluating a foveated rendering approach for head-mounted displays (HMDs). Foveated rendering methods adapt the image synthesis process to the user’s gaze and exploiting the human visual system’s limitations to increase rendering performance. Especially, foveated rendering has great potential when certain requirements have to be fulfilled, like low-latency rendering to cope with high display refresh rates. This is crucial for virtual reality (VR), as a high level of immersion, which can only be achieved with high rendering performance and also helps to reduce nausea, is an important factor in this field. We put things in context by first providing basic information about our rendering system, followed by a description of the user study and the collected data. This data stems from fixation tasks that subjects had to perform while being shown fly-through sequences of virtual scenes on an HMD. These fixation tasks consisted of a combination of various scenes and fixation modes. Besides static fixation targets, moving tar- gets on randomized paths as well as a free focus mode were tested. Using this data, we estimate the precision of the utilized eye tracker and analyze the participants’ accuracy in focusing the displayed fixation targets. Here, we also take a look at eccentricity-dependent quality ratings. Comparing this information with the users’ quality ratings given for the displayed sequences then reveals an interesting connection between fixation modes, fixation accuracy and quality ratings.
Studienverläufe von Studenten weichen nicht selten vom offiziell geplanten Curriculum ab. Für eine den Studienerfolg verbessernde Planung und Weiterentwicklung von Studiengängen und Curricula fehlen den Verantwortlichen häufig Erkenntnisse über tatsächliche sowie typischerweise erfolgreiche und weniger erfolgreiche Studienverlaufsmuster. Process-Mining-Techniken können helfen, mehr Transparenz bei der Auswertung von Studienverläufen zu schaffen und so die Erkennung typischer Studienverlaufsmuster, die Überprüfung der Übereinstimmung der konkreten Studienverläufe mit dem vorgegebenen Curriculum sowie eine zielgerechte Verbesserung des Curriculums zu unterstützen.
Real-World Performance of current Mesh Protocols in a small-scale Dual-Radio Multi-Link Environment
(2017)
Two key questions motivated the work in this paper: What is the impact of different usage schemes for multiple channels in a dual-radio Wireless Mesh Network (WMN), and what is the impact of some popular WMN routing protocols on its performance. These two questions were evaluated in a small and simple real-world scenario. A major concern was reproducibility of the results. We show that it is beneficial to use both radios on different frequencies in a fully meshed environment with four routers. The routing protocols Babel, B.A.T.M.A.N. V, BMX7 and OLSRv2 recognize a saturated channel and prefer the other one. We show that in our scenario all of the protocols perform equally well since the protocol overhead is comparably low not influencing the overall performance of the network.
Service robots performing complex tasks involving people in houses or public environments are becoming more and more common, and there is a huge interest from both the research and the industrial point of view. The RoCKIn@Home challenge has been designed to compare and evaluate different approaches and solutions to tasks related to the development of domestic and service robots. RoCKIn@Home competitions have been designed and executed according to the benchmarking methodology developed during the project and received very positive feedbacks from the participating teams. Tasks and functionality benchmarks are explained in detail.
RoCKIn@Work was focused on benchmarks in the domain of industrial robots. Both task and functionality benchmarks were derived from real world applications. All of them were part of a bigger user story painting the picture of a scaled down real world factory scenario. Elements used to build the testbed were chosen from common materials in modern manufacturing environments. Networked devices, machines controllable through a central software component, were also part of the testbed and introduced a dynamic component to the task benchmarks. Strict guidelines on data logging were imposed on participating teams to ensure gathered data could be automatically evaluated. This also had the positive effect that teams were made aware of the importance of data logging, not only during a competition but also during research as useful utility in their own laboratory. Tasks and functionality benchmarks are explained in detail, starting with their use case in industry, further detailing their execution and providing information on scoring and ranking mechanisms for the specific benchmark.
Das Cutting sticks-Problem ist in seiner allgemeinen Formulierung ein NP-vollständiges Problem mit Anwendungspotenzialen im Bereich der Logistik. Unter der Annahme, dass P ungleich NP (P != NP) ist, existieren keine effizienten, d.h. polynomiellen Algorithmen zur Lösung des allgemeinen Problems.
In diesem Papier werden für eine Reihe von Instanzen effiziente Lösungen angegeben.
Das Cutting sticks-Problem ist in seiner allgemeinen Formulierung ein NP-vollständiges Problem mit Anwendungspotenzialen im Bereich der Logistik. Unter der Annahme, dass P ungleich NP (P != NP) ist, existieren keine effizienten, d.h. polynomiellen Algorithmen zur Lösung des allgemeinen Problems.
In diesem Papier werden Ansätze aufgezeigt, mit denen bestimmte Instanzen des Problems effizient berechnet werden können. Für die Berechnung wichtige Parameter werden charakterisiert und deren Beziehung untereinander analysiert.
The combination of Software-Defined Networking (SDN) and Wireless Mesh Network (WMN) is challenging due to the different natures of both concepts. SDN describes networks with homogeneous, static and centralized controlled topologies. In contrast, a WMN is characterized by a dynamic and distributed network control, and adds new challenges with respect to time-critical operation. However, SDN and WMN are both associated with decreasing the operational costs for communication networks which is especially beneficial for internet provisioning in rural areas. This work surveys the current status for Software-Defined Wireless Mesh Networking. Besides a general overview in the domain of wireless SDN, this work focuses especially on different identified aspects: representing and controlling wireless interfaces, control-plane connection and topology discovery, modulation and coding, routing and load-balancing and client handling. A complete overview of surveyed solutions, open issues and new research directions is provided with regard to each aspect.
Emotional communication is a key element of habilitation care of persons with dementia. It is, therefore, highly preferable for assistive robots that are used to supplement human care provided to persons with dementia, to possess the ability to recognize and respond to emotions expressed by those who are being cared-for. Facial expressions are one of the key modalities through which emotions are conveyed. This work focuses on computer vision-based recognition of facial expressions of emotions conveyed by the elderly.
Although there has been much work on automatic facial expression recognition, the algorithms have been experimentally validated primarily on young faces. The facial expressions on older faces has been totally excluded. This is due to the fact that the facial expression databases that were available and that have been used in facial expression recognition research so far do not contain images of facial expressions of people above the age of 65 years. To overcome this problem, we adopt a recently published database, namely, the FACES database, which was developed to address exactly the same problem in the area of human behavioural research. The FACES database contains 2052 images of six different facial expressions, with almost identical and systematic representation of the young, middle-aged and older age-groups.
In this work, we evaluate and compare the performance of two of the existing imagebased approaches for facial expression recognition, over a broad spectrum of age ranging from 19 to 80 years. The evaluated systems use Gabor filters and uniform local binary patterns (LBP) for feature extraction, and AdaBoost.MH with multi-threshold stump learner for expression classification. We have experimentally validated the hypotheses that facial expression recognition systems trained only on young faces perform poorly on middle-aged and older faces, and that such systems confuse ageing-related facial features on neutral faces with other expressions of emotions. We also identified that, among the three age-groups, the middle-aged group provides the best generalization performance across the entire age spectrum. The performance of the systems was also compared to the performance of humans in recognizing facial expressions of emotions. Some similarities were observed, such as, difficulty in recognizing the expressions on older faces, and difficulty in recognizing the expression of sadness.
The findings of our work establish the need for developing approaches for facial expression recognition that are robust to the effects of ageing on the face. The scientific results of our work can be used as a basis to guide future research in this direction.
Population ageing and growing prevalence of disability have resulted in a growing need for personal care and assistance. The insufficient supply of personal care workers and the rising costs of long-term care have turned this phenomenon into a greater social concern. This has resulted in a growing interest in assistive technology in general, and assistive robots in particular, as a means of substituting or supplementing the care provided by humans, and as a means of increasing the independence and overall quality of life of persons with special needs. Although many assistive robots have been developed in research labs world-wide, very few are commercially available. One of the reasons for this, is the cost. One way of optimising cost is to develop solutions that address specific needs of users. As a precursor to this, it is important to identify gaps between what the users need and what the technology (assistive robots) currently provides. This information is obtained through technology mapping.
The current literature lacks a mapping between user needs and assistive robots, at the level of individual systems. The user needs are not expressed in uniform terminology across studies, which makes comparison of results difficult. In this research work, we have illustrated the technology mapping of assistive robots using the International Classification of Functioning, Disability and Health (ICF). ICF provides standard terminology for expressing user needs in detail. Expressing the assistive functions of robots also in ICF terminology facilitates communication between different stakeholders (rehabilitation professionals, robotics researchers, etc.).
We also investigated existing taxonomies for assistive robots. It was observed that there is no widely accepted taxonomy for classifying assistive robots. However, there exists an international standard, ISO 9999, which classifies commercially available assistive products. The applicability of the latest revision of ISO 9999 standard for classifying mobility assistance robots has been studied. A partial classification of assistive robots based on ISO 9999 is suggested. The taxonomy and technology mapping are illustrated with the help of four robots that have the potential to provide mobility assistance. These are the SmartCane, the SmartWalker, MAid and Care-O-bot (R) 3. SmartCane, SmartWalker and MAid provide assistance by supporting physical movement. Care-O-bot (R) 3 provides assistance by reducing the need to move.
Recent work in image captioning and scene-segmentation has shown significant results in the context of scene-understanding. However, most of these developments have not been extrapolated to research areas such as robotics. In this work we review the current state-ofthe- art models, datasets and metrics in image captioning and scenesegmentation. We introduce an anomaly detection dataset for the purpose of robotic applications, and we present a deep learning architecture that describes and classifies anomalous situations. We report a METEOR score of 16.2 and a classification accuracy of 97 %.
WiFi-based Long Distance (WiLD) networks have emerged as a promising alternative approach for Internet in rural areas. The main hardware components of these networks are commercial off-the-shelf WiFi radios and directional antennas. During our experiences with real-world WiLD networks, we encountered that interference among long-distance links is a major issue even with high gain directional antennas. In this work, we are providing an in-depth analysis of these interference effects by conducting simulations in ns-3. To closely match the real-world interference effects, we implemented a module to load radiation pattern of commonly used antennas. We analyze two different interference scenarios typically present as a part of larger networks. The results show that side-lobes of directional antennas significantly influence the throughput of long-distance WiFi links depending on the orientation. This work emphasizes that the usage of simple directional antenna models needs to be considered carefully.
This paper describes the security mechanisms of several wireless building automation technologies, namely ZigBee, EnOcean, ZWave, KNX, FS20, and Home-Matic. It is shown that none of the technologies provides the necessary measure ofsecurity that should be expected in building automation systems. One of the conclusions drawn is that software embedded in systems that are build for a lifetime of twenty years or more needs to be updatable.