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Matrix Metalloproteinase MMP-9 Promotes K/BxN Serum Induced Arthritis in Mice

  • Matrix metalloproteinases (MMPs) are matrix-degrading enzymes that are over-expressed in joints of rheumatoid arthritis (RA) patients. However, the contribution of specific MMPs for the development of arthritic joints is unknown. This study is aimed at studying the role of matrix metalloproteinase-9 (MMP-9) in mice, using the K/BxN serum-transfer model of RA. Arthritis was induced in Balb/c mice by injecting K/BxN serum. Development of arthritis was followed in these mice by measuring ankle thickness and clinical index score. MMP-9 expression in the joints of mice killed at various time points during the disease progression was determined by gelatin zymography using ankle lysates. We found that MMP-9 expression increased with the severity of arthritis. Importantly MMP-9 deficient mice injected with K/BxN serum showed a milder form of arthritis in comparison to the control C57BL/6 mice injected with K/BxN serum. We therefore conclude that MMP-9 promotes arthritis in mice.

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Metadaten
Document Type:Article
Language:English
Parent Title (English):OJRA (Open Journal of Rheumatology and Autoimmune Diseases)
Volume:4
Issue:1
First Page:22
Last Page:28
ISSN:2163-9914
URN:urn:nbn:de:hbz:1044-opus-22932
DOI:https://doi.org/10.4236/ojra.2014.41003
Publisher:Scientific Research Publishing
Publishing Institution:Hochschule Bonn-Rhein-Sieg
Date of first publication:2014/02/01
Note:
Copyright © 2014 Narendiran Rajasekaran, Harald Illges et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Tag:Antibody Induced Arthritis; Gelatin Zymography; K/BxN; MMP-9
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für funktionale Gen-Analytik (IfGA)
Dewey Decimal Classification (DDC):6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Entry in this database:2016/02/03
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 3.0