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The Unfolded Protein Response in Breast Cancer

  • In 2018, in the US alone, it is estimated that 268,670 people will be diagnosed with breast cancer, and that 41,400 will die from it. Since breast cancers often become resistant to therapies, and certain breast cancers lack therapeutic targets, new approaches are urgently required. A cell-stress response pathway, the unfolded protein response (UPR), has emerged as a promising target for the development of novel breast cancer treatments. This pathway is activated in response to a disturbance in endoplasmic reticulum (ER) homeostasis but has diverse physiological and disease-specific functions. In breast cancer, UPR signalling promotes a malignant phenotype and can confer tumours with resistance to widely used therapies. Here, we review several roles for UPR signalling in breast cancer, highlighting UPR-mediated therapy resistance and the potential for targeting the UPR alone or in combination with existing therapies.

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Metadaten
Document Type:Article
Language:English
Parent Title (English):Cancers
Volume:10
Issue:10
First Page:344
ISSN:2072-6694
DOI:https://doi.org/10.3390/cancers10100344
Publisher:MDPI
Date of first publication:2018/09/21
Tag:autophagy; breast cancer; cell death; endoplasmic reticulum (ER) stress; therapy; unfolded protein response (UPR)
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für funktionale Gen-Analytik (IfGA)
Dewey Decimal Classification (DDC):6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Entry in this database:2018/09/26