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Integrating physical simulation data into data ecosystems challenges the compatibility and interoperability of data management tools. Semantic web technologies and relational databases mostly use other data types, such as measurement or manufacturing design data. Standardizing simulation data storage and harmonizing the data structures with other domains is still a challenge, as current standards such as the ISO standard STEP (ISO 10303 ”Standard for the Exchange of Product model data”) fail to bridge the gap between design and simulation data. This challenge requires new methods, such as ontologies, to rethink simulation results integration. This research describes a new software architecture and application methodology based on the industrial standard ”Virtual Material Modelling in Manufacturing” (VMAP). The architecture integrates large quantities of structured simulation data and their analyses into a semantic data structure. It is capable of providing data permeability from the global digital twin level to the detailed numerical values of data entries and even new key indicators in a three-step approach: It represents a file as an instance in a knowledge graph, queries the file’s metadata, and finds a semantically represented process that enables new metadata to be created and instantiated.
Die Klimakrise stellt eine Bedrohung für das menschliche Wohlergehen und die planetare Gesundheit dar, welcher u.a. durch Lebens- und Verhaltensstiländerungen begegnet werden kann. Eine dieser individuellen und gesamtgesellschaftlichen Veränderungen könnte eine geschlechtergerechte Aufteilung der Care-Arbeit sein, weshalb es notwendig ist, an vorderster Stelle die dahinterliegenden Mechanismen und Zusammenhänge zu verstehen. Aus diesem Grund beschäftigt sich die vorliegende Bachelorarbeit mit der Frage „Wie kann geschlechtergerechte Care-Arbeit ausgestaltet werden, um einen Beitrag zum Klimaschutz zu leisten?“. Um die Forschungsfrage zu beantworten, wird eine systematische Literaturrecherche durchgeführt, welche durch den theoretischen Rahmen analysiert wird. Dieser setzt sich aus der Externalisierungsgesellschaft von Lessenich, dem Gerechtigkeitsansatz von Fraser und dem soziologischen Geschlecht von Pimminger zusammen. Die Analyse ergibt, dass sowohl die Ursachen, Auswirkungen und Lösungsansätze zur Klimakrise abhängig vom Geschlecht sind und ein Eco Gender Gap existiert.Des Weiteren ist die Aufteilung der Care-Arbeit durch das soziologische Geschlecht geprägt und weist sowohl im lokalen und globalen Kontext Parallelen zur Klimakrise auf. Lösungsansätze für beide Herausforderungen finden sich im Ökofeminismus und einer Verkürzung der Arbeitszeit wieder. In zukünftigen Wirtschaftsmodellen sollte die Care-Arbeit daher mehr Beachtung finden, da sie die unsichtbare Grundlage der derzeitigen Wirtschaftsweise ist, die zur Klimakrise geführt hat.
A firm link between endoplasmic reticulum (ER) stress and tumors has been wildly reported. Endoplasmic reticulum oxidoreductase 1 alpha (ERO1α), an ER-resident thiol oxidoreductase, is confirmed to be highly upregulated in various cancer types and associated with a significantly worse prognosis. Of importance, under ER stress, the functional interplay of ERO1α/PDI axis plays a pivotal role to orchestrate proper protein folding and other key processes. Multiple lines of evidence propose ERO1α as an attractive potential target for cancer treatment. However, the unavailability of specific inhibitor for ERO1α, its molecular inter-relatedness with closely related paralog ERO1β and the tightly regulated processes with other members of flavoenzyme family of enzymes, raises several concerns about its clinical translation. Herein, we have provided a detailed description of ERO1α in human cancers and its vulnerability towards the aforementioned concerns. Besides, we have discussed a few key considerations that may improve our understanding about ERO1α in tumors.
Blickpunkt
(2024)
In recent years, eXtended Reality (XR) technology like Augmented Reality and Virtual Reality became both technically feasible as well as affordable which lead to a drastic demand of professionally designed and developed applications. However, this demand combined with a rapid pace of innovation revealed a lack of design tool support for professional interaction designers as well as a knowledge gap regarding their approaches and needs. To address this gap, this thesis engages with the work of professional XR interaction designers in a qualitative research into XR interaction design approach. Therefore, this thesis applies two complementary lenses stemming from scientific design and social practice theory discourses to observe, describe, analyze, and understand professional XR interaction designers' challenges and approaches with a focus on application prototyping.