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Preleukemic clones carrying BCR-ABLp190 oncogenic lesions are found in neonatal cord blood, where the majority of preleukemic carriers do not convert into precursor B-cell acute lymphoblastic leukemia (pB-ALL). However, the critical question of how these preleukemic cells transform into pB-ALL remains undefined. Here we model a BCR-ABLp190 preleukemic state and show that limiting BCR-ABLp190 expression to hematopoietic stem/progenitor cells (HS/PC) in mice (Sca1-BCR-ABLp190) causes pB-ALL at low penetrance, which resembles the human disease. pB-ALL blast cells were BCR-ABL-negative and transcriptionally similar to pro-B/pre-B cells, suggesting disease onset upon reduced Pax5 functionality. Consistent with this, double Sca1-BCR-ABLp190+Pax5+/- mice developed pB-ALL with shorter latencies, 90% incidence, and accumulation of genomic alterations in the remaining wild-type Pax5 allele. Mechanistically, the Pax5-deficient leukemic pro-B cells exhibited a metabolic switch towards increased glucose utilization and energy metabolism. Transcriptome analysis revealed that metabolic genes (IDH1, G6PC3, GAPDH, PGK1, MYC, ENO1, ACO1) were upregulated in Pax5-deficient leukemic cells, and a similar metabolic signature could be observed in human leukemia. Our studies unveil the first in vivo evidence that the combination between Sca1-BCR-ABLp190 and metabolic reprogramming imposed by reduced Pax5 expression is sufficient for pB-ALL development. These findings might help to prevent conversion of BCR-ABLp190 preleukemic cells.
For many different applications, current information about the bandwidth-related metrics of the utilized connection is very useful as they directly impact the performance of throughput sensitive applications such as streaming servers, IPTV and VoIP applications. In literature, several tools have been proposed to estimate major bandwidth-related metrics such as capacity, available bandwidth and achievable throughput. The vast majority of these tools fall into one of Packet Pair (PP), Variable Packet Size (VPS), Self-Loading of Periodic Streams (SLoPS) or Throughput approaches. In this study, seven popular bandwidth estimation tools including nettimer, pathrate, pathchar, pchar, clink, pathload and iperf belonging to these four well-known estimation techniques are presented and experimentally evaluated in a controlled testbed environment. Differently from the rest of studies in literature, all tools have been uniformly classified and evaluated according to an objective and sophisticated classification and evaluation scheme. The performance comparison of the tools incorporates not only the estimation accuracy but also the probing time and overhead caused.
This work discusses how to use OSM for robotic applications and aims at starting a discussion between the OSM and the robotics community. OSM contains much topological and semantic information that can be directly used in robotics and offers various advantages: 1) Standardized format with existing tooling. 2) The graph structure allows to compose the OSM models with domain-specific semantics by adding custom nodes, relations, and key-value pairs. 3) Information about many places is already available and can be used by robots since it is driven by a community effort.
Friction effects impose a requirement for the supplementary amount of torque to be produced in actuators for a robot to move, which in turn increases energy consumption. We cannot eliminate friction, but we can optimize motions to make them more energy efficient, by considering friction effects in motion computations. Optimizing motions means computing efficient joint torques/accelerations based on different friction torques imposed in each joint. Existing friction forces can be used for supporting certain types of arm motions, e.g standing still.
Reducing energy consumption of robot's arms will provide many benefits, such as longer battery life of mobile robots, reducing heat in motor systems, etc.
The aim of this project is extending an already available constrained hybrid dynamic solver, by including static friction effects in the computations of energy optimal motions. When the algorithm is extended to account for static friction factors, a convex optimization (maximization) problem must be solved.
The author of this hybrid dynamic solver has briefly outlined the approach for including static friction forces in computations of motions, but without providing a detailed derivation of the approach and elaboration that will show its correctness. Additionally, the author has outlined the idea for improving the computational efficiency of the approach, but without providing its derivation.
In this project, the proposed approach for extending the originally formulated algorithm has been completely derived and evaluated in order to show its feasibility. The evaluation is conducted in simulation environment with one DOF robot arm, and it shows correct results from the computation of motions. Furthermore, this project presents the derivation of the outlined method for improving the computational efficiency of the extended solver.
Speech understanding is a fundamental feature for many applications focused on human-robot interaction. Although many techniques and several services for speech recognition and natural language understanding have been developed in the last years, specific implementation and validation on domestic service robots have not been performed. In this paper, we describe the implementation and the results of a functional benchmark for speech understanding in service robotics that has been developed and tested in the context of different robot competitions: RoboCup@Home, RoCKIn@Home and within the European Robotics League on Service Robots. Different approaches used by the teams in the competitions are presented and the evaluation results obtained in the competitions are discussed.