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Reliable and regional differentiated power forecasts are required to guarantee an efficient and economic energy transition towards renewable energies. Amongst other renewable energy technologies, e.g. wind mills, photovoltaic systems are an essential component of this transition being cost-efficient and simply to install. Reliable power forecasts are however required for a grid integration of photovoltaic systems, which among other data requires high-resolution spatio-temporal global irradiance data. Hence the generation of robust reviewed global irradiance data is an essential contribution for the energy transition.
Salts and proteins comprise two of the basic molecular components of biological materials. Kosmotropic/chaotropic co-solvation and matching ion water affinities explain basic ionic effects on protein aggregation observed in simple solutions. However, it is unclear how these theories apply to proteins in complex biological environments and what the underlying ionic binding patterns are. Using the positive ion Ca2+ and the negatively charged membrane protein SNAP25, we studied ion effects on protein oligomerization in solution, in native membranes and in molecular dynamics (MD) simulations. We find that concentration-dependent ion-induced protein oligomerization is a fundamental chemico-physical principle applying not only to soluble but also to membrane-anchored proteins in their native environment. Oligomerization is driven by the interaction of Ca2+ ions with the carboxylate groups of aspartate and glutamate. From low up to middle concentrations, salt bridges between Ca2+ ions and two or more protein residues lead to increasingly larger oligomers, while at high concentrations oligomers disperse due to overcharging effects. The insights provide a conceptual framework at the interface of physics, chemistry and biology to explain binding of ions to charged protein surfaces on an atomistic scale, as occurring during protein solubilisation, aggregation and oligomerization both in simple solutions and membrane systems.
Ohne Zweifel kein Wissen und keine Innovation, dies gilt für die Forschung im Allgemeinen und natürlich auch an unserer Hochschule. Gerade in der Wissenschaft ist der methodische Zweifel oft der Ausgangspunkt einer spezifischen Untersuchung. Er soll dabei behilflich sein, Klarheit zu erlangen. Frei nach dem Philosophen Rene Descartes: Was kann ich eigentlich mit Sicherheit wissen? Nur wer ab und an zweifelt, der schaut um die Ecke, stellt sich, andere und seine Umwelt in Frage, sucht nach neuen Wegen, Antworten und strebt nach Veränderung. Und auch dort, wo Wissenschaft vermittelt wird, also im Seminar, in einer Übung oder Vorlesung, muss Platz sein für eine selbstreflexive Grundhaltung. An der H-BRS ist Zweifeln also nicht nur erlaubt, sondern erwünscht.
Doubting - Path to Science
(2016)
Förderpreise 2016
(2016)