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Mesenchymal stem cells (MSCs) are an attractive cell source for Regenerative Dentistry in particular due to their ability to differentiate towards osteoblasts, among other lineages. Tooth and jaw bone loss are frequent sequelae of traumatic and pathological conditions in both the young and the elderly and must be met by appropriate prosthetic replacements. For successful osseointegration of the dental implant a sufficient bone level is necessary. Besides the utilization of bone autografts or synthetic biomaterials, medical research is more and more focused on the utilization of MSCs. Compared to cells obtained from liposuction material, ectomesenchymal stem cells derived from the head area e.g. out of dental follicles or particulate, non-vascularized bone chips show a higher differentiation potential towards osteoblasts.
Aufschiebende Wirkung eines Widerspruchs gegen die Einstellung des Verletztengeldes - JA oder NEIN?
(2015)
It is know that mesenchymal stem cells (MSCs) actively secretemultiple biologically-active factors during their process of differentiation which gives rise to a variey of cytotypes including bone and fatcells. It is also acknowledged that the chemokines secreted throughoutMSC differentiation may play an important role in the development and growth of tumor cells, although literature data appear somewhat indeterminate due to the contradictory evidence often found.
Background: Falls and fall-related injuries are a serious public health issue. Exercise programs can effectively reduce fall risk in older people. The iStoppFalls project developed an Information and Communication Technology-based system to deliver an unsupervised exercise program in older people’s homes. The primary aims of the iStoppFalls randomized controlled trial were to assess the feasibility (exercise adherence, acceptability and safety) of the intervention program and its effectiveness on common fall risk factors.
Methods: A total of 153 community-dwelling people aged 65+ years took part in this international, multicentre, randomized controlled trial. Intervention group participants conducted the exercise program for 16 weeks, with a recommended duration of 120 min/week for balance exergames and 60 min/week for strength exercises. All intervention and control participants received educational material including advice on a healthy lifestyle and fall prevention. Assessments included physical and cognitive tests, and questionnaires for health, fear of falling, number of falls, quality of life and psychosocial outcomes.
Results: The median total exercise duration was 11.7 h (IQR = 22.0) over the 16-week intervention period. There were no adverse events. Physiological fall risk (Physiological Profile Assessment, PPA) reduced significantly more in the intervention group compared to the control group (F1,127 = 4.54, p = 0.035). There was a significant three-way interaction for fall risk assessed by the PPA between the high-adherence (>90 min/week; n = 18, 25.4 %), low-adherence (<90 min/week; n = 53, 74.6 %) and control group (F2,125 = 3.12, n = 75, p = 0.044). Post hoc analysis revealed a significantly larger effect in favour of the high-adherence group compared to the control group for fall risk (p = 0.031), postural sway (p = 0.046), stepping reaction time (p = 0.041), executive functioning (p = 0.044), and quality of life (p for trend = 0.052).
Conclusions: The iStoppFalls exercise program reduced physiological fall risk in the study sample. Additional subgroup analyses revealed that intervention participants with better adherence also improved in postural sway, stepping reaction, and executive function.
The latest advances in the field of smart card technologies allow modern cards to be more than just simple security tokens. Recent developments facilitate the use of interactive components like buttons, displays or even touch-sensors within the card's body thus conquering whole new areas of application. With interactive functionalities the usability aspect becomes the most important one for designing secure and popularly accepted products. Unfortunately, the usability can only be tested fully with completely integrated hence expensive smart card prototypes. This restricts severely application specific research, case studies of new smart card user interfaces and the optimization of design aspects, as well as hardware requirements by making usability and acceptance tests in smart card development very costly and time-consuming. Rapid development and simulation of smart card interfaces and applications can help to avoid this restriction. This paper presents a rapid development process for new smart card interfaces and applications based on common smartphone technology using a tool called SCUID^Sim. We will demonstrate the variety of usability aspects that can be analyzed with such a simulator by discussing some selected example projects.
Duale Studiengänge liegen einerseits stark im Trend, andererseits funktioniert die Abstimmung zwischen Hochschulstudium und Praxisphasen oftmals nicht. Obwohl eine Lernortkooperation zwischen »Praxis« und »Hochschule« das Engagement beider Seiten erfordert, wird in einem Projekt der Hochschule Bonn-Rhein-Sieg, der Deutschen Gesetzlichen Unfallversicherung (DGUV) und des BIBB zunächst erprobt, wie das Verständnis der Praxisbetreuer/-innen für Studierende und Studium verbessert werden kann. Hierzu werden im Beitrag Konzeption und Zielsetzung eines zweitägigen Seminars bei der Akademie der DGUV vorgestellt und erste Erfahrungen geschildert.
Háttér és célkitűzések: A játékszenvedély vizsgálatával foglalkozó tudományos cikkek sora dinamikusan bővült az elmúlt években. Kutatások folynak a témában például Nagy-Britanniában, (1) Finnországban(2) és Svédországban(3) is. Ugyanakkor ezen kutatások empirikus eredményei még nem publikáltak, így az értékelésük is csak később lehetséges.(4)
Das Land Baden-Württemberg beauftragte im Auftrag aller in der Ministerpräsidentenkonferenz der Bundesrepublik Deutschland zusammengeschlossenen Länder die Goldmedia GmbH Strategy Consulting, Berlin, am 24.2.2014 mit der Erstellung einer wirtschaftswissenschaftlichen Studie, die mit dem Titel "International vergleichende Analyse des Glücksspielwesens" am 30.9.2014 dem Auftraggeber vorgelegt wurde. Zur nationalen Evaluierung des Ersten GlüÄndStV soll dessen Zielerreichung auch durch die hier betrachtete ökonomische Analyse erfasst und bewertet werden.
Nach einer wirtschaftswissenschaftlichen Bestandaufnahme ist festzustellen, dass diese Studie jedoch wissenschaftlich unzulänglich ist und aufgrund ihrer vielfältigen definitorischen und methodischen Defizite keinen tragfähigen Beitrag für die Evaluierung des Ersten GlüÄndStV bildet. Das gilt vor allem, weil ein Großteil des zu evaluierenden Glücksspielmarkts in Deutschland von der Studie gar nicht abgebildet wird.
Polyether and polyether/ester based TPU (thermoplastic polyurethanes) were investigated with wide-angle XRD (X-ray diffraction) and SAXS (small angle X-ray scattering). Furthermore, SAXS measurements were performed in the temperature range of 30 °C to 130 °C. Polyether based polymers exhibit only one broad diffraction signal in a region of 2 θ 15° to 25°. In case of polyurethanes with ether/ester modification, the broad diffraction signal arises with small sharp diffraction signals. SAXS measurements of polymers reveal the size and shape of the crystalline zones of the polymer. Between 30 °C and 130 °C the size of the crystalline zone changes significantly. The size decreases in most of investigated TPU. In the case of Desmopan 9365D an increase of the particle size was observed.
The steadily decreasing prices of display technologies and computer graphics hardware contribute to the increasing popularity of multiple-display environments, like large, high-resolution displays. It is therefore necessary that educational organizations give the new generation of computer scientists an opportunity to become familiar with this kind of technology. However, there is a lack of tools that allow for getting started easily. Existing frameworks and libraries that provide support for multi-display rendering are often complex in understanding, configuration and extension. This is critical especially in educational context where the time that students have for their projects is limited and quite short. These tools are also rather known and used in research communities only, thus providing less benefit for future non-scientists. In this work we present an extension for the Unity game engine. The extension allows – with a small overhead – for implementation of applications that are apt to run on both single-display and multi-display systems. It takes care of the most common issues in the context of distributed and multi-display rendering like frame, camera and animation synchronization, thus reducing and simplifying the first steps into the topic. In conjunction with Unity, which significantly simplifies the creation of different kinds of virtual environments, the extension affords students to build mock-up virtual reality applications for large, high-resolution displays, and to implement and evaluate new interaction techniques and metaphors and visualization concepts. Unity itself, in our experience, is very popular among computer graphics students and therefore familiar to most of them. It is also often employed in projects of both research institutions and commercial organizations; so learning it will provide students with qualification in high demand.
§ 28e Abs. 1 Satz 2 SGB IV – Lehrstück für den Gesetzgeber oder: Wie eine Norm sich selbst erledigt!
(2015)
Allgemeines Steuerrecht
(2015)
Big Data und aktuelle Trends
(2015)