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This study deals with the in-situ detection of volume fractions of melt in labradorite and basalt at 0.3 GPa pressure and temperatures ranging from 400–1500 °C. Methods used were frequency dependent electrical conductivity (EC) and energy dispersive X-ray diffraction (EDX). These techniques allowed melt fraction determination under in-situ pressure and temperature conditions, while optical analysis (SEM) was performed on quenched samples. EC allowed detecting melt frac- tions as low as 0.03 due to changes in dielectric properties. Increasing melt fractions caused the formerly isolated melt bubbles to interconnect along grain boundaries, thus increasing the bulk conductivity. Electrical conductivity thus provides a measure for both, the formation of melt (dielectric property) and the degree of interconnection of melt (bulk conductivity). Energy dispersive X-ray diffraction experiments (EDX) provided an additional measure for the volume fraction of melt. EDX diffraction data were used to calculate the volume fraction of melt on the basis of the peak to background ratio. In a final step the experimental data (SEM, EC, EDX) were compared with geometric models of melt distribution, namely the Archie-, cube-, tube-, Hashin-Shtrikman HS + and HS - model. The electrical "polarisability" data closely fit the HS + model, while bulk conductivity data were found to be less sensitive for melt fraction detection.
Infection Exposure Promotes ETV6-RUNX1 Precursor B-cell Leukemia via Impaired H3K4 Demethylases
(2017)
ETV6-RUNX1 is associated with the most common subtype of childhood leukemia. As few ETV6-RUNX1 carriers develop precursor B cell acute lymphocytic leukemia (pB-ALL), the underlying genetic basis for development of full-blown leukemia remains to be identified, but the appearance of leukemia cases in time-space clusters keeps infection as a potential causal factor. Here we present in vivo genetic evidence mechanistically connecting preleukemic ETV6-RUNX1 expression in hematopoetic stem cells/peripheral cells (HSC/PC) and postnatal infections for human-like pB-ALL. In our model, ETV6-RUNX1 conferred a low risk of developing pB-ALL after exposure to common pathogens, corroborating the low incidence observed in humans. Murine preleukemic ETV6-RUNX1 pro/preB cells showed high Rag1/2 expression, known for human ETV6-RUNX1 pB-ALL. Murine and human ETV6-RUNX1 pB-ALL revealed recurrent genomic alterations, with a relevant proportion affecting genes of the lysine demethylase (KDM) family. KDM5C loss-of-function resulted in increased levels of H3K4me3, which co-precipitated with RAG2 in a human cell line model, laying the molecular basis for recombination activity. We conclude that alterations of KDM family members represent a disease-driving mechanism and an explanation for RAG off-target cleavage observed in humans. Our results explain the genetic basis for clonal evolution of an ETV6-RUNX1 preleukemic clone to pB-ALL after infection exposure and offer the possibility of novel therapeutic approaches.
In today’s business, culture plays a vital role or to a high degree influences the attitude, perception and decision making process of an individual. Culture is an unavoidable state of rules and regulations that defines people’s daily life in a particular environment or society. There are plenty examples of business failures or stagnation or failure of joint ventures, on account of the management's inability to recognize cross-cultural challenges and tackle them appropriately.
OpenDaylight (ODL) is a commercial, collaborative, open-source platform to accelerate the adoption and innovation of Software Defined Networking (SDN) and Network Function Visualization. This paper describes the novel ODL architecture in a simplified way to grasp a better understanding of such architecture. ODL architecture intends to foster new innovation and accelerate adoption of programming the network. The innovation of Model-Driven Service Abstraction Layer (MD-SAL) in the architecture leads to developing models for automatic management and configuration of the networks. MD-SAL provides ODL with the ability to support any protocol talking to the network elements as well as any network application. The flexibility inherent in ODL architecture could enable ODL to shape the next generation networks.
This study sought to determine the relationship between entrepreneurial education and youth employability and economic development in Kenya. A descriptive cross sectional design was used to collect data, with the main data collection instrument being a semi structured questionnaire. The population of the study comprised the micro, small and medium scale enterprises in Nairobi, Kenya. Out of the 100 questionnaires issued, 93 were completed and returned giving a response rate of 93%. Descriptive analysis (means and standard deviations ) and inferential analysis was used to analyze the data. Regression and correlation analysis was done to test the hypotheses. It was found that several indicators of entrepreneurial education had a significantly positive influence on youth employability. For example, entrepreneurial education enhances opportunity recognition as an indicator of entrepreneurial education was statistically significantly correlated with the statement that entrepreneurship endeavor is an employment alternative as an indicator of youth employability (r = 331**, P = 0.01). Similarly, the statement that entrepreneurial education sharpens competitiveness had a significantly positive influence on the statement that entrepreneurship endevour is an employment alternative (r =.313** P = 0.01). The overall model for entrepreneurial education and youth employability had an R Square value of 0.151, and an F value of 3.086, (p = 0.013 < 0.05), indicating that the influence is significant at the 0.05 level. The study found that most indicators of youth employability had a significantly positive correlation with indicators of economic development. It was found that there was a significant positive correlation between entrepreneurial education enhances new product and service development and entrepreneurial education reduces youth unemployment (r =0.304**, P = 0.01), while entrepreneurial education enhances new product and service development also has a positive correlation with entrepreneurial education reduces youth unemployment (.304** , P = 0.01). The overall model for youth employability and economic development had an R square value of .087 and F value of 2.103, p =0.87 > 0.05, indication that although youth employability is responsible for 8.7% of economic development, the effect is not statistically significant. The implication for this is that entrepreneurial education should be encouraged as a way of enhancing entrepreneurial thinking among the youth, so that they can use this to venture into self employment. However, this study did not find a significant direct link between youth employability and economic development, and this can only be implied. We suggest increased government support for entrepreneurship training and for closer industry university collaboration and partnerships in order to accelerate economic development.
Access to affordable energy - for basic needs as well as for national economic development - is a crucial concern for developing countries. Access to modern and sustainable energy services in rural areas, where the majority of the population is living in poverty, is a particularly urgent challenge, and one which has been recognized as crucial within the global development agenda.
The current dominant development model, focused on achieving macro-economic growth, gives priority to large-scale or centralized energy infrastructures for national growth or for meeting the urban demand. Rural areas of poorer countries are often at a disadvantage in terms of access to all types of services – roads, health facilities, markets, information and clean water. The high cost of providing these services in remote areas has led to new approaches being tried, based on self-help and the private sector rather than traditional government-led solutions. The missing access to electricity is primarily the reason for the poor operational environment of entrepreneurship especially in rural areas of developing countries, which poses many barriers to their development and limits their competitiveness. Energy services for household, agriculture and production serve as best examples as sectors exposed to enable entrepreneurship by productive use of renewable energy.
This paper describes the line-up, the challenges and the outcome of a development project in rural Ethiopia to support entrepreneurship based on the usage of renewable energy, in this case mainly photo-voltaic technology. In particular, this study tries to show up key features which are required to enable sustainable energy access and foster implementation challenges of developed business models in practice. Based on this experience, the paper discusses implications and lessons learned for a further development.
The non-farm sector is critical for the socio-economic development of Ghana especially the rural poor. Literature suggest that people engage in non-farm enterprises as a way out of poverty or a survival strategy, perhaps as a substitute for the landless. This paper analyses the determinants of individual participation in non-farm enterprises and the intensity of participation. The paper uses EGC/ISSER Socio-Economic Panel Survey data collected in 2009. The paper estimated the determinants of participation using a probit model and then estimated the intensity of participation using a truncated regression model. The results indicate that majority of women (about 73%) are engaged in non-farm enterprises in rural Ghana. The study found that females tended to participate more in non-farm self-employment and are less likely to participate in non-farm wage employment. The results further showed that individual characteristics such as the gender of the individual, being head of a household, being the spouse of a household head, having formal education, age of the individual, having access to credit, possessing a mobile phone, per capita landing holding and ownership of livestock influenced the participation of individuals in self-and wage employment. Results from truncated regression model for self-employed enterprises showed that having access to mobile phones, owning more livestock and electricity are important in determining the intensity of participation in self-employed enterprises. For wage-employment, being a household head, spouse of household head, having access to mobile phone and owning more livestock increased the number of days working on wage employment. Education is relevant for employment in the non-farm sector especially wage-employment. Government should play a lead role in making formal education accessible to the rural people. Deliberate policies should focus on addressing critical factors such as access to credit, mobile phone, electricity and education which are relevant for increasing participation intensity in rural enterprises.
Over the past decades, growing trends in social media, e-literacy and globalisation have led to the increased use of electrical and electronic equipment (EEE) in offices, schools, homes, hospitals and other institutions. Although, there are more efforts at introducing diversity, innovation and increased use of EEE, there had been limited effort at managing the end?of?life of these electronic devices. Evidence from previous research showed that the management of the end of life of electronic waste is highly dominated by Micro, Small and Medium Sized Enterprises (MSMEs) in the informal sector who employ more crude technology in their operations. This exploratory study therefore, sought to examine the activities of corporate bodies and MSMEs (formal and informal) in the e-waste sector in the Accra and Kumasi Metropolitan Areas in Ghana. Data was collected via questionnaires and interview from randomly selected respondents in the two metropolises. Results reveal that even though corporate institutions import a lot of electrical and electronic equipment, they do not have any policies on disposal of the e-waste generated. Thus, a high percentage of the e-waste generated is processed by the informal sector. The implications of the results are that policy makers and other stakeholders should encourage MSMEs to formalize their activities, support investment and green business development as well as funding and training for MSMEs operating in the sector.
Small and Medium Enterprises (SMEs) are engine of economy both for developed and developing countries. They play a significant role in income generation, job creation, poverty reduction and reducing income inequality. In Burundi, key stakeholders such as policy-makers as well as other international and national actors have made more effort to develop the segment of SMEs. Indeed, many start-ups have been created but are however, exposed to several challenges in their business operations. This paper aimed at investigating main critical barriers to SMEs growth and development in Burundi. The research was based upon a sample survey of small firms in Burundi and 314 small enterprises were surveyed. Rural start-ups’ critical barriers identified are mainly poor management, lack of access to market flow, lack of working capital, inadequate qualified workforce and low selling prices. On the other hand, five severe obstacles for urban SMEs identified are insecurity, access to financing, macroeconomic situation, lack of customers and unfair competition. A better understanding of all these barriers that SMEs are facing is useful to set up best strategies susceptible to increase their growth.
Entrepreneurship education serves a conduit for new venture creation as it provides the knowledge and skills needed to increase the self-efficacy of individuals to start and run new businesses and to grow existing ones. This study, therefore, sought to assess the relationship between the approaches to the teaching of entrepreneur-ship and entrepreneurial intention on a cohort of 292 respondents consisting of students who have studied entrepreneurship in three selected Universities. A structured questionnaire was used to obtain data randomly from students. The canonical correlation results indicate that education for and through entrepreneurship is the best approach to promoting entrepreneurial intensity among University students, if the aim of teaching entrepreneur-ship is to promote start-up activities. The findings provide valuable insights for institutions of higher learning and policy makers in Ghana with respect to the appropriate methodologies to be adopted in the teaching of entrepreneurship in our universities.
Media development cooperation has aimed for decades at enhancing free and independent media in developing countries as well as economies in transition. Within this field of activity, the concept of media viability has gained more and more attention in recent years. This is mainly due to a proposal of UNESCO`s intergovernmental Bureau of the International Programme for the Development of Communication (IPDC). The UNESCO, in partnership with DW Akademie, has drafted a list of indicators that delineate the influencing factors of media viability for media organizations in any given country (UNESCO 2015).
As a consequence of the novelty of the media viability concept, the state of scientific research is restricted. It is frequently focused on isolated case studies without providing a scientific basis for comparison. Empirical studies and comparative analyses are limited to certain media sectors such as the print market, as well as for journalism startups and spin-offs in developed economies.
We present a new interface for interactive comparisons of more than two alternative documents in the context of a generative design system that uses generative data-flow networks defined via directed acyclic graphs. To better show differences between such networks, we emphasize added, deleted, (un)changed nodes and edges. We emphasize differences in the output as well as parameters using highlighting and enable post-hoc merging of the state of a parameter across a selected set of alternatives. To minimize visual clutter, we introduce new difference visualizations for selected nodes and alternatives using additive and subtractive encodings, which improve readability and keep visual clutter low. We analyzed similarities in networks from a set of alternative designs produced by architecture students and found that the number of similarities outweighs the differences, which motivates use of subtractive encoding. We ran a user study to evaluate the two main proposed difference visualization encodings and found that they are equally effective.
Biomass in general, wood and grasses in particular represent attractive renewable sources for the fabrication of so-called building block chemicals (1). Thus, environmentally benign antimicrobial nanoparticles based on a silver-infused lignin core were recently reported underlying the high potential for valorization of lignin (2). The contribution presents specific correlations regarding the structural differences of lignins depending on both: source (wood vs. grass) and isolation procedure (Kraft vs. Organosolv). Special focus will be drawn on detailed structure deviations caused by Miscanthus genotypes (M. gigantheus, M. robustus, M. sisnensis).
In Africa slowly but steadily a transformation is taking place in the management styles of enterprises. There is a trend towards more precise time management, more precision in dealing with increasingly sophisticated technology, more feedback from the bottom to the top in order to manage the processes properly, more professionalism and independence of the individual worker.
This contribution makes two points: first, neither cultures nor the so-called mental states of individuals are ever static, but always on the move. Second, the force of passion and inspiration by which particular cultural values are endorsed in a particular context makes all the difference in their impact.
The importance of these two propositions comes to the fore, if the concept of an “economic culture” is taken into consideration. The claim of the authors is that the ongoing cultural transformation can be better understood in the dynamic approach of cultural values as proposed here.
Entrepreneurship Development and New Business Challenges and Prospects for Ghanaian Entrepreneurs’
(2017)
This paper presents a framework for formulating strategies for business start-ups within the context of small and medium-scale enterprises (SMEs) in diverse industries. Using Ghana as a case study, it addresses how to increase entrepreneurs’ success rate in business ventures in developing countries. The objective of the study is to identify avenues through which entrepreneurs could address the challenges they face, and to take advantage of the emerging opportunities in the domestic and global business environments. The questions addressed are, what challenges face Ghanaian entrepreneurs’ new business start-ups and existing SME’s in developing countries? How could these challenges be addressed appropriately to make the private sector the engine of growth in Ghana’s economy? The methodology is based on the qualitative approach, involving interviews to achieve the study’s objectives. Four main themes emerged as challenges faced by the entrepreneurs business start-ups and operations which include the following: Funding availability & accessibility; Lack of planning, Skilled labour & proper management skills; Lack of competitiveness, technology innovation & customer loyalty; and finally, Legal & regulatory framework & social factors. Recommendations for entrepreneurs, policy makers, and scholars are discussed in the study.
Examining the Effect of Corruption and Bureaucracy on SMEs Growth in the Kumasi Metropolis of Ghana
(2017)
Small and Medium Enterprises (SMEs) are considered a seed-bed of entrepreneurship and innovation in most emerging economies; nevertheless, SMEs sometimes lack an enabling business climate, which hinders their potential growth. This paper examines the effect of corruption and bureaucracy on SMEs growth in the Kumasi Metropolis of Ghana. The study was a quantitative research, and convenience sampling method was employed to select 373 owners/managers as respondents for the study. Employing questionnaire as its main data collection instrument, the study used Gretl version 3.0 Statistical Software for the analysis of data collected. The results of the study revealed that 1% increase in corruption in the SMEs sector leads to 36.12% decline in SMEs growth (sales and employment), and 1% increase in bureaucracy leads to 28.76% decrease in the growth of SMEs. An interesting outcome of the study was that the excessive bureaucratic bottlenecks in the SMEs sector are implied by corruption. We, therefore, conclude that there is a significant negative relationship between corruption and bureaucracy and SMEs growth. It is, therefore, recommended that the government takes a giant-step to fight corruption in the SMEs sector by ensuring transparency and accountability of public officials and also streamline its systems and activities in the sector to reduce the excessive administrative barriers. The present study adds substantial value to the body of research on SMEs as it is the first research to have considered the joint effect of corruption and bureaucracy on SMEs growth in an emerging economy like Ghana.
Gender disproportions have been part and parcel of most African cultures since time immemorial. Demographically, women are over a half population in most of the African countries but their participation in sectors of socio-economic and political spheres have remained inadequately represented. The enduring and biased beliefs on gender roles that view women much less important as compared to men are what forms the basis of concern to the welfare of women and most importantly the women entrepreneurs. This study reveals the long-standing cultural practices that have contributed to gender inequality and goes further to demystify areas in which women have continually experienced inequality and thus affecting their entrepreneurial spirit. Through the desk research methodology, it can be deduced that the following are key areas that pause a threat to women socio-economic and political development and hence the inequality being experienced even today in the twenty first century: harmful marriage, female genital mutilation, wife inheritance and HIV scourge, access to land including land rights and right to property, over-emphasizing patriarchal system of family, and gender violence. These factors compounded together, have resulted for unfortunate experiences that have been witnessed in the education sector, political participation, participation in policy making, gender division of labour and inaccess to credit facility. These experiences have severely thwarted entrepreneurial growth of women. The study therefore recommends that there is imperative need for a paradigm shift in these areas to ensure women are not only liberated and empowered but also their full participation in the entrepreneurship activities are highly strengthened and promoted.
Climate change is having drastic effects on various areas of the planet, including extreme impacts on weather and rainfall, in various Sub-Saharan East African countries (Hendrix, C. S., & Glaser, S. M. (2007). The willingness (and need) of a niche market to actively improve the damaged ecosystems in small ways is rising. Weaver and Lawton (2007, p 1170) maintain that ecotourism should satisfy three core criteria: "(1) attractions should be predominantly nature-based; (2) visitor interactions with those attractions should be focused on learning or education, and (3) experience and product management should follow principles and practices associated with ecological, socio-cultural and economic sustainability." In this study, the niche market of active German "tree-planters" is to be defined and the potential willingness to travel to, learn from and invest in the ecosystem through tree-planting, specifically in Kenya, is explored.
This study sought to contribute to knowledge by assessing the moderating effect of industry forces on the relationship between linkage strategies and performance of universities in Kenya. Porter’s five forces model and Resource Based View (RBV) are the main theories anchoring the study. Cross-Sectional survey was adopted as the research design. The population of the study consists of sixtyfive (65) public and private universities incorporated in Kenya. Out of this, a sample of forty seven (47) universities which had undergone at least one graduation cycle was taken. Primary and secondary data was collected using semi-structured questionnaires and review of existing university documents and regulatory bodies websites respectively. The instrument was tested for reliability and found fit. Analysis was undertaken using correlation and regression analyses to test hypotheses. Analysis of variance was also used to determine the differences between group means. Coefficient of variation (C.V) was also used to measure variability and consistency in scores of different universities when standard deviation and arithmetic means are compared. Out of the targeted forty seven (47) respondents from forty seven (47) universities, a total of forty four (44) questionnaires were returned, representing 94% response rate. It was established that there is a moderating effect of industry forces on the relationship between linkage strategies and organizational performance. The results provided rich implications for theory, policy and practice. The significance of industry forces in strategy formulation and implementation requires concentrated attention. The findings offer insights to university authorities and policy makers by answering the question on the influence of industry forces on performance of higher learning institutions. The key recommendation that the study offers to the stakeholders, is the need to consider industry forces as critical determinants during strategy formulation and implementation process in order to enhance university performance. The main limitation of this study is that primary data was collected from only one respondent per university but common methods bias was mitigated through the use of additional secondary data to validate primary data. Thus, the limitation did not affect the credence of the results as presented and discussed. Secondly, although it was not possible to include all the determinants of institutional performance, balanced score card was appropriately used to represent financial and non-financial aspects that constitute performance indicators.
This paper focuses on entrepreneurship and private sector development in Ghana with regard to the government’s initiative towards supporting private sector development through the Microfinance & Small Loans Centre (MASLOC) and the National Board for Small Scale Industries (NBSSI) initiatives to support new and existing small and medium-scale enterprises (SMEs) in diverse industries. The study addresses some of the main problems facing the two government-sponsored initiatives and issues with accessing venture capital for business start-ups in Ghana. The objective of the study is to identify possible strategies through which the MASLOC and NBSSI could be improved to serve the needs of their customers more effectively and efficiently. Enhancing the performance of these public organizations could offer many SMEs in Ghana take advantage of the new opportunities in the domestic and global business environments. The questions to be addressed are; to what extent do the activities of the NBSSI and MASLOC meet the needs of SMEs in Ghana? What challenges are associated with their services and how can management of the two organizations address the challenges they face more appropriately? The methodology is based on the qualitative and quantitative approaches, involving interviews and the administration of questionnaires and surveys to achieve the study’s objectives and goals. Based on the identified challenges, the study concludes with findings and recommendations for the management of NBSSI and MASLOC as well as entrepreneurs engaged in different SMEs in diverse industries and policy makers.
Ghanaian tertiary graduates' perception of entrepreneurship education on employment opportunities
(2017)
This study focuses on whether entrepreneurship education increases entrepreneurial interest in students to set up new businesses. Entrepreneurship is a core course taken in the third year by all students of Ho Technical University. Out of the 1329 population of level 300 students of the 2016/2017 academic year, data were collected by convenience sampling from 325 (217 males and 108 females) with mean age of 24.75 years from 14 departments of four faculties. The students responded to 43-survey items derived from reviewed literature on a 5-Point Likert-Scale. It is concluded that more than 84% of the respondents agreed that entrepreneurship education informed students about entrepreneurship through the acquisition of practical skills, knowledge about acquisition of personal orientation, knowledge about business management principles and the availability of entrepreneurial support agencies. This shows that the students are highly confident of setting up their own businesses through the knowledge acquired. The study therefore has important implications for policy makers, management of tertiary institutions, students and educational evaluators on how to ensure that tertiary graduates set up entrepreneurship ventures in order to partially solve the unemployment problem in Ghana.
ICT integration by universities teaching professionals is emerging as a major concern, this study demonstrate the need to address the integration problem by encouraging existing metrics use in indexing ICT integration as an ICT governance strategy. Quality of integration depends on quality indexing which also depend on quality of existing metrics and their use. Considering the role that University Information Technology Teaching Professionals’ (UITTPs) continuous improvement indexing can offer, towards autonomic governance of the continuous emerging ICTs in the university teaching, this study examined extent in use of existing ICT integration metrics to index ICT integration by the UITTPs. Six metrics for ICT integration were investigated; time, workshop course content relevance, technical malfunctions, support conditions, support services, and motivation and commitment to student learning and staff professional development metrics. Descriptive survey design was used in which interviews were conducted to UITTPs in three (3) public and three (3) private purposively selected universities in Kenya. The findings were analyzed descriptively and inferentially using Kendall’s correlation of concordance and tested using Chi-square on the extent of concordance and presented with help of frequency tables, figures and percentages. The findings revealed that all the metrics are rarely used for indexing ICT integration (32.8%), and most UITTPs were in discordance on this level of all the six metrics use except for support condition. This implied that the use of metrics for indexing integration has not been formalized across the Kenyan universities. Universities need to be encouraged to identify suitable metrics, formalize them and improve their frequency in use. Secondly, socio based metrics such as content relevance are used more frequently for indexing integration as compared to Technical metrics, socio-technical metrics balance therefore need to be emphasized by the universities management when determining and using metrics for indexing ICT integration.
Experiential Learning through the Transformational Incubation Programme: a Ghanaian case study
(2017)
This paper explores experiential learning theory (ELT) from a case study describing the Transformational Incubation Programme for Coventry University Alumni in Ghana. The incubator represents a collaboration between Coventry University and British Council Ghana. The aim of the programme is to embed a blended, experiential learning approach to practice-based entrepreneurship education via an incubator designed to support scalable business start-up and growth. world venture creation, business development and acceleration. The paper offers a generic framework for Transformational entrepreneurship experiential learning in this context. The incubator offers an opportunity to engage with practice-oriented and experience based learning applied to real.
With trainings and research oriented towards sustainable development since 2006 (Water and Sanitation, Infrastructure, Renewable Energies and Energy Processes), Foundation 2iE is positioning itself as a reference institute that trains innovative engineers-entrepreneurs for the needs and challenges of Africa’s development. Center of Excellence of the UEMOA and the World Bank, CSR is at the heart of the Strategy of the institute which aims to be a showcase in this field in Africa.
Over the years, entrepreneurship has proven to be one of the key roles towards development. The cycle of business start-ups and growth are linked to the socio-economic benefits of the global world at large. With a growing world population of over 7billion people, the existence of universities (both public &private) as well as enterprises has increased globally in the 21st century. The mission and purpose behind Universities, Entrepreneurship and Enterprises thrive on development in the areas of capacity building, skill acquisition, training and knowledge amongst others. Africa alone has a population of over 1.2billion people with about 650 recognized universities and over 140,000 registered businesses (enterprises) in Ghana alone. A case study in Ghana reveals three key drivers towards entrepreneurship and the role university education has played in various business establishments. The drivers are problem statements, resources and research findings. Some of these notions to business include the management of risk, research findings and customer relationship. These are major features that need critical attention and play a role in business and entrepreneurship in Africa. A major success in business and entrepreneurship is the utilization of the human resource population and the lifeline support given to households in terms of income, while a barrier being the limited access to credit support from the financial companies at the inception stages. In conclusion, this conference should develop a practical book guide on business start-ups and entrepreneurship knowledge to be used at the various universities in Africa to enhance development.
Dare – Democracy and Science
(2017)
Do remittances and social assistance transfers have different impacts on household’s expenditure patterns? While two separate strands of literature have looked at how social assistance or remittances have been spent, few studies have compared them directly. Using data from a household survey conducted in Moldova in 2011, this paper assesses the impact both types of transfers have on household expenditure patterns. Contrary to the common assumption that money is fungible, we find that social assistance and remittances have different impacts on expenditure patterns (having controlled for potential endogeneity). In other words, where the income comes from can determine how it is spent. As such, different sources of income may have different poverty impacts. In our sample, the two types of transfers are received by different, but slightly overlapping population groups. The fact that the two transfers are spent in different ways means that, to some extent, social assistance and remittances are complements rather than substitutes.
The detection of human skin in images is a very desirable feature for applications such as biometric face recognition, which is becoming more frequently used for, e.g., automated border or access control. However, distinguishing real skin from other materials based on imagery captured in the visual spectrum alone and in spite of varying skin types and lighting conditions can be dicult and unreliable. Therefore, spoofing attacks with facial disguises or masks are still a serious problem for state of the art face recognition algorithms. This dissertation presents a novel approach for reliable skin detection based on spectral remission properties in the short-wave infrared (SWIR) spectrum and proposes a cross-modal method that enhances existing solutions for face verification to ensure the authenticity of a face even in the presence of partial disguises or masks. Furthermore, it presents a reference design and the necessary building blocks for an active multispectral camera system that implements this approach, as well as an in-depth evaluation. The system acquires four-band multispectral images within T = 50ms. Using a machine-learning-based classifier, it achieves unprecedented skin detection accuracy, even in the presence of skin-like materials used for spoofing attacks. Paired with a commercial face recognition software, the system successfully rejected all evaluated attempts to counterfeit a foreign face.
In recent years, there has been a growing interest in the start-up scene in sub-Saharan Africa. "Silicon Savannah" is today widely used to describe the thriving IT industry in and around Nairobi. Kenya's geographical advantage, its favorable economic reforms, and mature start-up ecosystem makes it stands out positively. Since a lot of hype exists around the start-up scene many investors are drawn to it, but in reality very few start-ups are investment-ready. The increasing start-up requirements and needs force incubators to diversify their offer. In contrast, to traditional incubators, an Innovation Hub (Hub) is characterized based on the concept of open innovation and collaboration. A Hub nurtures an enabling environment where a community of entrepreneurs can grow. At the same time, it serves as a nexus point for the local start-up community, investors, academia, technology companies and the wider private sector. It aims to create a structure where people serendipitously interact with others that they would not typically meet. Considering the great interest for and the large amounts of money invested in Hubs by governments, universities, private companies and other interested parties, not only researchers have been raising the question of the actual benefit of Hubs. This research study aims to investigate to what extent the support offered by the Hubs is tackling the challenges faced by start-ups in Nairobi, Kenya. The analysis can serve as a basis for identifying strength and weaknesses in the Hub models.
Solid-Phase Microextraction (SPME) is a very simple and efficient, solventless sample preparation method, invented by Pawliszyn and coworkers at the University of Waterloo (Canada) in 1989. This method has been widely used in different fields of analytical chemistry since its first applications to environmental and food analysis. SPME integrates sampling, extraction, concentration and sample introduction into a single solvent-free step. The method saves preparation time, disposal costs and can improve detection limits. It has been routinely used in combination with gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS) and successfully applied to a wide variety of ompounds, especially for the extraction of volatile and semi-volatile organic compounds from environmental, biological and food samples.
Since the last twenty years, SPME in headspace (HS) mode is used as a valuable sample preparation technique for identifying degradation products in polymers and for determination of rest monomers and other light-boiling substances in polymeric materials. For more than ten years, our laboratory has been involved in projects focused on the application of HS-SPME-GC/MS for the characterization of polymeric materials from many branches of manufacturing and building industries. This book chapter describes the application examples of this technique for identifying volatile organic compounds (VOCs), additives and degradation products in industrial plastics, rubber, and packaging materials.
A deployment of the Vehicle-2-Vehicle communication technology according to ETSI is in preparation in Europe. Currently, a policy for a necessary Public Key Infrastructure to enrol cryptographic keys and certificates for vehicles and infrastructure component is in discussion to enable an interoperable Vehicle-2-Vehicle communication. Vehicle-2-Vehicle communication means that vehicles periodically send Cooperative Awareness Messages. These messages contain the current geographic position, driving direction, speed, acceleration, and the current time of a vehicle. To protect privacy (location privacy, “speed privacy”) of vehicles and drivers ETSI provides a specific pseudonym concept. We show that the Vehicle-2-Vehicle communication can be misused by an attacker to plot a trace of sequent Cooperative Awareness Messages and to link this trace to a specific vehicle. Such a trace is non-disputable due to the cryptographic signing of the messages. So, the periodically sending of Cooperative Awareness Messages causes privacy problems even if the pseudonym concept is applied.
An increased bronchoconstrictor response is a hallmark in the progression of obstructive airway diseases. Acetylcholine and 5-hydroxytryptamine (5-HT, serotonin) are the major bronchoconstrictors. There is evidence that both cholinergic and serotonergic signaling in airway smooth muscle (ASM) involve caveolae. We hypothesized that caveolin-1 (cav-1), a structural protein of caveolae, plays an important regulatory role in ASM contraction. We analyzed airway contraction in different tracheal segments and extra-and intrapulmonary bronchi in cav-1 deficient (cav-1-/-) and wild-type mice using organ bath recordings and videomorphometry of methyl-beta-cyclodextrin (MCD) treated and non-treated precision-cut lung slices (PCLS). The presence of caveolae was investigated by electron microscopy. Receptor subtypes driving 5-HT-responses were studied by RT-PCR and videomorphometry after pharmacological inhibition with ketanserin. Cav-1 was present in tracheal epithelium and ASM. Muscarine induced a dose dependent contraction in all airway segments. A significantly higher Emax was observed in the caudal trachea. Although, caveolae abundancy was largely reduced in cav-1-/- mice, muscarine-induced airway contraction was maintained, albeit at diminished potency in the middle trachea, in the caudal trachea and in the bronchus without changes in the maximum efficacy. MCD-treatment of PLCS from cav-1-/- mice reduced cholinergic constriction by about 50%, indicating that cholesterol-rich plasma domains account for a substantial portion of the muscarine-induced bronchoconstriction. Notably, cav-1-deficiency fully abrogated 5-HT-induced contraction of extrapulmonary airways. In contrast, 5-HT-induced bronchoconstriction was fully maintained in cav-1-deficient intrapulmonary bronchi, but desensitization upon repetitive stimulation was enhanced. RT-PCR analysis revealed 5-HT1B, 5-HT2A, 5-HT6, and 5-HT7 receptors as the most prevalent subtypes in the airways. The 5-HT-induced-constriction in PCLS could be antagonized by ketanserin, a 5-HT2A receptor inhibitor. In conclusion, the role of cav-1, caveolae, and cholesterol-rich plasma domains in regulation of airway tone are highly agonist-specific and dependent on airway level. Cav-1 is indispensable for serotonergic contraction of extrapulmonary airways and modulates cholinergic constriction of the trachea and main bronchus. Thus, cav-1/caveolae shall be considered in settings such as bronchial hyperreactivity in common airway diseases and might provide an opportunity for modulation of the constrictor response.
Recently, we discovered a cholinergic mechanism that inhibits the adenosine triphosphate (ATP)-dependent release of interleukin-1 beta (IL-1 beta) by human monocytes via nicotinic acetylcholine receptors (nAChRs) composed of alpha 7, alpha 9 and/or alpha 10 subunits. Furthermore, we identified phosphocholine (PC) and dipalmitoylphosphatidylcholine (DPPC) as novel nicotinic agonists that elicit metabotropic activity at monocytic nAChR. Interestingly, PC does not provoke ion channel responses at conventional nAChRs composed of subunits alpha 9 and alpha 10. The purpose of this study is to determine the composition of nAChRs necessary for nicotinic signaling in monocytic cells and to test the hypothesis that common metabolites of phosphatidylcholines, lysophosphatidylcholine (LPC) and glycerophosphocholine (G-PC), function as nAChR agonists. In peripheral blood mononuclear cells from nAChR gene-deficient mice, we demonstrated that inhibition of ATP-dependent release of IL-1 beta by acetylcholine (ACh), nicotine and PC depends on subunits alpha 7, alpha 9 and alpha 10. Using a panel of nAChR antagonists and siRNA technology, we confirmed the involvement of these subunits in the control of IL-1 beta release in the human monocytic cell line U937. Furthermore, we showed that LPC (C16:0) and G-PC efficiently inhibit ATP-dependent release of IL-1 beta. Of note, the inhibitory effects mediated by LPC and G-PC depend on nAChR subunits alpha 9 and alpha 10, but only to a small degree on alpha 7. In Xenopus laevis oocytes heterologously expressing different combinations of human alpha 7, alpha 9 or alpha 10 subunits, ACh induced canonical ion channel activity, whereas LPC, G-PC and PC did not. In conclusion, we demonstrate that canonical nicotinic agonists and PC elicit metabotropic nAChR activity in monocytes via interaction of nAChR subunits alpha 7, alpha 9 and alpha 10. For the metabotropic signaling of LPC and G-PC, nAChR subunits alpha 9 and alpha 10 are needed, whereas alpha 7 is virtually dispensable. Furthermore, molecules bearing a PC group in general seem to regulate immune functions without perturbing canonical ion channel functions of nAChR.
Hydrogen sulfide stimulates CFTR in Xenopus oocytes by activation of the cAMP/PKA signalling axis
(2017)
Hydrogen sulfide (H2S) has been recognized as a signalling molecule which affects the activity of ion channels and transporters in epithelial cells. The cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial anion channel and a key regulator of electrolyte and fluid homeostasis. In this study, we investigated the regulation of CFTR by H2S. Human CFTR was heterologously expressed in Xenopus oocytes and its activity was electrophysiologically measured by microelectrode recordings. The H2S-forming sulphur salt Na2S as well as the slow-releasing H2S-liberating compound GYY4137 increased transmembrane currents of CFTR-expressing oocytes. Na2S had no effect on native, noninjected oocytes. The effect of Na2S was blocked by the CFTR inhibitor CFTR_inh172, the adenylyl cyclase inhibitor MDL 12330A, and the protein kinase A antagonist cAMPS-Rp. Na2S potentiated CFTR stimulation by forskolin, but not that by IBMX. Na2S enhanced CFTR stimulation by membranepermeable 8Br-cAMP under inhibition of adenylyl cyclase-mediated cAMP production by MDL 12330A. These data indicate that H2S activates CFTR in Xenopus oocytes by inhibiting phosphodiesterase activity and subsequent stimulation of CFTR by cAMP-dependent protein kinase A. In epithelia, an increased CFTR activity may correspond to a pro-secretory response to H2S which may be endogenously produced by the epithelium or H2S-generating microflora.
BACKGROUND
Given the unreliable self-report in patients with dementia, pain assessment should also rely on the observation of pain behaviors, such as facial expressions. Ideal observers should be well trained and should observe the patient continuously in order to pick up any pain-indicative behavior; which are requisitions beyond realistic possibilities of pain care. Therefore, the need for video-based pain detection systems has been repeatedly voiced. Such systems would allow for constant monitoring of pain behaviors and thereby allow for a timely adjustment of pain management in these fragile patients, who are often undertreated for pain.
METHODS
In this road map paper we describe an interdisciplinary approach to develop such a video-based pain detection system. The development starts with the selection of appropriate video material of people in pain as well as the development of technical methods to capture their faces. Furthermore, single facial motions are automatically extracted according to an international coding system. Computer algorithms are trained to detect the combination and timing of those motions, which are pain-indicative.
RESULTS/CONCLUSION
We hope to encourage colleagues to join forces and to inform end-users about an imminent solution of a pressing pain-care problem. For the near future, implementation of such systems can be foreseen to monitor immobile patients in intensive and postoperative care situations.
A device includes an input to sequential data associated to a face; a predictor configured to predict facial parameters; and a corrector configured to correct the predicted facial parameters on the basis of input data, the input data containing geometric measurements and other information. A related method and a related computer program are also disclosed.
This work presents the analysis of data recorded by an eye tracking device in the course of evaluating a foveated rendering approach for head-mounted displays (HMDs). Foveated rendering methods adapt the image synthesis process to the user’s gaze and exploiting the human visual system’s limitations to increase rendering performance. Especially, foveated rendering has great potential when certain requirements have to be fulfilled, like low-latency rendering to cope with high display refresh rates. This is crucial for virtual reality (VR), as a high level of immersion, which can only be achieved with high rendering performance and also helps to reduce nausea, is an important factor in this field. We put things in context by first providing basic information about our rendering system, followed by a description of the user study and the collected data. This data stems from fixation tasks that subjects had to perform while being shown fly-through sequences of virtual scenes on an HMD. These fixation tasks consisted of a combination of various scenes and fixation modes. Besides static fixation targets, moving tar- gets on randomized paths as well as a free focus mode were tested. Using this data, we estimate the precision of the utilized eye tracker and analyze the participants’ accuracy in focusing the displayed fixation targets. Here, we also take a look at eccentricity-dependent quality ratings. Comparing this information with the users’ quality ratings given for the displayed sequences then reveals an interesting connection between fixation modes, fixation accuracy and quality ratings.