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- bone tissue engineering (2)
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- employee well-being (2)
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The choice of suitable semiconducting metal oxide (MOX) gas sensors for the detection of a specific gas or gas mixture is time-consuming since the sensor’s sensitivity needs to be characterized at multiple temperatures to find its optimal operating conditions. To obtain reliable measurement results, it is very important that the power for the sensor’s integrated heater is stable, regulated and error-free (or error-tolerant). Especially the error-free requirement can be only be achieved if the power supply implements failure-avoiding and failure-detection methods. The biggest challenge is deriving multiple different voltages from a common supply in an efficient way while keeping the system as small and lightweight as possible. This work presents a reliable, compact, embedded system that addresses the power supply requirements for fully automated simultaneous sensor characterization for up to 16 sensors at multiple temperatures. The system implements efficient (avg. 83.3% efficiency) voltage conversion with low ripple output (<32 mV) and supports static or temperature-cycled heating modes. Voltage and current of each channel are constantly monitored and regulated to guarantee reliable operation. To evaluate the proposed design, 16 sensors were screened. The results are shown in the experimental part of this work.
This paper proposes an approach to an ANN-based temperature controller design for a plastic injection moulding system. This design approach is applied to the development of a controller based on a combination of a classical ANN and integrator. The controller provides a fast temperature response and zero steady-state error for three typical heaters (bar, nozzle, and cartridge) for a plastic moulding system. The simulation results in Matlab Simulink software and in comparison to an industrial PID regulator have shown the advantages of the controller, such as significantly less overshoot and faster transient (compared to PID with autotuning) for all examined heaters. In order to verify the proposed approach, the designed ANN controller was implemented and tested using an experimental setup based on an STM32 board.
More and more devices will be connected to the internet [3]. Many devicesare part of the so-called Internet of Things (IoT) which contains many low-powerdevices often powered by a battery. These devices mainly communicate with the manufacturers back-end and deliver personal data and secrets like passwords.
Lower back pain is one of the most prevalent diseases in Western societies. A large percentage of European and American populations suffer from back pain at some point in their lives. One successful approach to address lower back pain is postural training, which can be supported by wearable devices, providing real-time feedback about the user’s posture. In this work, we analyze the changes in posture induced by postural training. To this end, we compare snapshots before and after training, as measured by the Gokhale SpineTracker™. Considering pairs of before and after snapshots in different positions (standing, sitting, and bending), we introduce a feature space, that allows for unsupervised clustering. We show that resulting clusters represent certain groups of postural changes, which are meaningful to professional posture trainers.
The antiradical and antimicrobial activity of lignin and lignin-based films are both of great interest for applications such as food packaging additives. The polyphenolic structure of lignin in addition to the presence of O-containing functional groups is potentially responsible for these activities. This study used DPPH assays to discuss the antiradical activity of HPMC/lignin and HPMC/lignin/chitosan films. The scavenging activity (SA) of both binary (HPMC/lignin) and ternary (HPMC/lignin/chitosan) systems was affected by the percentage of the added lignin: the 5% addition showed the highest activity and the 30% addition had the lowest. Both scavenging activity and antimicrobial activity are dependent on the biomass source showing the following trend: organosolv of softwood > kraft of softwood > organosolv of grass. Testing the antimicrobial activities of lignins and lignin-containing films showed high antimicrobial activities against Gram-positive and Gram-negative bacteria at 35 °C and at low temperatures (0-7 °C). Purification of kraft lignin has a negative effect on the antimicrobial activity while storage has positive effect. The lignin release in the produced films affected the activity positively and the chitosan addition enhances the activity even more for both Gram-positive and Gram-negative bacteria. Testing the films against spoilage bacteria that grow at low temperatures revealed the activity of the 30% addition on HPMC/L1 film against both B. thermosphacta and P. fluorescens while L5 was active only against B. thermosphacta. In HPMC/lignin/chitosan films, the 5% addition exhibited activity against both B. thermosphacta and P. fluorescens.
Due to global ecological and economic challenges that have been correlated to the transition from fossil-based to renewable resources, fundamental studies are being performed worldwide to replace fossil fuel raw materials in plastic production. One aspect of current research is the development of lignin-derived polyols to substitute expensive fossil-based polyol components for polyurethane and polyester production. This article describes the synthesis of bioactive lignin-based polyurethane coatings using unmodified and demethylated Kraft lignins. Demethylation was performed to enhance the reaction selectivity toward polyurethane formation. The antimicrobial activity was tested according to a slightly modified standard test (JIS Z 2801:2010). Besides effects caused by the lignins themselves, triphenylmethane derivatives (brilliant green and crystal violet) were used as additional antimicrobial substances. Results showed increased antimicrobial capacity against Staphylococcus aureus. Furthermore, the coating color could be varied from dark brown to green and blue, respectively.
Change - shaping reality
(2019)
The complex nature of multifactorial diseases, such as Morbus Alzheimer, has produced a strong need to design multitarget-directed ligands to address the involved complementary pathways. We performed a purposive structural modification of a tetratarget small-molecule, that is contilisant, and generated a combinatorial library of 28 substituted chromen-4-ones. The compounds comprise a basic moiety which is linker-connected to the 6-position of the heterocyclic chromenone core. The syntheses were accomplished by Mitsunobu- or Williamson-type ether formations. The resulting library members were evaluated at a panel of seven human enzymes, all of which being involved in the pathophysiology of neurodegeneration. A concomitant inhibition of human acetylcholinesterase and human monoamine oxidase B, with IC50 values of 5.58 and 7.20 μM, respectively, was achieved with the dual-target 6-(4-(piperidin-1-yl)butoxy)-4H-chromen-4-one (7).
Currently, a variety of methods exist for creating different types of spatio-temporal world models. Despite the numerous methods for this type of modeling, there exists no methodology for comparing the different approaches or their suitability for a given application e.g. logistics robots. In order to establish a means for comparing and selecting the best-fitting spatio-temporal world modeling technique, a methodology and standard set of criteria must be established. To that end, state-of-the-art methods for this type of modeling will be collected, listed, and described. Existing methods used for evaluation will also be collected where possible.
Using the collected methods, new criteria and techniques will be devised to enable the comparison of various methods in a qualitative manner. Experiments will be proposed to further narrow and ultimately select a spatio-temporal model for a given purpose. An example network of autonomous logistic robots, ROPOD, will serve as a case study used to demonstrate the use of the new criteria. This will also serve to guide the design of future experiments that aim to select a spatio-temporal world modeling technique for a given task. ROPOD was specifically selected as it operates in a real-world, human shared environment. This type of environment is desirable for experiments as it provides a unique combination of common and novel problems that arise when selecting an appropriate spatio-temporal world model. Using the developed criteria, a qualitative analysis will be applied to the selected methods to remove unfit options.
Then, experiments will be run on the remaining methods to provide comparative benchmarks. Finally, the results will be analyzed and recommendations to ROPOD will be made.
Multi-robot systems (MRS) are capable of performing a set of tasks by dividing them among the robots in the fleet. One of the challenges of working with multirobot systems is deciding which robot should execute each task. Multi-robot task allocation (MRTA) algorithms address this problem by explicitly assigning tasks to robots with the goal of maximizing the overall performance of the system. The indoor transportation of goods is a practical application of multi-robot systems in the area of logistics. The ROPOD project works on developing multi-robot system solutions for logistics in hospital facilities. The correct selection of an MRTA algorithm is crucial for enhancing transportation tasks. Several multi-robot task allocation algorithms exist in the literature, but just few experimental comparative analysis have been performed. This project analyzes and assesses the performance of MRTA algorithms for allocating supply cart transportation tasks to a fleet of robots. We conducted a qualitative analysis of MRTA algorithms, selected the most suitable ones based on the ROPOD requirements, implemented four of them (MURDOCH, SSI, TeSSI, and TeSSIduo), and evaluated the quality of their allocations using a common experimental setup and 10 experiments. Our experiments include off-line and semi on-line allocation of tasks as well as scalability tests and use virtual robots implemented as Docker containers. This design should facilitate deployment of the system on the physical robots. Our experiments conclude that TeSSI and TeSSIduo suit best the ROPOD requirements. Both use temporal constraints to build task schedules and run in polynomial time, which allow them to scale well with the number of tasks and robots. TeSSI distributes the tasks among more robots in the fleet, while TeSSIduo tends to use a lower percentage of the available robots.
Subsequently, we have integrated TeSSI and TeSSIduo to perform multi-robot task allocation for the ROPOD project.
Scratch assays enable the study of the migration process of an injured adherent cell layer in vitro. An apparatus for the reproducible performance of scratch assays and cell harvesting has been developed that meets the requirements for reproducibility in tests as well as easy handling. The entirely autoclavable setup is divided into a sample translation and a scratching system. The translational system is compatible with standard culture dishes and can be modified to adapt to different cell culture systems, while the scratching system can be adjusted according to angle, normal force, shape, and material to adapt to specific questions and demanding substrates. As a result, a fully functional prototype can be presented. This system enables the creation of reproducible and clear scratch edges with a low scratch border roughness within a monolayer of cells. Moreover, the apparatus allows the collection of the migrated cells after scratching for further molecular biological investigations without the need for a second processing step. For comparison, the mechanical properties of manually performed scratch assays are evaluated.
This study presents a microindentation system which allows spatially resolved local as well as bulk viscoelastic material information to be obtained within one instrument. The microindentation method was merged with dynamic mechanical analysis (DMA) for a tungsten cone indenter. Three tungsten cone indenters were investigated: tungsten electrode, tungsten electrode + 2% lanthanum, and tungsten electrode + rare earth elements. Only the tungsten electrode + 2% lanthanum indenter showed the sinusoidal response, and its geometry remained unaffected by the repeated indentations. Complex moduli obtained from dynamic microindentation for high-density polyethylene, polybutylene terephthalate, polycarbonate, and thermoplastic polyurethane are in agreement with the literature. Additionally, by implementing a specially developed x-y-stage, this study showed that dynamic microindentation with a tungsten cone indenter was an adequate method to determine spatially resolved local viscoelastic surface properties.
Digital transformation in Higher Education and Science is a mission-critical demand to prepare educational institutions for their future competition on the international market. In many cases, the digitization goes along with the search for and acquisition of new software. For easily exchangeable software, wrong product decisions, in the worst case, lead to calculable financial losses. However, if a planned software requires a lot of technological adjustments and is to be applied as central component of a business- and/or security-critical environment, wrong decisions during the software acquisition process might lead to hardly calculable damage. Questions arising are how to decide for a product and how many resources should be invested for the acquisition process.
We planned to apply a commercial Business Support System, which should replace the currently used in-house developed software. Our goals were the increase of our university’s level of data security, to ease the interaction between stakeholders, to eliminate media discontinuities, to improve the process management and transparency, and to reduce the execution time of automated processes. Alongside with the introduction of the electronic case file, our agenda stipulates the digitization (and automation) of administrative university processes, especially, but not limited to, the student self-service and the administrative student life cycle. Usual tools and practices, commonly applied to (simple) software acquisition, failed in our scenario.
With the case study introduced in this paper, we address all persons, involved within software acquisition processes: From our experiences, we strongly recommend to place greater value on an exhaustively completed acquisition process, than on short-termed economic advantages.
Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem cell differentiation, growth, and proliferation. Here, the effect of silicon- and silicate-containing materials on osteogenesis at the molecular level has been a particular focus within the last decade. This review summarizes recently published scientific results, including material developments and analysis, with a special focus on silicon hybrid bone composites. First, the sources, bioavailability, and functions of silicon on various tissues are discussed. The second focus is on the effects of calcium-silicate biomineralization and corresponding analytical methods in investigating osteogenesis and bone formation. Finally, recent developments in the manufacturing of Si-containing scaffolds are discussed, including in vitro and in vivo studies, as well as recently filed patents that focus on the influence of silicon on hard tissue formation.
Zur Milderung des Klimawandels sind Maßnahmen zur Förderung von Energieeinsparungen notwendig. Energiespartipps informieren über energiesparende Verhaltensweisen und Produkte. Zur Formulierung wirkungsvoller Energiespartipps untersucht die Arbeit, welchen Einfluss Ergänzungen von CO2-Angaben und Formulierungen der Konsequenzen auf die wahrgenommene Informationsqualität, Nützlichkeit und Verhaltensabsicht haben. Außerdem wird untersucht, ob es diesbezüglich Unterschiede zwischen verhaltens- und investitionsorientierten Tipps gibt. Dazu wurde ein Onlineexperiment (N = 352) im 4 x 4 x 2 Design mit den vierstufigen Zwischensubjektfaktoren Framing der Währung (alleinige CO2-Angabe, Jahresvergleichswert, äquivalente Fahrstrecke, äquivalente Laptopnutzung) und Framing der Konsequenz (erreichte Einsparung, vermiedener Ausstoß, entgangene Einsparung, verursachter Ausstoß) sowie der Art des Energiespartipps (verhaltens- vs. investitionsorientiert) als zweistufigen Innersubjektfaktor konzipiert. Varianzanalysen ergaben, dass der verhaltensorientierte Tipp positiver als der investitionsorientierte Tipp bewertet wurde und verhaltensnahe Ergänzungen die Nützlichkeit von CO2-Angaben sowie die Verhaltensintention erhöhen. Das Framing der Konsequenz hatte keinen Effekt. Die Ergebnisse zeigen die Relevanz, zwischen verhaltens- und investitionsorientierten Energiespartipps zu differenzieren und verhaltensnahe Ergänzungen von CO2-Angaben in Kilogramm zu berücksichtigen.
Although work events can be regarded as pivotal elements of organizational life, only a few studies have examined how positive and negative events relate to and combine to affect work engagement over time. Theory suggests that to better understand how current events affect work engagement (WE), we have to account for recent events that have preceded these current events. We present competing theoretical views on how recent and current work events may affect employees (e.g., getting used to a high frequency of negative events or becoming more sensitive to negative events). Although the occurrence of events implies discrete changes in the experience of work, prior research has not considered whether work events actually accumulate to sustained mid-term changes in WE. To address these gaps in the literature, we conducted a week-level longitudinal study across a period of 15 consecutive weeks among 135 employees, which yielded 849 weekly observations. While positive events were associated with higher levels of WE within the same week, negative events were not. Our results support neither satiation nor sensitization processes. However, high frequencies of negative events in the preceding week amplified the beneficial effects of positive events on WE in the current week. Growth curve analyses show that the benefits of positive events accumulate to sustain high levels of WE. WE dissipates in the absence of continuous experience of positive events. Our study adds a temporal component and informs research that has taken a feature-oriented perspective on the dynamic interplay of job demands and resources.
Förderpreise 2018
(2019)