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Reduktion der Verlustleistung integrierter CMOS-Schaltungen durch Anpassung an Signaleigenschaften
(1995)
Cosynthesis in CASTLE
(1995)
Mobilität und Bindungsformen von Cd, Cr, As und V in urbanen Böden unterschiedlicher Belastung
(1995)
We propose a new alignment procedure that is capable of aligning protein sequences and structures in a unified manner. Recursive dynamic programming (RDP) is a hierarchical method which, on each level of the hierarchy, identifies locally optimal solutions and assembles them into partial alignments of sequences and/or structures. In contrast to classical dynamic programming, RDP can also handle alignment problems that use objective functions not obeying the principle of prefix optimality, e.g.\ scoring schemes derived from energy potentials of mean force. For such alignment problems, RDP aims at computing solutions that are near-optimal with respect to the involved cost function and biologically meaningful at the same time. Towards this goal, RDP maintains a dynamic balance between different factors governing alignment fitness such as evolutionary relationships and structural preferences. As in the RDP method gaps are not scored explicitly, the problematic assignment of gap cost parameters is circumvented. In order to evaluate the RDP approach we analyse whether known and accepted multiple alignments based on structural information can be reproduced with the RDP method. For this purpose, we consider the family of ferredoxins as our prime example. Our experiments show that, if properly tuned, the RDP method can outperform methods based on classical sequence alignment algorithms as well as methods that take purely structural information into account.
信息时代的制造业及信息的价值 任守
(1995)
Crystal stability limits at positive and negative pressures, and crystal-to-glass transitions
(1995)
Comparative analysis of US-American and German standard production planning and control systems
(1995)
This paper describes a codesign environment based on the WWW (World Wide Web) and its implementation. Tool invocations and their respective results are linked using hypertext documents. We show how to configure a WWW browser for spawning design tools and how frequent tasks like documentation generation and retrieval are facilitated. The design flow can be adopted to the given application very easily. In addition we introduce the concept of a work flow called ‘design by documentation’. A WWW link to the results is given and experience using it in a codesign project is described.