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A deployment of the Vehicle-2-Vehicle communication technology according to ETSI is in preparation in Europe. Currently, a policy for a necessary Public Key Infrastructure to enrol cryptographic keys and certificates for vehicles and infrastructure component is in discussion to enable an interoperable Vehicle-2-Vehicle communication. Vehicle-2-Vehicle communication means that vehicles periodically send Cooperative Awareness Messages. These messages contain the current geographic position, driving direction, speed, acceleration, and the current time of a vehicle. To protect privacy (location privacy, “speed privacy”) of vehicles and drivers ETSI provides a specific pseudonym concept. We show that the Vehicle-2-Vehicle communication can be misused by an attacker to plot a trace of sequent Cooperative Awareness Messages and to link this trace to a specific vehicle. Such a trace is non-disputable due to the cryptographic signing of the messages. So, the periodically sending of Cooperative Awareness Messages causes privacy problems even if the pseudonym concept is applied.
The combination of Software-Defined Networking (SDN) and Wireless Mesh Network (WMN) is challenging due to the different natures of both concepts. SDN describes networks with homogeneous, static and centralized controlled topologies. In contrast, a WMN is characterized by a dynamic and distributed network control, and adds new challenges with respect to time-critical operation. However, SDN and WMN are both associated with decreasing the operational costs for communication networks which is especially beneficial for internet provisioning in rural areas. This work surveys the current status for Software-Defined Wireless Mesh Networking. Besides a general overview in the domain of wireless SDN, this work focuses especially on different identified aspects: representing and controlling wireless interfaces, control-plane connection and topology discovery, modulation and coding, routing and load-balancing and client handling. A complete overview of surveyed solutions, open issues and new research directions is provided with regard to each aspect.
Infection Exposure Promotes ETV6-RUNX1 Precursor B-cell Leukemia via Impaired H3K4 Demethylases
(2017)
ETV6-RUNX1 is associated with the most common subtype of childhood leukemia. As few ETV6-RUNX1 carriers develop precursor B cell acute lymphocytic leukemia (pB-ALL), the underlying genetic basis for development of full-blown leukemia remains to be identified, but the appearance of leukemia cases in time-space clusters keeps infection as a potential causal factor. Here we present in vivo genetic evidence mechanistically connecting preleukemic ETV6-RUNX1 expression in hematopoetic stem cells/peripheral cells (HSC/PC) and postnatal infections for human-like pB-ALL. In our model, ETV6-RUNX1 conferred a low risk of developing pB-ALL after exposure to common pathogens, corroborating the low incidence observed in humans. Murine preleukemic ETV6-RUNX1 pro/preB cells showed high Rag1/2 expression, known for human ETV6-RUNX1 pB-ALL. Murine and human ETV6-RUNX1 pB-ALL revealed recurrent genomic alterations, with a relevant proportion affecting genes of the lysine demethylase (KDM) family. KDM5C loss-of-function resulted in increased levels of H3K4me3, which co-precipitated with RAG2 in a human cell line model, laying the molecular basis for recombination activity. We conclude that alterations of KDM family members represent a disease-driving mechanism and an explanation for RAG off-target cleavage observed in humans. Our results explain the genetic basis for clonal evolution of an ETV6-RUNX1 preleukemic clone to pB-ALL after infection exposure and offer the possibility of novel therapeutic approaches.
Wissenschaft trifft Praxis
(2017)
I. Einleitung II. Soziale Sicherung als Bestandteil entwicklungspolitischer Agenden – Eine internationale Perspektive III. Internationale Politikdiffusion und nationaler Politikwandel – Konzeptionelle Grundlagen IV. Die Rolle internationaler Politikdiffusion für den Wandel sozialer Sicherungssysteme – Empirische Evidenz V. Schlussfolgerungen
Exosomes derived from human autologous conditioned serum are nanocarriers for IL-6 and TNF-alfa
(2017)
Der Trend zum CTA-Model basiert auf Überlegungen zur Insolvenzsicherung, zur Verbesserung des Bilanzbilds und zur Steuerung des Risikos. Das Argument der Insolvenzsicherung ist nicht schlüssig, da einerseits die Sicherung der Verpflichtungen umfassender Personalbestände nicht im Vordergrund steht und andererseits potenzielle Konkursmasse verloren geht. Auch das Bilanz-, GuV- und Cash Flow-Bild wird bei einer sorgfältigen Arbeit der Analysten nur vordergründig beeinflusst. Bei Vorhandensein und Erkennbarkeit der potenziellen Auslagerungsmittel ändert sich die Effektivverschuldung nicht und im Fall der Notwendigkeit der Aufnahme von Fremdmitteln entsteht ein Passivtausch von zweifelhafter Wirkung. Insgesamt sei aber darauf hingewiesen, dass die Kombination von CTA-Modellen zusammen mit anderen externen Durchführungswegen, insbesondere dem Pensionsfonds, je nach unternehmerischer Präferenz der Grad der Zeilerreichung durchaus erhöht werden kann.