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Millimetron is a Russian-led 12 m diameter submillimeter and far-infrared space observatory which is included in the Space Plan of the Russian Federation for launch around 2017. With its large collecting area and state-of-the-art receivers, it will enable unique science and allow at least one order of magnitude improvement with respect to the Herschel Space Observatory. Millimetron will be operated in two basic observing modes: as a single-dish observatory, and as an element of a ground-space very long baseline interferometry (VLBI) system. As single-dish, angular resolutions on the order of 3 to 12 arc sec will be achieved and spectral resolutions of up to a million employing heterodyne techniques. As VLBI antenna, the chosen elliptical orbit will provide extremely large VLBI baselines (beyond 300,000 km) resulting in micro-arc second angular resolution.
Spectral surveys provide the only way to determine the full molecular inventory of an object and hence build a comprehensive view of the state of the molecular gas and its role in star formation and the structure and evolution of the ISM. Of course spectral surveys also provide the most efficient method of identifying new and unexpected species that have to be include in the chemical networks. The most extensive and complete survey of an extragalactic system has been the continuous spectral survey from 129 GHz to 175 GHz carried out by Martín et al. (2006) toward NGC253. This first spectral line surveys at 2 mm towards the prototypical starbursts galaxies NGC253 have shown an unexpected chemical richness.