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Stem Cells on Biomaterials for Synthetic Grafts to Promote Vascular Healing

  • This review is divided into two interconnected parts, namely a biological and a chemical one. The focus of the first part is on the biological background for constructing tissue-engineered vascular grafts to promote vascular healing. Various cell types, such as embryonic, mesenchymal and induced pluripotent stem cells, progenitor cells and endothelial- and smooth muscle cells will be discussed with respect to their specific markers. The in vitro and in vivo models and their potential to treat vascular diseases are also introduced. The chemical part focuses on strategies using either artificial or natural polymers for scaffold fabrication, including decellularized cardiovascular tissue. An overview will be given on scaffold fabrication including conventional methods and nanotechnologies. Special attention is given to 3D network formation via different chemical and physical cross-linking methods. In particular, electron beam treatment is introduced as a method to combine 3D network formation and surface modification. The review includes recently published scientific data and patents which have been registered within the last decade.

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Document Type:Article
Author:Patrick Babczyk, Clelia Conzendorf, Jens Klose, Margit Schulze, Kathrin Harre, Edda Tobiasch
Parent Title (English):Journal of Clinical Medicine
First Page:39
Last Page:87
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=26237251
Place of publication:Basel
Publishing Institution:Hochschule Bonn-Rhein-Sieg
Date of first publication:2014/01/15
© 2014 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Tag:biomaterial; biopolymer; blood vessel; collagen; cross-linking; endothelial cell; scaffold; smooth muscle cell; stem cell; surface modification
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Dewey Decimal Classification (DDC):6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Entry in this database:2015/05/13
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 3.0