Refine
H-BRS Bibliography
- yes (188) (remove)
Departments, institutes and facilities
- Fachbereich Informatik (59)
- Fachbereich Wirtschaftswissenschaften (57)
- Fachbereich Ingenieurwissenschaften und Kommunikation (26)
- Fachbereich Angewandte Naturwissenschaften (25)
- Institute of Visual Computing (IVC) (20)
- Fachbereich Sozialpolitik und Soziale Sicherung (14)
- Institut für Technik, Ressourcenschonung und Energieeffizienz (TREE) (13)
- Internationales Zentrum für Nachhaltige Entwicklung (IZNE) (10)
- Institut für Cyber Security & Privacy (ICSP) (8)
- Institut für funktionale Gen-Analytik (IFGA) (8)
- Institut für Verbraucherinformatik (IVI) (3)
- Centrum für Entrepreneurship, Innovation und Mittelstand (CENTIM) (2)
- Graduierteninstitut (1)
- Institut für Sicherheitsforschung (ISF) (1)
- Institut für Soziale Innovationen (ISI) (1)
- Präsidium (1)
- Sprachenzentrum (1)
- Verwaltung (1)
Document Type
- Conference Object (61)
- Article (54)
- Part of a Book (36)
- Book (monograph, edited volume) (18)
- Conference Proceedings (4)
- Contribution to a Periodical (4)
- Report (4)
- Working Paper (3)
- Preprint (2)
- Doctoral Thesis (1)
- Periodical (1)
Year of publication
- 2014 (188) (remove)
Has Fulltext
- no (188) (remove)
Keywords
- Lehrbuch (7)
- Nachhaltigkeit (6)
- parallel breadth-first search (3)
- BFS (2)
- Betriebswirtschaftslehre (2)
- Controlling (2)
- Exchangeable pairs (2)
- Formelsammlung (2)
- Garbage collection (2)
- Java virtual machine (2)
During space missions astronauts suffer from cardiovascular deconditioning, when they are exposed to microgravity conditions. Until now, no specific drugs are available for effective countermeasures, since the underlying mechanism is not completely understood. Endothelial cells (ECs) and smooth muscle cells (SMCs) play crucial roles in a variety of cardiovascular functions, many of which are regulated via P2 receptors. However, their function in ECs and SMCs under microgravity condition is still unknown. In this study, ECs and SMCs were isolated from bovine aorta and differentiated from human mesenchymal stem cells (hMSCs), respectively. Subsequently, the cells were verified based on specific markers. An altered P2 receptor expression pattern was detected during the commitment of hMSC towards ECs and SMCs. The administration of natural and artificial P2 receptor agonists and antagonists directly affected the differentiation process. By using EC growth medium as conditioned medium, a vessel cell model was created to culture SMCs and vice versa. Within this study, we were able to show for the first time that the expression of some P2 receptors were altered in ECs and SMCs grown for 24h under simulated microgravity conditions. On the other hand, in some P2 receptor expressions such as P2X7 conditioned medium compensated this change.
In conclusion, our data show that P2 receptors play an important functional role in hMSC differentiation towards ECs and SMCs. Since some P2 receptor artificial ligands are already used as drugs for patients with cardiovascular diseases, it is reasonable to assume that in the future they might be promising candidates for treating cardiovascular deconditioning.
Structure-activity relationships of thiostrepton derivatives: implications for rational drug design
(2014)
The Project SupraMetall: Towards Commercial Fabrication of High-Temperature Superconducting Tapes
(2014)
Informatikerinnen und Informatiker aller Fachrichtungen müssen die grundlegenden Konzepte, Methoden und Verfahren, die der Entwicklung und dem Einsatz von Informations- und Kommunikationstechnologien zugrunde liegen, verstehen und bei der Lösung von Problemen anwenden können. Das Buch stellt die algebraischen und zahlentheoretischen Grundlagen dafür vor und wendet diese bei der Lösung praktischer Problemstellungen, wie modulare Arithmetik, Primzahltests und Verschlüsselung an. Das Verständnis der Begriffe und deren Zusammenhänge und Zusammenwirken wird u.a. durch Lernziele, integrierte Übungsaufgaben mit Musterlösungen und Marginalien unterstützt. Das Buch ist zum Selbststudium gut geeignet.