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Scientists and engineers are using a distributed system Remote Component Environment (RCE) to design and simulate complex systems like airplanes, ships and satellites. During the simulation, RCE executes local and remote code. Remote code is classified as untrusted code. The execution of remote code comprises potential security risks for the host system of RCE. Additionally, RCE provides full access to system resources. The objective of this thesis is to implement a sandbox prototype to reduce the vulnerability of RCE during the execution of remote code.
A plethora of architectural patterns and elements for developing service-oriented applications can be gathered from the state-of-the-art. Most of these approaches are merely applicable for single-tenant applications. However, less methodical support is provided for scenarios, in which multiple different tenants with varying requirements access the same application stack concurrently. In order to fill this gap, both novel and existing architectural patterns, architectural elements, as well as fundamental design decisions must be considered and integrated into a framework that leverages the devel- opment of multi-tenant application. This paper addresses this demand and presents the SOAdapt framework. It promotes the development of adaptable multi-tenant applications based on a service-oriented architecture that is capable of incorporating specific requirements of new tenants in a flexible manner.
Systemunterstützung für wissensintensive Geschäftsprozesse – Konzepte und Implementierungsansätze
(2017)
Die gesättigten Konsumgütermärkte zwingen Handel und Hersteller der Fleischbranche immer wieder zur Suche nach neuen ausreichend großen Nischen, um Wachstum zu generieren. Nach Bio, Regionalität und Veggie könnte Halal die nächste sein. Eine persönliche Befragung von 900 Muslimen vorwiegend türkischer Abstammung beleuchtet die Hintergründe.
The design of future materials for biotechnological applications via deposition of molecules on surfaces will require not only exquisite control of the deposition procedure, but of equal importance will be our ability to predict the shapes and stability of individual molecules on various surfaces. Furthermore, one will need to be able to predict the structure patterns generated during the self-organization of whole layers of (bio)molecules on the surface. In this review, we present an overview over the current state of the art regarding the prediction and clarification of structures of biomolecules on surfaces using theoretical and computational methods.
Beta-ketothiolase deficiency, also known as mitochondrial acetoacetyl-CoA thiolase (T2) deficiency, is an autosomal recessive disease caused by mutations in the acetylCoA acetyltransferase 1 (ACAT1) gene. A German T2deficient patient that developed a severe ketoacidotic episode at the age of 11 months, was revealed to be a compound heterozygote of a previously reported null mutation, c.472A>G (p.N158D) and a novel mutation, c.949G>A (p.D317N), in ACAT1. The c.949G>A mutation was suspected to cause aberrant splicing as it is located within an exonic splicing enhancer sequence (c. 947CTGACGC) that is a potential binding site for serine/argininerich splicing factor 1. A mutation in this sequence, c.951C>T, results in exon 10 skipping. A minigene construct was synthesized that included exon 9truncated intron 9exon 10truncated intron 10exon 11, and the splicing of this minigene revealed that the c.949G>A mutant construct caused exon 10 skipping in a proportion of the transcripts. Furthermore, additional substitution of G for C at the first nucleotide of exon 10 (c.941G>C) abolished the effect of the c.949G>A mutation. Transient expression analysis of the c.949G>A mutant cDNA revealed no residual T2 activity in the mutated D317N enzyme. Therefore, c.949G>A (D317N) is a pathogenic missense mutation, and diminishes the effect of an exonic splicing enhancer and causes exon 10 skipping. The present study demonstrates that a missense mutation, or even a synonymous substitution, may disrupt enzyme function by interference with splicing.