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Scientists and engineers are using a distributed system Remote Component Environment (RCE) to design and simulate complex systems like airplanes, ships and satellites. During the simulation, RCE executes local and remote code. Remote code is classified as untrusted code. The execution of remote code comprises potential security risks for the host system of RCE. Additionally, RCE provides full access to system resources. The objective of this thesis is to implement a sandbox prototype to reduce the vulnerability of RCE during the execution of remote code.
A plethora of architectural patterns and elements for developing service-oriented applications can be gathered from the state-of-the-art. Most of these approaches are merely applicable for single-tenant applications. However, less methodical support is provided for scenarios, in which multiple different tenants with varying requirements access the same application stack concurrently. In order to fill this gap, both novel and existing architectural patterns, architectural elements, as well as fundamental design decisions must be considered and integrated into a framework that leverages the devel- opment of multi-tenant application. This paper addresses this demand and presents the SOAdapt framework. It promotes the development of adaptable multi-tenant applications based on a service-oriented architecture that is capable of incorporating specific requirements of new tenants in a flexible manner.
Systemunterstützung für wissensintensive Geschäftsprozesse – Konzepte und Implementierungsansätze
(2017)
Die gesättigten Konsumgütermärkte zwingen Handel und Hersteller der Fleischbranche immer wieder zur Suche nach neuen ausreichend großen Nischen, um Wachstum zu generieren. Nach Bio, Regionalität und Veggie könnte Halal die nächste sein. Eine persönliche Befragung von 900 Muslimen vorwiegend türkischer Abstammung beleuchtet die Hintergründe.
The design of future materials for biotechnological applications via deposition of molecules on surfaces will require not only exquisite control of the deposition procedure, but of equal importance will be our ability to predict the shapes and stability of individual molecules on various surfaces. Furthermore, one will need to be able to predict the structure patterns generated during the self-organization of whole layers of (bio)molecules on the surface. In this review, we present an overview over the current state of the art regarding the prediction and clarification of structures of biomolecules on surfaces using theoretical and computational methods.
Beta-ketothiolase deficiency, also known as mitochondrial acetoacetyl-CoA thiolase (T2) deficiency, is an autosomal recessive disease caused by mutations in the acetylCoA acetyltransferase 1 (ACAT1) gene. A German T2deficient patient that developed a severe ketoacidotic episode at the age of 11 months, was revealed to be a compound heterozygote of a previously reported null mutation, c.472A>G (p.N158D) and a novel mutation, c.949G>A (p.D317N), in ACAT1. The c.949G>A mutation was suspected to cause aberrant splicing as it is located within an exonic splicing enhancer sequence (c. 947CTGACGC) that is a potential binding site for serine/argininerich splicing factor 1. A mutation in this sequence, c.951C>T, results in exon 10 skipping. A minigene construct was synthesized that included exon 9truncated intron 9exon 10truncated intron 10exon 11, and the splicing of this minigene revealed that the c.949G>A mutant construct caused exon 10 skipping in a proportion of the transcripts. Furthermore, additional substitution of G for C at the first nucleotide of exon 10 (c.941G>C) abolished the effect of the c.949G>A mutation. Transient expression analysis of the c.949G>A mutant cDNA revealed no residual T2 activity in the mutated D317N enzyme. Therefore, c.949G>A (D317N) is a pathogenic missense mutation, and diminishes the effect of an exonic splicing enhancer and causes exon 10 skipping. The present study demonstrates that a missense mutation, or even a synonymous substitution, may disrupt enzyme function by interference with splicing.
Oft wird die Gewinnung von Gastärzten aus dem Ausland als Möglichkeit zur kurz- und mittelfristigen Deckung des Ärztebedarfs in Kliniken in Erwägung gezogen. Die hohen Anforderungen von Landesprüfungsämtern, Arbeitsagenturen, Ausländerbehörden und Botschaften erweisen sich sowohl für Ärzte als auch Kliniken als schwer überwindbare Hürden. Insbesondere Sprachschwierigkeiten sowie mangelhafte fachliche und kulturelle Kenntnisse der internationalen Ärzte sind ohne professionelle Unterstützung kaum zu kompensieren.
Background: Type 2 diabetes mellitus is associated with increased cardiovascular risk. One laboratory marker for cardiovascular risk assessment is high-sensitivity C-reactive protein (hsCRP).
Methods: This cross-sectional study attempted to analyze the association of hsCRP levels with insulin resistance, β-cell dysfunction and macrovascular disease in 4270 non-insulin-treated patients with type 2 diabetes [2146 male, 2124 female; mean age ±SD, 63.9±11.1years; body mass index (BMI) 30.1±5.5kg/m2; disease duration 5.4±5.6years; hemoglobin A1c (HbA1c) 6.8±1.3%]. It consisted of a single morning visit with collection of a fasting blood sample. Observational parameters included several clinical scores and laboratory biomarkers.
Results: Stratification into cardiovascular risk groups according to hsCRP levels revealed that 934 patients had low risk (hsCRP <1mg/L), 1369 patients had intermediate risk (hsCRP 1–3mg/L), 1352 patients had high risk (hsCRP >3–10mg/L), and 610 patients had unspecific hsCRP elevation (>10mg/L). Increased hsCRP levels were associated with other indicators of diabetes-related cardiovascular risk (homeostatic model assessment, intact proinsulin, insulin, BMI, β-cell dysfunction, all p<0.001), but showed no correlation with disease duration or glucose control. The majority of the patients were treated with diet (34.1%; hsCRP levels 2.85±2.39mg/L) or metformin monotherapy (21.1%; 2.95±2.50mg/L hsCRP). The highest hsCRP levels were observed in patients treated with sulfonylurea (17.0%; 3.00±2.43mg/L).
Conclusions: Our results indicate that hsCRP may be used as a cardiovascular risk marker in patients with type 2 diabetes mellitus and should be evaluated in further prospective studies.
High-sensitivity C-reactive protein as cardiovascular risk marker in patients with diabetes mellitus
(2006)
Eine Suite für den Patienten
(2006)
Improvement of Cardiovascular Risk Markers by Pioglitazone Is Independent From Glycemic Control
(2005)
Heilung mit Genuss
(2005)
Defect evolution in thermal barrier coating systems under multi-axial thermomechanical loading
(2005)
Die vorliegende Bachelorthesis setzt sich mit der Problematik auseinander, ob Produktbewertungen auf Youtube nutzwertjournalistisch sein können, wozu zunächst ein Kategoriensystem zur Identifikation von Nutzwertjournalismus entwickelt wird. Mithilfe der Methode der qualitativen Inhaltsanalyse und dem Kategoriensystem, werden vier Produkttests des Fotografie-Kanals Value-TechTV untersucht. Die Forschungsfrage lautet daher: Zählen die Produkttests des Kanals ValueTechTV zum Nutzwertjournalismus?