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Structure-activity relationships of thiostrepton derivatives: implications for rational drug design
(2014)
The case for basic human needs in coaching: A neuroscientific perspective - The SCOAP Coach Theory
(2014)
Realism and plausibility of computer controlled entities in entertainment software have been enhanced by adding both static personalities and dynamic emotions. Here a generic model is introduced that allows findings from real-life personality studies to be transferred to a computational model. Adaptive behavior patterns are enabled by introducing dynamic event-based emotions. The advantages of this model have been validated using a four-way crossroad in a traffic simulation. Driving agents using the introduced model enhanced by dynamics were compared to agents based on static personality profiles and simple rule-based behavior. The results show that adding a dynamic factor to agents improves perceivable plausibility and realism.
Perception is one of the most important cognitive capabilities of an entity since it determines how an entity perceives its environment. The presented work focuses on providing cost efficient but realistic perceptual processes for intelligent virtual agents (IVAs) or NPCs with the goal of providing a sound information basis for the entities' decision making processes. In addition, an agent-central perception process should rovide a common interface for developers to retrieve data from the IVAs' environment. The overall process is evaluated by applying it to a scenario demonstrating its benefits. The evaluation indicates, that such a realistically simulated perception process provides a powerful instrument to enhance the (perceived) realism of an IVA's simulated behavior.
Automatisierungstechnik
(2014)
Die Automatisierungstechnik wird aus praktischer Sicht mit vielen Beispielen und zahlreichen Bildern veranschaulicht. Studenten ingenieurwissenschaftlicher Fachrichtungen sowie Ingenieure und Techniker in der Ausbildung und der beruflichen Praxis können sich auf dem Stand der Technik selbständig einarbeiten.
Rendering techniques for design evaluation and review or for visualizing large volume data often use computationally expensive ray-based methods. Due to the number of pixels and the amount of data, these methods often do not achieve interactive frame rates. A view direction based rendering technique renders the users central field of view in high quality whereas the surrounding is rendered with a level of detail approach depending on the distance to the users central field of view thus giving the opportunity to increase rendering efficiency. We propose a prototype implementation and evaluation of a focus-based rendering technique based on a hybrid ray tracing/sparse voxel octree rendering approach.
Vor dem Hintergrund knapper Ressourcen, dem zunehmendem Reha-Bedarf und der politischen Diskussion um eine demografische Anpassung der Reha-Budgets gewinnt der Nachweis der Ergebnisqualität medizinischer Reha-Leistungen weiter an zentraler Bedeutung (z. B. Haaf, 2005; Steiner et al., 2009). Die kontinuierliche und klinikvergleichende Überprüfung der Behandlungsergebnisse ist darüber hinaus ein wichtiger Baustein eines funktionierenden Qualitätsmanagements (Schmidt et al., in press). Sie ermöglicht ein "Lernen von den Besten" und führt zu organisatorischen Lernprozessen (Toepler et. al., 2010).
The perceived direction of “up” is determined by gravity, visual information, and an internal estimate of body orientation (Mittelstaedt, 1983; Dyde et al., 2006). Is the gravity level found on other worlds sufficient to maintain gravity’s contribution to this perception? Difficulties in stability reported anecdotally by astronauts on the lunar surface (NASA 1972) suggest that the moon’s gravity may not be, despite this value being far above the threshold for detecting linear acceleration. Knowing how much gravity is needed to provide a reliable orientation cue is required for training and preparing astronauts for future missions to the moon, mars and beyond.
Humans exhibit flexible and robust behavior in achieving their goals. We make suitable substitutions for objects, actions, or tools to get the job done. When opportunities that would allow us to reach our goals with less effort arise, we often take advantage of them. Robots are not nearly as robust in handling such situations. Enabling a domestic service robot to find ways to get a job done by making substitutions is the goal of our work. In this paper, we highlight the challenges faced in our approach to combine Hierarchical Task Network planning, Description Logics, and the notions of affordances and conceptual similarity. We present open questions in modeling the necessary knowledge, creating planning problems, and enabling the system to handle cases where plan generation fails due to missing/unavailable objects.
Die Norm EN ISO 13849-1 stellt explizite Anforderungen an sicherheitsgerichtete SPS-Software. Wie lassen sich diese im Maschinenbau praxisgerecht umsetzen? Mit dieser Frage hat sich ein von der DGUV gefördertes und an der Hochschule Bonn-Rhein-Sieg durchgeführtes Projekt beschäftigt. Der Beitrag skizziert die Vorgehensweise zur möglichen Umsetzung der normativen Anforderungen. Diese Vorgehensweise ist unabhängig von der verwendeten Sicherheits-SPS und daher allgemein anwendbar. Es wird auf insgesamt 10 dokumentierte Beispiele und einen ausführlichen Forschungsbericht verwiesen, die downloadbar sind.
This paper gives an overview of the development of Fair Trade in six European countries: Austria, France, Germany, the Netherlands, Switzerland and the United Kingdom. After the description of the food retail industry and its market structures in these countries, the main European Fair Trade organizations are analyzed regarding their role within the Fair Trade system. The following part deals with the development of Fair Trade sales in general and with respect to the products coffee, tea, bananas, fruit juice and sugar. An overview of the main activities of national Fair Trade organizations, e.g. public relation activities, completes the analysis. This study shows the enormous upswing of Fair Trade during the last decade and the reasons for this development. Nevertheless, it comes to the conclusion that Fair Trade is still far away from being an essential part of the food retail industry in Europe.
Application systems are often advertised with features, and features are used heavily for requirements man- agement. However, often software manufacturers only have incomplete information about the features of their software. The information is distributed over different sources, such as requirements documents, issue trackers, user manuals, and code. In this paper, we research the occurrence of feature information in open source software engineering data. We report on a case study with three open source systems. We analyze what information about features can be found in issue trackers and user documentation. Furthermore, we study the abstraction levels on which the features are described, how feature information is related, and we discuss the possibility to discover such information semi-automatically. To mirror the diversity of software development contexts, we choose open source systems, which are quite different, e.g., in the rigor of issue tracker usage. The results differ accordingly. One main result is that the user documentation did not provide more accurate information than the issue tracker compared to a provided feature list. The results also give hints on how the management of feature relevant information can be supported.
Breadth-First Search is a graph traversal technique used in many applications as a building block, e.g., to systematically explore a search space or to determine single source shortest paths in unweighted graphs. For modern multicore processors and as application graphs get larger, well-performing parallel algorithms are favorable. In this paper, we systematically evaluate an important class of parallel algorithms for this problem and discuss programming optimization techniques for their implementation on parallel systems with shared memory. We concentrate our discussion on level-synchronous algorithms for larger multicore and multiprocessor systems. In our results, we show that for small core counts many of these algorithms show rather similar performance behavior. But, for large core counts and large graphs, there are considerable differences in performance and scalability influenced by several factors, including graph topology. This paper gives advice, which algorithm should be used under which circumstances.
Dysregulation of IL12 Signaling As a Novel Cause of an Autoimmune Lymphoproliferative like Syndrome
(2014)
Software repository data, for example in issue tracking systems, include natural language text and technical information, which includes anything from log files via code snippets to stack traces. However, data mining is often only interested in one of the two types e.g. in natural language text when looking at text mining. Regardless of which type is being investigated, any techniques used have to deal with noise caused by fragments of the other type i.e. methods interested in natural language have to deal with technical fragments and vice versa. This paper proposes an approach to classify unstructured data, e.g. development documents, into natural language text and technical information using a mixture of text heuristics and agglomerative hierarchical clustering. The approach was evaluated using 225 manually annotated text passages from developer emails and issue tracker data. Using white space tokenization as a basis, the overall precision of the approach is 0.84 and the recall is 0.85.
Updating a shared data structure in a parallel program is usually done with some sort of high-level synchronization operation to ensure correctness and consistency. The realization of such high-level synchronization operations is done with appropriate low-level atomic synchronization instructions that the target processor architecture provides. These instructions are costly and often limited in their scalability on larger multi-core / multi-processor systems. In this paper, a technique is discussed that replaces atomic updates of a shared data structure with ordinary and cheaper read/write operations. The necessary conditions are specified that must be fulfilled to ensure overall correctness of the program despite missing synchronization. The advantage of this technique is the reduction of access costs as well as more scalability due to elided atomic operations. But on the other side, possibly more work has to be done caused by missing synchronization. Therefore, additional work is traded against costly atomic operations. A practical application is shown with level-synchronous parallel Breadth-First Search on an undirected graph where two vertex frontiers are accessed in parallel. This application scenario is also used for an evaluation of the technique. Tests were done on four different large parallel systems with up to 64-way parallelism. It will be shown that for the graph application examined the amount of additional work caused by missing synchronization is neglectible and the performance is almost always better than the approach with atomic operations.
This review is divided into two interconnected parts, namely a biological and a chemical one. The focus of the first part is on the biological background for constructing tissue-engineered vascular grafts to promote vascular healing. Various cell types, such as embryonic, mesenchymal and induced pluripotent stem cells, progenitor cells and endothelial- and smooth muscle cells will be discussed with respect to their specific markers. The in vitro and in vivo models and their potential to treat vascular diseases are also introduced. The chemical part focuses on strategies using either artificial or natural polymers for scaffold fabrication, including decellularized cardiovascular tissue. An overview will be given on scaffold fabrication including conventional methods and nanotechnologies. Special attention is given to 3D network formation via different chemical and physical cross-linking methods. In particular, electron beam treatment is introduced as a method to combine 3D network formation and surface modification. The review includes recently published scientific data and patents which have been registered within the last decade.
During space missions astronauts suffer from cardiovascular deconditioning, when they are exposed to microgravity conditions. Until now, no specific drugs are available for effective countermeasures, since the underlying mechanism is not completely understood. Endothelial cells (ECs) and smooth muscle cells (SMCs) play crucial roles in a variety of cardiovascular functions, many of which are regulated via P2 receptors. However, their function in ECs and SMCs under microgravity condition is still unknown. In this study, ECs and SMCs were isolated from bovine aorta and differentiated from human mesenchymal stem cells (hMSCs), respectively. Subsequently, the cells were verified based on specific markers. An altered P2 receptor expression pattern was detected during the commitment of hMSC towards ECs and SMCs. The administration of natural and artificial P2 receptor agonists and antagonists directly affected the differentiation process. By using EC growth medium as conditioned medium, a vessel cell model was created to culture SMCs and vice versa. Within this study, we were able to show for the first time that the expression of some P2 receptors were altered in ECs and SMCs grown for 24h under simulated microgravity conditions. On the other hand, in some P2 receptor expressions such as P2X7 conditioned medium compensated this change.
In conclusion, our data show that P2 receptors play an important functional role in hMSC differentiation towards ECs and SMCs. Since some P2 receptor artificial ligands are already used as drugs for patients with cardiovascular diseases, it is reasonable to assume that in the future they might be promising candidates for treating cardiovascular deconditioning.
Die nachhaltige Organisation des Verkehrs soll auf kostengünstige, umweltfreundliche und nutzerfreundlichere Nahverkehrskonzepte, die möglichst viele Bürger zur Nutzung des ÖPNV einladen, abzielen. Vor diesem Hintergrund ist es das Ziel dieses Beitrags, instrumentelle Ansatzpunkte für ein Nachhaltigkeitscontrolling in ÖPNV-Unternehmen aufzuzeigen. Hierzu werden nachfolgend die Berücksichtigung der Nachhaltigkeit bei Investitionsentscheidungen, das Carbon Accounting (Transparenz über CO2-Emissionen), die Integration der ökologischen, ökonomischen und sozialen Nachhaltigkeitsdimension bei der Berichterstattung und die Einbindung der genannten Instrumente in ein Managementsystem skizziert. Die Nachhaltigkeitsdimensionen Ökologie, Ökonomie und Soziales lassen sich gut mit Hilfe mehrdimensionaler, integrierter Managementsysteme in der Organisation verankern und systematisch in interne Strukturen und Prozesse einbetten. Integrierte Managementsysteme können so eine wichtige Voraussetzung für ein effizientes Nachhaltigkeitscontrolling sein.
Social cash transfers (SCTs) are considered a priority in least-developed countries, where the gap between the need for basic social protection and existing provisions is greatest. This study represents one of the first comprehensive treatments of the impact of social cash transfers in low-income sub-Saharan Africa, and the first for Zambia's oldest SCT scheme. The results, based on propensity score matching and fully efficient odds-weighted regression, and data from the Kalomo SCT pilot scheme, confirm positive SCT effects on per capita consumption expenditure. We also discover threshold effects with SCT mostly impacting food expenditure among poorer beneficiary households and non-food expenditure among wealthier beneficiaries.
Analytical pyrolysis technique hyphenated to gas chromatography/mass spectrometry (Py-GC/MS) has extended the range of possible tools for characterization of synthetic polymers/copolymers. Pyrolysis involves thermal fragmentation of the analytical sample at elevated temperature between 500 and 1400 °C. In the presence of an inert gas, reproducible decomposition products characteristic for the original polymer/copolymer sample are formed. The pyrolysis products are chromatographically separated by using a fused silica capillary column and subsequently identified by interpretation of the obtained mass spectra or by using mass spectra libraries. The analytical technique eliminate the need for pre-treatment by performing analyses directly on the solid or liquid polymer sample.
In this paper, application examples of the analytical pyrolysis hyphenated to gas chromatography/mass spectrometry for the identification of different polymeric materials in the plastic and automotive industry, dentistry and occupational safety are demonstrated. For the first time results of identification of commercially light-curing dental filling material and a car wrapping foil by pyrolysis-GC/MS are presented.
Verantwortliches Wirtschaften beschreibt die Betrachtung ökonomischer, ökologischer und sozialer Aspekte als ganzheitliches Konzept sowie deren Integration in die betriebswirtschaftliche Praxis mit dem Ziel, Wettbewerbsfähigkeit zu erhalten und Unternehmensrisiken zu minimieren. Verantwortliches Wirtschaften steht zudem für die Verpflichtung eines Unternehmens gegenüber seinen Stakeholdern sowie seiner Verantwortung gegenüber der Gesellschaft.
Exposure to microgravity conditions causes cardiovascular deconditioning in astronauts during spaceflight. Until now, no specific drugs are available for countermeasure, since the underlying mechanism is largely unknown. Endothelial cells (ECs) and smooth muscle cells (SMCs) play key roles in various vascular functions, many of which are regulated by purinergic 2 (P2) receptors. However, their function in ECs and SMCs under microgravity conditions is still unclear. In this study, primary ECs and SMCs were isolated from bovine aorta and verified with specific markers. We show for the first time that the P2 receptor expression pattern is altered in ECs and SMCs after 24 h exposure to simulated microgravity using a clinostat. However, conditioned medium compensates this change in specific P2 receptors, for example, P2X7. Notably, P2 receptors such as P2X7 might be the important players during the paracrine interaction. Additionally, ECs and SMCs secreted different cytokines under simulated microgravity, leading into a pathogenic proliferation and migration. In conclusion, our data indicate P2 receptors might be important players responding to gravity changes in ECs and SMCs. Since some artificial P2 receptor ligands are applied as drugs, it is reasonable to assume that they might be promising candidates against cardiovascular deconditioning in the future.
The analytical pyrolysis technique hyphenated to gas chromatography–mass spectrometry (GC–MS) has extended the range of possible tools for the characterization of synthetic polymers and copolymers. Pyrolysis involves thermal fragmentation of the analytical sample at temperatures of 500–1400 °C. In the presence of an inert gas, reproducible decomposition products characteristic for the original polymer or copolymer sample are formed. The pyrolysis products are chromatographically separated using a fused-silica capillary column and are subsequently identified by interpretation of the obtained mass spectra or by using mass spectra libraries. The analytical technique eliminates the need for pretreatment by performing analyses directly on the solid or liquid polymer sample. In this article, application examples of analytical pyrolysis hyphenated to GC–MS for the identification of different polymeric materials in the plastic and automotive industry, dentistry, and occupational safety are demonstrated. For the first time, results of identification of commercial light-curing dental filling material and a car wrapping foil by pyrolysis–GC–MS are presented.
It is a euphemism to say that humans use tools. Humans possess a vast repertoire of tools they use every day. In fact, as language or bipedal locomotion, tool use is a hallmark of humans. Tool use has also been often viewed as an important step during evolution (van Schaik et al., 1999) or even as a marker of the evolution of human intelligence (Wynn, 1985). So a fundamental issue is, what are the cognitive and neural bases of human tool use? The present series of papers in this special topic represents the newest additions to that research topic.
Nachhaltigkeit aus institutionenökonomischer Perspektive am Beispiel der Schiefergasförderung
(2014)
Improving the study entry supports students in a decisive phase of their university education. Implementing improvements is a change process and can only be successful if the relevant stakeholders are addressed and convinced. In the described Teaching Quality Pact project evaluation data is used as a mean to discuss in the university the situation of the study programs. As these discussions were based on empirical data rather than on opinion, it was possible to achieve an open discussion about measures that are implemented. The open discussion is maintained during the project when results of the measures taken are analyzed.
This article describes an approach to rapidly prototype the parameters of a Java application run on the IBM J9 Virtual Machine in order to improve its performance. It works by analyzing VM output and searching for behavioral patterns. These patterns are matched against a list of known patterns for which rules exist that specify how to adapt the VM to a given application. Adapting the application is done by adding parameters and changing existing ones. The process is fully automated and carried out by a toolkit. The toolkit iteratively cycles through multiple possible parameter sets, benchmarks them and proposes the best alternative to the user. The user can, without any prior knowledge about the Java application or the VM improve the performance of the deployed application and quickly cycle through a multitude of different settings to benchmark them. When tested with the representative benchmarks, improvements of up to 150% were achieved.
In general, mathematics plays a central role in our lives because today mathematics regulates our everyday life with techniques, technologies and procedures, for example coding techniques for credit cards or the drafting of curves and surfaces for construction procedures [5]. Obviously, mathematics continues to be an important element of engineering education and it still represents a major obstacle for the students. Lacking the knowledge of several topics, changing learning behavior and inadequate overall conditions at universities for the repetition of school mathematics were mentioned to be causes for the constantly increasing gap between the initial level of mathematics at university and the prior knowledge of the first semester students [2].
Seit vielen Jahren ist der Übergang von der Schule zur Hochschule eines der zentralen Themen für didaktische Theorien, empirische Untersuchungen und bildungspolitische Diskussionen. Ein dabei identifiziertes großes Problem vieler Studierender ist, dass mit dem Abitur „eine Lebensphase mit meist klar definierten Zielen in überschaubaren räumlichen, familiären und schulischen Strukturen endet“.1) Entscheidet man sich als Studierender gegen die nicht akademische Laufbahn und nimmt ein Hochschulstudium auf, trifft man auf Studienstrukturen und -bedingungen, die einem fremd und chaotisch vorkommen können. Der Weg an die Hochschulen ermöglicht den Individuen eine Reihe von Optionen, ist aber leider auch immer mit Risiken und Unsicherheiten behaftet. Entscheidungen müssen nun selbstständig vorbereitet und getroffen werden und dies in einem Umfeld, das sehr unterschiedlich im Vergleich zur bekannten Schulstruktur sein kann.
Improving data acquisition techniques and rising computational power keep producing more and larger data sets that need to be analyzed. These data sets usually do not fit into a GPU's memory. To interactively visualize such data with direct volume rendering, sophisticated techniques for problem domain decomposition, memory management and rendering have to be used. The volume renderer Volt is used to show how CUDA is efficiently utilised to manage the volume data and a GPU's memory with the aim of low opacity volume renderings of large volumes at interactive frame rates.
Abstract Classical ballet requires dancers to exercise significant muscle control and strength both while stationary and when moving. Following the Royal Academy of Dance (RAD) syllabus, 8 male and 27 female dancers (aged 20.2 + 1.9 yr) in a full-time university undergraduate dance training program were asked to stand in first position for 10 seconds and then perform 10 repeats of a demi-plié exercise to a counted rhythm. Accelerometer records from the wrist, sacrum, knee and ankle were compared with the numerical scores from a professional dance instructor. The sacrum mounted sensor detected lateral tilts of the torso in dances with lower scores (Spearman’s rank correlation coefficient r = -0.64, p < 0.005). The 5RMS6 acceleration amplitude of wrist mounted sensor was linearly correlated to the movement scores (Spearman’s rank correlation coefficient r = 0.63, p < 0.005). The application of sacrum and wrist mounted sensors for biofeedback during dance training is a realistic, low cost option.
The analytical pyrolysis technique hyphenated to gas chromatography–mass spectrometry (GC–MS) has extended the range of possible tools for the characterization of synthetic polymers and copolymers. Pyrolysis involves thermal fragmentation of the analytical sample at temperatures of 500–1400 °C. In the presence of an inert gas, reproducible decomposition products characteristic for the original polymer or copolymer sample are formed. The pyrolysis products are chromatographically separated using a fused-silica capillary column and are subsequently identified by interpretation of the obtained mass spectra or by using mass spectra libraries. The analytical technique eliminates the need for pretreatment by performing analyses directly on the solid or liquid polymer sample. In this article, application examples of analytical pyrolysis hyphenated to GC–MS for the identification of different polymeric materials in the plastic and automotive industry, dentistry, and occupational safety are demonstrated. For the first time, results of identification of commercial light-curing dental filling material and a car wrapping foil by pyrolysis–GC–MS are presented.
Nachhaltigkeit als Megatrend. Die Arbeit der Weltkommission für Umwelt und Entwicklung unter Vorsitz von Brundtland machte bereits 1987 deutlich, dass v.a. das Management von Gemeingütern wie Ozeanen und der Atmosphäre, die Erhaltung des Weltfriedens, die weltweite Bevölkerungsentwicklung, die globale Ernährungssicherheit, die begrenzten Energieressourcen sowie die Folgen des Wirtschaftswachstums globale Herausforderungen darstellen, die nur durch eine nachhaltige Entwicklung gemeistert werden können.
It has become increasingly clear that caspases, far from being merely cell death effectors, have a much wider range of functions within the cell. These functions are as diverse as signal transduction and cytoskeletal remodeling, and caspases are now known to have an essential role in cell proliferation, migration, and differentiation. There is also evidence that apoptotic cells themselves can direct the behavior of nearby cells through the caspase-dependent secretion of paracrine signaling factors. In some processes, including the differentiation of skeletal muscle myoblasts, both caspase activation in differentiating cells as well as signaling from apoptotic cells has been reported. Here, we review the non-apoptotic outcomes of caspase activity in a range of different model systems and attempt to integrate this knowledge.
Robots, which are able to carry out their tasks robustly in real world environments, are not only desirable but necessary if we want them to be more welcome for a wider audience. But very often they may fail to execute their actions successfully because of insufficient information about behaviour of objects used in the actions.
Unexpected Situations in Service Robot Environment: Classification and Reasoning Using Naive Physics
(2014)
In the field of domestic service robots, recovery from faults is crucial to promote user acceptance. In this context we focus in particular on some specific faults, which arise from the interaction of a robot with its real world environment. Even a well-modelled robot may fail to perform its tasks successfully due to unexpected situations, which occur while interacting. These situations occur as deviations of properties of the objects (manipulated by the robot) from their expected values. Hence, they are experienced by the robot as external faults.
Chemie kann im Studium ganz schön kompliziert sein, besonders wenn es etwas mehr in die Tiefe geht. Dass man aber auch komplizierte Dinge leicht verständlich und bisweilen amüsant erklären kann, beweist dieses Lehrbuch. Stefanie Ortanderl und Ulf Ritgen erklären die Grundlagen der Chemie und so erfahren Sie, was Sie über Atommodelle, Bindungstypen und das Periodensystem wissen sollten.
People are getting older because of the demographic changes and the rate of disabled people is also going up. This article shows the challenge for BPMTool developer due to these circumstances. It illustrates how these changes impact the usage of BPM-Tools based on an Evaluation of an exemplary BPMTool (Cooper & Patterson, 2007) in terms of IT-Usability and IT-Accessibility. This evaluation was conducted in a research laboratory at the university.
Ziel des hier beschriebenen Forschungsprojekts war die Entwicklung eines prototypischen Fahrradfahrsimulators für den Einsatz in der Verkehrserziehung und im Verkehrssicherheitstraining. Der entwickelte Prototyp soll möglichst universell für verschiedene Altersklassen und Applikationen einsetzbar sowie mobil sein.