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Nachhaltigkeitsökonomie
(2014)
It has become increasingly clear that caspases, far from being merely cell death effectors, have a much wider range of functions within the cell. These functions are as diverse as signal transduction and cytoskeletal remodeling, and caspases are now known to have an essential role in cell proliferation, migration, and differentiation. There is also evidence that apoptotic cells themselves can direct the behavior of nearby cells through the caspase-dependent secretion of paracrine signaling factors. In some processes, including the differentiation of skeletal muscle myoblasts, both caspase activation in differentiating cells as well as signaling from apoptotic cells has been reported. Here, we review the non-apoptotic outcomes of caspase activity in a range of different model systems and attempt to integrate this knowledge.
An Universitäten und Fachhochschulen ist die Mathematik-Ausbildung eines der Nadelöhre für angehende Ingenieurinnen und Ingenieure. Viele Studierende der Ingenieurwissenschaften scheitern in den ersten Studiensemestern an den Anforderungen der Mathematik. Lehrende, Fach- und Hochschuldidaktiker/innen und zunehmend auch Fachvertretungen und Verbände stellen sich die Frage, was an den Fakultäten und Fachbereichen getan werden kann, damit Studierende ihre mathematischen Fähigkeiten vergrößern und den anspruchsvollen Studienweg zur Ingenieurin oder zum Ingenieur meistern können.
In diesem Paper wird das abbildende Millimeterwellen-Radarsystem SAMMI® (Stand Alone MilliMeter wave Imager) des Fraunhofer-Institutes für Hochfrequenzphysik und Radartechnik FHR vorgestellt. SAMMI ist ein CW System welches bei einer Messfrequenz von 78 GHz die Proben in Transmission vermisst. Durch ein Endlosband wird ein kontinuierlicher Materialstrom sichergestellt, wobei ein DIN A4 Blatt innerhalb von 20 s durchleuchtet wird. SAMMI besitzt die Größe eines durchschnittlichen Laserdruckers wodurch es leicht zu transportieren und in wenigen Minuten einsatzbereit ist. Die mittels SAMMI erfassten Messdaten, können bereits während der Datenerfassung mit verschiedenen bereits vorinstallierten Verfahren aufbereitet und analysiert werden. Zu den integrierten Algorithmen in SAMMI® gehören unter anderen Verfahren zum 2D-Phase Unwrapping-, Cluster- und Rekonstruktions-Algorithmen zur Berechnung der Materialparameter. Die offene Softwareschnittstelle erlaubt auch die Implementierung eigener Verfahren auf der mitgelieferten Computer-Hardware. Mit den integrierten Algorithmen bietet SAMMI® eine Vielzahl an Möglichkeiten um z.B. Verunreinigungen in Materialien zu detektieren oder Schwankungen im Fertigungsprozess frühzeitig zu identifizieren. Desweiteren ist SAMMI® eine optimale Ausbildungsplattform in den Bereichen der industriellen Bildverarbeitung mittels Hochfrequenzsensoren. Insbesondere können Verfahren für unterschiedliche Anwendungen getestet bzw. für Anwendungen weiterentwickelt werden. Es werden konkrete Beispiele aus dem Bereich der Qualitätssicherung erläutert und Möglichkeiten des Gerätes und der Millimeterwellen-Technologie für die zerstörungsfreie Prüfung in Detail beschrieben.
Der Begriff der Nachhaltigkeit ist heute weit verbreitet, und seine Nutzung erstreckt sich auf alle Gesellschaftsbereiche. Als abstraktes Leitprinzip bleibt oftmals unklar, wie der Begriff definiert und ausgelegt wird. Seine Unbestimmtheit trägt zur Verwässerung und inflationären Verwendung bei. Erschwerend wirkt zusätzlich die unzureichende Trennung des politischen vom alltagssprachlichen Begriff der Nachhaltigkeit.
The RoCKIn@Work Challenge
(2014)
Der Beitrag beschreibt die Einführung eines prozessorientierten Qualitätsmanagementsystems (QM-System) an der Hochschule Bonn-Rhein-Sieg. Diese wurde 1995 gegründet und hat derzeit rund 6500 Studierende an drei Standorten: Sankt Augustin, Rheinbach und Hennef. Hier lehren und forschen rund 140 engagierte Professorinnen und Professoren, unterstützt durch über 300 Mitarbeiterinnen und Mitarbeiter und ebenso viele Lehrbeauftragte aus Wirtschaft, Politik und Wissenschaft. Angesichts der Verteilung über mehrere Standorte mit unterschiedlichen fachlichen Schwerpunkt- und Zielsetzungen wird der Aufbau eines gemeinsamen QM zugleich als Organisationsentwicklungsprozess gestaltet. Strategische Basis dafür ist der Hochschulentwicklungsplan. Begonnen wurde Ende 2009 mit der Erstellung einer Feasibility-Studie, um die zukünftige Rolle von QM an der Hochschule zu untersuchen und einen gangbaren Weg für die Integration in die Hochschulentwicklung zu beschreiben. Der folgende Bericht gibt einen Überblick über die daraus entstandenen Aktivitäten sowie einen Eindruck von den damit verbundenen Chancen und Schwierigkeiten. Einer der größten Erfolge besteht bislang in der Anerkennung von QM als Daueraufgabe der Hochschule und ihrer Mitglieder. Herausfordernd ist, diesen Anspruch im Hochschulalltag umzusetzen.
We consider the Hopfield model with n neurons and an increasing number p=p(n) of randomly chosen patterns and use Stein's method to obtain rates of convergence for the central limit theorem of overlap parameters, which holds for every fixed choice of the overlap parameter for almost all realisations of the random patterns.
In general, mathematics plays a central role in our lives because today mathematics regulates our everyday life with techniques, technologies and procedures, for example coding techniques for credit cards or the drafting of curves and surfaces for construction procedures [5]. Obviously, mathematics continues to be an important element of engineering education and it still represents a major obstacle for the students. Lacking the knowledge of several topics, changing learning behavior and inadequate overall conditions at universities for the repetition of school mathematics were mentioned to be causes for the constantly increasing gap between the initial level of mathematics at university and the prior knowledge of the first semester students [2].
Unternehmen nutzen teilweise veraltete Betriebssystem-Software, die nicht mehr gewartet werden. Beispiele sind "Windows XP" oder ab 14.05.2015 "Windows Server 2003" der Firma Microsoft. Das Paper analysiert die Situation im Hinblick auf signifikante Risiken wie z.B. die mögliche Versagung von Jahresabschlusstestaten und schlägt Maßnahmen für das Management vor.
Masterkurs IT-Controlling
(2014)
Das AD 2000-Regelwerk ist der dominierende Standard für den Druckbehälterbau in Deutschland. Die bereits in anderen europäischen Ländern verbreitete DIN EN 13445 findet kaum Berücksichtigung. Dies allerdings zu Unrecht, denn ein aktueller Vergleich, der im Rahmen einer Bachelorarbeit durchgeführte wurde, zeigt: Die EN 13445 ist zu einer echten Alternative gereift. Gerade das Hauptargument gegen eine Umstellung, die steigenden Kosten, ist längst überholt.
The case for basic human needs in coaching: A neuroscientific perspective - The SCOAP Coach Theory
(2014)
The perceived direction of “up” is determined by gravity, visual information, and an internal estimate of body orientation (Mittelstaedt, 1983; Dyde et al., 2006). Is the gravity level found on other worlds sufficient to maintain gravity’s contribution to this perception? Difficulties in stability reported anecdotally by astronauts on the lunar surface (NASA 1972) suggest that the moon’s gravity may not be, despite this value being far above the threshold for detecting linear acceleration. Knowing how much gravity is needed to provide a reliable orientation cue is required for training and preparing astronauts for future missions to the moon, mars and beyond.
Might the gravity levels found on other planets and on the moon be sufficient to provide an adequate perception of upright for astronauts? Can the amount of gravity required be predicted from the physiological threshold for linear acceleration? The perception of upright is determined not only by gravity but also visual information when available and assumptions about the orientation of the body. Here, we used a human centrifuge to simulate gravity levels from zero to earth gravity along the long-axis of the body and measured observers' perception of upright using the Oriented Character Recognition Test (OCHART) with and without visual cues arranged to indicate a direction of gravity that differed from the body's long axis. This procedure allowed us to assess the relative contribution of the added gravity in determining the perceptual upright. Control experiments off the centrifuge allowed us to measure the relative contributions of normal gravity, vision, and body orientation for each participant. We found that the influence of 1 g in determining the perceptual upright did not depend on whether the acceleration was created by lying on the centrifuge or by normal gravity. The 50% threshold for centrifuge-simulated gravity's ability to influence the perceptual upright was at around 0.15 g, close to the level of moon gravity but much higher than the threshold for detecting linear acceleration along the long axis of the body. This observation may partially explain the instability of moonwalkers but is good news for future missions to Mars.
Perception is one of the most important cognitive capabilities of an entity since it determines how an entity perceives its environment. The presented work focuses on providing cost efficient but realistic perceptual processes for intelligent virtual agents (IVAs) or NPCs with the goal of providing a sound information basis for the entities' decision making processes. In addition, an agent-central perception process should rovide a common interface for developers to retrieve data from the IVAs' environment. The overall process is evaluated by applying it to a scenario demonstrating its benefits. The evaluation indicates, that such a realistically simulated perception process provides a powerful instrument to enhance the (perceived) realism of an IVA's simulated behavior.
The work being described in this paper is the result of a cooperation project between the Institute of Visual Computing at the Bonn-Rhein-Sieg University of Applied Sciences, Germany and the Laboratory of Biomedical Engineering at the Federal University of Uberlândia, Brazil. The aim of the project is the development of a virtual environment based training simulator which enables for better and faster learning the control of upper limb prostheses. The focus of the paper is the description of the technical setup since learning tutorials still need to be developed as well as a comprehensive evaluation still needs to be carried out.
The objective of this research project is to develop a user-friendly and cost-effective interactive input device that allows intuitive and efficient manipulation of 3D objects (6 DoF) in virtual reality (VR) visualization environments with flat projections walls. During this project, it was planned to develop an extended version of a laser pointer with multiple laser beams arranged in specific patterns. Using stationary cameras observing projections of these patterns from behind the screens, it is planned to develop an algorithm for reconstruction of the emitter’s absolute position and orientation in space. Laser pointer concept is an intuitive way of interaction that would provide user with a familiar, mobile and efficient navigation though a 3D environment. In order to navigate in a 3D world, it is required to know the absolute position (x, y and z position) and orientation (roll, pitch and yaw angles) of the device, a total of 6 degrees of freedom (DoF). Ordinary laser-based pointers when captured on a flat surface with a video camera system and then processed, will only provide x and y coordinates effectively reducing available input to 2 DoF only. In order to overcome this problem, an additional set of multiple (invisible) laser pointers should be used in the pointing device. These laser pointers should be arranged in a way that the projection of their rays will form one fixed dot pattern when intersected with the flat surface of projection screens. Images of such a pattern will be captured via a real-time camera-based system and then processed using mathematical re-projection algorithms. This would allow the reconstruction of the full absolute 3D pose (6 DoF) of the input device. Additionally, multi-user or collaborative work should be supported by the system, would allow several users to interact with a virtual environment at the same time. Possibilities to port processing algorithms into embedded processors or FPGAs will be investigated during this project as well.
Ziel des hier beschriebenen Forschungsprojekts war die Entwicklung eines prototypischen Fahrradfahrsimulators für den Einsatz in der Verkehrserziehung und im Verkehrssicherheitstraining. Der entwickelte Prototyp soll möglichst universell für verschiedene Altersklassen und Applikationen einsetzbar sowie mobil sein.
We are happy to present you the special issue on Best Practice in Robot Software Development of the Journal on Software Engineering for Robotics! The spark for this special issue came during the eighth workshop on Software Development and Integration in Robotics (SDIR) at the 2013 IEEE International Conference on Robotics and Automation. The workshop focused on Robot Software Architectures, and the fruitful discussions made it clear that the design, development, and deployment of robot software is always an interplay between competing aspects. These are often couched in antagonistic pairs, such as dependability versus performance, and prominently include quality attributes as well as functional, nonfunctional, and application requirements.
Auch eine hervorragende Geschäftsidee braucht Zeit, bis sie von potenziellen Kunden bemerkt und honoriert wird. Trotz guter Planung und engagierter Kundenakquisition kann das Auftragsvolumen, auch aufgrund konjunktureller Schwächen, hinter den Erwartungen zurückbleiben. Zudem können sich Schwierigkeiten in der Produktentwicklung, in der Leistungserstellung und in der Auftragsabwicklung einstellen.
Trotz einer sauber aufgesetzten Projektplanung und der konsequenten Einhaltung der vorgeschriebenen PM-Methodik verfehlen Projekte oft ihre Zielvorgaben. Einer der wichtigsten Gründe hierfür ist die stark gestiegene Komplexität. Diese erfordert eine neue Sichtweise auf das Projektmanagement, wie Olaf Ihlow in seinem Trend-Beitrag meint.
Improving data acquisition techniques and rising computational power keep producing more and larger data sets that need to be analyzed. These data sets usually do not fit into a GPU's memory. To interactively visualize such data with direct volume rendering, sophisticated techniques for problem domain decomposition, memory management and rendering have to be used. The volume renderer Volt is used to show how CUDA is efficiently utilised to manage the volume data and a GPU's memory with the aim of low opacity volume renderings of large volumes at interactive frame rates.
Current computer architectures are multi-threaded and make use of multiple CPU cores. Most garbage collections policies for the Java Virtual Machine include a stop-the-world phase, which means that all threads are suspended. A considerable portion of the execution time of Java programs is spent in these stop-the-world garbage collections. To improve this behavior, a thread-local allocation and garbage collection that only affects single threads, has been proposed. Unfortunately, only objects that are not accessible by other threads ("do not escape") are eligible for this kind of allocation. It is therefore necessary to reliably predict the escaping of objects. The work presented in this paper analyzes the escaping of objects based on the line of code (program counter – PC) the object was allocated at. The results show that on average 60-80% of the objects do not escape and can therefore be locally allocated.
The ability to track moving people is a key aspect of autonomous robot systems in real-world environments. Whilst for many tasks knowing the approximate positions of people may be sufficient, the ability to identify unique people is needed to accurately count people in the real world. To accomplish the people counting task, a robust system for people detection, tracking and identification is needed.
Mit dem Projekt Pro-MINT-us hat sich die Hochschule Bonn-Rhein-Sieg erfolgreich im „Qualitätspakt Lehre“ beworben. Im Fokus steht dabei eine bessere Begleitung der Studierenden im Übergang von der Schule zur Hochschule. Mit Hilfe der Projektmittel konnten u.a. zwei Stellen geschaffen werden, die die Studierenden im Bereich „wissenschaftliches Schreiben“ unterstützen sollen.
CSR-Handbuch : ein Ratgeber
(2014)
Aus dem Projekt "Förderung angehender weiblicher Führungskräfte in kleinen und mittleren Unternehmen als CSR-Maßnahme"; ein Projekt der Hochschule Bonn-Rhein-Sieg im Rahmen des Programms "CSR-Gesellschaftliche Verantwortung im Mittelstand" gefördert durch das Bundesministerium für Arbeit und Soziales und durch den Europäischen Sozialfonds.
Realism and plausibility of computer controlled entities in entertainment software have been enhanced by adding both static personalities and dynamic emotions. Here a generic model is introduced that allows findings from real-life personality studies to be transferred to a computational model. Adaptive behavior patterns are enabled by introducing dynamic event-based emotions. The advantages of this model have been validated using a four-way crossroad in a traffic simulation. Driving agents using the introduced model enhanced by dynamics were compared to agents based on static personality profiles and simple rule-based behavior. The results show that adding a dynamic factor to agents improves perceivable plausibility and realism.
Automated parameterization of intermolecular pair potentials using global optimization techniques
(2014)
In this work, different global optimization techniques are assessed for the automated development of molecular force fields, as used in molecular dynamics and Monte Carlo simulations. The quest of finding suitable force field parameters is treated as a mathematical minimization problem. Intricate problem characteristics such as extremely costly and even abortive simulations, noisy simulation results, and especially multiple local minima naturally lead to the use of sophisticated global optimization algorithms. Five diverse algorithms (pure random search, recursive random search, CMA-ES, differential evolution, and taboo search) are compared to our own tailor-made solution named CoSMoS. CoSMoS is an automated workflow. It models the parameters’ influence on the simulation observables to detect a globally optimal set of parameters. It is shown how and why this approach is superior to other algorithms. Applied to suitable test functions and simulations for phosgene, CoSMoS effectively reduces the number of required simulations and real time for the optimization task.
In the field of domestic service robots, recovery from faults is crucial to promote user acceptance. In this context we focus in particular on some specific faults, which arise from the interaction of a robot with its real world environment. Even a well-modelled robot may fail to perform its tasks successfully due to unexpected situations, which occur while interacting. These situations occur as deviations of properties of the objects (manipulated by the robot) from their expected values. Hence, they are experienced by the robot as external faults.
Robots, which are able to carry out their tasks robustly in real world environments, are not only desirable but necessary if we want them to be more welcome for a wider audience. But very often they may fail to execute their actions successfully because of insufficient information about behaviour of objects used in the actions.
The analytical pyrolysis technique hyphenated to gas chromatography–mass spectrometry (GC–MS) has extended the range of possible tools for the characterization of synthetic polymers and copolymers. Pyrolysis involves thermal fragmentation of the analytical sample at temperatures of 500–1400 °C. In the presence of an inert gas, reproducible decomposition products characteristic for the original polymer or copolymer sample are formed. The pyrolysis products are chromatographically separated using a fused-silica capillary column and are subsequently identified by interpretation of the obtained mass spectra or by using mass spectra libraries. The analytical technique eliminates the need for pretreatment by performing analyses directly on the solid or liquid polymer sample. In this article, application examples of analytical pyrolysis hyphenated to GC–MS for the identification of different polymeric materials in the plastic and automotive industry, dentistry, and occupational safety are demonstrated. For the first time, results of identification of commercial light-curing dental filling material and a car wrapping foil by pyrolysis–GC–MS are presented.
Analytical pyrolysis technique hyphenated to gas chromatography/mass spectrometry (Py-GC/MS) has extended the range of possible tools for characterization of synthetic polymers/copolymers. Pyrolysis involves thermal fragmentation of the analytical sample at elevated temperature between 500 and 1400 °C. In the presence of an inert gas, reproducible decomposition products characteristic for the original polymer/copolymer sample are formed. The pyrolysis products are chromatographically separated by using a fused silica capillary column and subsequently identified by interpretation of the obtained mass spectra or by using mass spectra libraries. The analytical technique eliminate the need for pre-treatment by performing analyses directly on the solid or liquid polymer sample.
In this paper, application examples of the analytical pyrolysis hyphenated to gas chromatography/mass spectrometry for the identification of different polymeric materials in the plastic and automotive industry, dentistry and occupational safety are demonstrated. For the first time results of identification of commercially light-curing dental filling material and a car wrapping foil by pyrolysis-GC/MS are presented.
Gas chromatography with flame-ionization detection (FID) and gas chromatography-mass spectrometry (GC/MS) with electron impact ionization (EI) and chemical ionization (PCI and NCI) were successfully used for separation and identification of commercially available longchain primary alkyl amines. The investigated compounds were used as corrosion inhibiting and antifouling agents in a water-steam circuit of energy systems in the power industry. Solidphase extraction (SPE) with octadecyl bonded silica (C18) sorbents followed by gas chromatography were used for quantification of the investigated Primene JM-T™ alkyl amines in boiler water, condensate and superheated steam samples from the power plant. Amine formulations from Kotamina group favor formation of protective layers on internal surfaces and keep them free from corrosion and scale. Alkyl amines contained in those formulations both render the environment alkaline and limit the corrosion impact of ionic and gaseous impurities by formation of protective layers. Moreover, alkyl amines limit scaling on heating surfaces of boilers and in turbine, ensuring failure-free operation. Application of alkyl amine formulation enhances heat exchange during boiling and condensation processes. Alkyl amines with branched structure are more thermally stable than linear alkyl amines, exhibit better adsorption and effectiveness of surface shielding. As a result, application of thermostable long-chain branched alkyl amines increases the efficiency of anti-corrosive protection. Moreover, the concentration of ammonia content in water and in steam was also considerably decreased.
Unexpected Situations in Service Robot Environment: Classification and Reasoning Using Naive Physics
(2014)
We investigated graphene structures grafted with fullerenes. The size of the graphene sheets ranges from 6400 to 640,000 atoms. The fullerenes (C60 and C240) are placed on top of the graphene sheets, using different impact velocities we could distinguish three types of impact. Furthermore, we investigated the changes of the vibrational properties. The modified graphene planes show additional features in the vibronic density of states.
The contribution of the most common reciprocal translocation in childhood B-cell precursor leukemia t(12;21)(p13;q22) to leukemia development is still under debate. Direct as well as secondary indirect effects of the TEL-AML1 fusion protein are commonly recorded by using cell lines and patient samples, often bearing the TEL-AML1 fusion protein for decades. To identify direct targets of the fusion protein a short-term induction of TEL-AML1 is needed. We here describe in detail the experimental procedure, quality controls and contents of the ChIP, mRNA expression and SILAC datasets associated with the study published by Linka and colleagues in the Blood Cancer Journal [1] utilizing a short term induction of TEL-AML1 in an inducible precursor B-cell line model.
Breadth-First Search is a graph traversal technique used in many applications as a building block, e.g., to systematically explore a search space or to determine single source shortest paths in unweighted graphs. For modern multicore processors and as application graphs get larger, well-performing parallel algorithms are favorable. In this paper, we systematically evaluate an important class of parallel algorithms for this problem and discuss programming optimization techniques for their implementation on parallel systems with shared memory. We concentrate our discussion on level-synchronous algorithms for larger multicore and multiprocessor systems. In our results, we show that for small core counts many of these algorithms show rather similar performance behavior. But, for large core counts and large graphs, there are considerable differences in performance and scalability influenced by several factors, including graph topology. This paper gives advice, which algorithm should be used under which circumstances.
Seit vielen Jahren ist der Übergang von der Schule zur Hochschule eines der zentralen Themen für didaktische Theorien, empirische Untersuchungen und bildungspolitische Diskussionen. Ein dabei identifiziertes großes Problem vieler Studierender ist, dass mit dem Abitur „eine Lebensphase mit meist klar definierten Zielen in überschaubaren räumlichen, familiären und schulischen Strukturen endet“.1) Entscheidet man sich als Studierender gegen die nicht akademische Laufbahn und nimmt ein Hochschulstudium auf, trifft man auf Studienstrukturen und -bedingungen, die einem fremd und chaotisch vorkommen können. Der Weg an die Hochschulen ermöglicht den Individuen eine Reihe von Optionen, ist aber leider auch immer mit Risiken und Unsicherheiten behaftet. Entscheidungen müssen nun selbstständig vorbereitet und getroffen werden und dies in einem Umfeld, das sehr unterschiedlich im Vergleich zur bekannten Schulstruktur sein kann.