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Fixed-dose combination of pioglitazone and glimepiride in the treatment of Type 2 diabetes mellitus (2007)

Forst, Thomas ; Pfützner, Andreas

Type 2 diabetes is characterized by impaired insulin sensitivity and disturbances in β-cell function. While glimepiride stimulates β-cell secretion and leads to a reduction of blood glucose levels, pioglitazone activates peroxisome proliferator-activated receptor-γ and improves insulin resistance. Combining these two modes of action has been shown to improve glucose and lipid metabolism, and to improve the overall cardiovascular risk in patients with Type 2 diabetes. The combination of glimepiride and pioglitazone is generally well tolerated and a fixed combination may lead to an improved compliance in patients. The purpose of this review is to evaluate the clinical data that has been published on this combination, appearing to represent a convenient way to obtain therapeutic targets in patients with Type 2 diabetes mellitus.

Unternehmenssteuern (2007)

Schneider, Bettina ; Schneider, Wilhelm

Finanzierung (2007)

Schneider, Bettina ; Schneider, Wilhelm

Investition und Finanzierung (2007)

ter Horst, Klaus W.

Materielle Prüfung (2007)

Schneider, Bettina ; Schneider, Wilhelm

Wirtschaftsgut (2007)

Schneider, Bettina ; Schneider, Wilhelm

Konzernarten (2007)

Schneider, Bettina ; Schneider, Wilhelm

Formelle Prüfung (2007)

Schneider, Bettina ; Schneider, Wilhelm

Fachhochschulen, Lehre im Prüfungswesen (2007)

Schneider, Bettina ; Schneider, Wilhelm

Fachhochschulen, Forschung im Prüfungswesen (2007)

Schneider, Bettina ; Schneider, Wilhelm

Betriebsausgaben (2007)

Schneider, Bettina ; Schneider, Wilhelm

SAP R/3: kompletní průvodce (2007)

Maassen, André ; Schoenen, Markus ; Frick, Detlev ; Gadatsch, Andreas

Marketing und Vertrieb (2007)

Juszczak, Jens ; Gadatsch, Andreas

IT-Controlling - Zielsetzungen, Instrumente und Konzepte (2007)

Gadatsch, Andreas ; Tiemeyer, Ernst

Grundlagen des Informations- und Wissensmanagements (2007)

Gadatsch, Andreas

Prozessmanagement (2007)

Gadatsch, Andreas

IT Governance: A new concept or an innovative development of Information Management (2007)

Joisten, Claudia

Digitale Musikdistribution: Grundlagen, Potenziale, Strategien (2007)

Oepkemeier, Frank

Musik über das Internet ist die Zukunft, daran besteht kein Zweifel. Das Interesse und die Leidenschaft an Musik ist beständig, das Konsumverhalten jedoch hat sich deutlich verändert. Dies wird bestehende Geschäftsmodelle nachhaltig verändern. Wirkungsvolle Strategien, welche die Wertschöpfung und die darin liegenden Potenziale mit einbeziehen sind gefragt. Der Strukturwandel der Branche birgt enorme Chancen für beide Seiten. Sowohl Anbieter als auch Kunde werden sich vor allem mit immateriellen Informationsgütern beschäftigen. Grundlage wird daher sein, durch entsprechende Wertschöpfungspotenziale eine neue Industrielandschaft zur etablieren.

Introduction to Business Intelligence: Concepts and Tools (2007)

Hartenauer, Jörg

During the past few years, fast changes in the economic environment and massive technological developments in the field of information technology constitute challenges for many companies. The growing capabilities to collect and store loads of internal and external data make it more and more difficult for a business’s management to find the realyy important pieces of information. This situation of information overload is tackeled by a variety of analytic concepts and tools which can be subsumed under the opalescent term of “Business Intelligence”.

Self-Monitoring of Blood Glucose Levels Requires Intensive Training for Use of Meters to Obtain Reliable and Clinically Relevant Measurements (2007)

Mohr, Thomas A. ; Pfützner, Andreas ; Forst, Senait ; Forst, Thomas ; Schöndorf, Thomas

Background:Anecdotal reports from pediatric sites have indicated that some blood glucose meters may display wrong and misleading numbers rather than error indications, when operated in deviation from the instructions for use (IFU), eg by manipulating the strip during the count-down phase.Methods:This study was performed with 60 patients with diabetes (32 female, 28 male, 21 type 1, 39 type 2, age (mean±SD): 56±11 years) who measured their blood glucose levels twice with five different blood glucose meters (Precision? Xceed? [Abbott Medisense], Freestyle Mini? [Abbott Medisense], Accu-Chek? Comfort [Roche Diagnostics], Accu-Chek? Aviva [Roche Diagnostics], and Ascensia Contour? [Bayer Vital]). The first measurement was performed in accordance with the IFU, and the second by manipulating the test strip using a standardised inflexion/release procedure during the count-down phase. A standard glucose oxidase method (SuperGL) served as laboratory reference.Results:All meters worked in full compliance with current accuracy standards when operated according to the IFU. When manipulating the test strip, the results varied considerably: While changes in reliability were acceptable for two devices (Precision? Xceed?, Freestyle Mini?), the other devices produced an unacceptable number of errors and a series of entirely wrong values without error indication.Conclusions:The use of all devices is recommended when used according to the IFU. The use under the artificially induced impaired testing conditions is a major concern. This study underlines the importance of appropriate patient training regarding adherence to the IFU of glucose meters.

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