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Kommentierung zu § 39 BDSG
(2013)
Botnets
(2013)
Malware poses one of the major threats to all currently operated computer systems. The scale of the problem becomes obvious by looking at the global economic loss caused by different kinds of malware, which is estimated to be more than US$ 10 billion every year. Botnets, a special kind of malware, are used to reap economic gains by criminals as well as for politically motivated activities. In contrast to other kinds of malware, botnets utilize a hidden communication channel to receive commands from their operator and communicate their current status. The ability to execute almost arbitrary commands on the infected machines makes botnets a general-purpose tool to perform malicious cyber-activities. (Verlagsangaben)
Tamoxifen therapy of invasive breast cancer has been associated with increased levels of endothelin-1 (ET-1) so that an endothelin-1 receptor (ETR) blockade has been suggested as a new therapeutic approach. This study analyzed the relationship between Tamoxifen and ET-1 signalling in invasive breast cancer. Using paraffinized tissue from 50 randomly chosen cases of invasive and in-situ ductal carcinoma from our archive, the expression of ETRs was analyzed by immune histology. ETRs were regularly detectable in normal breast tissue, but rarely in adjacent tumor areas (3/50 cases). By immunoprecipitation, a complex was found consisting of ET-1, estrogen receptors and Tamoxifen. Consequently, transcription of several target genes of ET-1 and estrogen receptors was detectable (interleukin-6, wnt-11 and a vimentin spliceform). In particular, the combination of Tamoxifen, ET-1, and estrogen receptors induced further increasing levels of these target genes. Some of these genes have been found upregulated in metastatically spreading breast cancer cells. We conclude: i) ETRs do not play a role in invasive or in-situ ductal breast cancer; ii) estrogen receptors and Tamoxifen build a complex with ET-1; and iii) upregulated transcription of target genes by ET-1–estrogen receptor–Tamoxifen complex may negatively influence breast cancer prognosis. These results indicate a role for ET-1 in Tamoxifen treated breast cancer patients leading to a potentially worsening prognosis.
Corporate Social Responsibility ist freiwillig, aber keineswegs beliebig. Um sich als CSR-Unternehmen zu qualifizieren, muss ein systematisches und geplantes Engagement als nachhaltiges Unternehmen nachgewiesen und auch dokumentiert werden. Dies wird auch für Unternehmen der Immobilienwirtschaft zunehmend wichtiger, weil die Anforderungen vonseiten der Stakeholder der Unternehmen wachsen. Die Analyse zeigt, dass die deutschen Immobilienunternehmen im internationalen Vergleich gut dastehen. Ihr Anteil an allen nach der Global Reporting Initiative berichtenden Immobilienunternehmen lag im Jahr 2012 bei 15 Prozent. Von den betrachteten 135 Unternehmen in Deutschland klassifiziert sich jedoch nur ein kleiner Teil als CSR-Unternehmen. Durch eine bessere Dokumentation des Engagements kann die Anzahl an Unternehmen rasch vergrößert werden.
Marketing und Recht kompakt
(2013)
This paper presents recent research on an active multispectral scanning sensor capable of classifying an object's surface material in order to distinguish between different kinds of materials and human skin. The sensor itself has already been presented in previous work and can be used in conjunction with safeguarding equipment at manually-fed machines or robot workplaces, for example. This work shows how an extended sensor system with advanced material classifiers can be used to provide additional value by distinguishing different materials of work pieces in order to suggest different tools or parameters for the machine (e.g. the use of a different saw blade or rotation speed at table saws). Additionally, a first implementation and evaluation of an active multispectral camera system addressing new safety applications is described. Both approaches intend to increase the productivity and the user's acceptance of the sensor technology.
Open Discovery Space
(2013)
Fast täglich werden neue Angriffe auf IT-Systeme bekannt, bei denen sensible Daten entwendet werden. Das vorliegende Buch vermittelt die wesentlichen Grundlagen und Technologien, die zur Absicherung von Computernetzwerken benötigt werden. Stets legen die Autoren dabei Wert auf eine verständliche Darstellung, die – soweit möglich – auf abstrakte Modelle und formalen Notationen verzichtet. Zu jedem Kapitel werden Aufgaben zur Kontrolle von Wissensstand und Verständnis angeboten.
Introduction: Matrix metalloproteinases (MMPs) are important in tissue remodelling. Here we investigate the role of collagenase-3 (MMP-13) in antibody-induced arthritis.
Methods: For this study we employed the K/BxN serum-induced arthritis model. Arthritis was induced in C57BL/6 wild type (WT) and MMP-13-deficient (MMP-13–/–) mice by intraperitoneal injection of 200 μl of K/BxN serum. Arthritis was assessed by measuring the ankle swelling. During the course of the experiments, mice were sacrificed every second day for histological examination of the ankle joints. Ankle sections were evaluated histologically for infiltration of inflammatory cells, pannus tissue formation and bone/cartilage destruction. Semi-quantitative PCR was used to determine MMP-13 expression levels in ankle joints of untreated and K/BxN serum-injected mice.
Results: This study shows that MMP-13 is a regulator of inflammation. We observed increased expression of MMP-13 in ankle joints of WT mice during K/BxN serum-induced arthritis and both K/BxN serum-treated WT and MMP-13–/– mice developed progressive arthritis with a similar onset. However, MMP-13–/– mice showed significantly reduced disease over the whole arthritic period. Ankle joints of WT mice showed severe joint destruction with extensive inflammation and erosion of cartilage and bone. In contrast, MMP-13–/– mice displayed significantly decreased severity of arthritis (50% to 60%) as analyzed by clinical and histological scoring methods.
Conclusions: MMP-13 deficiency acts to suppress the local inflammatory responses. Therefore, MMP-13 has a role in the pathogenesis of arthritis, suggesting MMP-13 is a potential therapeutic target.
In this paper we present the steps towards a well-designed concept of a 5VR6 system for school experiments in scientific domains like physics, biology and chemistry. The steps include the analysis of system requirements in general, the analysis of school experiments and the analysis of input and output devices demands. Based on the results of these steps we show a taxonomy of school experiments and provide a comparison between several currently available devices which can be used for building such a system. We also compare the advantages and shortcomings of 5VR6 and 5AR6 systems in general to show why, in our opinion, 5VR6 systems are better suited for school-use.
Embodied artificial agents operating in dynamic, real-world environments need architectures that support the special requirements that exist for them. Architectures are not always designed from scratch and the system then implemented all at once, but rather, a step-wise integration of components is often made to increase functionality. Our work aims to increase flexibility and robustness by integrating a task planner into an existing architecture and coupling the planning process with the preexisting execution and the basic monitoring processes. This involved the conversion of monolithic SMACH scenario scripts (state-machine execution scripts) into modular states that can be called dynamically based on the plan that was generated by the planning process. The procedural knowledge encoded in such state machines was used to model the planning domain for two RoboCup@Home scenarios on a Care-O-Bot 3 robot [GRH+08]. This was done for the JSHOP2 [IN03] hierarchical task network (HTN) planner. A component which iterates through a generated plan and calls the appropriate SMACH states [Fie11] was implemented, thus enabling the scenarios. Crucially, individual monitoring actions which enable the robot to monitor the execution of the actions were designed and included, thus providing additional robustness.
A structural mapping of mutations causing succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency
(2013)
Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency is a rare inherited metabolic disorder of ketone metabolism, characterized by ketoacidotic episodes and often permanent ketosis. To date there are ~20 disease-associated alleles on the OXCT1 gene that encodes the mitochondrial enzyme SCOT. SCOT catalyzes the first, rate-limiting step of ketone body utilization in peripheral tissues, by transferring a CoA moiety from succinyl-CoA to form acetoacetyl-CoA, for entry into the tricarboxylic acid cycle for energy production. We have determined the crystal structure of human SCOT, providing a molecular understanding of the reported mutations based on their potential structural effects. An interactive version of this manuscript (which may contain additional mutations appended after acceptance of this manuscript) may be found on the web address:
http://www.thesgc.org/jimd/SCOT
Für die Durchführung größerer Projekte innerhalb des DLR ist es häufig notwendig, dass sich Wissenschaftler fachübergreifend in Themengebiete einarbeiten müssen. Im Rahmen dieser Einarbeitung führen Wissenschaftler Recherchen in fremden Fachbereichen durch. Das DLR hat zu diesem Zweck das Wissensportal KnowledgeFinder entwickelt. Dieses Framework setzt klassische Suchverfahren zum Auffinden von Informationen in beliebigen Datenbeständen ein. Wenn Wissenschaftler in fremden Fachbereichen recherchieren, dann fällt es ihnen aufgrund des oberflächlichen Einblicks oftmals schwer, zielgerichtet nach Informationen zu suchen. Die im KnowledgeFinder eingesetzten klassischen Suchverfahren, die auf textueller und struktureller Ähnlichkeit basieren, können bei diesen unspezifischen Suchanfragen nur bedingt beim Auffinden von relevanten Informationen helfen. Aufgrund von Mehrdeutigkeiten und unterschiedlichen Kontexten stoße solche Verfahren oftmals an ihre Grenzen. Semantische Technologien haben zum Ziel diesen Mangel zu beheben. Hier wird neben der textuellen und strukturellen Ähnlichkeit zusätzlich die Dimension der Bedeutung betrachtet. In dieser Masterthesis wurde untersucht, ob die Suchergebnisqualität des KnowledgeFinder durch den Einsatz semantischer Technologien verbessert werden kann. Innerhalb einer Machbarkeitsstudie wurde dazu das KnowledgeFinder Framework um semantische Suchverfahren erweitert. Diese Verfahren sollen die fachübergreifende Recherche von DLR-Wissenschaftlern erleichtern, indem sie ihnen helfen, passende Suchergebnisse in den entsprechenden Fachbereichen zu finden.
The use of manually fed machines (e.g. table saws) bares risks of injury that are clearly above the average level of other high risk workplaces.
The wide use of such machines causes severe problems for occupational safety and implies high costs for medical treatments and accident annuities.
This thesis presents a new concept of a multispectral sensor to monitor an area in front of a danger zone to detect the user’s limbs and trigger safeguarding measures to prevent an accident in time.
The sensor concept realizes a contact-free material classification, which comprises the development of a system design and specific safety requirements with respect to international safety standards.
Furthermore, a prototypical implementation using four wavebands, which were determined for skin detection through an analysis of reflectance spectra acquired specifically for this purpose, was built.