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Internet, Soziale Netzwerke, Spiele, Smartphones, DVDs, digitaler Rundfunk und digitales Fernsehen funktionieren nur deshalb, weil zu ihrer Entwicklung und Anwendung mathematisch abgesicherte Verfahren zur Verfügung stehen. Dieses Buch vermittelt Einsichten in grundlegende Konzepte und Methoden der Linearen Algebra, auf denen diese Verfahren beruhen. Am Beispiel fehlertoleranter Codierung wird einführend gezeigt, wie diese Konzepte und Methoden in der Praxis eingesetzt werden, und am Beispiel von Quantenalgorithmen, die möglicherweise in Zukunft eine Rolle spielen, wird deutlich, dass die Lineare Algebra zeitinvariante Konzepte, Methoden und Verfahren bereitstellt, mit denen IT-Technologien konzipiert, implementiert, angewendet und weiterentwickelt werden können. Wegen seiner didaktischen Elemente wie Vorgabe von Lernzielen, Zusammenfassungen, Marginalien und einer Vielzahl von Übungen mit Musterlösungen eignet sich das Buch nicht nur als Begleitlektüre zu entsprechenden Informatik- und Mathematik-Lehrveranstaltungen, sondern insbesondere auch zum Selbststudium.
The reciprocal translocation t(12;21)(p13;q22), the most common structural genomic alteration in B-cell precursor acute lymphoblastic leukaemia in children, results in a chimeric transcription factor TEL-AML1 (ETV6-RUNX1). We identified directly and indirectly regulated target genes utilizing an inducible TEL-AML1 system derived from the murine pro B-cell line BA/F3 and a monoclonal antibody directed against TEL-AML1. By integration of promoter binding identified with chromatin immunoprecipitation (ChIP)-on-chip, gene expression and protein output through microarray technology and stable labelling of amino acids in cell culture, we identified 217 directly and 118 indirectly regulated targets of the TEL-AML1 fusion protein. Directly, but not indirectly, regulated promoters were enriched in AML1-binding sites. The majority of promoter regions were specific for the fusion protein and not bound by native AML1 or TEL. Comparison with gene expression profiles from TEL-AML1-positive patients identified 56 concordantly misregulated genes with negative effects on proliferation and cellular transport mechanisms and positive effects on cellular migration, and stress responses including immunological responses. In summary, this work for the first time gives a comprehensive insight into how TEL-AML1 expression may directly and indirectly contribute to alter cells to become prone for leukemic transformation.
Die Vorstandsperspektive
(2013)
In this paper we present the steps towards a well-designed concept of a 5VR6 system for school experiments in scientific domains like physics, biology and chemistry. The steps include the analysis of system requirements in general, the analysis of school experiments and the analysis of input and output devices demands. Based on the results of these steps we show a taxonomy of school experiments and provide a comparison between several currently available devices which can be used for building such a system. We also compare the advantages and shortcomings of 5VR6 and 5AR6 systems in general to show why, in our opinion, 5VR6 systems are better suited for school-use.
Real-Time Simulation of Camera Errors and Their Effect on Some Basic Robotic Vision Algorithms
(2013)
Generating and visualizing large areas of vegetation that look natural makes terrain surfaces much more realistic. However, this is a challenging field in computer graphics, because ecological systems are complex and visually appealing plant models are geometrically detailed. This work presents Silva (System for the Instantiation of Large Vegetated Areas), a system to generate and visualize large vegetated areas based on the ecological surrounding. Silva generates vegetation on Wang-tiles with associated reusable distributions enabling multi-level instantiation. This paper presents a method to generate Poisson Disc Distributions (PDDs) with variable radii on Wang-tile sets (without a global optimization) that is able to generate seamless tilings. Because Silva has a freely configurable generation pipeline and can consider plant neighborhoods it is able to incorporate arbitrary abiotic and biotic components during generation. Based on multi-levelinstancing and nested kd-trees, the distributions on the Wang-tiles allow their acceleration structures to be reused during visualization. This enables Silva to visualize large vegetated areas of several hundred square kilometers with low render times and a small memory footprint.
Application performance improvements through VM parameter modification after runtime analysis
(2013)
Traffic simulations are generally used to forecast traffic behavior or to simulate non-player characters in computer games and virual environments. These systems are usually modeled in such a way that traffic rules are strictly followed. However, rule violations are a common part of real-life traffic and thus should be integrated into such models.
YAWL Symposium 2013. Proceedings of the First YAWL Symposium, Sankt Augustin, Germany, June 7, 2013
(2013)
In this paper, we describe an approach that enables an autonomous system to infer the semantics of a command (i.e. a symbol sequence representing an action) in terms of the relations between changes in the observations and the action instances. We present a method of how to induce a theory (i.e. a semantic description) of the meaning of a command in terms of a minimal set of background knowledge. The only thing we have is a sequence of observations from which we extract what kinds of effects were caused by performing the command. This way, we yield a description of the semantics of the action and, hence, a definition.