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The solvent exchange as one of the most important steps during the manufacturing process of organic aerogels was investigated. This step is crucial as a preparatory step for the supercritical drying, since the pore solvent must be soluble in supercritical carbon dioxide to enable solvent extraction. The development and subsequent optimization of a suitable system with a peristaltic pump for automatic solvent exchange proved to be a suitable approach. In addition, the influence of zeolites on the acceleration of the process was found to be beneficial. To investigate the process, the water content in acetone was determined at different times using Karl Fischer titration. The shrinkage, densities, as well as the surface areas of the aerogels were analyzed. Based on these, the influence of various process parameters on the final structure of the obtained aerogels was investigated and evaluated. Modeling on diffusion in porous materials completes this study.
Over the last decades, different kinds of design guides have been created to maintain consistency and usability in interactive system development. However, in the case of spatial applications, practitioners from research and industry either have difficulty finding them or perceive such guides as lacking relevance, practicability, and applicability. This paper presents the current state of scientific research and industry practice by investigating currently used design recommendations for mixed reality (MR) system development. We analyzed and compared 875 design recommendations for MR applications elicited from 89 scientific papers and documentation from six industry practitioners in a literature review. In doing so, we identified differences regarding four key topics: Focus on unique MR design challenges, abstraction regarding devices and ecosystems, level of detail and abstraction of content, and covered topics. Based on that,we contribute to the MR design research by providing three factors for perceived irrelevance and six main implications for design recommendations that are applicable in scientific and industry practice.
Augmented/Virtual Reality (AR/VR) is still a fragmented space to design for due to the rapidly evolving hardware, the interdisciplinarity of teams, and a lack of standards and best practices. We interviewed 26 professional AR/VR designers and developers to shed light on their tasks, approaches, tools, and challenges. Based on their work and the artifacts they generated, we found that AR/VR application creators fulfill four roles: concept developers, interaction designers, content authors, and technical developers. One person often incorporates multiple roles and faces a variety of challenges during the design process from the initial contextual analysis to the deployment. From analysis of their tool sets, methods, and artifacts, we describe critical key challenges. Finally, we discuss the importance of prototyping for the communication in AR/VR development teams and highlight design implications for future tools to create a more usable AR/VR tool chain.
Mebendazole Mediates Proteasomal Degradation of GLI Transcription Factors in Acute Myeloid Leukemia
(2021)
The prognosis of elderly AML patients is still poor due to chemotherapy resistance. The Hedgehog (HH) pathway is important for leukemic transformation because of aberrant activation of GLI transcription factors. MBZ is a well-tolerated anthelmintic that exhibits strong antitumor effects. Herein, we show that MBZ induced strong, dose-dependent anti-leukemic effects on AML cells, including the sensitization of AML cells to chemotherapy with cytarabine. MBZ strongly reduced intracellular protein levels of GLI1/GLI2 transcription factors. Consequently, MBZ reduced the GLI promoter activity as observed in luciferase-based reporter assays in AML cell lines. Further analysis revealed that MBZ mediates its anti-leukemic effects by promoting the proteasomal degradation of GLI transcription factors via inhibition of HSP70/90 chaperone activity. Extensive molecular dynamics simulations were performed on the MBZ-HSP90 complex, showing a stable binding interaction at the ATP binding site. Importantly, two patients with refractory AML were treated with MBZ in an off-label setting and MBZ effectively reduced the GLI signaling activity in a modified plasma inhibitory assay, resulting in a decrease in peripheral blood blast counts in one patient. Our data prove that MBZ is an effective GLI inhibitor that should be evaluated in combination to conventional chemotherapy in the clinical setting.
In this contribution, we perform computer simulations to expedite the development of hydrogen storages based on metal hydride. These simulations enable in-depth analysis of the processes within the systems which otherwise could not be achieved. That is, because the determination of crucial process properties require measurement instruments in the setup which are currently not available. Therefore, we investigate the reliability of reaction values that are determined by a design of experiments.
Specifically, we first explain our model setup in detail. We define the mathematical terms to obtain insights into the thermal processes and reaction kinetics. We then compare the simulated results to measurements of a 5-gram sample consisting of iron-titanium-manganese (FeTiMn) to obtain the values with the highest agreement with the experimental data. In addition, we improve the model by replacing the commonly used Van’t-Hoff equation by a mathematical expression of the pressure-composition-isotherms (PCI) to calculate the equilibrium pressure.
Finally, the parameters’ accuracy is checked in yet another with an existing metal hydride system. The simulated results demonstrate high concordance with experimental data, which advocate the usage of approximated kinetic reaction properties by a design of experiments for further design studies. Furthermore, we are able to determine process parameters like the entropy and enthalpy.
The identification of energetic materials in containments is an important challenge for analytical methods in the field of safety and security. Opening a package without knowledge of its contents and the resulting hazards is highly involved with risks and should be avoided whenever possible. Therefore, preferable methods work non-destructive with minimal interaction and are capable of identifying target substances in a containment quickly and reliably. Most spectroscopic methods find their limits, if the target substance is shielded by a covering material. To solve this problem, a combined laser drilling method with subsequent identification of the target substance by means of Raman spectroscopic measurements through microscopic bore holes of the covering material is presented. A pulsed laser beam is used for both the drilling process and as an excitation source for Raman measurements in the same optical setup. Results show the ability of this new method to gain high-quality spectra even when performed through microscopic small bore channels. With the laser parameters chosen right, the method can even be performed on highly sensitive explosives like triacetone triperoxide (TATP). Another advantageous effect arises in an observed reduction in unwanted fluorescence signal in the spectral data, resulting from the confocal-like measurement setup with the bore hole acting as aperture.
Die vorliegende Forschungsarbeit behandelt die Filtrierung von sozialen Medien durch die Content Moderatoren. Die Content Moderatoren sind Menschen, die unter schlechten Arbeitsbedingungen und hoher psychischer Belastung Plattformen wie Facebook tagtäglich von strafbaren Inhalten filtern. Durch dieses Löschregime werden zwar gewaltzeigende Inhalte gelöscht, aber auch aufklärende oder künstlerische Inhalte zensiert.
Mithilfe von durchgeführten Fokusgruppendiskussionen wurde der Einfluss der Gruppenzusammensetzung und Darbietung positiver und negativer Informationen auf die individuelle und eindimensionale Wahrnehmung der Teilnehmer bezüglich sozialer Medien, Content Moderatoren und Löschrichtlinien erforscht.
Die Ergebnisse zeigen, dass die Darbietung der Informationen keinen Einfluss auf die mehrdimensionale Wahrnehmung der Probanden hatte und sie unabhängig von der Gruppenzusammensetzung nonkonforme Meinungen vertraten. Trotz des erweiterten Wissenstandes und der entwickelten Alternativlösungen äußerten die meisten Probanden nicht die Absicht, ihr Nutzungsverhalten künftig zu ändern. Trotz der Annahme, dass die meisten Probanden eine eindimensionale Wahrnehmung sozialer Medien haben, zeigten die Ergebnisse, dass viele Probanden eine ähnlich positive und kritische Haltung gegenüber den Plattformen hatten. Darüber hinaus wird deutlich, dass es einen starken Forschungsbedarf in Bezug auf die Langzeitfolgen der Arbeit als Content Moderator und Auswirkungen von Zensur und Filtrierung auf die Nutzer sozialer Medien gibt.
The clear-sky radiative effect of aerosol-radiation interactions is of relevance for our understanding of the climate system. The influence of aerosol on the surface energy budget is of high interest for the renewable energy sector. In this study, the radiative effect is investigated in particular with respect to seasonal and regional variations for the region of Germany and the year 2015 at the surface and top of atmosphere using two complementary approaches.
First, an ensemble of clear-sky models which explicitly consider aerosols is utilized to retrieve the aerosol optical depth and the surface direct radiative effect of aerosols by means of a clear sky fitting technique. For this, short-wave broadband irradiance measurements in the absence of clouds are used as a basis. A clear sky detection algorithm is used to identify cloud free observations. Considered are measurements of the shortwave broadband global and diffuse horizontal irradiance with shaded and unshaded pyranometers at 25 stations across Germany within the observational network of the German Weather Service (DWD). Clear sky models used are MMAC, MRMv6.1, METSTAT, ESRA, Heliosat-1, CEM and the simplified Solis model. The definition of aerosol and atmospheric characteristics of the models are examined in detail for their suitability for this approach.
Second, the radiative effect is estimated using explicit radiative transfer simulations with inputs on the meteorological state of the atmosphere, trace-gases and aerosol from CAMS reanalysis. The aerosol optical properties (aerosol optical depth, Ångström exponent, single scattering albedo and assymetrie parameter) are first evaluated with AERONET direct sun and inversion products. The largest inconsistency is found for the aerosol absorption, which is overestimated by about 0.03 or about 30 % by the CAMS reanalysis. Compared to the DWD observational network, the simulated global, direct and diffuse irradiances show reasonable agreement within the measurement uncertainty. The radiative kernel method is used to estimate the resulting uncertainty and bias of the simulated direct radiative effect. The uncertainty is estimated to −1.5 ± 7.7 and 0.6 ± 3.5 W m−2 at the surface and top of atmosphere, respectively, while the annual-mean biases at the surface, top of atmosphere and total atmosphere are −10.6, −6.5 and 4.1 W m−2, respectively.
The retrieval of the aerosol radiative effect with the clear sky models shows a high level of agreement with the radiative transfer simulations, with an RMSE of 5.8 W m−2 and a correlation of 0.75. The annual mean of the REari at the surface for the 25 DWD stations shows a value of −12.8 ± 5 W m−2 as average over the clear sky models, compared to −11 W m−2 from the radiative transfer simulations. Since all models assume a fixed aerosol characterisation, the annual cycle of the aerosol radiation effect cannot be reproduced. Out of this set of clear sky models, the largest level of agreement is shown by the ESRA and MRMv6.1 models.
Universities, Entrepreneurship and Enterprise Development in Africa – Conference Proceedings 2020
(2021)
These proceedings are the outcome of the 8th annual joint conference on "Universities Entrepreneurship and Enterprise Development in Africa" between the University of Cape Coast, Ghana and Hochschule Bonn-Rhein-Sieg University of Applied Sciences, Germany, held on 19-20 February 2020 on Campus Sankt Augustin, Hochschule Bonn-Rhein-Sieg University of Applied Sciences.
Science Track FrOSCon 2018
(2021)
The genetic basis of brain tumor development is poorly understood. Here, leukocyte DNA of 21 patients from 15 families with ≥ 2 glioma cases each was analyzed by whole-genome or targeted sequencing. As a result, we identified two families with rare germline variants, p.(A592T) or p.(A817V), in the E-cadherin gene CDH1 that co-segregate with the tumor phenotype, consisting primarily of oligodendrogliomas, WHO grade II/III, IDH-mutant, 1p/19q-codeleted (ODs). Rare CDH1 variants, previously shown to predispose to gastric and breast cancer, were significantly overrepresented in these glioma families (13.3%) versus controls (1.7%). In 68 individuals from 28 gastric cancer families with pathogenic CDH1 germline variants, brain tumors, including a pituitary adenoma, were observed in three cases (4.4%), a significantly higher prevalence than in the general population (0.2%). Furthermore, rare CDH1 variants were identified in tumor DNA of 6/99 (6%) ODs. CDH1 expression was detected in undifferentiated and differentiating oligodendroglial cells isolated from rat brain. Functional studies using CRISPR/Cas9-mediated knock-in or stably transfected cell models demonstrated that the identified CDH1 germline variants affect cell membrane expression, cell migration and aggregation. E-cadherin ectodomain containing variant p.(A592T) had an increased intramolecular flexibility in a molecular dynamics simulation model. E-cadherin harboring intracellular variant p.(A817V) showed reduced β-catenin binding resulting in increased cytosolic and nuclear β-catenin levels reverted by treatment with the MAPK interacting serine/threonine kinase 1 inhibitor CGP 57380. Our data provide evidence for a role of deactivating CDH1 variants in the risk and tumorigenesis of neuroepithelial and epithelial brain tumors, particularly ODs, possibly via WNT/β-catenin signaling.
Fabry disease (FD) is an X‐linked lysosomal storage disorder. Deficiency of the lysosomal enzyme alpha‐galactosidase (GLA) leads to accumulation of potentially toxic globotriaosylceramide (Gb3) on a multisystem level. Cardiac and cerebrovascular abnormalities as well as progressive renal failure are severe, life‐threatening long‐term complications. The complete pathophysiology of chronic kidney disease (CKD) in FD and the role of tubular involvement for its progression are unclear.
We established human renal tubular epithelial cell lines from the urine of male FD patients and male controls. The renal tubular system is rich in mitochondria and involved in transport processes at high energy costs. Our studies revealed fragmented mitochondria with disrupted cristae structure in FD patient cells. Oxidative stress levels were elevated and oxidative phosphorylation was up‐regulated in FD pointing at enhanced energetic needs. Mitochondrial homeostasis and energy metabolism revealed major changes as evidenced by differences in mitochondrial number, energy production and fuel consumption. The changes were accompanied by activation of the autophagy machinery in FD. Sirtuin1, an important sensor of (renal) metabolic stress and modifier of different defense pathways, was highly expressed in FD.
Our data show that lysosomal FD impairs mitochondrial function and results in severe disturbance of mitochondrial energy metabolism in renal cells. This insight on a tissue‐specific level points to new therapeutic targets which might enhance treatment efficacy.
Since stationary self-checkout is widely introduced and well understood, previous research barely examined newer generations of smartphone-based Scan&Go. Especially from a design perspective, we know little about the factors contributing to the adoption of Scan&Go solutions and how design enables consumers to take full advantage of this development rather than being burdened with using complex and unenjoyable systems. To understand the influencing factors and the design from a consumer perspective, we conducted a mixed-methods study where we triangulated data of an online survey with 103 participants and a qualitative study with 20 participants. Based on the results, our study presents a refined and nuanced understanding of technology as well as infrastructure-related factors that influence adoption. Moreover, we present several implications for designing and implementing of Scan&Go in retail environments.
Atomic oxygen in the mesosphere and lower thermosphere measured by terahertz heterodyne spectroscopy
(2021)
Atomic oxygen is a main component of the mesosphere and lower thermosphere (MLT). The photochemistry and the energy balance of the MLT are governed by atomic oxygen. In addition, it is a tracer for dynamical motions in the MLT. It is difficult to measure with remote sensing techniques. Concentrations can be inferred indirectly from the oxygen air glow or from observations of OH, which is involved in photochemical processes related to atomic oxygen. Such measurements have been performed with several satellite instruments such as SCIAMACHY, SABER, WINDII and OSIRIS. However, the methods are indirect and rely on photochemical models and assumptions such as quenching rates, radiative lifetimes, and reaction coefficients. The results are not always in agreement, particularly when obtained with different instruments.
3-Hydroxyisobutyrate Dehydrogenase (HIBADH) deficiency - a novel disorder of valine metabolism
(2021)
3-Hydroxyisobutyric acid (3HiB) is an intermediate in the degradation of the branched-chain amino acid valine. Disorders in valine degradation can lead to 3HiB accumulation and its excretion in the urine. This article describes the first two patients with a new metabolic disorder, 3-hydroxyisobutyrate dehydrogenase (HIBADH) deficiency, its phenotype and its treatment with a low-valine diet. The detected mutation in the HIBADH gene leads to nonsense-mediated mRNA decay of the mutant allele and to a complete loss-of-function of the enzyme. Under strict adherence to a low-valine diet a rapid decrease of 3HiB excretion in the urine was observed. Due to limited patient numbers and intrafamilial differences in phenotype with one affected and one unaffected individual, the clinical phenotype of HIBADH deficiency needs further evaluation.
An der Hochschule Bonn-Rhein-Sieg fand am Donnerstag, den 23.9.21 das erste Verbraucherforum für Verbraucherinformatik statt. Im Rahmen der Online-Tagesveranstaltung diskutierten mehr als 30 Teilnehmer:innen über Themen und Ideen rund um den Bereich Verbraucherdatenschutz. Dabei kamen sowohl Beiträge aus der Informatik, den Verbraucher- und Sozialwissenschaften sowie auch der regulatorischen Perspektive zur Sprache. Der folgende Beitrag stellt den Hintergrund der Veranstaltung dar und berichtet über Inhalte der Vorträge sowie Anknüpfungspunkte für die weitere Konstituierung der Verbraucherinformatik. Veranstalter waren das Institut für Verbraucherinformatik an der H-BRS in Zusammenarbeit mit dem Lehrstuhl IT-Sicherheit der Universität Siegen sowie dem Kompetenzzentrum Verbraucherforschung NRW der Verbraucherzentrale NRW e. V. mit Förderung des Bundesministeriums der Justiz und für Verbraucherschutz.
Isolated methylmalonic acidaemia (MMA) and propionic acidaemia (PA) are rare inherited metabolic diseases. Six years ago, a detailed evaluation of the available evidence on diagnosis and management of these disorders has been published for the first time. The article received considerable attention, illustrating the importance of an expert panel to evaluate and compile recommendations to guide rare disease patient care. Since that time, a growing body of evidence on transplant outcomes in MMA and PA patients and use of precursor free amino acid mixtures allows for updates of the guidelines. In this article, we aim to incorporate this newly published knowledge and provide a revised version of the guidelines. The analysis was performed by a panel of multidisciplinary health care experts, who followed an updated guideline development methodology (GRADE). Hence, the full body of evidence up until autumn 2019 was re‐evaluated, analysed and graded. As a result, 21 updated recommendations were compiled in a more concise paper with a focus on the existing evidence to enable well‐informed decisions in the context of MMA and PA patient care.
The actomyosin system generates mechanical work with the execution of the power stroke, an ATP-driven, two-step rotational swing of the myosin-neck that occurs post ATP hydrolysis during the transition from weakly to strongly actin-bound myosin states concomitant with Pi release and prior to ADP dissociation. The activating role of actin on product release and force generation is well documented; however, the communication paths associated with weak-to-strong transitions are poorly characterized. With the aid of mutant analyses based on kinetic investigations and simulations, we identified the W-helix as an important hub coupling the structural changes of switch elements during ATP hydrolysis to temporally controlled interactions with actin that are passed to the central transducer and converter. Disturbing the W-helix/transducer pathway increased actin-activated ATP turnover and reduced motor performance as a consequence of prolonged duration of the strongly actin-attached states. Actin-triggered Pi release was accelerated, while ADP release considerably decelerated, both limiting maximum ATPase, thus transforming myosin-2 into a high-duty-ratio motor. This kinetic signature of the mutant allowed us to define the fractional occupancies of intermediate states during the ATPase cycle providing evidence that myosin populates a cleft-closure state of strong actin interaction during the weak-to-strong transition with bound hydrolysis products before accomplishing the power stroke.
Cysticfibrosis (CF) arises from mutations in the CF transmembrane conductance regulator (CFTR) gene, resulting in progressiveand life-limiting respiratory disease. R751L is a rare CFTR mutation that is poorly characterized. Our aims were to describe theclinical and molecular phenotypes associated with R751L. Relevant clinical data were collected from three heterozygote individu-als harboring R751L (2 patients with G551D/R751L and 1 with F508del/R751L). Assessment of R751L-CFTR function was made inprimary human bronchial epithelial cultures (HBEs) andXenopusoocytes. Molecular properties of R751L-CFTR were investigatedin the presence of known CFTR modulators. Although sweat chloride was elevated in all three patients, the clinical phenotypeassociated with R751L was mild. Chloride secretion in F508del/R751L HBEs was reduced compared with non-CF HBEs and asso-ciated with a reduction in sodium absorption by the epithelial sodium channel (ENaC). However, R751L-CFTR function inXenopusoocytes, together with folding and cell surface transport of R751L-CFTR, was not different from wild-type CFTR. Overall,R751L-CFTR was associated with reduced sodium chloride absorption but had functional properties similar to wild-type CFTR.This is thefirst report of R751L-CFTR that combines clinical phenotype with characterization of functional and biological proper-ties of the mutant channel. Our work will build upon existing knowledge of mutations within this region of CFTR and, importantly,inform approaches for clinical management. Elevated sweat chloride and reduced chloride secretion in HBEs may be due to al-ternative non-CFTR factors, which require further investigation.
Frequently the main purpose of domestic artifacts equipped with smart sensors is to hide technology, like previous examples of a Smart Mirror show. However, current Smart Homes often fail to provide meaningful IoT applications for all residents’ needs. To design beyond efficiency and productivity, we propose to realize the potential of the traditional artifact for calm and engaging experiences. Therefore, we followed a design case study approach with 22 participants in total. After an initial focus group, we conducted a diary study to examine home routines and developed a conceptual design. The evaluation of our mid-fidelity prototype shows, that we need to study carefully the practices of the residents to leverage the physical material of the artifact to fit the routines. Our Smart Mirror, enhanced by digital qualities, supports meaningful activities and makes the bathroom more appealing. Thereby, we discuss domestic technology design beyond automation.
Background: Atypical myopathy (AM), an acquired multiple acyl-CoA dehydrogenase deficiency (MADD) in horses, induce changes in mitochondrial metabolism. Only few veterinary laboratories offer diagnostic testing for this disease. Inborn and acquired MADD exist in humans, therefore determination of organic acids (OA) in urine and acylcarnitines (AC) in blood by assays available in medical laboratories can serve as AM diagnostics. The evolution of OA and AC profiles in surviving horses is unreported.
Methods: AC profiles using electrospray ionization tandem mass spectrometry (ESI-MS/MS) and OA in urine using gas chromatography mass spectrometry (GC–MS) were determined in dried blot spots (DBS, n = 7) and urine samples (n = 5) of horses with AM (n = 7) at disease presentation and in longitudinal samples from 3/4 survivors and compared to DBS (n = 16) and urine samples (n = 7) from control horses using the Wilcoxon test.
Results: All short- (C2-C5) and medium-chain (C6-C12) AC in blood differed significantly (p < 0.008) between horses with AM and controls, except for C5:1 (p = 0.45) and C5OH + C4DC (p = 0.06). In AM survivors the AC concentrations decreased over time but were still partially elevated after 7 days. 14/62 (23%) of OA differed significantly between horses with AM and control horses. Concentrations of ethylmalonic acid, 2-hydroxyglutaric acid and the acylglycines (butyryl-, valeryl-, and hexanoylglycine) were highly elevated in the urine of all horses with AM at the day of disease presentation. In AM survivors, concentrations of those metabolites were initially lower and decreased during remission to approach normalization after 7 days.
Conclusion: OA and AC profiling by specialized human medical laboratories was used to diagnose AM in horses. Elevation of specific metabolites were still evident several days after disease presentation, allowing diagnosis via analysis of samples from convalescent animals.
Unsere interdisziplinäre Forschungsarbeit „Die Gestaltung wirksamer Bildsymbole für Verarbeitungszwecke und ihre Folgen für Betroffene“ („Designing Effective Privacy Icons through an Interdisciplinary Research Methodology“) baut auf dem „Data Protection by Design“-Ansatz (Art. 25(1) DSGVO) auf und zielt auf folgende Forschungsfragen ab: Wie müssen das Transparenzprinzip (Art. 5(1)(a) DSGVO) und die Informationspflichten (Art. 12-14 DSGVO) insbesondere im Hinblick auf die Festlegung der Verarbeitungszwecke (Art. 5(1)(b) DSGVO) umgesetzt werden, damit sie die Nutzer:innen effektiv vor Risiken der Datenverarbeitung schützen? Mit welchen Methoden lässt sich die Wirksamkeit der Umsetzung ermitteln und diese auch durchsetzen?1 Im vorliegenden Projekt erweitern wir juristische Methoden um solche aus der HCI-Forschung (Human Computer Interaction) und der Visuellen Gestaltung. In einer ersten Phase haben wir mit empirischen Methoden der HCI-Forschung untersucht, welche Datennutzungstypen Nutzer:innen technologieübergreifend als relevant empfinden. Diese Erkenntnisse können als Ausgangspunkt für eine neue Zweckbestimmung dienen, die bestimmte Datennutzungstypen deutlicher ein- oder ausschließt. Erste Umformulierungen von Zweckbestimmungen haben wir in zwei Praxisworkshops mit Verantwortlichen der Datenverarbeitung getestet. In einer darauffolgenden qualitativen Studie untersuchten wir dann die Einstellungen und Erwartungen von Internetnutzerinnen und -nutzern am Beispiel der Personalisierung von Internetinhalten, um die entsprechenden Zwecke anhand eines konkreten Beispiels, in unserem Fall der personalisierten Werbung, neu zu formulieren. Auf dieser Basis haben wir nun die zweite Forschungsphase begonnen, in der wir Designs für Datenschutzhinweise und Kontrollmöglichkeiten unter besonderer Berücksichtigung des Verarbeitungszwecks entwickeln. Da der Einsatz von Cookies eine wichtige Rolle bei der Personalisierung von Werbung spielt, ist eine zentrale Aufgaben die Neugestaltung des sogenannten „Cookie-Banners“.
An der Hochschule Bonn-Rhein-Sieg fand am Donnerstag, den 23.9.21 das erste Verbraucherforum für Verbraucherinformatik statt. Im Rahmen der Online-Tagesveranstaltung diskutierten mehr als 30 Teilnehmer:innen über Themen und Ideen rund um den Bereich Verbraucherdatenschutz. Dabei kamen sowohl Beiträge aus der Informatik, den Verbraucher- und Sozialwissenschaften sowie auch der regulatorischen Perspektive zur Sprache. Der folgende Beitrag stellt den Hintergrund der Veranstaltung dar und berichtet über Inhalte der Vorträge sowie Anknüpfungspunkte für die weitere Konstituierung der Verbraucherinformatik. Veranstalter waren das Institut für Verbraucherinformatik an der H-BRS in Zusammenarbeit mit dem Lehrstuhl IT-Sicherheit der Universität Siegen sowie dem Kompetenzzentrum Verbraucherforschung NRW der Verbraucherzentrale NRW e. V. mit Förderung des Bundesministeriums der Justiz und für Verbraucherschutz.
Advocates of autonomous driving predict that the occupation of taxi driver could be made obsolete by shared autonomous vehicles (SAV) in the long term. Conducting interviews with German taxi drivers, we investigate how they perceive the changes caused by advancing automation for the future of their business. Our study contributes insights into how the work of taxi drivers could change given the advent of autonomous driving: While the task of driving could be taken over by SAVs for standard trips, taxi drivers are certain that other areas of their work such as providing supplementary services and assistance to passengers would constitute a limit to such forms of automation, but probably involving a shifting role for the taxi drivers, one which focuses on the sociality of the work. Our findings illustrate how taxi drivers see the future of their work, suggesting design implications for tools that take various forms of assistance into account, and demonstrating how important it is to consider taxi drivers in the co-design of future taxis and SAV services.
The epithelial sodium channel (ENaC) plays a key role in salt and water homeostasis in tetrapod vertebrates. There are four ENaC subunits (α, β, γ, δ), forming heterotrimeric αβγ- or δβγ-ENaCs. While the physiology of αβγ-ENaC is well understood, for decades the field has stalled with respect to δβγ-ENaC due to the lack of mammalian model organisms. The SCNN1D gene coding for δ-ENaC was previously believed to be absent in rodents, hindering studies using standard laboratory animals. We analysed all currently available rodent genomes and discovered that SCNN1D is present in rodents but was independently lost in five rodent lineages, including the Muridae (mice and rats). The independent loss of SCNN1D in rodent lineages may be constrained by phylogeny and taxon-specific adaptation to dry habitats, however habitat aridity does not provide a selection pressure for maintenance of SCNN1D across Rodentia. A fusion of two exons coding for a structurally flexible region in the extracellular domain of δ-ENaC appeared in the Hystricognathi (a group that includes guinea pigs). This conserved pattern evolved at least 41 Ma ago and represents a new autapomorphic feature for this clade. Exon fusion does not impair functionality of guinea pig (Cavia porcellus) δβγ-ENaC expressed in Xenopus oocytes. Electrophysiological characterisation at the whole-cell and single-channel level revealed conserved biophysical features and mechanisms controlling guinea pig αβγ- and δβγ-ENaC function as compared to human orthologues. Guinea pigs therefore represent commercially available mammalian model animals that will help shed light on the physiological function of δ-ENaC.