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The V109G Polymorphism of the p27 Gene CDKN1B Indicates a Worse Outcome in Node-Negative Breast Cancer Patients

  • Although p27 plays a central role in cell cycle regulation, its role in breast cancer prognosis is controversial. Furthermore, the p27 gene CDKN1B carries a polymorphism with unknown functional relevance. This study was designed to evaluate p27 expression and p27 genotyping with respect to early breast cancer prognosis. 279 patients with infiltrating metastasis-free breast cancer were included in this study. p27 expression was determined in tumor tissue specimens from 261 patients by immunohistochemistry. From 108 patients, the CDKN1B genotype was examined by PCR and subsequent direct sequencing. 55.2% of the tumors were considered p27 positive. p27 expression did not correlate with any of the established parameters except for nodal involvement but significantly correlated to prolonged disease-free survival. In 35% of the tumors analyzed, the CDKN1B gene showed a polymorphism at codon 109 (V109G). The V109G polymorphism correlated with greater nodal involvement. In the node-negative subgroup, V109G correlated significantly with a shortened disease-free survival. In conclusion, the determination of the CDKN1B genotype might be a powerful tool for the prognosis of patients with early breast cancer.

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Metadaten
Document Type:Article
Language:English
Author:Thomas Schöndorf, Lewin Eisele, Uwe-Jochen Göhring, Markus M. Valter, Mathias Warm, Peter Mallmann, Martina Becker, Roland Fechteler, Maria-Paz Weisshaar, Markus Hoopmann
Parent Title (English):Tumor Biol. (Tumor Biology)
Volume:25
Issue:5-6
First Page:306
Last Page:312
ISSN:1010-4283
URN:urn:nbn:de:hbz:1044-opus-2219
DOI:https://doi.org/10.1159/000081396
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=15627896
Publisher:Karger
Place of publication:Basel
Publishing Institution:Hochschule Bonn-Rhein-Sieg
Date of first publication:2004/12/27
Embargo Date:2005/12/27
Note:
© 2004 S. Karger AG, Basel. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
Note:
© 2004 S. Karger AG, Basel. Dieser Beitrag ist mit Zustimmung des Rechteinhabers  aufgrund  einer  (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
Tag:CDKN1B; breast cancer; chemotherapy; node involvement; p27; polymorphism; prognosis
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Dewey Decimal Classification (DDC):6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Open Access Funding:Deutsche Forschungsgemeinschaft DFG / Allianz- und Nationallizenzen: Diese Beiträge sind mit Zustimmung der Rechteinhaber aufgrund einer DFG-geförderten National- bzw. Allianzlizenz frei zugänglich.
Entry in this database:2015/04/02
Licence (Multiple languages):License LogoIn Copyright (Urheberrechtsschutz)