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3D-Printed Replica and Porcine Explants for Pre-Clinical Optimization of Endoscopic Tumor Treatment by Magnetic Targeting

  • Animal models are often needed in cancer research but some research questions may be answered with other models, e.g., 3D replicas of patient-specific data, as these mirror the anatomy in more detail. We, therefore, developed a simple eight-step process to fabricate a 3D replica from computer tomography (CT) data using solely open access software and described the method in detail. For evaluation, we performed experiments regarding endoscopic tumor treatment with magnetic nanoparticles by magnetic hyperthermia and local drug release. For this, the magnetic nanoparticles need to be accumulated at the tumor site via a magnetic field trap. Using the developed eight-step process, we printed a replica of a locally advanced pancreatic cancer and used it to find the best position for the magnetic field trap. In addition, we described a method to hold these magnetic field traps stably in place. The results are highly important for the development of endoscopic tumor treatment with magnetic nanoparticles as the handling and the stable positioning of the magnetic field trap at the stomach wall in close proximity to the pancreatic tumor could be defined and practiced. Finally, the detailed description of the workflow and use of open access software allows for a wide range of possible uses.

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Document Type:Article
Author:Anjali A. Roeth, Ian Garretson, Maja Beltz, Till Herbold, Maximilian Schulze-Hagen, Sebastian Quaisser, Alex Georgens, Dirk Reith, Ioana Slabu, Christian D. Klink, Ulf P. Neumann, Barbara S. Linke
Parent Title (English):Cancers
Article Number:5496
Number of pages:17
Place of publication:Basel
Publishing Institution:Hochschule Bonn-Rhein-Sieg
Date of first publication:2021/11/01
Copyright:© 2021 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Funding:This research was partly funded by the Medical Faculty of the RWTH Aachen University Hospital (Habilitation Grant for A.A.R.) and by the Federal Ministry of Education and Research (BMBF) and the Ministry of Culture and Science of the German State of North Rhine-Westphalia under the Excellence Strategy of the Federal Government and the States.
Keyword:3D printing; digital manufacturing; endoscopy; magnetic hyperthermia; magnetic nanoparticles; models; pancreatic cancer; replica
Departments, institutes and facilities:Fachbereich Ingenieurwissenschaften und Kommunikation
Institut für Technik, Ressourcenschonung und Energieeffizienz (TREE)
Dewey Decimal Classification (DDC):6 Technik, Medizin, angewandte Wissenschaften / 62 Ingenieurwissenschaften / 620 Ingenieurwissenschaften und zugeordnete Tätigkeiten
Entry in this database:2021/11/10
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International