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Nanomedicine-based strategies to improve treatment of cutaneous leishmaniasis

  • Nanomedicine strategies were first adapted and successfully translated to clinical application for diseases, such as cancer and diabetes. These strategies would no doubt benefit unmet diseases needs as in the case of leishmaniasis. The latter causes skin sores in the cutaneous form and affects internal organs in the visceral form. Treatment of cutaneous leishmaniasis (CL) aims at accelerating wound healing, reducing scarring and cosmetic morbidity, preventing parasite transmission and relapse. Unfortunately, available treatments show only suboptimal effectiveness and none of them were designed specifically for this disease condition. Tissue regeneration using nano-based devices coupled with drug delivery are currently being used in clinic to address diabetic wounds. Thus, in this review, we analyse the current treatment options and attempt to critically analyse the use of nanomedicine-based strategies to address CL wounds in view of achieving scarless wound healing, targeting secondary bacterial infection and lowering drug toxicity.

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Document Type:Article
Author:Nowsheen Goonoo, Marie Andrea Laetitia Huët, Itisha Chummun, Nancy Karuri, Kingsley Badu, Fanny Gimié, Jonas Bergrath, Margit Schulze, Mareike Müller, Archana Bhaw-Luximon
Parent Title (English):Royal Society Open Science
Article Number:220058
Number of pages:28
Publisher:Royal Society
Publishing Institution:Hochschule Bonn-Rhein-Sieg
Date of first publication:2022/06/15
Copyright:© 2022 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License
Funding:N.G., N.K., M.M., M.S. and A.B.-L. would like to thank the German Federal Ministry of Education and Research for funding the preliminary phase of the Leishmacure project under the Programme Advocating Women Scientists in STEM (PAWS) (BMBF-PAWS).
Keyword:drug delivery; leishmaniasis; nanomedicine; scaffolds; tissue engineering
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Entry in this database:2022/06/28
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International