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BWL kompakt für Dummies
(2016)
Möchten Sie einen umfassenden Überblick über die Teilgebiete der Allgemeinen Betriebswirtschaftslehre bekommen? Dieses Buch hilft Ihnen dabei! Ausgewiesene Experten ihres Fachs erklären Ihnen in verständlicher Sprache und mit anschaulichen Beispielen alles, was Sie wissen müssen von der Materialwirtschaft über die Produktion und Logistik bis hin zum Marketing. Auch alle wichtigen Themen der Investition und Finanzierung, des internen und externen Rechnungswesens und der Unternehmensführung und -organisation werden auf fast 1000 Seiten ausführlich behandelt. (Verlagsangaben)
BWL für Dummies
(2021)
BWL für Dummies
(2009)
BWL für Dummies
(2016)
"BWL für Dummies" führt kompetent, prägnant und umfassend in die Betriebswirtschaftslehre ein. Dabei werden die wesentlichen Elemente der Betriebswirtschaftslehre praxisorientiert vorgestellt und in ihrem Zusammenhang dargestellt. Folgende Themen werden behandelt: Materialwirtschaft, Leistungsbereitstellung und Produktion, Marketing, Investition und Finanzierung, Unternehmensorganisation und -führung, Rechnungswesen, Controlling.
BWL für Dummies
(2013)
Critical consumerism is complex as ethical values are difficult to negotiate, appropriate products are hard to find, and product information is overwhelming. Although recommender systems offer solutions to reduce such complexity, current designs are not appropriate for niche practices and use non-personalized intransparent ethics. To support critical consumption, we conducted a design case study on a personalized food recommender system. Therefore, we first conducted an empirical pre-study with 24 consumers to understand value negotiations and current practices, co-designed the recommender system, and finally evaluated it in a real-world trial with ten consumers. Our findings show how recommender systems can support the negotiation of ethical values within the context of consumption practices, reduce the complexity of finding products and stores, and strengthen consumers. In addition to providing implications for the design to support critical consumption practices, we critically reflect on the scope of such recommender systems and its appropriation.
Business Process Management
(2010)
Business Process Management
(2023)
This article provides insights into the modalities of business-model change and innovation. On the basis of an analysis of empirical data of small and medium enterprises, a transition from wine production centrism to its expanded use in hospitality and tourism is explored. Previous research on wine tourism and hospitality predominantly focuses on a destination perspective, neglecting the organizational winery perspective. The article deploys a mixed methods approach, combining netnography and a content analysis for data collection with grounded research and clustering for theory building. The sample size included 885 German wineries. Data stemmed from two distinct sources (websites and a secondary publication in form of a wine guide) and has been analyzed through a two-step clustering algorithm as well as a Principal Component Analysis (PCA). The two-step clustering algorithm resulted in nine different business models while the PCA analysis grouped the variables into the following two categories: basic winery business model (BM) and BM extension into hospitality and tourism, thereby validating the difference between the two constructs. The results point to the diverse nature of business model extensions of wineries in tourism and hospitality, depending on their organizational type and size. This study offers a classification of small and medium sized enterprise’s strategic business model expansion, and explores the expansion of the wine industry through wine hospitality and tourism services, starting with the winery organizational perspective, which has not been done before.
Business Management
(2020)
This Business English course in entrepreneurship goes beyond communicative language instruction and offers a course designed to introduce students to innovative thinking, entrepreneurship and sustainable business practices. About 120 students in their first year are enrolled as part of the required foreign language module in Business Management (B.Sc.). Each week students learn new concepts and terminology in sustainable business practices while applying the material in a simulation task-based course using English as a lingua franca. It prepares students to work in an international context while offering online components for autonomous learning. This 12-14 week course is designed in a student-centered and blended learning format with a flipped classroom approach. Through a grant from the German Federal Ministry of Education and Research the “work&study project” will offer additional online materials by developing new educational apps to enhance autonomous language learning and making the app content available under the Creative Commons license. The research project focuses on offering new learning environments to enhance the opportunities for non-traditional students enrolled at Bonn-Rhein-Sieg University of Applied Sciences. This paper will focus on the development of the first apps and results of the first testing phase. It shows how game-based learning and elements of gamification were added for educational purposes to enhance teaching and learning processes that were already well established.
AI (artificial intelligence) systems are increasingly being used in all aspects of our lives, from mundane routines to sensitive decision-making and even creative tasks. Therefore, an appropriate level of trust is required so that users know when to rely on the system and when to override it. While research has looked extensively at fostering trust in human-AI interactions, the lack of standardized procedures for human-AI trust makes it difficult to interpret results and compare across studies. As a result, the fundamental understanding of trust between humans and AI remains fragmented. This workshop invites researchers to revisit existing approaches and work toward a standardized framework for studying AI trust to answer the open questions: (1) What does trust mean between humans and AI in different contexts? (2) How can we create and convey the calibrated level of trust in interactions with AI? And (3) How can we develop a standardized framework to address new challenges?
The purpose of the study is to provide empirical evidence about the under-researched area of university–government relations in building a culture of entrepreneurial initiatives inside the triple helix model in a rural region. The study deploys a qualitative case study research method based on the content analysis of project documentation and further internal documents both from universities and municipalities. The propositions in the research question are guided by the previous literature and were then analyzed through an “open coding” process to iteratively analyze, verify, and validate the results from the documents against the previous literature. Results presented in the case study are related both to the project of a municipality–university innovation partnership, as well as the historic development of the university in its three missions, and, related to the important third mission, themes relevant for the project. In addition, a “toolkit” of relevant project activities is presented against the major identified themes, major project stakeholders, as well as relevant Sustainable Development Goals (SDGs). Universities should look beyond a purely economic contribution and should augment all three missions (teaching, research, engagement) by considering social, environmental, and economic aspects of its activities. Instead of considering a government’s role solely as that of a regulator, a much more creative and purposeful cooperation between university and government is possible for creating a regional culture of entrepreneurial initiatives in a rural region.
Buchbesprechung
(2022)
Buch-Diskurse
(2022)
Buch-Aisthesis
(2022)
Literatur kann auch als Verbund von Medien betrachtet werden, die in Kooperations- und Konkurrenzverhältnissen auftreten. Dies wird umso deutlicher, wenn aus literatur- und designwissenschaftlicher Perspektive auf die Beobachtung der Differenz von typographischen und anderen, grundsätzlich nonverbalen visuellen Daten abgestellt wird. Die Beiträger*innen des Bandes leiten daraus ein Verhältnis von Literatur- und Kunstwissenschaft zu ihren Gegenständen ab, das nicht zuletzt zu einer neuen Aufmerksamkeit für die skripturale und typographische Materialität und Medialität der Literatur führt. Dabei geht es um die Theorie der Reflexion und die Praxis der Erzeugung einer je spezifischen Buch-Ästhetik.
The Web has become an indispensable prerequisite of everyday live and the Web browser is the most used application on a variety of distinct devices. The content delivered by the Web has changed drastically from static pages to media-rich and interactive Web applications offering nearly the same functionality as native applications, a trend which is further pushed by the Cloud and more specifically the Cloud’s SaaS layer. In the light of this development, security and performance of Web browsing has become a crucial issue.
Die New Economy ist durch die Konvergenz zuvor getrennter Bereiche (Telekommunikation, Medien, Informationstechnik, Internet) gekennzeichnet, die gegenwärtig unterschiedlichen regulatorischen Rahmenbedingungen unterworfen sind. Ist dieser heterogene Ordnungsrahmen noch geeignet, um den ökonomischen Strukturen der New Economy Rechnung zu tragen, oder sind grundlegende Veränderungen erforderlich?
Brainstorming
(2021)
Botnets
(2013)
Malware poses one of the major threats to all currently operated computer systems. The scale of the problem becomes obvious by looking at the global economic loss caused by different kinds of malware, which is estimated to be more than US$ 10 billion every year. Botnets, a special kind of malware, are used to reap economic gains by criminals as well as for politically motivated activities. In contrast to other kinds of malware, botnets utilize a hidden communication channel to receive commands from their operator and communicate their current status. The ability to execute almost arbitrary commands on the infected machines makes botnets a general-purpose tool to perform malicious cyber-activities. (Verlagsangaben)
We propose a high-performance GPU implementation of Ray Histogram Fusion (RHF), a denoising method for stochastic global illumination rendering. Based on the CPU implementation of the original algorithm, we present a naive GPU implementation and the necessary optimization steps. Eventually, we show that our optimizations increase the performance of RHF by two orders of magnitude when compared to the original CPU implementation and one order of magnitude compared to the naive GPU implementation. We show how the quality for identical rendering times relates to unfiltered path tracing and how much time is needed to achieve identical quality when compared to an unfiltered path traced result. Finally, we summarize our work and describe possible future applications and research based on this.
Switched power electronic subsystems are widely used in various applications. A fault in one of their components may have a significant effect on the system’s load or may even cause a damage. Therefore, it is important to detect and isolate faults and to report true faults to a supervisory system in order to avoid malfunction of or damage to a load. If, in a model-based approach to fault detection and isolation of hybrid systems, switching devices are considered as ideal switches then some equations must be reformulated whenever some devices have switched. In this paper, a fixed causality bond graph representation of hybrid system models is used, i.e., computational causalities assigned according to the Standard Causality Assignment Procedure (SCAP) are independent of system modes of operation. The latter are taken into account by transformer moduli mi(t) ∈ {0, 1} ∀t ≥ 0 in a unique set of equations of motion. In a case study, this approach is used for fault diagnosis in a three-phase full-wave rectifier. Residuals of Analytical Redundancy Relations (ARRs) holding for all modes of operations and serving as fault indicators are computed in an offline simulation as part of a DAE system by using a bond graph model of the faulty system instead of the real one and by coupling it to a bond graph of the healthy system by means of residual sinks.
For the case when the abstraction of instantaneous state transitions is adopted, this paper proposes to start fault detection and isolation in an engineering system from a single time-invariant causality bond graph representation of a hybrid model. To that end, the paper picks up on a long-known proposal to model switching devices by a transformer modulated by a Boolean variable and a resistor in fixed conductance causality accounting for its ON resistance. Bond graph representations of hybrid system models developed in this way have been used so far mainly for the purpose of simulation. The paper shows that they can well constitute an approach to the bond-graph-based quantitative fault detection and isolation of hybrid models. Advantages are that the standard sequential causality assignment procedure can be a used without modification. A single set of analytical redundancy relations valid for all physically feasible system modes can be (automatically) derived from the bond graph. Stiff model equations due to small values of the ON resistance in the switch model may be avoided by symbolic reformulation of equations and letting the ON resistance of some switches tend to zero, turning them into ideal switches.
First, for two examples considered in the literature, it is shown that the approach proposed in this paper can produce the same analytical redundancy relations as were obtained from a hybrid bond graph with controlled junctions and the use of a sequential causality assignment procedure especially for fault detection and isolation purpose. Moreover, the usefulness of the proposed approach is illustrated in two case studies by its application to standard switching circuits extensively used in power electronic systems and by simulation of some fault scenarios. The approach, however, is not confined to the fault detection and isolation of such systems. Analytically validated simulation results obtained by means of the program Scilab give confidence in the approach.
This book presents theory and latest application work in Bond Graph methodology with a focus on:
Hybrid dynamical system models, Model-based fault diagnosis, model-based fault tolerant control, fault prognosis and also addresses Open thermodynamic systems with compressible fluid flow, and Distributed parameter models of mechanical subsystems.
In addition, the book covers various applications of current interest ranging from motorised wheelchairs, in-vivo surgery robots, walking machines to wind-turbines.The up-to-date presentation has been made possible by experts who are active members of the worldwide bond graph modelling community.
This book is the completely revised 2nd edition of the 2011 Springer compilation text titled Bond Graph Modelling of Engineering Systems – Theory, Applications and Software Support. It extends the presentation of theory and applications of graph methodology by new developments and latest research results.
Like the first edition, this book addresses readers in academia as well as practitioners in industry and invites experts in related fields to consider the potential and the state-of-the-art of bond graph modelling.
Bond graph modelling was devised by Professor Paynter at the Massachusetts Institute of Technology in 1959 and subsequently developed into a methodology for modelling multidisciplinary systems at a time when nobody was speaking of object-oriented modelling. On the other hand, so-called object-oriented modelling has become increasingly popular during the last few years. By relating the characteristics of both approaches, it is shown that bond graph modelling, although much older, may be viewed as a special form of object-oriented modelling. For that purpose the new object-oriented modelling language Modelica is used as a working language which aims at supporting multiple formalisms. Although it turns out that bond graph models can be described rather easily, it is obvious that Modelica started from generalized networks and was not designed to support bond graphs. The description of bond graph models in Modelica is illustrated by means of a hydraulic drive. Since VHDL-AMS as an important language standardized and supported by IEEE has been extended to support also modelling of non-electrical systems, it is briefly investigated as to whether it can be used for description of bond graphs. It turns out that currently it does not seem to be suitable.
Bond Graph Modelling of Engineering Systems: Theory, Applications and Software Support addresses readers to consider the potential and the state-of-the-art of bond graph modeling of engineering systems with respect to theory, applications and software support. Bond graph modelling is a physical modelling methodology based on first principles that is particularly suited for modelling multidisciplinary or mechatronic systems. This book covers theoretical issues and methodology topics that have been subject of ongoing research during past years, presents new promising applications such as the bond graph modeling of fuel cells and illustrates how bond graph modeling and simulation of mechatronic systems can be supported by software. This up-to-date comprehensive presentation of various topics has been made possible by the cooperation of a group of authors who are experts in various fields and share the “bond graph way of thinking.”
This book shows in a comprehensive presentation how Bond Graph methodology can support model-based control, model-based fault diagnosis, fault accommodation, and failure prognosis by reviewing the state-of-the-art, presenting a hybrid integrated approach to Bond Graph model-based fault diagnosis and failure prognosis, and by providing a review of software that can be used for these tasks.
Bond Graph Modelling and Simulation of Mechatronic Systems: An Introduction into the Methodology
(2006)
This paper introduces into a graphical, computer aided modelling methodology that is particularly suited for the concurrent design of mechatronic systems, viz. of engineering systems with mechanical, electrical, hydraulic or pneumatic components including interactions of physical effects from various energy domains. Beyond the introduction, bond graph modelling of multibody systems, as an example of an advanced topic, is briefly addressed in order to demonstrate the potential of this powerful approach to modelling mechatronic systems. It is outlined how models of multibody systems including flexible bodies can be build in a systematic manner.
A bond graph representation of switching devices known for a long time has been a modulated transformer with a modulus b(t)∈{0,1}∀t≥0 in conjunction with a resistor R:Ron accounting for the ON-resistance of a switch considered non-ideal. Besides other representations, this simple model has been used in bond graphs for simulation of the dynamic behaviour of hybrid systems. A previous article of the author has proposed to use the transformer–resistor pair in bond graphs for fault diagnosis in hybrid systems. Advantages are a unique bond graph for all system modes, the application of the unmodified standard Sequential Causality Assignment Procedure, fixed computational causalities and the derivation of analytical redundancy relations incorporating ‘Boolean’ transformer moduli so that they hold for all system modes. Switches temporarily connect and disconnect model parts. As a result, some independent storage elements may temporarily become dependent, so that the number of state variables is not time-invariant. This article addresses this problem in the context of modelling and simulation of fault scenarios in hybrid systems. In order to keep time-invariant preferred integral causality at storage ports, residual sinks previously introduced by the author are used. When two storage elements become dependent at a switching time instance ts, a residual sink is activated. It enforces that the outputs of two dependent storage elements become immediately equal by imposing the conjugate3 power variable of appropriate value on their inputs. The approach is illustrated by the bond graph modelling and simulation of some fault scenarios in a standard three-phase switched power inverter supplying power into an RL-load in a delta configuration. A well-developed approach to model-based fault detection and isolation is to evaluate the residual of analytical redundancy relations. In this article, analytical redundancy relation residuals have been computed numerically by coupling a bond graph of the faulty system to one of the non-faulty systems by means of residual sinks. The presented approach is not confined to power electronic systems but can be used for hybrid systems in other domains as well. In further work, the RL-load may be replaced by a bond graph model of an alternating current motor in order to study the effect of switch failures in the power inverter on to the dynamic behaviour of the motor.
Bond graph modelling
(2006)
Hybrid system models exploit the modelling abstraction that fast state transitions take place instantaneously so that they encompass discrete events and the continuous time behaviour for the while of a system mode. If a system is in a certain mode, e.g. two rigid bodies stick together, then residuals of analytical redundancy relations (ARRs) within certain small bounds indicate that the system is healthy. An unobserved mode change, however, invalidates the current model for the dynamic behaviour. As a result, ARR residuals may exceed current thresholds indicating faults in system components that have not happened. The paper shows that ARR residuals derived from a bond graph cannot only serve as fault indicators but may also be used for bond graph model-based system mode identification. ARR residuals are numerically computed in an off-line simulation by coupling a bond graph of the faulty system to a non-faulty system bond graph through residual sinks. In real-time simulation, the faulty system model is to be replaced by measurements from the real system. As parameter values are uncertain, it is important to determine adaptive ARR thresholds that, given uncertain parameters, allow to decide whether the dynamic behaviour in a current system mode is the one of the healthy system so that false alarms or overlooking of true faults can be avoided. The paper shows how incremental bond graphs can be used to determine adaptive mode-dependent ARR thresholds for switched linear time-invariant systems with uncertain parameters in order to support robust fault detection. Bond graph-based hybrid system mode identification as well as the determination of adaptive fault thresholds is illustrated by application to a power electronic system easy to survey. Some simulation results have been analytically validated.
This book presents bond graph model-based fault detection with a focus on hybrid system models. The book addresses model design, simulation, control and model-based fault diagnosis of multidisciplinary engineering systems. The text beings with a brief survey of the state-of-the-art, then focuses on hybrid systems. The author then uses different bond graph approaches throughout the text and provides case studies.
In this paper, residual sinks are used in bond graph model-based quantitative fault detection for the coupling of a model of a faultless process engineering system to a bond graph model of the faulty system. By this way, integral causality can be used as the preferred computational causality in both models. There is no need for numerical differentiation. Furthermore, unknown variables do not need to be eliminated from power continuity equations in order to obtain analytical redundancy relations (ARRs) in symbolic form. Residuals indicating faults are computed numerically as components of a descriptor vector of a differential algebraic equation system derived from the coupled bond graphs. The presented bond graph approach especially aims at models with non-linearities that make it cumbersome or even impossible to derive ARRs from model equations by elimination of unknown variables. For illustration, the approach is applied to a non-controlled as well as to a controlled hydraulic two-tank system. Finally, it is shown that not only the numerical computation of residuals but also the simultaneous numerical computation of their sensitivities with respect to a parameter can be supported by bond graph modelling.
Bond Graph Methodology
(2010)
Nowadays, engineering systems are becoming increasingly complex and, for design purposes, must be considered as multidisciplinary systems made up of components from different engineering disciplines. With regard to the systematic development and the analysis of models, interdisciplinary methodologies supported by software become more and more important. Bond graphs are a graphical description formalism particularly suited for multidisciplinary systems and used by modellers across the world.
Bond Graph Methodology gives a comprehensive, in-depth representation of the state of the art, including recent results gathered from research articles, dissertations and contributions by the author on a number of topics. The structured and rigorous presentation systematically covers model development, analysis of models, numerical computation of models and modern software that can be used for a bond graph approach. The book also includes a range of case studies illustrating various applications of the methodology and provides a glossary.
Bond Graph Methodology addresses fundamentals, as well as advanced topics, e.g., models of variable structure, bond graphs for sensitivity analysis and generation of equations for the study of robustness. The compilation and presentation of the material has been inspired by the author's extensive experience in research and teaching.
A useful text for advanced courses in modelling, simulation and control, Bond Graph Methodology can also be used for self-study. It has been designed to serve readers interested in the subject of bond graph modelling and those with expertise in related areas, as well as members of the worldwide community of bond graph modellers.
Multidisciplinary systems are described most suitably by bond graphs. In order to determine unnormalized frequency domain sensitivities in symbolic form, this paper proposes to construct in a systematic manner a bond graph from another bond graph, which is called the associated incremental bond graph in this paper. Contrary to other approaches reported in the literature the variables at the bonds of the incremental bond graph are not sensitivities but variations (incremental changes) in the power variables from their nominal values due to parameter changes. Thus their product is power. For linear elements their corresponding model in the incremental bond graph also has a linear characteristic. By deriving the system equations in symbolic state space form from the incremental bond graph in the same way as they are derived from the initial bond graph, the sensitivity matrix of the system can be set up in symbolic form. Its entries are transfer functions depending on the nominal parameter values and on the nominal states and the inputs of the original model. The sensitivities can be determined automatically by the bond graph preprocessor CAMP-G and the widely used program MATLAB together with the Symbolic Toolbox for symbolic mathematical calculation. No particular program is needed for the approach proposed. The initial bond graph model may be non-linear and may contain controlled sources and multiport elements. In that case the sensitivity model is linear time variant and must be solved in the time domain. The rationale and the generality of the proposed approach are presented. For illustration purposes a mechatronic example system, a load positioned by a constant-excitation d.c. motor, is presented and sensitivities are determined in symbolic form by means of CAMP-G/MATLAB.
BonaRes (Modul A): Überwindung der Bodenmüdigkeit mithilfe eines integrierten Ansatzes - ORDIAmur
(2019)
Introduction: Chronic pain is a frequent severe disease and often associated with anxiety, depression, insomnia, disability, and reduced quality of life. This maladaptive condition is further characterized by sensory loss, hyperalgesia, and allodynia. Blue light has been hypothesized to modulate sensory neurons and thereby influence nociception.
Objectives: Here, we compared the effects of blue light vs red light and thermal control on pain sensation in a human experimental pain model.
Methods: Pain, hyperalgesia, and allodynia were induced in 30 healthy volunteers through high-density transcutaneous electrical stimulation. Subsequently, blue light, red light, or thermal control treatment was applied in a cross-over design. The nonvisual effects of the respective light treatments were examined using a well-established quantitative sensory testing protocol. Somatosensory parameters as well as pain intensity and quality were scored.
Results: Blue light substantially reduced spontaneous pain as assessed by numeric rating scale pain scoring. Similarly, pain quality was significantly altered as assessed by the German counterpart of the McGill Pain Questionnaire. Furthermore, blue light showed antihyperalgesic, antiallodynic, and antihypesthesic effects in contrast to red light or thermal control treatment.
Conclusion: Blue-light phototherapy ameliorates pain intensity and quality in a human experimental pain model and reveals antihyperalgesic, antiallodynic, and antihypesthesic effects. Therefore, blue-light phototherapy may be a novel approach to treat pain in multiple conditions.
Noch sind sich die Experten nicht einig, wie schnell Blockchain das Internet revolutionieren wird. Dass das Potenzial dafür riesig ist, ist sich Professor Jens Böcker sicher. Er unterhält eine Professur für Betriebswirtschaftslehre und Marketing an der Hochschule Bonn-Rhein-Sieg und forscht zu diesem Thema.
Blickpunkt
(2024)
Blended Learning Set up of the Master Programme "Analysis and Design of Social Protection Systems"
(2017)
The master's programme "Analysis and Design of Social Protection Systems" is a newly designed programme. The international Master’s programme is aimed at students who wish to deal with social security systems and who are also interested in intercultural exchange. The on-campus and online phases provide students with the opportunity to develop an international network, while facilitating the combination of studies and professional engagement.
Object detectors have improved considerably in the last years by using advanced CNN architectures. However, many detector hyper-parameters are generally manually tuned, or they are used with values set by the detector authors. Automatic Hyper-parameter optimization has not been explored in improving CNN-based object detectors hyper-parameters. In this work, we propose the use of Black-box optimization methods to tune the prior/default box scales in Faster R-CNN and SSD, using Bayesian Optimization, SMAC, and CMA-ES. We show that by tuning the input image size and prior box anchor scale on Faster R-CNN mAP increases by 2% on PASCAL VOC 2007, and by 3% with SSD. On the COCO dataset with SSD there are mAP improvement in the medium and large objects, but mAP decreases by 1% in small objects. We also perform a regression analysis to find the significant hyper-parameters to tune.
Object detectors have improved considerably in the last years by using advanced Convolutional Neural Networks (CNNs) architectures. However, many detector hyper-parameters are not generally tuned, and they are used with values set by the detector authors. Blackbox optimization methods have gained more attention in recent years because of its ability to optimize the hyper-parameters of various machine learning algorithms and deep learning models. However, these methods are not explored in improving CNN-based object detector's hyper-parameters. In this research work, we propose the use of blackbox optimization methods such as Gaussian Process based Bayesian Optimization (BOGP), Sequential Model-based Algorithm Configuration (SMAC), and Covariance Matrix Adaptation Evolution Strategy (CMA-ES) to tune the hyper-parameters in Faster R-CNN and Single Shot MultiBox Detector (SSD). In Faster R-CNN, tuning the input image size, prior box anchor scales and ratios using BOGP, SMAC, and CMA-ES has increased the performance around 1.5% in terms of Mean Average Precision (mAP) on PASCAL VOC. Tuning the anchor scales of SSD has increased the mAP by 3% on PASCAL VOC and marine debris datasets. On the COCO dataset with SSD, mAP improvement is observed in the medium and large objects, but mAP decreases by 1% in small objects. The experimental results show that the blackbox optimization methods have proved to increase the mAP performance by optimizing the object detectors. Moreover, it has achieved better results than the hand-tuned configurations in most of the cases.
Bionik
(2020)
Wie machen die das... kann angesichts der erstaunlichen Fähigkeiten mancher Lebewesen gefragt werden. Die Bionik fragt noch weiter …und wie kann man das nachmachen? Hier liegt ein Schwerpunkt dieses Lehrbuches, das die Bionik nicht nur an zahlreichen Beispielen erklärt, sondern auch eine Vorgehensweise für die Identifizierung biologischer Lösungen und deren Übertragung auf technische Anwendungen vermittelt. Basisinformationen der Biologie und Grundlagen der Konstruktionstechnik gewährleisten einen leichten Zugang zum Stoff. Mit dem 3D-Druck als Schlüsseltechnologie und der Thematisierung der Nachhaltigkeit geht das Buch zudem auf aktuelle Entwicklungen ein. Dieser ganzheitliche Blick auf die Bionik soll den Leser zur Durchführung bionischer Projekte befähigen und motivieren. (Verlagsangaben)
Bionik
(2022)
Wie machen die das… kann angesichts der erstaunlichen Fähigkeiten mancher Lebewesen gefragt werden. Die Bionik fragt noch weiter …und wie kann man das nachmachen? Hier liegt ein Schwerpunkt dieses Lehrbuches, das die Bionik nicht nur an zahlreichen Beispielen erklärt, sondern auch eine Vorgehensweise für die Identifizierung biologischer Lösungen und deren Übertragung auf technische Anwendungen vermittelt. Basisinformationen der Biologie und Grundlagen der Konstruktionstechnik gewährleisten einen leichten Zugang zum Stoff. Mit dem 3D-Druck als Schlüsseltechnologie und der Thematisierung der Nachhaltigkeit geht das Buch zudem auf aktuelle Entwicklungen ein. Dieser ganzheitliche Blick auf die Bionik soll den Leser zur Durchführung bionischer Projekte befähigen und motivieren. Die vorliegende Auflage wurde überarbeitet und um aktuelle Forschungserkenntnisse und Entwicklungen ergänzt. (Verlagsangaben)
In the past decade computer models have become very popular in the field of biomechanics due to exponentially increasing computer power. Biomechanical computer models can roughly be subdivided into two groups: multi-body models and numerical models. The theoretical aspects of both modelling strategies will be introduced. However, the focus of this chapter lies on demonstrating the power and versatility of computer models in the field of biomechanics by presenting sophisticated finite element models of human body parts. Special attention is paid to explain the setup of individual models using medical scan data. In order to reach the goal of individualising the model a chain of tools including medical imaging, image acquisition and processing, mesh generation, material modelling and finite element simulation –possibly on parallel computer architectures- becomes necessary. The basic concepts of these tools are described and application results are presented. The chapter ends with a short outlook into the future of computer biomechanics.
There is an unmet need for the development and validation of biomarkers and surrogate endpoints for clinical trials in propionic acidemia (PA) and methylmalonic acidemia (MMA). This review examines the pathophysiology and clinical consequences of PA and MMA that could form the basis for potential biomarkers and surrogate endpoints. Changes in primary metabolites such as methylcitric acid (MCA), MCA:citric acid ratio, oxidation of 13C-propionate (exhaled 13CO2), and propionylcarnitine (C3) have demonstrated clinical relevance in patients with PA or MMA. Methylmalonic acid, another primary metabolite, is a potential biomarker, but only in patients with MMA. Other potential biomarkers in patients with either PA and MMA include secondary metabolites, such as ammonium, or the mitochondrial disease marker, fibroblast growth factor 21. Additional research is needed to validate these biomarkers as surrogate endpoints, and to determine whether other metabolites or markers of organ damage could also be useful biomarkers for clinical trials of investigational drug treatments in patients with PA or MMA. This review examines the evidence supporting a variety of possible biomarkers for drug development in propionic and methylmalonic acidemias.
A firm link between endoplasmic reticulum (ER) stress and tumors has been wildly reported. Endoplasmic reticulum oxidoreductase 1 alpha (ERO1α), an ER-resident thiol oxidoreductase, is confirmed to be highly upregulated in various cancer types and associated with a significantly worse prognosis. Of importance, under ER stress, the functional interplay of ERO1α/PDI axis plays a pivotal role to orchestrate proper protein folding and other key processes. Multiple lines of evidence propose ERO1α as an attractive potential target for cancer treatment. However, the unavailability of specific inhibitor for ERO1α, its molecular inter-relatedness with closely related paralog ERO1β and the tightly regulated processes with other members of flavoenzyme family of enzymes, raises several concerns about its clinical translation. Herein, we have provided a detailed description of ERO1α in human cancers and its vulnerability towards the aforementioned concerns. Besides, we have discussed a few key considerations that may improve our understanding about ERO1α in tumors.
Negative Schlagzeilen über den Klimawandel, die Verschwendung nichterneuerbarer Ressourcen und Umweltverschmutzung werden täglich über die Medien verbreitet. Durch immer neue Lebensmittelskandale sind die Verbraucher verunsichert. Ihr Vertrauen in Produzenten und Anbieter ist erschüttert. Zunehmend mehr Konsumenten versuchen, umweltbewusstes und nachhaltiges Handeln in ihren Alltag zu integrieren. Auch die gesellschaftliche Verantwortung von Unternehmen wurde noch nie so aktiv wie heute in der Öffentlichkeit herausgestellt und diskutiert. Beide Entwicklungen tragen dazu bei, dass der Begriff „Bio“ zurzeit in aller Munde ist. Er findet außer im Bereich der Lebensmittel auch in Sektoren wie Kosmetik und Mode Anwendung. Ziel dieser Arbeit ist es, Handlungsempfehlungen für den Einzelhandel herauszuarbeiten, um sein am Markt bestehendes Potential auszuschöpfen, insbesondere um, Kunden zu binden und Neukunden zu gewinnen. Zusätzlich werden mögliche Kooperationsfelder von Handel und Industrie systematisiert sowie Handlungsempfehlungen erarbeitet, die zur Verbesserung der Kooperation von im Bereich des Category Management für Bio-Produkte beitragen.
Die Bilanzierung von Pensionsverpflichtungen hat große Auswirkungen sowohl auf das Eigenkapital eines Unternehmens als auch auf Erfolgsgrößen wie EBIT, Jahresüberschuss, Cashflow. Für die Einschätzung des Unternehmenserfolgs oder die Analyse der Kreditwürdigkeit sind die pensionsrelevanten Informationen von wesentlichem Interesse. Das Werk zeigt, wie man Pensions- und weitere Personalverpflichtungen richtig in den unterschiedlichen Rechenwerken nach handels- und steuerrechtlichen sowie internationalen Regelungen abbildet. Die Neuauflage enthält die aktuelle Rechtsprechnung und neue Richtlinien.
Die nationale Politik- und Forschungsstrategie Bioökonomie sieht eine Transformation der Wirtschaft vor, bei der die Verwendung fossiler Rohstoffe zunehmend durch den Einsatz nachwachsender Rohstoffe ersetzt wird. Der Einsatz biobasierter Kunststoffe soll dabei gefördert werden. Erste Analysen der Berichterstattung zu Biokunststoffen im Rahmen einer Pilotstudie ergaben, dass der Grundgedanke biologisch abbaubarer Kunststoffe breite Zustimmung im öffentlichen Diskurs erfährt. Abseits der soziopolitischen Diskursebene entwickelt sich jedoch eine medial geführte Diskussion um erhebliche Probleme mit den Stoffen in der Abfallwirtschaft. Die Gefahr besteht nun, dass diese Haltung verbreitet durch die Massenmedien auf die öffentliche Meinung abfärbt. Mangelnde öffentliche Akzeptanz könnte den Erfolg von innovativen Biokunststoff-Produkten gefährden.