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Business process infrastructures like BPMS (Business Process Management Systems) and WfMS (Workflow Management Systems) traditionally focus on the automation of processes predefined at design time. This approach is well suited for routine tasks which are processed repeatedly and which are described by a predefined control flow. In contrast, knowledge-intensive work is more goal and data-driven and less control-flow oriented. Knowledge workers need the flexibility to decide dynamically at run-time and based on current context information on the best next process step to achieve a given goal. Obviously, in most practical scenarios, these decisions are complex and cannot be anticipated and modeled completely in a predefined process model. Therefore, adaptive and dynamic process management techniques are necessary to augment the control-flow oriented part of process management (which is still a need also for knowledge workers) with flexible, context-dependent, goaloriented support.
Methylmalonic and propionic acidemia (MMA/PA) are inborn errors of metabolism characterized by accumulation of propionic acid and/or methylmalonic acid due to deficiency of methylmalonyl-CoA mutase (MUT) or propionyl-CoA carboxylase (PCC). MMA has an estimated incidence of ~ 1: 50,000 and PA of ~ 1:100'000 -150,000. Patients present either shortly after birth with acute deterioration, metabolic acidosis and hyperammonemia or later at any age with a more heterogeneous clinical picture, leading to early death or to severe neurological handicap in many survivors. Mental outcome tends to be worse in PA and late complications include chronic kidney disease almost exclusively in MMA and cardiomyopathy mainly in PA. Except for vitamin B12 responsive forms of MMA the outcome remains poor despite the existence of apparently effective therapy with a low protein diet and carnitine. This may be related to under recognition and delayed diagnosis due to nonspecific clinical presentation and insufficient awareness of health care professionals because of disease rarity.
Propionic acidemia in a previously healthy adolescent with acute onset of dilated cardiomyopathy
(2014)
The Fifth International Workshop on Domain-Specific Languages and Models for Robotic Systems (DSLRob'14) was held in conjunction with the 2014 International Conference on Simulation, Modeling, and Programming for Autonomous Robots (SIMPAR 2014), October 2014 in Bergamo, Italy. The main topics of the workshop were Domain-Specific Languages (DSLs) and Model-driven Software Development (MDSD) for robotics. A domain-specific language is a programming language dedicated to a particular problem domain that offers specific notations and abstractions that increase programmer productivity within that domain. Model-driven software development offers a high-level way for domain users to specify the functionality of their system at the right level of abstraction. DSLs and models have historically been used for programming complex systems. However recently they have garnered interest as a separate field of study. Robotic systems blend hardware and software in a holistic way that intrinsically raises many crosscutting concerns (concurrency, uncertainty, time constraints, ...), for which reason, traditional general-purpose languages often lead to a poor fit between the language features and the implementation requirements. DSLs and models offer a powerful, systematic way to overcome this problem, enabling the programmer to quickly and precisely implement novel software solutions to complex problems within the robotics domain.
Psychische Belastungen stehen in ihren negativen Ausprägungen als psychische Fehlbeanspruchungen im Zentrum der Diskussion im Arbeitsschutz. Ihr kontinuierlicher Anstieg sowie die Verbindung mit verschiedenen psychischen und körperlichen Erkrankungen werden durch zahlreiche internationale Studien belegt. Die Herausgeber möchten mit dem Praxishandbuch eine Hilfe für diejenigen bieten, die mit der Aufgabe des Erkennens und der Prävention psychischer Fehlbelastungen konfrontiert sind. Die Anregungen sind für alle Akteure im Bereich der Verhütung arbeitsbedingter Gesundheitgefahren geeignet: Betriebsärzte, Sozialmediziner, Psychologen, Sicherheitsfachkräfte, Führungskräfte, Betriebsräte und sonstige Ansprechpartner, Personalverantwortliche und Sozialpädagogen.
PhD Project Management
(2014)
Current computer architectures are multi-threaded and make use of multiple CPU cores. Most garbage collections policies for the Java Virtual Machine include a stop-the-world phase, which means that all threads are suspended. A considerable portion of the execution time of Java programs is spent in these stop-the-world garbage collections. To improve this behavior, a thread-local allocation and garbage collection that only affects single threads, has been proposed. Unfortunately, only objects that are not accessible by other threads ("do not escape") are eligible for this kind of allocation. It is therefore necessary to reliably predict the escaping of objects. The work presented in this paper analyzes the escaping of objects based on the line of code (program counter – PC) the object was allocated at. The results show that on average 60-80% of the objects do not escape and can therefore be locally allocated.
Open educational resources (OERs) provide opportunities as enablers of societal development, but they also create new challenges. From the perspective of content providers and educational institutions, particularly, cultural and context-related challenges emerge. Even though barriers regarding large-scale adoption of OERs are widely discussed, empirical evidence for determining challenges in relation to particular contexts is still rare. Such context-specific barriers generally can jeopardize the acceptance of OERs and, in particular, social OER environments. We conducted a large-scale (N = 855) cross-European investigation in the school context to determine how teachers and learners perceive cultural distance as a barrier against the use of social OER environments. The findings indicate how nationality and age of the respondents are strong predictors of cultural distance barrier. The study concludes with identification of context-sensitive interventions for overcoming the related bar riers. These consequences are vital for OER initiatives and educational institutions for aligning their efforts on OER.
Open Educational Resources in the Context of School Education: Barriers and possible solutions
(2014)
Due to the increasing professional mobility of their parents, pupils often find themselves in new and unfamiliar learning scenarios in foreign contexts and countries. Besides having to leave their familiar environments, these pupils additionally may face language barriers, different curricula, and have to cope with foreign cultures. Printed textbooks, which are the most commonly used educational resources in schools, provide little support for these pupils to manage the new challenges. Teachers are the professionals designated to provide the necessary support. However, they often may not fully appreciate the pupils’ individual challenges. Possible solutions could be the provision of alternative learning contents in the pupils’ native languages and an international open exchange of knowledge and experiences amongst schoolteachers. These issues are addressed by the Open Discovery Space platform. In order to empower this platform to provide the best possible support to teachers, we explored barriers to adoption of Open Educational Practices in the context of school education and asked for manageable solutions. The investigation took place in an action research scenario. After an introduction of the ODS project, we will present the identified barriers and recommendations for solutions to overcome these, and the mechanisms which we are going to implement in the ODS platform in order to provide the best possible support to the community.
We consider the Hopfield model with n neurons and an increasing number p=p(n) of randomly chosen patterns and use Stein's method to obtain rates of convergence for the central limit theorem of overlap parameters, which holds for every fixed choice of the overlap parameter for almost all realisations of the random patterns.
On nothing
(2014)
It has become increasingly clear that caspases, far from being merely cell death effectors, have a much wider range of functions within the cell. These functions are as diverse as signal transduction and cytoskeletal remodeling, and caspases are now known to have an essential role in cell proliferation, migration, and differentiation. There is also evidence that apoptotic cells themselves can direct the behavior of nearby cells through the caspase-dependent secretion of paracrine signaling factors. In some processes, including the differentiation of skeletal muscle myoblasts, both caspase activation in differentiating cells as well as signaling from apoptotic cells has been reported. Here, we review the non-apoptotic outcomes of caspase activity in a range of different model systems and attempt to integrate this knowledge.
Nachhaltigkeitsökonomie
(2014)
Die nachhaltige Organisation des Verkehrs soll auf kostengünstige, umweltfreundliche und nutzerfreundlichere Nahverkehrskonzepte, die möglichst viele Bürger zur Nutzung des ÖPNV einladen, abzielen. Vor diesem Hintergrund ist es das Ziel dieses Beitrags, instrumentelle Ansatzpunkte für ein Nachhaltigkeitscontrolling in ÖPNV-Unternehmen aufzuzeigen. Hierzu werden nachfolgend die Berücksichtigung der Nachhaltigkeit bei Investitionsentscheidungen, das Carbon Accounting (Transparenz über CO2-Emissionen), die Integration der ökologischen, ökonomischen und sozialen Nachhaltigkeitsdimension bei der Berichterstattung und die Einbindung der genannten Instrumente in ein Managementsystem skizziert. Die Nachhaltigkeitsdimensionen Ökologie, Ökonomie und Soziales lassen sich gut mit Hilfe mehrdimensionaler, integrierter Managementsysteme in der Organisation verankern und systematisch in interne Strukturen und Prozesse einbetten. Integrierte Managementsysteme können so eine wichtige Voraussetzung für ein effizientes Nachhaltigkeitscontrolling sein.
Nachhaltigkeit aus institutionenökonomischer Perspektive am Beispiel der Schiefergasförderung
(2014)
Der Begriff der Nachhaltigkeit ist heute weit verbreitet, und seine Nutzung erstreckt sich auf alle Gesellschaftsbereiche. Als abstraktes Leitprinzip bleibt oftmals unklar, wie der Begriff definiert und ausgelegt wird. Seine Unbestimmtheit trägt zur Verwässerung und inflationären Verwendung bei. Erschwerend wirkt zusätzlich die unzureichende Trennung des politischen vom alltagssprachlichen Begriff der Nachhaltigkeit.
Mobbing
(2014)
Menschenrechte und Unternehmen: von der konzeptionellen Definition bis zur praktischen Integration
(2014)
Improving data acquisition techniques and rising computational power keep producing more and larger data sets that need to be analyzed. These data sets usually do not fit into a GPU's memory. To interactively visualize such data with direct volume rendering, sophisticated techniques for problem domain decomposition, memory management and rendering have to be used. The volume renderer Volt is used to show how CUDA is efficiently utilised to manage the volume data and a GPU's memory with the aim of low opacity volume renderings of large volumes at interactive frame rates.
Matrix metalloproteinases (MMPs) are matrix-degrading enzymes that are over-expressed in joints of rheumatoid arthritis (RA) patients. However, the contribution of specific MMPs for the development of arthritic joints is unknown. This study is aimed at studying the role of matrix metalloproteinase-9 (MMP-9) in mice, using the K/BxN serum-transfer model of RA. Arthritis was induced in Balb/c mice by injecting K/BxN serum. Development of arthritis was followed in these mice by measuring ankle thickness and clinical index score. MMP-9 expression in the joints of mice killed at various time points during the disease progression was determined by gelatin zymography using ankle lysates. We found that MMP-9 expression increased with the severity of arthritis. Importantly MMP-9 deficient mice injected with K/BxN serum showed a milder form of arthritis in comparison to the control C57BL/6 mice injected with K/BxN serum. We therefore conclude that MMP-9 promotes arthritis in mice.
In diesem Paper wird das abbildende Millimeterwellen-Radarsystem SAMMI® (Stand Alone MilliMeter wave Imager) des Fraunhofer-Institutes für Hochfrequenzphysik und Radartechnik FHR vorgestellt. SAMMI ist ein CW System welches bei einer Messfrequenz von 78 GHz die Proben in Transmission vermisst. Durch ein Endlosband wird ein kontinuierlicher Materialstrom sichergestellt, wobei ein DIN A4 Blatt innerhalb von 20 s durchleuchtet wird. SAMMI besitzt die Größe eines durchschnittlichen Laserdruckers wodurch es leicht zu transportieren und in wenigen Minuten einsatzbereit ist. Die mittels SAMMI erfassten Messdaten, können bereits während der Datenerfassung mit verschiedenen bereits vorinstallierten Verfahren aufbereitet und analysiert werden. Zu den integrierten Algorithmen in SAMMI® gehören unter anderen Verfahren zum 2D-Phase Unwrapping-, Cluster- und Rekonstruktions-Algorithmen zur Berechnung der Materialparameter. Die offene Softwareschnittstelle erlaubt auch die Implementierung eigener Verfahren auf der mitgelieferten Computer-Hardware. Mit den integrierten Algorithmen bietet SAMMI® eine Vielzahl an Möglichkeiten um z.B. Verunreinigungen in Materialien zu detektieren oder Schwankungen im Fertigungsprozess frühzeitig zu identifizieren. Desweiteren ist SAMMI® eine optimale Ausbildungsplattform in den Bereichen der industriellen Bildverarbeitung mittels Hochfrequenzsensoren. Insbesondere können Verfahren für unterschiedliche Anwendungen getestet bzw. für Anwendungen weiterentwickelt werden. Es werden konkrete Beispiele aus dem Bereich der Qualitätssicherung erläutert und Möglichkeiten des Gerätes und der Millimeterwellen-Technologie für die zerstörungsfreie Prüfung in Detail beschrieben.
Masterkurs IT-Controlling
(2014)
Das Management von Sicherheit und Gesundheit bei der Arbeit beinhaltet die Praevention psychischer Fehlbelastungen und psychischer Erkrankungen. Die gesetzliche Grundlage der Praeventionsaktivitaeten der gesetzlichen Unfallversicherung wird aufgefuehrt. Anschliessend wird verdeutlicht, in welchen Handlungsfeldern und mit welchen Instrumenten die gesetzliche Unfallversicherung die Praevention psychischer Erkrankungen in den Betrieben unterstuetzt. Als theoretischer Rahmen fuer Praeventionsmassnahmen werden das Dreiebenenmodell psychischer Belastungen (Mitarbeiter, Unternehmen, Gesellschaft) und das Dreiebenen-Interventionsmodell psychischer Erkrankungen skizziert. Die betriebliche Praevention erfolgt im Idealfall auf der Basis konkreter innerbetrieblicher Regelungen. Dies wird beispielhaft fuer den Umgang mit E-Mails und die Regelungen zur Erreichbarkeit naeher beschrieben.
Level-Synchronous Parallel Breadth-First Search Algorithms For Multicore and Multiprocessor Systems
(2014)
Breadth-First Search (BFS) is a graph traversal technique used in many applications as a building block, e.g.,~to systematically explore a search space. For modern multicore processors and as application graphs get larger, well-performing parallel algorithms are favourable. In this paper, we systematically evaluate an important class of parallel BFS algorithms and discuss programming optimization techniques for their implementation. We concentrate our discussion on level-synchronous algorithms for larger multicore and multiprocessor systems. In our results, we show that for small core counts many of these algorithms show rather similar behaviour. But, for large core counts and large graphs, there are considerable differences in performance and scalability influenced by several factors. This paper gives advice, which algorithm should be used under which circumstances.
Culture, at least to some extent, is related to particular (individual and collective) experiences. In terms of education, this means that a learner, who experienced particular services in his/her past, might perceive such services as usual for educational culture and thus, expect them to be delivered in any kind of learning scenario. In German universities, education is meant to be a full-time job and usually is designed to provide a broad basis of theoretical and methodological knowledge. Achieving methodological competences is a core goal of German academic education: Once a student leaves the university, he/she is expected to decide about appropriate methods for any kind of problem (in the field of study and beyond) and how to modify the known methods in case of need. In contrast, in professional training, the learners have to study in extra-occupational situations (time is a serious issue) and might expect training that pointedly prepares them for very specific tasks. We assumed that scenarios of professional training have their own educational cultures. When designing learning contents and learning scenarios for professional training, it might be essential for the learning success to meet the learners’ expectations and contextual peculiarities.
We found remarkable differences between the results of the investigated enterprises, but even more significant diversity between the results of the German enterprises and the priory investigated German universities. As a general conclusion we can assume that generalizing research results that were solely achieved from national university students might lead to an inappropriate design of learning scenarios for particular professional contexts. Professional training for a particular enterprise should be developed according to its specific educational culture.
Rendering techniques for design evaluation and review or for visualizing large volume data often use computationally expensive ray-based methods. Due to the number of pixels and the amount of data, these methods often do not achieve interactive frame rates. A view direction based rendering technique renders the users central field of view in high quality whereas the surrounding is rendered with a level of detail approach depending on the distance to the users central field of view thus giving the opportunity to increase rendering efficiency. We propose a prototype implementation and evaluation of a focus-based rendering technique based on a hybrid ray tracing/sparse voxel octree rendering approach.
Obwohl kulturbezogene Fragestellungen eine zentrale Rolle für die erfolgreiche Implementierung von Anwendungssystemen und IKT spielen, erfolgen kulturbezogene Untersuchungen in der Disziplin oft zu unkritisch: Kulturelle Kontexte werden in der Literatur häufig nicht klar abgegrenzt, und verwendete Begriffe werden nicht oder nur unzureichend definiert. Darüber hinaus werden kulturbezogene Untersuchungen, die eigentlich Besonderheiten abgegrenzter Gesellschaften (z. B. Kundensegmente) aufdecken sollen, oft ohne weitere Prüfung auf der Ebene von Nationalkultur untersucht. Die Problematik eines zu unkritischen und bisweilen sogar unangemessenen Umgangs mit kulturbezogenen Fragestellungen ist nicht auf die Wirtschaftsinformatik begrenzt sondern zieht sich durch nahezu alle Disziplinen, die "Kultur" als eine unter vielen Einflussgrößen betrachten. In dieser Arbeit wird ein praktischer Ansatz entwickelt, mit dessen Hilfe nicht nur der eigene kulturbezogene Forschungskontext abgegrenzt werden, sondern darüber hinaus auch noch herausgefunden werden kann, ob bereits verfügbare Forschungsansätze ggf. auf den eigenen Kontext passen könnten. Als Ergebnisse der Arbeit wurde ein Schritt-für-Schritt Leitfaden erstellt und eine Vergleichsbasis geschaffen, die auf einer in ihrem Umfang bislang einzigartigen Sammlung bereits verfügbarer Kulturbeschreibungsansätze beruht.
Kriminalistik
(2014)
In den letzten Jahren ist das Thema Nachhaltigkeit zu einem Schlüsselthema in vielen wissenschaftlichen und gesellschaftlichen Diskursen geworden. Ausgehend von natur-, technik-, politik- und zunehmend wirtschaftswissenschaftlichen Auseinandersetzung mit Fragestellungen im Kontext von Nachhaltigkeit, sind diese in den Mittelpunkt gesellschaftlicher und politischer Wahrnehmung gerückt.
The perceived direction of “up” is determined by gravity, visual information, and an internal estimate of body orientation (Mittelstaedt, 1983; Dyde et al., 2006). Is the gravity level found on other worlds sufficient to maintain gravity’s contribution to this perception? Difficulties in stability reported anecdotally by astronauts on the lunar surface (NASA 1972) suggest that the moon’s gravity may not be, despite this value being far above the threshold for detecting linear acceleration. Knowing how much gravity is needed to provide a reliable orientation cue is required for training and preparing astronauts for future missions to the moon, mars and beyond.
Over the past two decades social protection has gained importance at the international and the national level of many low and middle income countries. Despite reforms in this sector being a global phenomenon, they differ from country to country. Traditional efforts to explain these dif- ferences focus on domestic factors. Yet it remains unclear how international influences and interdependencies contrib- ute to policy change. The study ‘International Policy Learn- ing and Policy Change’ aims at providing an answer to this question, by focusing on ‘soft governance’ via horizontal processes, meaning processes between equal actors. The studie was carried out in two parts. While in Part I the cur- rent state of the art in relevant research fields was assessed, in Part II the findings from Part I were used to conduct a survey which analyses the role of policy networks.
Nachhaltigkeit als Megatrend. Die Arbeit der Weltkommission für Umwelt und Entwicklung unter Vorsitz von Brundtland machte bereits 1987 deutlich, dass v.a. das Management von Gemeingütern wie Ozeanen und der Atmosphäre, die Erhaltung des Weltfriedens, die weltweite Bevölkerungsentwicklung, die globale Ernährungssicherheit, die begrenzten Energieressourcen sowie die Folgen des Wirtschaftswachstums globale Herausforderungen darstellen, die nur durch eine nachhaltige Entwicklung gemeistert werden können.
The contribution of the most common reciprocal translocation in childhood B-cell precursor leukemia t(12;21)(p13;q22) to leukemia development is still under debate. Direct as well as secondary indirect effects of the TEL-AML1 fusion protein are commonly recorded by using cell lines and patient samples, often bearing the TEL-AML1 fusion protein for decades. To identify direct targets of the fusion protein a short-term induction of TEL-AML1 is needed. We here describe in detail the experimental procedure, quality controls and contents of the ChIP, mRNA expression and SILAC datasets associated with the study published by Linka and colleagues in the Blood Cancer Journal [1] utilizing a short term induction of TEL-AML1 in an inducible precursor B-cell line model.
Gas chromatography with flame-ionization detection (FID) and gas chromatography-mass spectrometry (GC/MS) with electron impact ionization (EI) and chemical ionization (PCI and NCI) were successfully used for separation and identification of commercially available longchain primary alkyl amines. The investigated compounds were used as corrosion inhibiting and antifouling agents in a water-steam circuit of energy systems in the power industry. Solidphase extraction (SPE) with octadecyl bonded silica (C18) sorbents followed by gas chromatography were used for quantification of the investigated Primene JM-T™ alkyl amines in boiler water, condensate and superheated steam samples from the power plant. Amine formulations from Kotamina group favor formation of protective layers on internal surfaces and keep them free from corrosion and scale. Alkyl amines contained in those formulations both render the environment alkaline and limit the corrosion impact of ionic and gaseous impurities by formation of protective layers. Moreover, alkyl amines limit scaling on heating surfaces of boilers and in turbine, ensuring failure-free operation. Application of alkyl amine formulation enhances heat exchange during boiling and condensation processes. Alkyl amines with branched structure are more thermally stable than linear alkyl amines, exhibit better adsorption and effectiveness of surface shielding. As a result, application of thermostable long-chain branched alkyl amines increases the efficiency of anti-corrosive protection. Moreover, the concentration of ammonia content in water and in steam was also considerably decreased.
Might the gravity levels found on other planets and on the moon be sufficient to provide an adequate perception of upright for astronauts? Can the amount of gravity required be predicted from the physiological threshold for linear acceleration? The perception of upright is determined not only by gravity but also visual information when available and assumptions about the orientation of the body. Here, we used a human centrifuge to simulate gravity levels from zero to earth gravity along the long-axis of the body and measured observers' perception of upright using the Oriented Character Recognition Test (OCHART) with and without visual cues arranged to indicate a direction of gravity that differed from the body's long axis. This procedure allowed us to assess the relative contribution of the added gravity in determining the perceptual upright. Control experiments off the centrifuge allowed us to measure the relative contributions of normal gravity, vision, and body orientation for each participant. We found that the influence of 1 g in determining the perceptual upright did not depend on whether the acceleration was created by lying on the centrifuge or by normal gravity. The 50% threshold for centrifuge-simulated gravity's ability to influence the perceptual upright was at around 0.15 g, close to the level of moon gravity but much higher than the threshold for detecting linear acceleration along the long axis of the body. This observation may partially explain the instability of moonwalkers but is good news for future missions to Mars.