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Das Deutsche Zentrum für Luft- und Raumfahrt (DLR) führt viele Forschungen und Studien im Bereich der Luft- und Raumfahrt durch. Dabei spielen die Studien für die Gesundheit und Medizin auch eine sehr wichtige Rolle bei der DLR. Zu diesem Zweck führt die DLR die Artificial Gravity bed rest study (AGBRESA) im Auftrag der European Space Agency (esa) und in Kooperation der NASA durch. In dieser Studie werden die negativen Auswirkungen der Schwerelosigkeit auf dem Menschen im Weltall simuliert. Dabei werden Experimente durchgeführt, um die negative Auswirkungen entgegenzuwirken. Die Ergebnisse der Experimente werden in der DLR digital, aber auch auf Papier dokumentiert. In diesem Master-Projekt habe ich nun die Aufgabe, die Papierprotokolle für den Bereich der Blutabnahme und der Labordokumentation in eine digitale Form zu ersetzen.
This work presents the preliminary research towards developing an adaptive tool for fault detection and diagnosis of distributed robotic systems, using explainable machine learning methods. Autonomous robots are complex systems that require high reliability in order to operate in different environments. Even more so, when considering distributed robotic systems, the task of fault detection and diagnosis becomes exponentially difficult.
To diagnose systems, models representing the behaviour under investigation need to be developed, and with distributed robotic systems generating large amount of data, machine learning becomes an attractive method of modelling especially because of its high performance. However, with current day methods such as artificial neural networks (ANNs), the issue of explainability arises where learnt models lack the ability to give explainable reasons behind their decisions.
This paper presents current trends in methods for data collection from distributed systems, inductive logic programming (ILP); an explainable machine learning method, and fault detection and diagnosis.
Healing of large bone defects requires implants or scaffolds that provide structural guidance for cell growth, differentiation, and vascularization. In the present work, an agarose-hydroxyapatite composite scaffold was developed that acts not only as a 3D matrix, but also as a release system. Hydroxyapatite (HA) was incorporated into the agarose gels in situ in various ratios by a simple procedure consisting of precipitation, cooling, washing, and drying. The resulting gels were characterized regarding composition, porosity, mechanical properties, and biocompatibility. A pure phase of carbonated HA was identified in the scaffolds, which had pore sizes of up to several hundred micrometers. Mechanical testing revealed elastic moduli of up to 2.8 MPa for lyophilized composites. MTT testing on Lw35human mesenchymal stem cells (hMSCs) and osteosarcoma MG-63 cells proved the biocompatibility of the scaffolds. Furthermore, scaffolds were loaded with model drug compounds for guided hMSC differentiation. Different release kinetic models were evaluated for adenosine 5′-triphosphate (ATP) and suramin, and data showed a sustained release behavior over four days.
Bone tissue engineering is an ever-changing, rapidly evolving, and highly interdisciplinary field of study, where scientists try to mimic natural bone structure as closely as possible in order to facilitate bone healing. New insights from cell biology, specifically from mesenchymal stem cell differentiation and signaling, lead to new approaches in bone regeneration. Novel scaffold and drug release materials based on polysaccharides gain increasing attention due to their wide availability and good biocompatibility to be used as hydrogels and/or hybrid components for drug release and tissue engineering. This article reviews the current state of the art, recent developments, and future perspectives in polysaccharide-based systems used for bone regeneration.
This work introduces a semi-Lagrangian lattice Boltzmann (SLLBM) solver for compressible flows (with or without discontinuities). It makes use of a cell-wise representation of the simulation domain and utilizes interpolation polynomials up to fourth order to conduct the streaming step. The SLLBM solver allows for an independent time step size due to the absence of a time integrator and for the use of unusual velocity sets, like a D2Q25, which is constructed by the roots of the fifth-order Hermite polynomial. The properties of the proposed model are shown in diverse example simulations of a Sod shock tube, a two-dimensional Riemann problem and a shock-vortex interaction. It is shown that the cell-based interpolation and the use of Gauss-Lobatto-Chebyshev support points allow for spatially high-order solutions and minimize the mass loss caused by the interpolation. Transformed grids in the shock-vortex interaction show the general applicability to non-uniform grids.
Although work events can be regarded as pivotal elements of organizational life, only a few studies have examined how positive and negative events relate to and combine to affect work engagement over time. Theory suggests that to better understand how current events affect work engagement (WE), we have to account for recent events that have preceded these current events. We present competing theoretical views on how recent and current work events may affect employees (e.g., getting used to a high frequency of negative events or becoming more sensitive to negative events). Although the occurrence of events implies discrete changes in the experience of work, prior research has not considered whether work events actually accumulate to sustained mid-term changes in WE. To address these gaps in the literature, we conducted a week-level longitudinal study across a period of 15 consecutive weeks among 135 employees, which yielded 849 weekly observations. While positive events were associated with higher levels of WE within the same week, negative events were not. Our results support neither satiation nor sensitization processes. However, high frequencies of negative events in the preceding week amplified the beneficial effects of positive events on WE in the current week. Growth curve analyses show that the benefits of positive events accumulate to sustain high levels of WE. WE dissipates in the absence of continuous experience of positive events. Our study adds a temporal component and informs research that has taken a feature-oriented perspective on the dynamic interplay of job demands and resources.
In the literature on occupational stress and recovery from work several facets of thinking about work in off-job time have been conceptualized. However, research on the focal concepts is currently rather disintegrated. In this study we take a closer look at the five most established concepts, namely (1) psychological detachment, (2) affective rumination, (3) problem-solving pondering, (4) positive work reflection, and (5) negative work reflection. More specifically, we scrutinized (1) whether the five facets of work-related rumination are empirically distinct, (2) whether they yield differential associations with different facets of employee well-being (burnout, work engagement, thriving, satisfaction with life, and flourishing), and (3) to what extent the five facets can be distinguished from and relate to conceptually similar constructs, such as irritation, worry, and neuroticism. We applied structural equation modeling techniques to cross-sectional survey data from 474 employees. Our results provide evidence that (1) the five facets of work-related rumination are highly related, yet empirically distinct, (2) that each facet contributes uniquely to explain variance in certain aspects of employee well-being, and (3) that they are distinct from related concepts, albeit there is a high overlap between (lower levels of) psychological detachment and cognitive irritation. Our study contributes to clarify the structure of work-related rumination and extends the nomological network around different types of thinking about work in off-job time and employee well-being.
In the literature on occupational stress and recovery from work, several facets of thinking about work during off-job time have been conceptualized. However, research on the focal concepts is currently rather diffuse. In this study we take a closer look at the five most well-established concepts: (1) psychological detachment, (2) affective rumination, (3) problem-solving pondering, (4) positive work reflection, and (5) negative work reflection. More specifically, we scrutinized (1) whether the five facets of work-related rumination are empirically distinct, (2) whether they yield differential associations with different facets of employee well-being (burnout, work engagement, thriving, satisfaction with life, and flourishing), and (3) to what extent the five facets can be distinguished from and relate to conceptually similar constructs, such as irritation, worry, and neuroticism. We applied structural equation modeling techniques to cross-sectional survey data from 474 employees. Our results provide evidence for (1) five correlated, yet empirically distinct facets of work-related rumination. (2) Each facet yields a unique pattern of association with the eight aspects of employee well-being. For instance, detachment is strongly linked to satisfaction with life and flourishing. Affective rumination is linked particularly to burnout. Problem-solving pondering and positive work reflection yield the strongest links to work engagement. (3) The five facets of work-related rumination are distinct from related concepts, although there is a high overlap between (lower levels of) psychological detachment and cognitive irritation. Our study contributes to clarifying the structure of work-related rumination and extends the nomological network around different types of thinking about work during off-job time and employee well-being.
Computer graphics research strives to synthesize images of a high visual realism that are indistinguishable from real visual experiences. While modern image synthesis approaches enable to create digital images of astonishing complexity and beauty, processing resources remain a limiting factor. Here, rendering efficiency is a central challenge involving a trade-off between visual fidelity and interactivity. For that reason, there is still a fundamental difference between the perception of the physical world and computer-generated imagery. At the same time, advances in display technologies drive the development of novel display devices. The dynamic range, the pixel densities, and refresh rates are constantly increasing. Display systems enable a larger visual field to be addressed by covering a wider field-of-view, due to either their size or in the form of head-mounted devices. Currently, research prototypes are ranging from stereo and multi-view systems, head-mounted devices with adaptable lenses, up to retinal projection, and lightfield/holographic displays. Computer graphics has to keep step with, as driving these devices presents us with immense challenges, most of which are currently unsolved. Fortunately, the human visual system has certain limitations, which means that providing the highest possible visual quality is not always necessary. Visual input passes through the eye’s optics, is filtered, and is processed at higher level structures in the brain. Knowledge of these processes helps to design novel rendering approaches that allow the creation of images at a higher quality and within a reduced time-frame. This thesis presents the state-of-the-art research and models that exploit the limitations of perception in order to increase visual quality but also to reduce workload alike - a concept we call perception-driven rendering. This research results in several practical rendering approaches that allow some of the fundamental challenges of computer graphics to be tackled. By using different tracking hardware, display systems, and head-mounted devices, we show the potential of each of the presented systems. The capturing of specific processes of the human visual system can be improved by combining multiple measurements using machine learning techniques. Different sampling, filtering, and reconstruction techniques aid the visual quality of the synthesized images. An in-depth evaluation of the presented systems including benchmarks, comparative examination with image metrics as well as user studies and experiments demonstrated that the methods introduced are visually superior or on the same qualitative level as ground truth, whilst having a significantly reduced computational complexity.
Due to increased emissions of palladium nanoparticles in recent years, it is important to develop analytical techniques to characterize these particles. The synthesis of defined and stable particles plays a key role in this process, as there are not many materials commercially available yet which could act as reference materials. Polyvinylpyrrolidone- (PVP-) stabilized palladium nanoparticles were synthesized through the reduction of palladium chloride by tetraethylene glycol (TEG) in the presence of KOH. Four different methods were used for particle size analysis of the palladium nanoparticles. Palladium suspensions were analyzed by scanning electron microscopy (SEM), small angle X-ray scattering (SAXS), single-particle ICP-MS (SP-ICP-MS), and X-ray diffraction (XRD). Secondary particles between 30 nm and 130 nm were detected in great compliance with SAXS and SP-ICP-MS. SEM analysis showed that the small particulates tend to form agglomerates.
Die Globalisierung führt zu immer komplexeren, für die Einzelnen kaum nachvollziehbaren Wertschöpfungsketten in der Lebensmittelindustrie. Zugleich eröffnet die Digitalisierung neue Möglichkeiten, Informationen entlang der Kette zu sammeln, und so mehr Transparenz und Vertrauen für den Verbraucherbeziehungsweise die Verbraucherin zu schaffen. Jedoch finden Verbraucherinformations-Apps wie fTRACE bisher nur eine geringe Verbreitung. Daher haben wir in einer qualitativen Studie mit 16 Teilnehmer/-innen Bedürfnisse und Nutzungshürden von Verbraucher/-innen im Zusammenhang mit Verbraucherinformations-Apps analysiert. Es zeigt sich, dass das Vertrauen in die Informationen, sowie der einfache Zugang dazu für Verbraucher/-innen zentral sind. Durch die gut sichtbare Bereitstellung der Informationen am Point-of-Sale, sowie der automatisierten Informationsversorgung z. B. mittels digitaler Kassenzettel in Kombination mit weiteren Verbraucher-Services kann die Bekanntheit und Akzeptanz von Rückverfolgbarkeitssystemen weiter gesteigert werden.
Stakeholder-Analyse zum Einsatz IIoT-basierter Frischeinformationen in der Lebensmittelindustrie
(2019)
Eine Herausforderung bei der Implementierung des industriellen Internet of Things (IIoT) besteht darin, Mehrwerte in Wertschöpfungsketten zu identifizieren, um darauf aufbauend Lösungen nutzerzentriert zu gestalten. Dieser Beitrag stellt das Forschungsprojekt FreshIndex vor, bei dem diese Herausforderung durch eine Kombination aus Stakeholder-Analyse und User-Centered-Design-Methoden adressiert wurde. Ziel des Projekts ist es, eine IIoT-basierte Lösung zum Monitoring der Kühlkette in der Lebensmittelindustrie zu entwickeln. Hierzu ist es wichtig zu wissen, welche Nutzer/-innen mit den Daten in Berührung kommen und welche Erfahrungen, Fähigkeiten, Anforderungen und Wünsche sie mitbringen. Die Berücksichtigung dieser Aspekte ist relevant für den Erfolg der Konzeption, Implementierung und des Betriebs eines IIoT-Systems. So können nützliche und handhabbare Produktideen generiert und Anwendungen gestaltet werden, die von Mitarbeiter/-innen und Konsument/-innen angenommen werden. IIoT schließt somit die lokale Verwendbarkeit von Daten entlang der Wertschöpfungskette ein und beschränkt sich nicht auf zentrale Verfügbarkeit von Daten.
Interactive Object Detection
(2019)
The success of state-of-the-art object detection methods depend heavily on the availability of a large amount of annotated image data. The raw image data available from various sources are abundant but non-annotated. Annotating image data is often costly, time-consuming or needs expert help. In this work, a new paradigm of learning called Active Learning is explored which uses user interaction to obtain annotations for a subset of the dataset. The goal of active learning is to achieve superior object detection performance with images that are annotated on demand. To realize active learning method, the trade-off between the effort to annotate (annotation cost) unlabeled data and the performance of object detection model is minimised.
Random Forests based method called Hough Forest is chosen as the object detection model and the annotation cost is calculated as the predicted false positive and false negative rate. The framework is successfully evaluated on two Computer Vision benchmark and two Carl Zeiss custom datasets. Also, an evaluation of RGB, HoG and Deep features for the task is presented.
Experimental results show that using Deep features with Hough Forest achieves the maximum performance. By employing Active Learning, it is demonstrated that performance comparable to the fully supervised setting can be achieved by annotating just 2.5% of the images. To this end, an annotation tool is developed for user interaction during Active Learning.
Luxusgut Wohnen
(2019)
Das Forschungsprojekt beruht auf zwei Elementen: Die erste Untersuchung, ein Verhaltensexperiment mit 35 Studierenden der Hochschule Bonn-Rhein-Sieg, erforschte den Einfluss von Gruppengröße (Zuschauereffekt) und dargebotenen Informationen zu Verantwortungsdiffusion (Priming) auf nachhaltiges Verhalten. Mithilfe eines zweiten Online-Experiments folgte eine Erhebung zum Einfluss von wahrgenommener persönlicher Bedrohung auf die Bereitschaft zu nachhaltigem Verhalten (N = 72). Die Ergebnisse des ersten Experimentes zeigen einen schwachen, statistisch nicht signifikanten Einfluss der Gruppengröße sowie einen, z.T. statistisch signifikanten, Einfluss der dargebotenen Informationen zu Verantwortungsdiffusion auf das gemessene nachhaltige Verhalten. Bequemlichkeit sowie monetärer Aufwand stellen mit Abstand die größten Hindernisse für nachhaltiges Verhalten dar, während die Beeinflussung durch andere und das Ziel des Umweltschutzes als positive Argumente für nachhaltiges Verhalten genannt wurden. In der Folgestudie konnte ein statistisch signifikanter kausaler Zusammenhang zwischen der wahrgenommenen persönlichen Bedrohung durch die aktuelle Umwelt- und Klimasituation und der Bereitschaft zu nachhaltigem Verhalten nachgewiesen werden. Alle Resultate zu Verhaltensintentionen zeigten insgesamt eine hohe Bereitschaft der Probanden zu nachhaltigem Verhalten.