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Scientific or statistical research has long been the domain of dedicated programming languages such as R, SPSS or SAS. A few years other competitors entered the arena, among them Python with its powerful SciPy package. The following article introduces SciPy by applying a small subset of its functionality to a well-known dataset.
The epithelial sodium channel (ENaC) is a critical regulator of vertebrate electrolyte homeostasis. ENaC is the only constitutively open ion channel in the degenerin/ENaC protein family, and its expression, membrane abundance, and open probability therefore are tightly controlled. The canonical ENaC is composed of three subunits (, , and ), but a fourth -subunit may replace and form atypical -ENaCs. Using Xenopus laevis as a model, here we found that mRNAs of the - and -subunits are differentially expressed in different tissues and that -ENaC predominantly is present in the urogenital tract. Using whole-cell and single-channel electrophysiology of oocytes expressing Xenopus - or -ENaC, we demonstrate that the presence of the -subunit enhances the amount of current generated by ENaC due to an increased open probability, but also changes current into a transient form. Activity of canonical ENaCs is critically dependent on proteolytic processing of the - and -subunits, and immunoblotting with epitope-tagged ENaC subunits indicated that, unlike -ENaC, the -subunit does not undergo proteolytic maturation by the endogenous protease furin. Furthermore, currents generated by -ENaC were insensitive to activation by extracellular chymotrypsin, and presence of the -subunit prevented cleavage of -ENaC at the cell surface. Our findings suggest that subunit composition constitutes an additional level of ENaC regulation, and we propose that the Xenopus -ENaC subunit represents a functional example that demonstrates the importance of proteolytic maturation during ENaC evolution.
Der globalisierte Kapitalismus, Umweltkatastrophen, Überbevölkerung sowie zunehmende politisch und religiös motivierte Konflikte fordern ein Umdenken ökonomischer Konzepte. Allein mit den herkömmlichen Sozial- und Wirtschaftssystemen lassen sich existenzbedrohende Probleme wie Armut, Hunger, Krankheit, mangelnde Bildung und Betreuung nicht lösen. Es gilt dringend, neue, zukunftsweisende unternehmerische Konzepte zu entwickeln und zu fördern. Seit geraumer Zeit hat sich unter dem Begriff „Social Entrepreneurship“ eine Bewegung etabliert, die versucht, unter Beachtung klassischer Ökonomiegrundsätze gesellschaftliche Herausforderungen nachhaltig zu lösen.
Towards explaining deep learning networks to distinguish facial expressions of pain and emotions
(2018)
Deep learning networks are successfully used for object and face recognition in images and videos. In order to be able to apply such networks in practice, for example in hospitals as a pain recognition tool, the current procedures are only suitable to a limited extent. The advantage of deep learning methods is that they can learn complex non-linear relationships between raw data and target classes without limiting themselves to a set of hand-crafted features provided by humans. However, the disadvantage is that due to the complexity of these networks, it is not possible to interpret the knowledge that is stored inside the network. It is a black-box learning procedure. Explainable Artificial Intelligence (AI) approaches mitigate this problem by extracting explanations for decisions and representing them in a human-interpretable form. The aim of this paper is to investigate the explainable AI method Layer-wise Relevance Propagation (LRP) and apply it to explain how a deep learning network distinguishes facial expressions of pain from facial expressions of emotions such as happiness and disgust.
Text is one of the key sources of information for social sciences and humanities which, with the rise and development of computational technologies, has been mostly available via digital libraries, archives and websites. It enables researchers to increasingly deal with large scale text corpora that require the use of advanced software tools to process them and extract information. Computational linguistics - a discipline that has emerged on the border of computer science, linguistics and statistics - has achieved certain results in automated text analysis and information extraction, e.g., tools for part-of-speech tagging, grammar parsing, semantic role labelling, sentiment analysis and anaphora resolution have been developed and successfully used in many scientific projects. However, there still exists a gap between technology available and the needs of social sciences: named entity recognizers are incapable of identifying actors, sentiment analysis just provides the overall mood of an expression but is not able to identify the evaluation of information by the utterer, topic modeling tools can only assign a topic to a document, but fall short of measuring its frame.
Beim Entwurf eines effizienten und sicheren Luftfahrzeugs müssen viele fachliche Aspekte berücksichtigt werden. Die Bereiche Aerodynamik, Strukturmechanik als auch Flugmechanik spielen eine wichtige Rolle und hängen voneinander ab. Daher ist ein iterativer Entwurfsprozess erforderlich, um einen an die Anforderungen bestmöglich angepassten Kompromiss zu finden. In der Forschung am Deutschen Zentrum für Luft- und Raumfahrt e.V. (DLR) werden dafür automatisierte Prozessketten entwickelt, die zur Bewertung und Entwicklung von neuen Flugzeugkonzepten dienen.
The labor market is dynamic and frequently calls for new skills, knowledge, and abilities. The changing needs of industry place a higher demand on institutions of higher learning to monitor trends in labor needs, identify skill gaps, and to use industry insights for developing programs and curricula that mold human resources to create value for employers and society at large. While several institutions of higher learning are responsive to industry needs through curricula reviews and the development of new programs, little attention is given to pedagogical issues that affect the delivery of knowledge and the development of skills intended by various education programs. Consequently, teachers are entrusted with the freedom to decide the teaching methods that are appropriate under each circumstance. Despite the changing face of the labor market, not much energy has been channeled towards adjusting teaching methods for effective delivery of skills required by students. The failure to adjust teaching methods for training graduates has led to what is commonly known as ‘halfbaked graduates’. In other words, graduates who lack the skills and abilities necessary for placement in the industry. However, the success of an institution of higher learning is illustrated by its ability to train people who perfectly match the needs of the industry.
Culture is the constellation of shared believes, mores, values, and traditions that define the behavior of people and it is unique to each community at local and national levels. Culture determines the languages spoken by the people, their attitude towards others, and their behavior. While the family is the immediate point through which culture is learned by children, socialization at institutions such as religious organizations, places of worship, schools, and the society’s dispute resolution system reinforce culture. Unlike the Internet, traditional media in the forms of local and national print and audio-visual content tend to reinforce cultural beliefs, values, and practices of specific communities. The uniqueness of culture creates market penetration challenges to entrepreneurs in international markets. Therefore, intercultural communication is a necessary skill for reducing cultural liability and increasing the success of entrepreneurial ventures.
This case study is based on Azuri Health Ltd, a small company in Kenya that specializes mainly in the manufacture of dried fruit and flours. The company was started in 2010 and currently has 15 employees. It buys fruits, especially mangoes from farmers, processes them and markets them in- and outside of Kenya as dried fruits. This value addition enhances the shelf life of the products which would otherwise spoil within a few days after ripening.
The exchange program enables students to travel from their home countries to a partner university in the German-African University project. Students from the University of Nairobi in Kenya and University of Cape Coast in Ghana travel to the Hochschule Bonn-Rhein-Sieg University of Applied Sciences and stay for three months attending classes and participating in academic activities together with German students. Similarly, students from Hochschule Bonn-Rhein-Sieg, University of Applied Sciences, travel to either West or East Africa and are hosted for three months by universities participating in the project. The program enables Kenyan students to accustom themselves to the German way of life and student-centered learning and disciplines. The program integrates fieldwork into the learning activities making education both a skill-imparting and fun process.
Consolidating Principles and Patterns for Human-centred Usable Security Research and Development
(2018)
We present an evaluation of usable security principles and patterns to facilitate the transfer of existing knowledge to researchers and practitioners. Based on a literature review we extracted 23 common usable security principles and 47 usable security patterns and identified their interconnection. The results indicate that current research tends to focus on only a subset of important principles. The fact that some principles are not yet addressed by any design patterns suggests that further work on refining these patterns is needed. We developed an online repository, which stores the harmonized principles and patterns. The tool enables users to search for relevant patterns and explore them in an interactive and programmatic manner. We argue that both the insights presented in this paper and the repository will be highly valuable for students for getting a good overview, practitioners for implementing usable security and researchers for identifying areas of future research.
In Fortführung zu den drei erfolgreichen „Usable Security und Privacy“ Workshops der letzten drei Jahre, sollen in einem vierten ganztätigen wissenschaftlichen Workshop auf der diesjährigen Mensch und Computer sechs bis acht Arbeiten auf dem Gebiet Usable Security and Privacy vorgestellt und diskutiert werden. Vorgesehen sind Beiträge aus Forschung und Praxis, die neue nutzerzentrierte Ansätze aber auch praxisrelevante Lösungen zur nutzerzentrierten Entwicklung und Ausgestaltung von digitalen Schutzmechanismen thematisieren. Mit dem Workshop soll das etablierte Forum weiterentwickelt werden, in dem sich Experten aus unterschiedlichen Domänen, z. B. dem Usability-Engineering und Security-Engineering, transdisziplinär austauschen können. Der Workshop wird von den Organisatoren als klassischer wissenschaftlicher Workshop ausgestaltet. Ein Programmkomitee bewertet die Einreichungen und wählt daraus die zur Präsentation akzeptierten Beiträge aus. Diese werden zudem im Poster- und Workshopband der Mensch und Computer 2018 veröffentlicht.