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Novel hybrid agarose hydrogels for bone tissue engineering and drug delivery

  • Recent approaches in scaffold engineering for bone defects feature hybrid hydrogels made of a polymeric network (retains water and provides light and porous structures) and inorganic ceramics (add mechanical strength and improve cell-adhesion). Innovative scaffold materials should also induce bone tissue formation and incorporation of stem cells (osteogenic differentiation) and/or growth factors (inducing/supporting differentiation). Recently, purinergic P2X and P2Y receptors have been found to significantly influence the osteogenic differentiation process of human mesenchymal stem cells (hMSC). (1) Aim of this work is to develop polysaccharide (PS) composites to be used as scaffolds containing complementary receptor ligands to enable guided stem cell differentiation towards bone formation.

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Document Type:Conference Object
Author:Markus Witzler, Martin Gericke, Thomas Heinze, Patrick Ottensmeyer, Edda Tobiasch, Margit Schulze
Parent Title (English):5th EPNOE International Polysaccharide Conference, 20–24 AUGUST 2017, Jena, Germany. Abstract book
First Page:100
Publication year:2017
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für Technik, Ressourcenschonung und Energieeffizienz (TREE)
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Entry in this database:2017/09/29