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The design of an efficient digital circuit in term of low-power has become a very challenging issue. For this reason, low-power digital circuit design is a topic addressed in electrical and computer engineering curricula, but it also requires practical experiments in a laboratory. This PhD research investigates a novel approach, the low-power design laboratory system by developing a new technical and pedagogical system. The low-power design laboratory system is composed of two types of laboratories: the on-site (hands-on) laboratory and the remote laboratory. It has been developed at the Bonn-Rhine-Sieg University of Applied Sciences to teach low-power techniques in the laboratory. Additionally, this thesis contributes a suggestion on how the learning objectives can be complemented by developing a remote system in order to improve the teaching process of the low-power digital circuit design. This laboratory system enables online experiments that can be performed using physical instruments and obtaining real data via the internet. The laboratory experiments use a Field Programmable Gate Array (FPGA) as a design platform for circuit implementation by students and use image processing as an application for teaching low-power techniques.
This thesis presents the instructions for the low-power design experiments which use a top-down hierarchical design methodology. The engineering student designs his/her algorithm with a high level of abstraction and the experimental results are obtained and measured at a low level (hardware) so that more information is available to correctly estimate the power dissipation such as specification, latency, thermal effect, and technology used. Power dissipation of the digital system is influenced by specification, design, technology used, as well as operating temperature. Digital circuit designers can observe the most influential factors in power dissipation during the laboratory exercises in the on-site system and then use the remote system to supplement investigating the other factors. Furthermore, the remote system has obvious benefits such as developing learning outcomes, facilitating new teaching methods, reducing costs and maintenance, cost-saving by reducing the numbers of instructors, saving instructor time and simplifying their tasks, facilitating equipment sharing, improving reliability, and finally providing flexibility of usage the laboratories.
For many different applications, current information about the bandwidth-related metrics of the utilized connection is very useful as they directly impact the performance of throughput sensitive applications such as streaming servers, IPTV and VoIP applications. In literature, several tools have been proposed to estimate major bandwidth-related metrics such as capacity, available bandwidth and achievable throughput. The vast majority of these tools fall into one of Packet Pair (PP), Variable Packet Size (VPS), Self-Loading of Periodic Streams (SLoPS) or Throughput approaches. In this study, seven popular bandwidth estimation tools including nettimer, pathrate, pathchar, pchar, clink, pathload and iperf belonging to these four well-known estimation techniques are presented and experimentally evaluated in a controlled testbed environment. Differently from the rest of studies in literature, all tools have been uniformly classified and evaluated according to an objective and sophisticated classification and evaluation scheme. The performance comparison of the tools incorporates not only the estimation accuracy but also the probing time and overhead caused.
The nature of the program was an exchange program between Hochschule Bonn-Rhein-Sieg, University of Applied Sciences and the University of Cape Coast. The program was advertised and we applied. We were shortlisted for interview and we were selected as the candidates for the exchange program. The program took a period of five months. We set off from Accra, Ghana to Germany on 7th September 2015, and returned to Ghana on 25th January 2016.
Competency-Based Teaching Using Simulation Exercises: Evidence of the University of Cape Coast
(2018)
Tertiary institutions exist to train manpower to solve local, national, and international problems. Products from such institutions should not be a problem to countries as in the case of some Sub-Saharan African countries including Ghana which has a high level of graduate unemployment. Among the causes of the problem is the nature of teaching or the syllabus or the programs students pursue while in such institutions. The paper discusses one of the teaching strategies used to make a course relevant for a program and for the working world. In this course, students are introduced to practice-oriented learning through simulation exercises. The project activities specifically seek to assess the students’ understanding of business formation; examine students’ understanding of sustainability, creativity and innovation of business ideas; assess their understanding of the functional areas of business including marketing & sales, finance, human resource management, operations, and accounting, among others. Feedback from students who have participated indicates the exercise gave much more exposure and meaning to the concepts they learned in class. In this exercise, students build teams, develop a product, learn to set up a business, and design organogram, business vision, mission, and core values. The exercise empowers students to learn by doing. It accords students the opportunity to review their own knowledge and skills with respect to the concepts they have learned in the course. More than 3000 students have participated in this project since its inception in the academic year 2013/2014. It is estimated that 1000 students will participate in this project in the academic year 2017/2018.
Conclusion
(2018)
There is a paradigm shift from traditional content-based education and training to competencybased and practice-oriented training. This shift has occurred because practice-oriented teaching has been found to produce a training outcome that is industry focused, generating the relevant occupational standards. Competency-based training program often comprises of modules broken into segments called learning outcomes. These learning outcomes are based on criteria set by industry and assessment is designed to ensure students become competent in their respective areas of specialization.
Multidisciplinary, multicultural, and multitasking has taken center stage in the global educational debate. Globalization and improvement in communication have affected the way organisations operate and hence influenced whom they hire. Today, it is common practice to work with people from diverse backgrounds and it requires competencies that go beyond general project management. Intercultural awareness, networking in different global communities, and learning to develop specific communication strategies for different stakeholders is all part of the package of skills and competencies that are required in today's interconnected world. This has indirect implication on the nature of skills and competencies institutions/universities must equip their students with to enable them to compete successfully in the working world.
Estimation of Prediction Uncertainty for Semantic Scene Labeling Using Bayesian Approximation
(2018)
With the advancement in technology, autonomous and assisted driving are close to being reality. A key component of such systems is the understanding of the surrounding environment. This understanding about the environment can be attained by performing semantic labeling of the driving scenes. Existing deep learning based models have been developed over the years that outperform classical image processing algorithms for the task of semantic labeling. However, the existing models only produce semantic predictions and do not provide a measure of uncertainty about the predictions. Hence, this work focuses on developing a deep learning based semantic labeling model that can produce semantic predictions and their corresponding uncertainties. Autonomous driving needs a real-time operating model, however the Full Resolution Residual Network (FRRN) [4] architecture, which is found as the best performing architecture during literature search, is not able to satisfy this condition. Hence, a small network, similar to FRRN, has been developed and used in this work. Based on the work of [13], the developed network is then extended by adding dropout layers and the dropouts are used during testing to perform approximate Bayesian inference. The existing works on uncertainties, do not have quantitative metrics to evaluate the quality of uncertainties estimated by a model. Hence, the area under curve (AUC) of the receiver operating characteristic (ROC) curves is proposed and used as an evaluation metric in this work. Further, a comparative analysis about the influence of dropout layer position, drop probability and the number of samples, on the quality of uncertainty estimation is performed. Finally, based on the insights gained from the analysis, a model with optimal configuration of dropout is developed. It is then evaluated on the Cityscape dataset and shown to be outperforming the baseline model with an AUC-ROC of about 90%, while the latter having AUC-ROC of about 80%.
Sind kleinere und mittlere Unternehmen (KMU) bereits auf die Digitale Transformation vorbereitet?
(2018)
Eine von den Autoren durchgeführte Untersuchung konnte deutliche Indizien dafür ausmachen, dass viele kleinere und mittlere Unternehmen (KMU) aktuell noch keine ausreichende Reife zur Digitalen Transformation haben. Zur Lösung des Problems wird vorgeschlagen, ein agiles IT-Management-Konzept zu entwickeln, um den IT-Bereich dynamisch und ohne formalen Ballast des klassischen IT-Managements zu steuern.
Digitalisierung für kleinere und mittlere Unternehmen (KMU): Anforderungen an das IT-Management
(2018)
Renewable resources gain increasing interest as source for environmentally benign biomaterials, such as drug encapsulation/release compounds, and scaffolds for tissue engineering in regenerative medicine. Being the second largest naturally abundant polymer, the interest in lignin valorization for biomedical utilization is rapidly growing. Depending on resource and isolation procedure, lignin shows specific antioxidant and antimicrobial activity. Today, efforts in research and industry are directed toward lignin utilization as renewable macromolecular building block for the preparation of polymeric drug encapsulation and scaffold materials. Within the last five years, remarkable progress has been made in isolation, functionalization and modification of lignin and lignin-derived compounds. However, literature so far mainly focuses lignin-derived fuels, lubricants and resins. The purpose of this review is to summarize the current state of the art and to highlight the most important results in the field of lignin-based materials for potential use in biomedicine (reported in 2014–2018). Special focus is drawn on lignin-derived nanomaterials for drug encapsulation and release as well as lignin hybrid materials used as scaffolds for guided bone regeneration in stem cell-based therapies.
Antioxidant activity is an essential aspect of oxygen-sensitive merchandise and goods, such as food and corresponding packaging, cosmetics, and biomedicine. Technical lignin has not yet been applied as a natural antioxidant, mainly due to the complex heterogeneous structure and polydispersity of lignin. This report presents antioxidant capacity studies completed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The influence of purification on lignin structure and activity was investigated. The purification procedure showed that double-fold selective extraction is the most efficient (confirmed by ultraviolet-visible (UV/Vis), Fourier transform infrared (FTIR), heteronuclear single quantum coherence (HSQC) and 31P nuclear magnetic resonance spectroscopy, size exclusion chromatography, and X-ray diffraction), resulting in fractions of very narrow polydispersity (3.2⁻1.6), up to four distinct absorption bands in UV/Vis spectroscopy. Due to differential scanning calorimetry measurements, the glass transition temperature increased from 123 to 185 °C for the purest fraction. Antioxidant capacity is discussed regarding the biomass source, pulping process, and degree of purification. Lignin obtained from industrial black liquor are compared with beech wood samples: antioxidant activity (DPPH inhibition) of kraft lignin fractions were 62⁻68%, whereas beech and spruce/pine-mixed lignin showed values of 42% and 64%, respectively. Total phenol content (TPC) of the isolated kraft lignin fractions varied between 26 and 35%, whereas beech and spruce/pine lignin were 33% and 34%, respectively. Storage decreased the TPC values but increased the DPPH inhibition.
Antioxidant activity is an essential feature required for oxygen-sensitive merchandise and goods, such as food and corresponding packaging as well as materials used in cosmetics and biomedicine. For example, vanillin, one of the most prominent antioxidants, is fabricated from lignin, the second most abundant natural polymer in the world. Antioxidant potential is primarily related to the termination of oxidation propagation reactions through hydrogen transfer. The application of technical lignin as a natural antioxidant has not yet been implemented in the industrial sector, mainly due to the complex heterogeneous structure and polydispersity of lignin. Thus, current research focuses on various isolation and purification strategies to improve the compatibility of lignin material with substrates and enhancing its stabilizing effect.
Once aberrantly activated, the Wnt/βcatenin pathway may result in uncontrolled proliferation and eventually cancer. Efforts to counter and inhibit this pathway are mainly directed against βcatenin, as it serves a role on the cytoplasm and the nucleus. In addition, speciallygenerated lymphocytes are recruited for the purpose of treating liver cancer. Peripheral blood mononuclear lymphocytes are expanded by the timely addition of interferon γ, interleukin (IL)1β, IL2 and anticluster of differentiation 3 antibody. The resulting cells are called cytokineinduced killer (CIK) cells. The present study utilised these cells and combine them with drugs inhibiting the Wnt pathway in order to examine whether this resulted in an improvement in the killing ability of CIK cells against liver cancer cells. Drugs including ethacrynic acid (EA) and ciclopirox olamine (CPX) were determined to be suitable candidates, as determined by previous studies. Drugs were administered on their own and combined with CIK cells and then a cell viability assay was performed. These results suggest that EAtreated cells demonstrated apoptosis and were significantly affected compared with untreated cells. Unlike EA, CPX killed normal and cancerous cells even at low concentrations. Subsequent to combining EA with CIK cells, the potency of killing was increased and a greater number of cells died, which proves a synergistic action. In summary, EA may be used as an antihepatocellular carcinoma drug, while CPX possesses a high toxicity to cancerous as well as to normal cells. It was proposed that EA should be integrated into present therapeutic methods for cancer.
BWL kompakt für Dummies
(2018)
"BWL kompakt für Dummies" bietet Ihnen eine verständliche Einführung in die Betriebswirtschaftslehre, egal ob Sie sie für die Aus- oder Weiterbildung brauchen oder sich einfach schlau machen wollen. Tobias Amely stellt Ihnen die wesentlichen Elemente und Grundbegriffe der Betriebswirtschaftslehre vor und zeigt die Bezüge zur Unternehmenspraxis auf: Materialwirtschaft, Leistungsbereitstellung und Produktion, Marketing, Investition und Finanzierung, Unternehmensorganisation und -führung, Rechnungswesen und Controlling.
BWL-Formeln für Dummies
(2018)
Können Sie sich auch Formeln so schlecht merken? Das ist mit diesem handlichen Nachschlagewerk auch gar nicht mehr nötig! Der Autor des Bestsellers "BWL für Dummies" Tobias Amely hat für Sie die wichtigsten BWL-Formeln zusammengestellt. Zu jeder Formel finden Sie auch gleich ein anschauliches Beispiel, wie sie eingesetzt wird und eine Erklärung, wofür man sie eigentlich braucht. "BWL-Formeln für Dummies" ist also viel mehr als eine reine Auflistung von Formeln.
Investition und Finanzierung sind wichtige Themen in der Unternehmenspraxis und im Studium der Betriebswirtschaftslehre. Dieses Buch führt Sie anhand anschaulicher Beispiele in die Grundlagen des Themas ein und zeigt die Ziele finanzwirtschaftlichen Handelns auf. Tobias Amely und Christine Immenkötter zeigen Ihnen die Grundzüge der Finanzwirtschaft und stellen Ihnen die wichtigsten Instrumente sowohl der Außen- und Innenfinanzierung als auch des Finanzmanagements vor. Lernen Sie die statische und dynamische Investitionsrechnung kennen und erfahren Sie, was man über Investitionen in Wertpapiere wissen muss. So liefert Ihnen dieses Buch im bewährten ... für Dummies-Stil einen guten und leicht verständlichen Überblick über alle wichtigen Themen der Investition und Finanzierung. (Verlagsangaben)
The exchange program was aimed at giving students an international exposure through teaching and intercultural communication and to also enhance the existing relationship among the partner schools. The program lasted for a period of six months from September 2016 to February 2017. The main part of the program was the International Management program which comprised of four courses. The program offered us an opportunity to travel to four European countries to broaden our academic and social network.
I had an opportunity to visit Germany in 2016/2017 during which period I was on an exchange staff program between the University of Nairobi, Hochschule Bonn-Rhein-Sieg, University of Applied Sciences, Germany, and the University of Cape Coast, Ghana. My visit took me to the city of Bonn where the University of Bonn-Rhein-Sieg is located in the suburban area in the cities of Sankt Augustin, Rheinbach, and Hennef. I was able to interact with faculty members and students. During this period, the discussion I had with faculty mainly focused on various programs offered by the university and how they have been able to interact and partner with the industry and create linkages with various firms in Germany. It emerged from our discussion that the development of the curriculum by the university depends on such partnerships.
Evolutionary conservation of the antimicrobial function of mucus: a first defence against infection
(2018)
Mucus layers often provide a unique and multi-functional hydrogel interface between the epithelial cells of organisms and their external environment. Mucus has exceptional properties including elasticity, changeable rheology and an ability to self-repair by reannealing, and is therefore an ideal medium for trapping and immobilising pathogens and serving as a barrier to microbial infection. The ability to produce a functional surface mucosa was an important evolutionary step, which evolved first in the Cnidaria, which includes corals, and the Ctenophora. This allowed the exclusion of non-commensal microbes and the subsequent development of the mucus-lined digestive cavity seen in higher metazoans. The fundamental architecture of the constituent glycoprotein mucins is also evolutionarily conserved. Although an understanding of the biochemical interactions between bacteria and the mucus layer are important to the goal of developing new antimicrobial strategies, they remain relatively poorly understood. This review summarises the physicochemical properties and evolutionary importance of mucus, which make it so successful in the prevention of bacterial infection. In addition, the strategies developed by bacteria to counteract the mucus layer are also explored.
The formulation of transport network problems is represented as a translation between two domain specific languages: from a network description language, used by network simulation community, to a problem description language, understood by generic non-linear solvers. A universal algorithm for this translation is developed, an estimation of its computational complexity given, and an efficient application of the algorithm demonstrated on a number of realistic examples. Typically, for a large gas transport network with about 10K elements the translation and solution of non-linear system together require less than 1 sec on the common hardware. The translation procedure incorporates several preprocessing filters, in particular, topological cleaning filters, which accelerate the solution procedure by factor 8.
Umwelt: Technologien, um die Folgen des Klimawandels zu begrenzen, gibt es. Die soziale und politische Dimension ist der Hemmschuh, so dass sie teils nur zögernd zum Einsatz kommen.
Die Redaktion der VDI nachrichten betreute drei Studierende, die aktuell von jedem Vortrag einen Artikel für unser Ingenieurportal www.ingenieur.de schrieben sowie eine Meldung für die VDI-nachrichten-E-Paper-App. Dieser Artikel ist das Resümee der drei zur Ringvorlesung, aber keine inhaltlich komplette Zusammenfassung. Alle Artikel lesen Sie online unter: www.ingenieur.de/Ringvorlesung2018
ICT has traditionally been a hostile territory for women. In information societies, this implies a drastic reduction in opportunities and autonomy for women. In emergent economies, the situation is even worse due to women’s subordinate status in society and little research regarding the intersection between gender and the digital divide. Such is the case in Latin America. In light of this, the purpose of this essay is to introduce a first comprehensive review of the few studies made in Latin America, against the background of the history of women’s digital exclusion. Based on a review of literature, we identify the main causes for women’s digital exclusion in the region and talk about the prospects for development of gender policies in the BRICS countries (Brazil, Russia, India, China and South Africa). We conclude that what this group of countries may achieve in regard to gender equality, will mark the future of the world. The aim of this essay is to make a call for the creation of inter - national research networks and propose the BRICS as host for these efforts, as they combine characteristics that will make them leaders of change in vast regions.
Due to regionalization and global competition, many companies have turned their attention to other markets outside the domestic ones in anticipation of securing profitable market(s) for their products. Cormart (Nigeria) Limited is one of such companies, seeking to expand beyond its domestic borders. Cormart is a Nigerian trading company specializing in Industrial Raw Materials and Chemicals. It represents the business interests of top Multinational Companies that wish to do business in Nigeria. In line with its expansion strategy, Cormart seeks to introduce its newly developed spray starch product (RENEW) into the Ghanaian market.
Analytical redundancy relations are fundamental in model-based fault detection and isolation. Their numerical evaluation yields a residual that may serve as a fault indicator. Considering switching linear time-invariant system models that use ideal switches, it is shown that analytical redundancy relations can be systematically deduced from a diagnostic bond graph with fixed causalities that hold for all modes of operation. Moreover, as to a faultless system, the presented bond graph–based approach enables to deduce a unique implicit state equation with coefficients that are functions of the discrete switch states. Devices or phenomena with fast state transitions, for example, electronic diodes and transistors, clutches, or hard mechanical stops are often represented by ideal switches which give rise to variable causalities. However, in the presented approach, fixed causalities are assigned only once to a diagnostic bond graph. That is, causal strokes at switch ports in the diagnostic bond graph reflect only the switch-state configuration in a specific system mode. The actual discrete switch states are implicitly taken into account by the discrete values of the switch moduli. The presented approach starts from a diagnostic bond graph with fixed causalities and from a partitioning of the bond graph junction structure and systematically deduces a set of equations that determines the wanted residuals. Elimination steps result in analytical redundancy relations in which the states of the storage elements and the outputs of the ideal switches are unknowns. For the later two unknowns, the approach produces an implicit differential algebraic equations system. For illustration of the general matrix-based approach, an electromechanical system and two small electronic circuits are considered. Their equations are directly derived from a diagnostic bond graph by following causal paths and are reformulated so that they conform with the matrix equations obtained by the formal approach based on a partitioning of the bond graph junction structure. For one of the three mode-switching examples, a fault scenario has been simulated.
Here, we present a miR mechanism which is active in the nucleus and is essential for the production of intron included, C-terminal truncated and biologically active proteins, like e.g. Vim3. We exemplified this mechanism by miRs, miR-15a and miR-498, which are overexpressed in clear cell renal carcinoma or oncocytoma. Both miRs directly interact with DNA in an intronic region, leading to transcriptional stop, and therefore repress the full length version of the pre-mRNA, resulting in intron included truncated proteins (Mxi-2 and Vim3). A computational survey shows that this miR:DNA interactions mechanism may be generally involved in regulating the human transcriptome, with putative interaction sites in intronic regions for over 1000 genes. In this work, an entirely new mechanism is revealed how miRs can repress full length protein translation, resulting in C-terminal truncated proteins.
Softwarenutzung im Umbruch: Von der Software-Lizenz zum Cloudbasierten Business Process Outsourcing
(2018)
This Business English course in entrepreneurship goes beyond communicative language instruction and offers a course designed to introduce students to innovative thinking, entrepreneurship and sustainable business practices. About 120 students in their first year are enrolled as part of the required foreign language module in Business Management (B.Sc.). Each week students learn new concepts and terminology in sustainable business practices while applying the material in a simulation task-based course using English as a lingua franca. It prepares students to work in an international context while offering online components for autonomous learning. This 12-14 week course is designed in a student-centered and blended learning format with a flipped classroom approach. Through a grant from the German Federal Ministry of Education and Research the “work&study project” will offer additional online materials by developing new educational apps to enhance autonomous language learning and making the app content available under the Creative Commons license. The research project focuses on offering new learning environments to enhance the opportunities for non-traditional students enrolled at Bonn-Rhein-Sieg University of Applied Sciences. This paper will focus on the development of the first apps and results of the first testing phase. It shows how game-based learning and elements of gamification were added for educational purposes to enhance teaching and learning processes that were already well established.
The curricula of all degree programs at H-BRS have many different practice-oriented activities and focus on hands-on learning. In labs and small classrooms (30–60 persons), students get a personalized learning environment which is complemented with many individual and group projects that foster collaborative work situations. There are several main areas that students learn from working with industry, local organizations or public institutions.
The most prominent education reform in Europe started in Bologna, Italy, in 1999, when the European Ministers responsible for higher education met to set the foundation for the European Higher Education Area (EHEA). The following process to reform and unify higher education and its systems in Europe is therefore known as the Bologna Process.
Telecollaborating and communicating in online contexts using English as a Lingua Franca (ELF) requires students to develop multiple literacies in addition to foreign language skills and intercultural communicative competence. This chapter looks at the intersection of technology and teaching ELF, examining mutual contributions of technologies, more specifically Web 2.0, and ELF to each other, and the challenges in designing and implementing collaboration projects across cultures. Moreover, it looks at how the development of digital competencies in ELF (DELF) can be enhanced through the implementation of Web 2.0 mediated intercultural dialogues. The detail of the research design including internet tools used, participants and tasks are also discussed. Data analysis points to a positive attitude towards telecollaboration, also providing confirmation of some of the problems identified in theoretical framework, such as different levels of personal engagement.
Technische Innovationen verändern den Alltag enorm – auch den von Journalisten. Technik-Fachjournalisten sind daher gefragt wie nie. Was sie können müssen, wie in den Medien über Digitalisierung berichtet wird und inwiefern künstliche Intelligenz (KI) Journalisten in Zukunft überflüssig machen wird, beantwortet der Medienwissenschaftler Andreas Schümchen im Gespräch mit dem "Fachjournalist".
Die im Jahre 2013 begonnene Workshop-Reihe „Usability in der betrieblichen Praxis“ auf der Mensch und Computer wird mit diesem Workshop als Aktivität des Mittelstand 4.0-Kompetenzzentrums Usability des BMWi fortgesetzt. Unter dem Stichwort „Digitalisierung“ ergeben sich neue Herausforderungen der Umsetzung von Usability und positiver User Experience (UUX) in der betrieblichen Praxis kleiner und mittelständischer Unternehmen (UUX-Praxis). Diese werden in vier Schwerpunktthemen im Workshop behandelt: „UUX - Erfolgsfaktor für Innovation und Zukunft der Arbeit“, „UUX und digitale Nutzerforschung“, „UUX und Agilität“ sowie „UUX - Unterstützung mittelständischer Unternehmensnetzwerke“. Der Workshop richtet sich an Entwicklungs- und UUX-Praktiker aus Softwareentwicklungs-, Anwendungs- und UUX-Beratungsunternehmen sowie Wissenschaftler, die sich mit Umsetzung der UUX-Praxis in Unternehmen beschäftigen.
Innovative Technologien, veränderte Anbieterstrukturen, stets neue Leistungsangebote und wandelnde Kundenanforderungen prägen und verändern von Beginn an das Erscheinungsbild des TK-Marktes. Unter Berücksichtigung einer Betrachtung im Zeitablauf lässt sich der Markt in drei aufeinanderfolgende Phasen einteilen: 1. Marktöffnung, 2. Konsolidierung und Optimierung, 3. Automatisierung. Die Phasen sind selbstverständlich nicht Überschneidungsfrei, geben jedoch einen Hinweis auf die strukturellen Veränderungen des Marktes.
Amaç: Keton cisim oluşumu (ketogenez) bozuklukları; mitokondriyel 3-hidroksi-3metil glutaril CoA sentaz (Mhs) ve 3-hidroksi-3-metil glutaril CoA liyaz (HL) enzim eksiklikleri sonucu oluşur. Keton cisim yıkımı (ketoliz) bozuklukları ise suksinil CoA: 3 oksoasit CoA transferaz (SCOT) ve asetoasetil CoA thiolaz-beta ketotiolaz (MAT) enzim eksiklikleri sonucu oluşmaktadır. Keton metabolizma bozukluğu tanısıyla izlenen hastaların klinik ve laboratuvar bulguları ile değerlendirilmesi amaçlandı.
Yöntem: Keton metabolizması bozukluğu tanısıyla izlenen hasta verileri retrospektif olarak incelendi.
Bulgular: Dört hastada HL eksikliği, 3 hastada MAT eksikliği ve 2 hastada SCOT eksikliği tanısı mevcuttu. Hastaların ortanca yaşı 5 yıl (6 ay-15,5 yıl), ilk metabolik dekompanzasyon atak yaşı ortalama 7,7 ay (22 gün-19 ay) idi. MAT eksikliği olan bir hasta, kardeş taraması ile asemptomatik dönemde tanı aldı. İki hastada spastik tetraparezi gibi ağır nörolojik defisit gelişti. Dekompanzasyon ataklarının beslenememe, kusma ve gastroenterit gibi infeksiyon sonrası geliştiği görüldü.
Sonuç: Açıklanamayan metabolik asidoz atakları durumunda keton metabolizma bozuklukları akılda tutulmalıdır. Akut dekompanzasyon değişik yaşlarda ortaya çıkabilir, klinik şiddeti değişken olabilir. Erken tanı ve uygun tedavi mortalite ve morbidite açısından çok önemlidir.
Further development on globally convergent algorithms for solution of stationary network problems is presented. The algorithms make use of global non-degeneracy of Jacobi matrix of the system, composed of Kirchhoff's flow conservation conditions and transport element equations. This property is achieved under certain monotonicity conditions on element equations and guarantees an existence of a unique solution of the problem as well as convergence to this solution from an arbitrary starting point. In application to gas transport networks, these algorithms are supported by a proper modeling of gas compressors, based on individually calibrated physical characteristics. This paper extends the modeling of compressors by hierarchical methods of topological reduction, combining the working diagrams for parallel and sequential connections of compressors. Estimations are also made for application of topological reduction methods beyond the compressor stations in generic network problems. Efficiency of the methods is tested by numerical experiments on realistic networks.
In the context of the Franco-German research project Re(h)strain, this work focuses on a global system analysis integrating both safety and security analysis of international and/or urban railway stations. The Re(h)strain project focuses on terrorist attacks on high speed train systems and investigates prevention and mitigation measures to reduce the overall vulnerability and strengthen the system resilience. One main criterion regarding public transport issues is the number of passengers. For example, the railway station of Paris “Gare du Nord” deals with a bigger number of passengers than the biggest airport in the world (SNCF open Data 2014), the Atlanta airport, but in terms of passengers, it is only around the 23rd rank railway station in the world. Due to the enormous mass of people, this leads to the system approach of breaking out the station into several classes of zones, e.g. entrance, main hall, quays, trains, etc. All classes are analysed considering state-of-the-art parameters, like targets attractiveness, feasibility of attack, possible damage, possible mitigation and defences. Then, safety incidence of security defence is discussed in order to refine security requirement with regard to the considered zone. Finally, global requirements of security defence correlated to the corresponding class of zones are proposed.
The Fragile X Syndrome (FXS) is one of the most common forms of inherited intellectual disability in all human societies. Caused by the transcriptional silencing of a single gene, the fragile x mental retardation gene FMR1, FXS is characterized by a variety of symptoms, which range from mental disabilities to autism and epilepsy. More than 20 years ago, a first animal model was described, the Fmr1 knock-out mouse. Several other models have been developed since then, including conditional knock-out mice, knock-out rats, a zebrafish and a drosophila model. Using these model systems, various targets for potential pharmaceutical treatments have been identified and many treatments have been shown to be efficient in preclinical studies. However, all attempts to turn these findings into a therapy for patients have failed thus far. In this review, I will discuss underlying difficulties and address potential alternatives for our future research.
Gesellschaftliche Verantwortung von Familienunternehmen – theoretische Zusammenhänge und Messung
(2018)
Variable Sterne sind Sterne, welche in bestimmten Messparametern variabel sind. In unserem Fall ist dies die Helligkeit der Sterne. Grundsätzlich gibt es hier zwei Arten der Variabilität, intrinsiche und extrinsische Prozesse. Unter intrinischen Prozessen versteht man Variabilität, deren Ursache im Stern selbst liegt.
This policy brief is part of a wider research project entitled ‘Building the Economic Case for Investments in Social Protection’. The research aims at demonstrating the potential impacts of social protection on inclusive growth. The project is a collaborative effort between the Maastricht Graduate School of Governance at the University of Maastricht and United Nations University-MERIT, NL; the Global Development Institute at the University of Manchester, UK; the School of Social Science at the University of Makerere, Uganda; and the Expanding Social Protection Programme of the Ugandan Ministry of Gender, Labour and Social Development. This project is part of the research agenda of the Knowledge Platform Inclusive Development Policies and funded by the Ministry of Foreign Affairs of the Netherlands through the NWO-WOTRO programme.
Anne Dreller shows that data sharing offers great opportunities and huge value creation potential for the business world. Despite many opportunities that data sharing promises, the business world has not fully operationalized this fact yet, due to various existing challenges. Thus, an exemplary, future-oriented, and platform-based data sharing business model is developed for the startup Quemey. This business model is also equipped with prioritized implementation advice, including measures like focusing on strong values for all platform participants, growing their business into a powerful monopolist position, and eliminating barriers of technological, contractual and legal or data privacy uncertainties.
A Method for the Sustainable Documentation of Operations Processes in Parcel Distribution Centers
(2018)
There is often no common understanding on operational processes in logistics companies as they are not properly documented. Hence, people execute the same process differently and training is conducted by experienced operators on an ad-hoc basis. Furthermore, continuous process improvement is hampered as neither the ideal process nor current issues in as-is processes are visible. A major reason for the missing documentation is the complexity of existing business process modelling languages. Modelling experts are required for initially describing the processes and also for updating the models after process changes. Furthermore, operations people are usually not used to read complex process models in EPCs or BPMN diagrams. In order to overcome these limitations, a domain-specific modelling language which facilitates maintaining up-to-date process models has been designed with a large logistics company in Germany. The paper at hand briefly describes this language and illustrates the method on how to apply it in operations environments.
Persons with disabilities have much lower employment rates than the population as a whole and are at a significantly higher risk of living in poverty (OECD, 2011, pp. 50-56 and WHO, 2011, pp. 237-239). However, many of the barriers people with disabilities face, with regards to labor market reintegration, are in fact avoidable. There has for quite some time been evidence that differences in employment and wages, between disabled and non-disabled workers, can only to a limited extent be explained by differences in human capital endowments and productivity (Kidd, Sloane, & Ferko, 2000). Instead, factors such as the absence of access to education and training, and the lack of financial assistance provided are actually significant drivers of labor market exclusion (OECD, 2009, p.15; WHO, 2011, p.239).
Die Diskussion um die Nachhaltigkeit von Dienstleistungen im öffentlichen Sektor steht in einem engen Zusammenhang mit der Frage, ob sich der Einsatz finanzieller Mittel für die Beteiligten lohnt. Daher besteht ein breites Interesse, herauszufinden, ob der Nutzen von Rehabilitationsarbeit auch finanziell messbar ist, und falls ja, wie hoch das ökonomische Potential der Investitionen ist. Um diese Frage zu beantworten, ist es notwendig Leistungen sowie die dadurch anfallenden Ausgaben statistisch zu erfassen und in einem ökonomischen Modell zu bewerten.
This paper introduces a random number generator (RNG) based on the avalanche noise of two diodes. A true random number generator (TRNG) generates true random numbers with the use of the electronic noise produced by two avalanche diodes. The amplified outputs of the diodes are sampled and digitized. The difference between the two concurrently sampled and digitized outputs is calculated and used to select a seed and to drive a pseudo-random number generator (PRNG). The PRNG is an xorshift generator that generates 1024 bits in each cycle. Every sequence of 1024 bits is moderately modified and output. The TRNG delivers the next seed and the next cycle begins. The statistical behavior of the generator is analyzed and presented.
Project Overview
(2018)
The project "German-African University Partnership Platform for the Development of Entrepreneurs and Small/Medium Enterprises" started in 2015 within the framework of the program "University-Business-Partnerships between Higher Education Institutions and Business Partners in Germany and in Developing Countries", funded by the German Ministry of Economic Cooperation and Development (BMZ), and the German Academic Exchange Service (DAAD). It is carried out by Hochschule Bonn-Rhein-Sieg, University of Applied Sciences in Germany (H-BRS), the University of Cape Coast (UCC) in Ghana, and the University of Nairobi (UoN) in Kenya.
Argentina substantially contributes to the global organic agriculture and food sector due to its large areas of organically managed agricultural land. However, most of the organic production is intended for export. Overall, food supply for the domestic organic market is hardly tapped. Based on this, we investigate the current importance of organic agriculture and food production as well as consumption attitudes and behavior within the country. The novelty of the study also lies in the observation, documentation and analysis of latest stakeholder‐driven developments towards organic agriculture and food. Furthermore, the publication allows the Argentinean organic market to be significantly more visible for the international audience.
The Life Cycle Assessment (LCA) approach is the most important tool in the evaluation of environmental (sustainability) impacts of products and processes. We used the method to conduct an impact analysis with regard to raw material inputs (pulp) for the German paper production industry. In our analysis, we compare the environmental effects of primary sulphate pulp, scrap paper pulp and grass-based pulp and estimate their impacts in the impact categories "greenhouse gas emissions", "eutrophication" as well as "energy and water consumption". Furthermore, we discuss the opportunities of the methodical approach and some general problems and limits of the application of a LCA. In conclusion, we found environmental advantages for the use of grass as an alternative resource in the German paper production industry, especially in the fields of transport and water consumption.
Design optimization techniques are often used at the beginning of the design process to explore the space of possible designs. In these domains illumination algorithms, such as MAP-Elites, are promising alternatives to classic optimization algorithms because they produce diverse, high-quality solutions in a single run, instead of only a single near-optimal solution. Unfortunately, these algorithms currently require a large number of function evaluations, limiting their applicability. In this article we introduce a new illumination algorithm, Surrogate-Assisted Illumination (SAIL), that leverages surrogate modeling techniques to create a map of the design space according to user-defined features while minimizing the number of fitness evaluations. On a two-dimensional airfoil optimization problem SAIL produces hundreds of diverse but high-performing designs with several orders of magnitude fewer evaluations than MAP-Elites or CMA-ES. We demonstrate that SAIL is also capable of producing maps of high-performing designs in realistic three-dimensional aerodynamic tasks with an accurate flow simulation. Data-efficient design exploration with SAIL can help designers understand what is possible, beyond what is optimal, by considering more than pure objective-based optimization.
Surrogate-assistance approaches have long been used in computationally expensive domains to improve the data-efficiency of optimization algorithms. Neuroevolution, however, has so far resisted the application of these techniques because it requires the surrogate model to make fitness predictions based on variable topologies, instead of a vector of parameters. Our main insight is that we can sidestep this problem by using kernel-based surrogate models, which require only the definition of a distance measure between individuals. Our second insight is that the well-established Neuroevolution of Augmenting Topologies (NEAT) algorithm provides a computationally efficient distance measure between dissimilar networks in the form of "compatibility distance", initially designed to maintain topological diversity. Combining these two ideas, we introduce a surrogate-assisted neuroevolution algorithm that combines NEAT and a surrogate model built using a compatibility distance kernel. We demonstrate the data-efficiency of this new algorithm on the low dimensional cart-pole swing-up problem, as well as the higher dimensional half-cheetah running task. In both tasks the surrogate-assisted variant achieves the same or better results with several times fewer function evaluations as the original NEAT.
Social Assistance
(2018)
If the first Sustainable Development Goal (SDG) to “End poverty in all its forms everywhere” is to be taken seriously, most low- and middle-income countries face a huge challenge. An estimated 1 billion people have indeed escaped extreme poverty since the early 1990s, and the global poverty rate fell from 35% in 1990 to 10.7% in 2013, but the absolute number of people living below the international poverty line of $1.90 at purchasing power parity has hardly changed. Countries in Asia contributed greatly to the overall decline in poverty rates: from 2012 to 2013, over 100 million people in Asia left extreme poverty behind, notably in India, Indonesia, and the People’s Republic of China (PRC) (World Bank 2016). Yet the living standards of those still below that line have hardly improved (Ravallion 2016). The achievement of the first SDG requires additional efforts at global and national levels, particularly on policies that address chronic poverty traps and that improve the outcomes of poor and vulnerable populations.
This policy brief investigates the costs of child poverty in the Balkans, including deprivation in terms of education, health, and social mobility. It then lays out the potential of social protection, most notably in terms of building resilence and fostering development. Set against recent case studies from around the world, including Cambodia and Uganda, the brief gives policy recommendations on various critical issues including transfer schemes, transformative measures, and (alternative) care for children with disabilities.
Mehr machen, weniger planen!
(2018)
Im Zusammenhang mit der Rhythmisierung des Schulalltags spielen Pausen eine wichtige Rolle. Dass Pausen für die Regeneration und Wiederherstellung der Leistungsfähigkeit bedeutsam sind, scheint allgemein anerkannt. Die Autoren fassen im folgenden Beitrag zusammen, welche wissenschaftlichen Erkenntnisse es über die Effekte der Gestaltung und der Dauer von Pausen gibt.
The main objective of this chapter is to give insights into how H-BRS as a German University of Applied Sciences supports small and medium-sized enterprises (SMEs) in exploring African markets. The university achieves this objective by engaging its Bachelor and Master level students in applied market research. Students engage in this research as part of their final thesis writing. This chapter lays out a process for successful marketing research projects for German SMEs in nine steps.
Internships and professional experience are becoming more and more important requisites for students and graduates and are almost taken for granted by many HR officials. In opposition to this, many newly created Bachelor and Master programmes make it difficult for students to integrate internships into their studies without having to add another semester and thereby "losing" valuable time. This becomes all the more relevant with private universities or universities generally that charge considerable tuition fees.
Kontemporäre Service-orientierte Systeme sind hochgradig vernetzt und haben zudem die Eigenschaft massiv-skalierbar zu sein. Diese Charakteristiken stellen im besonderen Maße Anforderungen an die Datensicherheit der Anwender solcher Systeme und damit primär an alle Stakeholder der Softwareentwicklung, die in der Verantwortung sind, passgenaue Sicherheitsmechanismen effektiv in die Softwareprodukte zu bringen. Die Effektivität von Sicherheitsarchitekturen in service-orientierten Systemen hängt maßgeblich von der richtigen Nutzung und Integration von Security-APIs durch eine heterogene Gruppe von Softwareentwicklern ab, bei der nicht per se ein fundiertes Hintergrundwissen über komplexe digitale Sicherheitsmechanismen vorausgesetzt werden kann. Die Diskrepanz zwischen komplexen und in der Anwendung fehleranfälligen APIs und einem fehlenden Verständnis für die zugrundeliegenden Sicherheitskonzepte auf Seiten der Nutzer begünstigt in der Praxis unsichere Softwaresysteme. Aus diesem Grund ist die Gebrauchstauglichkeit von Security-APIs besonders relevant, damit Programmierer den benötigten Funktionsumfang effektiv, effizient und zufriedenstellend verwenden können. Abgeleitet von dieser Problemstellung, konzentriert sich das Dissertationsvorhaben auf die gebrauchstaugliche Ausgestaltung von Security-APIs und den Herausforderungen die sich aus den Methoden zur Evaluation der Usability in typischen Umgebungen der Softwareentwicklung ergeben.
Cryptographic API misuse is responsible for a large number of software vulnerabilities. In many cases developers are overburdened by the complex set of programming choices and their security implications. Past studies have identified significant challenges when using cryptographic APIs that lack a certain set of usability features (e.g. easy-to-use documentation or meaningful warning and error messages) leading to an especially high likelihood of writing functionally correct but insecure code.
To support software developers in writing more secure code, this work investigates a novel approach aimed at these hard-to-use cryptographic APIs. In a controlled online experiment with 53 participants, we study the effectiveness of API-integrated security advice which informs about an API misuse and places secure programming hints as guidance close to the developer. This allows us to address insecure cryptographic choices including encryption algorithms, key sizes, modes of operation and hashing algorithms with helpful documentation in the guise of warnings. Whenever possible, the security advice proposes code changes to fix the responsible security issues. We find that our approach significantly improves code security. 73% of the participants who received the security advice fixed their insecure code.
We evaluate the opportunities and challenges of adopting API-integrated security advice and illustrate the potential to reduce the negative implications of cryptographic API misuse and help developers write more secure code.
Software development is a complex task. Merely focussing on functional requirements is not sufficient any more. Developers are responsible to take many non-functional requirements carefully into account. Security is amongst the most challenging, as getting it wrong will result in a large user-base being potentially at risk. A similar situation exists for administrators. Security defaults have been put into place here to encounter lacking security controls. As first attempts to establish security by default in software development are flourishing, the question on their usability for developers arises.
In this paper we study the effectiveness and efficiency of Content Security Policy (CSP) enforced as security default in a web framework. When deployed correctly, CSP is a valid protection mean in a defence-in-depth strategy against code injection attacks. In this paper we present a first qualitative laboratory study with 30 participants to discover how developers deal with CSP when deployed as security default. Our results emphasize that the deployment as security default has its benefits but requires careful consideration of a comprehensive information flow in order to improve and not weaken security. We provide first insights to inform research about aiding developers in the creation of secure web applications with usable security by default.
Evaluation is of crucial importance and should meet professional standards in its design. In practice, organizational peculiarities and available resources characterize the search for the "right" approach. When used as a quality development tool, internal or self-evaluation should primarily be useful. It should generate information to answer organizational questions and provide results as a basis for discussion in decision-making processes.
One of the main aims of current social robotic research is to improve the robots’ abilities to interact with humans. In order to achieve an interaction similar to that among humans, robots should be able to communicate in an intuitive and natural way and appropriately interpret human affects during social interactions. Similarly to how humans are able to recognize emotions in other humans, machines are capable of extracting information from the various ways humans convey emotions-including facial expression, speech, gesture or text-and using this information for improved human computer interaction. This can be described as Affective Computing, an interdisciplinary field that expands into otherwise unrelated fields like psychology and cognitive science and involves the research and development of systems that can recognize and interpret human affects. To leverage these emotional capabilities by embedding them in humanoid robots is the foundation of the concept Affective Robots, which has the objective of making robots capable of sensing the user’s current mood and personality traits and adapt their behavior in the most appropriate manner based on that. In this paper, the emotion recognition capabilities of the humanoid robot Pepper are experimentally explored, based on the facial expressions for the so-called basic emotions, as well as how it performs in contrast to other state-of-the-art approaches with both expression databases compiled in academic environments and real subjects showing posed expressions as well as spontaneous emotional reactions. The experiments’ results show that the detection accuracy amongst the evaluated approaches differs substantially. The introduced experiments offer a general structure and approach for conducting such experimental evaluations. The paper further suggests that the most meaningful results are obtained by conducting experiments with real subjects expressing the emotions as spontaneous reactions.