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Machine learning-based solutions are frequently adapted in several applications that require big data in operations. The performance of a model that is deployed into operations is subject to degradation due to unanticipated changes in the flow of input data. Hence, monitoring data drift becomes essential to maintain the model’s desired performance. Based on the conducted review of the literature on drift detection, statistical hypothesis testing enables to investigate whether incoming data is drifting from training data. Because Maximum Mean Discrepancy (MMD) and Kolmogorov-Smirnov (KS) have shown to be reliable distance measures between multivariate distributions in the literature review, both were selected from several existing techniques for experimentation. For the scope of this work, the image classification use case was experimented with using the Stream-51 dataset. Based on the results from different drift experiments, both MMD and KS showed high Area Under Curve values. However, KS exhibited faster performance than MMD with fewer false positives. Furthermore, the results showed that using the pre-trained ResNet-18 for feature extraction maintained the high performance of the experimented drift detectors. Furthermore, the results showed that the performance of the drift detectors highly depends on the sample sizes of the reference (training) data and the test data that flow into the pipeline’s monitor. Finally, the results also showed that if the test data is a mixture of drifting and non-drifting data, the performance of the drift detectors does not depend on how the drifting data are scattered with the non-drifting ones, but rather their amount in the test set
Trueness and precision of milled and 3D printed root-analogue implants: A comparative in vitro study
(2023)
When dialogues with voice assistants (VAs) fall apart, users often become confused or even frustrated. To address these issues and related privacy concerns, Amazon recently introduced a feature allowing Alexa users to inquire about why it behaved in a certain way. But how do users perceive this new feature? In this paper, we present preliminary results from research conducted as part of a three-year project involving 33 German households. This project utilized interviews, fieldwork, and co-design workshops to identify common unexpected behaviors of VAs, as well as users’ needs and expectations for explanations. Our findings show that, contrary to its intended purpose, the new feature actually exacerbates user confusion and frustration instead of clarifying Alexa's behavior. We argue that such voice interactions should be characterized as explanatory dialogs that account for VA’s unexpected behavior by providing interpretable information and prompting users to take action to improve their current and future interactions.
ENaC channels
(2023)
RELA haploinsufficiency is a recently described autoinflammatory condition presenting with intermittent fevers and mucocutaneous ulcerations. The RELA gene encodes the p65 protein, one of five NF-κB family transcription factors. As RELA is an essential regulator of mucosal homeostasis, haploinsufficiency leads to decreased NF-κB signaling which promotes TNF-driven mucosal apoptosis with impaired epithelial recovery. Thus far, only eight cases have been reported in the literature. Here, we report four families with three novel and one previously described pathogenic variant in RELA. These four families included 23 affected individuals for which genetic testing was available in 16. Almost half of these patients had been previously diagnosed with more common rheumatologic entities (such as Behcet's Disease; BD) prior to the discovery of their pathogenic RELA variants. The most common clinical features were orogenital ulcers, rash, joint inflammation, and fever. The least common were conjunctivitis and recurrent infections. Clinical variability was remarkable even among familial cases, and incomplete penetrance was observed. Patients in our series were treated with a variety of medications, and benefit was observed with glucocorticoids, colchicine, and TNF inhibitors. Altogether, our work adds to the current literature and doubles the number of reported cases with RELA-Associated Inflammatory Disease (RAID). It reaffirms the central importance of the NF-κB pathway in immunity and inflammation, as well as the important regulatory role of RELA in mucosal homeostasis. RELA associated inflammatory disease should be considered in all patients with BD, particularly those with early onset and/or with a strong family history.
LiDAR-based Indoor Localization with Optimal Particle Filters using Surface Normal Constraints
(2023)
Representing 3D surfaces as level sets of continuous functions over R3 is the common denominator of neural implicit representations, which recently enabled remarkable progress in geometric deep learning and computer vision tasks. In order to represent 3D motion within this framework, it is often assumed (either explicitly or implicitly) that the transformations which a surface may undergo are homeomorphic: this is not necessarily true, for instance, in the case of fluid dynamics. In order to represent more general classes of deformations, we propose to apply this theoretical framework as regularizers for the optimization of simple 4D implicit functions (such as signed distance fields). We show that our representation is capable of capturing both homeomorphic and topology-changing deformations, while also defining correspondences over the continuously-reconstructed surfaces.
Die Beziehungen zwischen der EU und der Türkei sind seit vielen Jahren von wachsender Entfremdung gekennzeichnet. Zur Ursachenforschung wird zumeist auf die demokratischen Rückschritte der Türkei hingewiesen – dabei wird übersehen, dass das Verhältnis von wechselseitigen Irritationen geprägt ist, die zu tiefen Brüchen führten. Der Autor analysiert die Ursachen und Ausdrucksformen dieser normativen und strategischen Spannungsfelder anhand der Debatten des Europäischen Parlaments (2004-2019). Auf einzigartige Weise legt er dar, wie die polarisierende Beitrittsfrage auf die verschiedenen Fraktionen des Parlaments einwirkt und woran eine gelungene Integration der Türkei in die EU scheitert. (Verlagsangaben)
There has been a growing interest in taste research in the HCI and CSCW communities. However, the focus is more on stimulating the senses, while the socio-cultural aspects have received less attention. However, individual taste perception is mediated through social interaction and collective negotiation and is not only dependent on physical stimulation. Therefore, we study the digital mediation of taste by drawing on ethnographic research of four online wine tastings and one self-organized event. Hence, we investigated the materials, associated meanings, competences, procedures, and engagements that shaped the performative character of tasting practices. We illustrate how the tastings are built around the taste-making process and how online contexts differ in providing a more diverse and distributed environment. We then explore the implications of our findings for the further mediation of taste as a social and democratized phenomenon through online interaction.