Refine
H-BRS Bibliography
- yes (301) (remove)
Departments, institutes and facilities
- Fachbereich Informatik (69)
- Fachbereich Angewandte Naturwissenschaften (68)
- Fachbereich Wirtschaftswissenschaften (65)
- Institut für Technik, Ressourcenschonung und Energieeffizienz (TREE) (50)
- Fachbereich Ingenieurwissenschaften und Kommunikation (43)
- Fachbereich Sozialpolitik und Soziale Sicherung (33)
- Institut für Verbraucherinformatik (IVI) (18)
- Institute of Visual Computing (IVC) (18)
- Internationales Zentrum für Nachhaltige Entwicklung (IZNE) (13)
- Präsidium (13)
Document Type
- Article (106)
- Conference Object (75)
- Part of a Book (32)
- Book (monograph, edited volume) (20)
- Part of Periodical (17)
- Report (15)
- Preprint (10)
- Doctoral Thesis (8)
- Master's Thesis (6)
- Working Paper (3)
Year of publication
- 2019 (301) (remove)
Keywords
- Lehrbuch (4)
- lignin (4)
- Lignin (3)
- Navigation (3)
- work engagement (3)
- Aminoacylase (2)
- Chemie (2)
- Design (2)
- Drosophila (2)
- Exergame (2)
Survival of patients with pediatric acute lymphoblastic leukemia (ALL) after allogeneic hematopoietic stem cell transplantation (allo-SCT) is mainly compromised by leukemia relapse, carrying dismal prognosis. As novel individualized therapeutic approaches are urgently needed, we performed whole-exome sequencing of leukemic blasts of 10 children with post–allo-SCT relapses with the aim of thoroughly characterizing the mutational landscape and identifying druggable mutations. We found that post–allo-SCT ALL relapses display highly diverse and mostly patient-individual genetic lesions. Moreover, mutational cluster analysis showed substantial clonal dynamics during leukemia progression from initial diagnosis to relapse after allo-SCT. Only very few alterations stayed constant over time. This dynamic clonality was exemplified by the detection of thiopurine resistance-mediating mutations in the nucleotidase NT5C2 in 3 patients’ first relapses, which disappeared in the post–allo-SCT relapses on relief of selective pressure of maintenance chemotherapy. Moreover, we identified TP53 mutations in 4 of 10 patients after allo-SCT, reflecting acquired chemoresistance associated with selective pressure of prior antineoplastic treatment. Finally, in 9 of 10 children’s post–allo-SCT relapse, we found alterations in genes for which targeted therapies with novel agents are readily available. We could show efficient targeting of leukemic blasts by APR-246 in 2 patients carrying TP53 mutations. Our findings shed light on the genetic basis of post–allo-SCT relapse and may pave the way for unraveling novel therapeutic strategies in this challenging situation.
Scratch assays enable the study of the migration process of an injured adherent cell layer in vitro. An apparatus for the reproducible performance of scratch assays and cell harvesting has been developed that meets the requirements for reproducibility in tests as well as easy handling. The entirely autoclavable setup is divided into a sample translation and a scratching system. The translational system is compatible with standard culture dishes and can be modified to adapt to different cell culture systems, while the scratching system can be adjusted according to angle, normal force, shape, and material to adapt to specific questions and demanding substrates. As a result, a fully functional prototype can be presented. This system enables the creation of reproducible and clear scratch edges with a low scratch border roughness within a monolayer of cells. Moreover, the apparatus allows the collection of the migrated cells after scratching for further molecular biological investigations without the need for a second processing step. For comparison, the mechanical properties of manually performed scratch assays are evaluated.
The number of studies on work breaks and the importance of this subject is growing rapidly, with research showing that work breaks increase employees’ wellbeing and performance and workplace safety. However, comparing the results of work break research is difficult since the study designs and methods are heterogeneous and there is no standard theoretical model for work breaks. Based on a systematic literature search, this scoping review included a total of 93 studies on experimental work break research conducted over the last 30 years. This scoping review provides a first structured evaluation regarding the underlying theoretical framework, the variables investigated, and the measurement methods applied. Studies using a combination of measurement methods from the categories “self-report measures,” “performance measures,” and “physiological measures” are most common and to be preferred in work break research. This overview supplies important information for ergonomics researchers allowing them to design work break studies with a more structured and stronger theory-based approach. A standard theoretical model for work breaks is needed in order to further increase the comparability of studies in the field of experimental work break research in the future.
Although work events can be regarded as pivotal elements of organizational life, only a few studies have examined how positive and negative events relate to and combine to affect work engagement over time. Theory suggests that to better understand how current events affect work engagement (WE), we have to account for recent events that have preceded these current events. We present competing theoretical views on how recent and current work events may affect employees (e.g., getting used to a high frequency of negative events or becoming more sensitive to negative events). Although the occurrence of events implies discrete changes in the experience of work, prior research has not considered whether work events actually accumulate to sustained mid-term changes in WE. To address these gaps in the literature, we conducted a week-level longitudinal study across a period of 15 consecutive weeks among 135 employees, which yielded 849 weekly observations. While positive events were associated with higher levels of WE within the same week, negative events were not. Our results support neither satiation nor sensitization processes. However, high frequencies of negative events in the preceding week amplified the beneficial effects of positive events on WE in the current week. Growth curve analyses show that the benefits of positive events accumulate to sustain high levels of WE. WE dissipates in the absence of continuous experience of positive events. Our study adds a temporal component and informs research that has taken a feature-oriented perspective on the dynamic interplay of job demands and resources.
Application developers constitute an important part of a digital platform’s ecosystem. Knowledge about psychological processes that drive developer behavior in platform ecosystems is scarce. We build on the lead userness construct which comprises two dimensions, trend leadership and high expected benefits from a solution, to explain how developers’ innovative work behavior (IWB) is stimulated. We employ an efficiencyoriented and a social-political perspective to investigate the relationship between lead userness and IWB. The efficiency-oriented view resonates well with the expected benefit dimension of lead userness, while the social-political view might be interpreted as a reflection of trend leadership. Using structural equation modeling, we test our model with a sample of over 400 developers from three platform ecosystems. We find that lead userness is indirectly associated with IWB and the performance-enhancing view to be the stronger predictor of IWB. Finally, we unravel differences between paid and unpaid app developers in platform ecosystems.
Data-Driven Robot Fault Detection and Diagnosis Using Generative Models: A Modified SFDD Algorithm
(2019)
This paper presents a modification of the data-driven sensor-based fault detection and diagnosis (SFDD) algorithm for online robot monitoring. Our version of the algorithm uses a collection of generative models, in particular restricted Boltzmann machines, each of which represents the distribution of sliding window correlations between a pair of correlated measurements. We use such models in a residual generation scheme, where high residuals generate conflict sets that are then used in a subsequent diagnosis step. As a proof of concept, the framework is evaluated on a mobile logistics robot for the problem of recognising disconnected wheels, such that the evaluation demonstrates the feasibility of the framework (on the faulty data set, the models obtained 88.6% precision and 75.6% recall rates), but also shows that the monitoring results are influenced by the choice of distribution model and the model parameters as a whole.
Atmospheric aerosols affect the power production of solar energy systems. Their impact depends on both the atmospheric conditions and the solar technology employed. By being a region with a lack in power production and prone to high solar insolation, West Africa shows high potential for the application of solar power systems. However, dust outbreaks, containing high aerosol loads, occur especially in the Sahel, located between the Saharan desert in the north and the Sudanian Savanna in the south. They might affect the whole region for several days with significant effects on power generation. This study investigates the impact of atmospheric aerosols on solar energy production for the example year 2006 making use of six well instrumented sites in West Africa. Two different solar power technologies, a photovoltaic (PV) and a parabolic through (PT) power plant, are considered. The daily reduction of solar power due to aerosols is determined over mostly clear-sky days in 2006 with a model chain combining radiative transfer and technology specific power generation. For mostly clear days the local daily reduction of PV power (at alternating current) (PVAC) and PT power (PTP) due to the presence of aerosols lies between 13 % and 22 % and between 22 % and 37 %, respectively. In March 2006 a major dust outbreak occurred, which serves as an example to investigate the impact of an aerosol extreme event on solar power. During the dust outbreak, daily reduction of PVAC and PTP of up to 79 % and 100 % occur with a mean reduction of 20 % to 40 % for PVAC and of 32 % to 71 % for PTP during the 12 days of the event.
„Auf uns hört ja keiner“
(2019)
Mehr machen, weniger planen!
(2019)
The design of self-driving cars is one of the most exciting and ambitious challenges of our days and every day, new research work is published. In order to give an orientation, this article will present an overview of various methods used to study the human side of autonomous driving. Simplifying roughly, you can distinguish between design science-oriented methods (such as Research through Design, Wizard of Oz or driving simulator ) and behavioral science methods (such as survey, interview, and observation). We show how these methods are adopted in the context of autonomous driving research and dis-cuss their strengths and weaknesses. Due to the complexity of the topic, we will show that mixed method approaches will be suitable to explore the impact of autonomous driving on different levels: the individual, the social interaction and society.
Bisherige Versuche der HCI-Community die Lebensmittelverschwendung oder den CO2-Fußabdruck zu reduzieren, basierten meist auf Persuasive Design Ansätzen. Diese werden jedoch kritisiert, die Alltagswelten und Konsumpraktiken für eine Langzeitwirkung nur unzureichend zu berücksichtigen. Das Problem aufgreifend, untersucht dieser Beitrag die Rolle (digitaler) Medien im Übergang zu einer veganen Ernährungspraktik. Hierfür wurden semi-strukturierte Interviews mit 9 VeganerInnen geführt und vor dem Hintergrund der Praxistheorie analysiert. Die Ergebnisse deuten dabei auf eine intensive Nutzung (digitaler) Medien, insbesondere in der frühen Phase der Änderung der Konsumpraktik. Statt Gamification oder Persuasive Design, zeigt sich Mediennutzung in Form von Irritation, Informationsbereitstellung zur Ausbildung eines vegan-spezifischen Konsumwissens sowie als Vermittler zwischen Gleichgesinnten.
In the literature on occupational stress and recovery from work, several facets of thinking about work during off-job time have been conceptualized. However, research on the focal concepts is currently rather diffuse. In this study we take a closer look at the five most well-established concepts: (1) psychological detachment, (2) affective rumination, (3) problem-solving pondering, (4) positive work reflection, and (5) negative work reflection. More specifically, we scrutinized (1) whether the five facets of work-related rumination are empirically distinct, (2) whether they yield differential associations with different facets of employee well-being (burnout, work engagement, thriving, satisfaction with life, and flourishing), and (3) to what extent the five facets can be distinguished from and relate to conceptually similar constructs, such as irritation, worry, and neuroticism. We applied structural equation modeling techniques to cross-sectional survey data from 474 employees. Our results provide evidence for (1) five correlated, yet empirically distinct facets of work-related rumination. (2) Each facet yields a unique pattern of association with the eight aspects of employee well-being. For instance, detachment is strongly linked to satisfaction with life and flourishing. Affective rumination is linked particularly to burnout. Problem-solving pondering and positive work reflection yield the strongest links to work engagement. (3) The five facets of work-related rumination are distinct from related concepts, although there is a high overlap between (lower levels of) psychological detachment and cognitive irritation. Our study contributes to clarifying the structure of work-related rumination and extends the nomological network around different types of thinking about work during off-job time and employee well-being.
Luxusgut Wohnen
(2019)
Virtueller Journalismus
(2019)
§ 3c. Anteilige Abzüge
(2019)
§ 3. [Steuerfreie Einnahmen]
(2019)
TREE Jahresbericht 2018
(2019)
PosturePairsDB19
(2019)
Lower back pain is one of the most prevalent diseases in Western societies. A large percentage of European and American populations suffer from back pain at some point in their lives. One successful approach to address lower back pain is postural training, which can be supported by wearable devices, providing real-time feedback about the user’s posture. In this work, we analyze the changes in posture induced by postural training. To this end, we compare snapshots before and after training, as measured by the Gokhale SpineTracker™. Considering pairs of before and after snapshots in different positions (standing, sitting, and bending), we introduce a feature space, that allows for unsupervised clustering. We show that resulting clusters represent certain groups of postural changes, which are meaningful to professional posture trainers.
Die Globalisierung führt zu immer komplexeren, für die Einzelnen kaum nachvollziehbaren Wertschöpfungsketten in der Lebensmittelindustrie. Zugleich eröffnet die Digitalisierung neue Möglichkeiten, Informationen entlang der Kette zu sammeln, und so mehr Transparenz und Vertrauen für den Verbraucherbeziehungsweise die Verbraucherin zu schaffen. Jedoch finden Verbraucherinformations-Apps wie fTRACE bisher nur eine geringe Verbreitung. Daher haben wir in einer qualitativen Studie mit 16 Teilnehmer/-innen Bedürfnisse und Nutzungshürden von Verbraucher/-innen im Zusammenhang mit Verbraucherinformations-Apps analysiert. Es zeigt sich, dass das Vertrauen in die Informationen, sowie der einfache Zugang dazu für Verbraucher/-innen zentral sind. Durch die gut sichtbare Bereitstellung der Informationen am Point-of-Sale, sowie der automatisierten Informationsversorgung z. B. mittels digitaler Kassenzettel in Kombination mit weiteren Verbraucher-Services kann die Bekanntheit und Akzeptanz von Rückverfolgbarkeitssystemen weiter gesteigert werden.
Stakeholder-Analyse zum Einsatz IIoT-basierter Frischeinformationen in der Lebensmittelindustrie
(2019)
Eine Herausforderung bei der Implementierung des industriellen Internet of Things (IIoT) besteht darin, Mehrwerte in Wertschöpfungsketten zu identifizieren, um darauf aufbauend Lösungen nutzerzentriert zu gestalten. Dieser Beitrag stellt das Forschungsprojekt FreshIndex vor, bei dem diese Herausforderung durch eine Kombination aus Stakeholder-Analyse und User-Centered-Design-Methoden adressiert wurde. Ziel des Projekts ist es, eine IIoT-basierte Lösung zum Monitoring der Kühlkette in der Lebensmittelindustrie zu entwickeln. Hierzu ist es wichtig zu wissen, welche Nutzer/-innen mit den Daten in Berührung kommen und welche Erfahrungen, Fähigkeiten, Anforderungen und Wünsche sie mitbringen. Die Berücksichtigung dieser Aspekte ist relevant für den Erfolg der Konzeption, Implementierung und des Betriebs eines IIoT-Systems. So können nützliche und handhabbare Produktideen generiert und Anwendungen gestaltet werden, die von Mitarbeiter/-innen und Konsument/-innen angenommen werden. IIoT schließt somit die lokale Verwendbarkeit von Daten entlang der Wertschöpfungskette ein und beschränkt sich nicht auf zentrale Verfügbarkeit von Daten.
Trust is the lubricant of the sharing economy, especially in peer-to-peer carsharing where you leave a valuable good to a stranger in the hope of getting it backunscathed. Central mechanisms for handling this information gap nowadays are ratings and reviews of other users. The rising of connected car technology opens new possibilities to increase trust by collecting and providing e.g. driving behavior data. At the same time, this means an intrusion into the privacy of the user. Therefore, in this work we explore technological approaches that allow building trust without violating the privacy of individuals. We evaluate to what extent blockchain technology and smart contracts are suitable technologies to meet these challengesby setting upa prototype implementation of a block-chain-based carsharing approach. In this context, we present our research approachand evaluate the prototype in terms of trust and privacy.
The initially large number of variants is reduced by applying custom variant annotation and filtering procedures. This requires complex software toolchains to be set up and data sources to be integrated. Furthermore, increasing study sizes subsequently require higher efforts to manage datasets in a multi-user and multi-institution environment. It is common practice to expect numerous iterations of continuative respecification and refinement of filter strategies, when the cause for a disease or phenotype is unknown. Data analysis support during this phase is fundamental, because handling the large volume of data is not possible or inadequate for users with limited computer literacy. Constant feedback and communication is necessary when filter parameters are adjusted or the study grows with additional samples. Consequently, variant filtering and interpretation becomes time-consuming and hinders a dynamic and explorative data analysis by experts.