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The work at hand outlines a recording setup for capturing hand and finger movements of musicians. The focus is on a series of baseline experiments on the detectability of coloured markers under different lighting conditions. With the goal of capturing and recording hand and finger movements of musicians in mind, requirements for such a system and existing approaches are analysed and compared. The results of the experiments and the analysis of related work show that the envisioned setup is suited for the expected scenario.
Beta-ketothiolase deficiency, also known as mitochondrial acetoacetyl-CoA thiolase (T2) deficiency, is an autosomal recessive disease caused by mutations in the acetylCoA acetyltransferase 1 (ACAT1) gene. A German T2deficient patient that developed a severe ketoacidotic episode at the age of 11 months, was revealed to be a compound heterozygote of a previously reported null mutation, c.472A>G (p.N158D) and a novel mutation, c.949G>A (p.D317N), in ACAT1. The c.949G>A mutation was suspected to cause aberrant splicing as it is located within an exonic splicing enhancer sequence (c. 947CTGACGC) that is a potential binding site for serine/argininerich splicing factor 1. A mutation in this sequence, c.951C>T, results in exon 10 skipping. A minigene construct was synthesized that included exon 9truncated intron 9exon 10truncated intron 10exon 11, and the splicing of this minigene revealed that the c.949G>A mutant construct caused exon 10 skipping in a proportion of the transcripts. Furthermore, additional substitution of G for C at the first nucleotide of exon 10 (c.941G>C) abolished the effect of the c.949G>A mutation. Transient expression analysis of the c.949G>A mutant cDNA revealed no residual T2 activity in the mutated D317N enzyme. Therefore, c.949G>A (D317N) is a pathogenic missense mutation, and diminishes the effect of an exonic splicing enhancer and causes exon 10 skipping. The present study demonstrates that a missense mutation, or even a synonymous substitution, may disrupt enzyme function by interference with splicing.
WiFi-based Long Distance (WiLD) networks have emerged as a promising alternative technology approach for providing Internet in rural areas. An important factor in network planning of these wireless networks is estimating the path loss. In this work, we present various propagation models we found suitable for point-to-point (P2P) operation in the WiFi frequency bands. We conducted outdoor experiments with commercial offthe- shelf (COTS) hardware in our testbed made of 7 different long-distance links ranging from 450 m to 10.3 km and a mobile measurement station. We found that for short links with omni-directional antennas ground-reflection is a measurable phenomenon. For longer links, we show that either FSPL or the Longley-Rice model provides accurate results for certain links. We conclude that a good site survey is needed to exclude influences not included in the propagation models.
SDN and WMN evolved to be sophisticated technologies used in a variety of applications. However, a combined approach called wmSDN has not been widely addressed in the research community. Our idea in this field consists of WiFi-based point-to-point links managed by the OpenFlow protocol. We investigate two different issues regarding this idea. First, which WiFi operational mode is suitable in an OpenFlow managed broadcast domain? Second, does the performance decrease compared with other routing or switching principles? Therefore, we set up a real-world testbed and a suitable simulation environment. Unlike previous work, we show that it is possible to use WiFi links without conducting MAC address rewriting at each hop by utilizing the 4-address-mode.
Background: Falls are common in older adults and can result in serious injuries. Due to demographic changes, falls and related healthcare costs are likely to increase over the next years. Participation and motivation of older adults in fall prevention measures remain a challenge. The iStoppFalls project developed an information and communication technology (ICT)-based system for older adults to use at home in order to reduce common fall risk factors such as impaired balance and muscle weakness. The system aims at increasing older adults’ motivation to participate in ICT-based fall prevention measures. This article reports on usability, user-experience and user-acceptance aspects affecting the use of the iStoppFalls system by older adults.
Methods: In the course of a 16-week international multicenter study, 153 community-dwelling older adults aged 65+ participated in the iStoppFalls randomized controlled trial, of which half used the system in their home to exercise and assess their risk of falling. During the study, 60 participants completed questionnaires regarding the usability, user experience and user acceptance of the iStoppFalls system. Usability was measured with the System Usability Scale (SUS). For user experience the Physical Activity Enjoyment Scale (PACES) was applied. User acceptance was assessed with the Dynamic Acceptance Model for the Re-evaluation of Technologies (DART). To collect more detailed data on usability, user experience and user acceptance, additional qualitative interviews and observations were conducted with participants.
Results: Participants evaluated the usability of the system with an overall score of 62 (Standard Deviation, SD 15.58) out of 100, which suggests good usability. Most users enjoyed the iStoppFalls games and assessments, as shown by the overall PACES score of 31 (SD 8.03). With a score of 0.87 (SD 0.26), user acceptance results showed that participants accepted the iStoppFalls system for use in their own home. Interview data suggested that certain factors such as motivation, complexity or graphical design were different for gender and age.
Conclusions: The results suggest that the iStoppFalls system has good usability, user experience and user acceptance. It will be important to take these along with factors such as motivation, gender and age into consideration when designing and further developing ICT-based fall prevention systems.
Die Prognose über den Studienerfolg von Studierenden in MINT-Fächern wird häufig an ihre Prüfungsleistungen in mathematischen und naturwissenschaftlichen Veranstaltungen geknüpft. Die Relevanz von sprachlichen Kompetenzen, insbesondere der Textrezeption und -produktion, für Studium und Berufstätigkeit, gerade auch in ingenieurwissenschaftlichen Betätigungsfeldern, wird sowohl von den Studierenden als auch von Dozent*innen nicht erkannt oder zurückgestellt.
Fault-Channel Watermarks
(2016)
In this paper, several blocking techniques are applied to matrices that do not have a strong blocked structure. The aim is to efficiently use vectorization with current CPUs, even for matrices without an explicit block structure on nonzero elements. Different approaches are known to find fixed or variable sized blocks of nonzero elements in a matrix. We present a new matrix format for 2D rectangular blocks of variable size, allowing fill-ins per block of explicit zero values up to a user definable threshold. We give a heuristic to detect such 2D blocks in a sparse matrix. The performance of a Sparse Matrix Vector Multiplication for chosen block formats is measured and compared. Results show that the benefit of blocking formats depend – as to be expected – on the structure of the matrix and that variable sized block formats can have advantages over fixed size formats.
Diese etablierte Formelsammlung enthält und erklärt mathematische Formeln die in den Wirtschaftswissenschaften unbedingt notwendig sind. Das Verständnis der Formeln und deren praktische Anwendung werden durch nützliche Hilfen und Beispiele sinnvoll unterstützt. Damit ist das Buch ein unverzichtbares Tool für Studierende; es eignet sich aber auch als Nachschlagewerk für Verantwortliche aus Wirtschaft, Politik und Lehre.
Within qualitative interviews we examine attitudes towards driverless cars in order to investigate new mobility services and explore the impact of such services on everyday mobility. We identified three main issues that we would like to discuss in the workshop: (I) Designing beyond a driver-centric approach; (II) Developing mobility services for cars which drive themselves; and (III) Exploring self-driving practices.
The Eighth International Conference on Future Computational Technologies and Applications (FUTURE COMPUTING 2016), held between March 20-24, 2016 in Rome, Italy, continued a series of events targeting advanced computational paradigms and their applications. The target was to cover (i) the advanced research on computational techniques that apply the newest human-like decisions, and (ii) applications on various domains. The new development led to special computational facets on mechanism-oriented computing, large-scale computing and technology-oriented computing. They are largely expected to play an important role in cloud systems, on-demand services, autonomic systems, and pervasive applications and services.
Förderpreise 2016
(2016)
Gleichlaufgelenke als Teil der Antriebswellen (Seitenwellen und Längswellen) sind in allen maßgeblichen Triebstrangkonfigurationen im direkten Leistungsfluss angeordnet. Ihre Hauptfunktion ist die Übertragung einer Antriebsleistung unter Ermöglichung von Abbeugung und Axialverschiebung. Dieser Beitrag soll einen Überblick zu den wesentlichen, auf dem heutigen Markt verbreiteten Bauweisen und ihren jeweiligen Einsatzgebieten geben. Besonders berücksichtigt werden hierbei neue Gelenkkonzepte, die sich aufgrund ihrer besonderen Gestaltung durch deutlich höhere Wirkungsgrade auszeichnen. Der Einfluss auf den Energieverbrauch soll quantifiziert werden, hierzu wird ein neuartiger Berechnungsansatz vorgestellt, der eine einfache Abschätzung des Einflusses von Wirkungsgradverbesserungen auf den Energieverbrauch für verschiedener Antriebskonzepte (ICE / Hybrid / E-Fahrzeuge) erlaubt.
Diese Theorie-Einführung hat konsequent praktische Anwendungen im Blick. Seien es Workflow-Systeme, Web Services, Verschlüsselung von Informationen, Authentifizierungsprotokolle oder selbstfahrende Autos - all diese Technologien haben enge Bezüge zu den theoretischen Grundlagen der Informatik. So trägt das Buch dazu bei, dass Studierende die Grundlagen der Theoretischen Informatik nicht nur verstehen, sondern auch anwenden können, um effektiv und produktiv an informationstechnischen Problemlösungen mitwirken zu können. Wegen seiner speziellen inhaltlichen und didaktischen Qualität ist das Buch neben dem Einsatz in der Lehre auch für das Selbststudium geeignet.
Helping Johnny to Analyze Malware: A Usability-Optimized Decompiler and Malware Analysis User Study
(2016)
Reliable and regional differentiated power forecasts are required to guarantee an efficient and economic energy transition towards renewable energies. Amongst other renewable energy technologies, e.g. wind mills, photovoltaic systems are an essential component of this transition being cost-efficient and simply to install. Reliable power forecasts are however required for a grid integration of photovoltaic systems, which among other data requires high-resolution spatio-temporal global irradiance data. Hence the generation of robust reviewed global irradiance data is an essential contribution for the energy transition.
Large bone defects require fabricated bone constructs that consist of three main components: an artificial extracellular matrix scaffold, stem cells with the potential to differentiate into osteoblasts, and bioactive substances, such as osteoinductive growth factors to direct the growth and differentiation of cells toward osteogenic lineage within the scaffold.
Hydrogen sulfide contributes to hypoxic inhibition of airway transepithelial sodium absorption
(2016)
Falls and their consequences are arguably most important events for transition from independent living to institutional care for older adults. Information and communication technology (ICT)-based support of fall prevention and fall risk assessment under the control of the user has a tremendous potential to, over time, prevent falls and reduce associated harm and costs. Our research uses participative design and a persuasive health approach to allow for seamless integration of an ICT-based fall prevention system into older adults’ everyday life. Based on a 6-month field study with 12 participants, we present qualitative results regarding the system use and provide insights into attitudes and practices of older adults concerning fall prevention and ICT-supported self-management of health. Our study demonstrates how it can lead to positive aspects of embodiment and health literacy through continuous monitoring of personal results, improved technical confidence, and quality of life. Implications are provided for designing similar systems.
Brentuximab vedotin (SGN-35) is an antibody–drug conjugate with a high selectivity against CD30+ cell lines and more than 300-fold less activity against antigen-negative cells. In the last years, the results of many in vitro and in vivo studies have led to the fast approval of this drug to treat lymphoma patients. Another innovative method to treat tumor cells including lymphoma cells is the use cytokine-induced killer (CIK) cells, which have also been approved and proven to be a safe treatment with only minor adverse events. In this study, a possible additive effect when combining SGN-35 with CIK cells was investigated. The combinational treatment showed that it reduces the viability of CD30+ cell lines significantly in vitro. Additionally, the amount of lymphoma cells was significantly reduced when exposed to CIK cells as well as when exposed to SGN-35. A significant negative effect of SGN-35 on the function of CIK cells could be excluded. These results lead to the assumption that SGN-35 and CIK cells in combination might achieve better results in an in vitro setting compared to the single use of SGN-35 and CIK cells. Further investigations in in vivo models must be conducted to obtain a better understanding of the exact mechanisms of both treatments when applied in combination.
Für die prototypische Erstellung von Virtual Reality (VR) Szenen auf Grundlage realer Umgebungen bieten sich Daten aus aktuellen Panorama-Kameras an. Diese Daten eignen sich jedoch nicht unmittelbar für die Integration in eine Game Engine. Wir stellen daher ein projektionsbasiertes Verfahren vor, mit dem Bilder und Videos im Fischaugenformat, wie sie z.B. die 360 Kamera Ricoh Theta erstellt, ohne Konvertierung in Echtzeit mit Hilfe der Unity Game Engine visualisiert werden können. Es wird weiterhin gezeigt, dass ein Panoramabild mit diesem Verfahren leicht manuell um grobe Tiefeninformation erweitert werden kann, sodass bei einer Darstellung in VR ein grober räumlicher Eindruck der Szene für einfach prototypische Umsetzungen ermöglicht wird.
Internet-Ökonomie
(2016)
Dieses Buch zeigt wie Unternehmen wie Apple, Amazon, Facebook und Google zu den wertvollsten Unternehmen der Welt werden konnten. Ihr Erfolg basiert auf dem Ergreifen von Chancen, die die digitale Welt und das Internet bieten. Traditionelle Geschäftsmodelle werden dadurch verändert und über Jahrzehnte gewachsene Marktstrukturen teilweise in Frage gestellt. Die dritte Auflage dieses Lehrbuchs ist in Form eines modularen Ansatzes grundlegend neu gestaltet.
The mechanical properties of plastic components, especially if they are made of semi-crystalline polymers, are considerably influenced by the process conditions. The degree of crystallization influences thermal and mechanical properties. Even more important is the orientation of molecules due to stretching of the polymer melt. Anisotropic material properties are the result of such orientations. Up to now all these effects are not considered within the simulation models of blow molded parts.
IT-Controlling
(2016)
Knowledge-Based Instrumentation and Control for Competitive Industry-Inspired Robotic Domains
(2016)
Job-related migration has been fostered across Europe balancing unemployment in one country with demands for employees in others. However, the numbers of early school leavers and university dropouts significantly increased in the hosting countries. We propose a higher measure of cultural sensitivity in education in order to prevent frustration. The Learning Culture Survey investigates learners’ expectations towards and perceptions of education on international level with the aim to make culture in the context of education better understandable. After a brief introduction, we subsume the steps taken during the past seven years and found results. Subsequently, we introduce a method for the determination of conflict potential, which bases on the understanding of culture as the level to which people within a society accept deviations from the usual. We close with demonstrating the usefulness of the data and insights from our Learning Culture Survey in the context of practical scenarios.
The Participation Act, introduced in the Netherlands in 2015, puts into practice the idea that every individual has to make a contribution in a participatory society. The Act includes aspects of income support, compulsory activities in return for benefits, and labour market reintegration. Drawing on 45 interviews, we provide insights into interactions between the individual financial and social situation, an individual’s position in society, and reintegration activities. The narratives show the fundamental need for individual freedom and societal meaning, recognition, and appreciation, as well as the complex circumstances in which social assistance recipients make decisions. Conflicts between those needs and the Act lead to the question of how personal and societal objectives can be reconciled.
Informations- und Kommunikationstechnologie (IKT) in den Bereichen Smart Home und Smart Living ist durch die zunehmende Vernetzung des häuslichen Anwendungsfelds mit der Digitalisierung des Stromnetzes, alternativen Möglichkeiten der Energiegewinnung und -speicherung und neuer Mobilitätskonzepte geprägt und zu einem unverzichtbaren Bestandteil privaten wie unternehmerischen Handelns geworden.
Marketing und Recht kompakt
(2016)
"Marketing und Recht - was soll das denn?" So oder ähnlich wird der eine oder andere auf den Titel des vorliegenden Buches spontan reagieren. Das verwundert nicht, ist die Buch-Landschaft doch vor allem dadurch geprägt, dass Marketing-Werke und Abhandlungen zu marketingrelevanten Rechtsthemen am Büchermarkt stets "getrennt marschieren". Wer Marketingkonzepte entwirft, Vorhaben im Rahmen der Marketingforschung durchführen will oder beabsichtigt, Entscheidungen im Rahmen des Marketings zu treffen, sollte unseres Erachtens möglichst frühzeitig die gängigen "juristischen Fallstricke" erkennen und in seinen Überlegungen berücksichtigen.
Studierende unserer Informatik-Studiengänge sehen nach unserer Erfahrung mehrheitlich die Relevanz von Usability und User Experience für eine erfolgreiche Produktentwicklung. Gleichzeitig sind die Studierenden durch ihr Informatik-Studium von der Auseinandersetzung mit Techniken geprägt. Sie zeigen dadurch teils große Schwierigkeiten sich in einem MCI-Kurs mit von der technischen Ebene abstrahierenden Methoden zu befassen. Diese Barriere erschwert es, die Studierenden in der Breite zur Mitarbeit in MCI-Kursen oder anderen auf Methoden ausgerichteten Kursen wie bspw. Requirements Engineering zu motivieren, und stellt Dozenten damit vor Herausforderungen bei der Gestaltung von Informatik-Curricula, die über MCI-Kurse hinausgehen.
Mensch-Roboter-Kollaboration
(2016)
Eine enge Zusammenarbeit von Mensch und Roboter, die sogenannte Mensch-Roboter-Kollaboration (MRK), könnte eine bisher beispielslose Produktivität entstehen lassen. Bis zur allgemeinen Nutzung der Technologie sind noch zahlreiche Probleme zu lösen, insbesondere die des Arbeits- und Gesundheitsschutzes. Am Institut für Sicherheitsforschung der Hochschule Bonn-Rhein-Sieg wurde in den vergangenen Jahren eine Reihe von Projekten zur Entwicklung von optischen Sensorsystemen für Schutzeinrichtungen durchgeführt. Im Projekt SPAI (Sichere Personendetektion im Arbeitsbereich von Industrierobotern durch ein aktives NIR-Kamerasystem) wurde ein spezielles Kamerasystem für den nahinfraroten (NIR) Spektralbereich entwickelt.
This paper presents methods for the reduction and compression of meteorological data for web-based wind flow visualizations, which are tailored to the flow visualization technique. Flow data sets represent a large amount of data and are therefore not well suited for mobile networks with low data throughput rates and high latency. Using the mechanisms introduced in this paper, an efficient transfer of thinned out and compressed data can be achieved, while keeping the accuracy of the visualized information almost at the same quality level as for the original data.
MOOCs in POM Education
(2016)
Basic demand from enterprises towards academic education: provide students not only methodological/theoretical knowledge, but also prepare them for the future tasks in the world of works! This contradicts academia’s focus on sustainably teaching basic principles. With the extra-curricular international online program erp4students, we successfully managed to bridge this "conflict-of-interest”.
Nachhaltiges Innovationsmanagement in KMU: Eine empirische Untersuchung zu Living Labs as a Service
(2016)
Die neue europäische Umweltstrategie der Integrierten Produktpolitik fordert von produzierenden kleinen und mittleren Unternehmen (KMU) eine eigenverantwortliche und produktbezogene Nachhaltigkeitsstrategie. Obgleich die Gestaltung von IKT-Services in nachhaltigkeitsrelevanten Bereichen ein großes Marktpotential verspricht, birgt das Innovationsmanagement für KMU einige Risiken. Um diese Herausforderungen zu adressieren motiviert diese Arbeit Living Labs, als Innovationsinfrastruktur, um den spezifischen Bedarfen von KMU für ein nachhaltiges Innovationsmanagement gerecht zu werden. Auf der Basis von 15 semi-strukturierten Interviews mit 7 KMU, die IKT-Lösungen in den Bereichen Wohnen und Mobilität entwickeln, wurden Herausforderungen sowie etablierte Strategien für ein nachhaltiges Innovationsmanagement erhoben sowie Potenziale und mögliche Risiken von Living Labs exploriert. Die Studie zeigt KMU spezifische Bedarfe auf, die eine Anpassung des Living Lab Ansatzes als Service-Dienstleistungen erforderlich machen.
Neues Lizenzmanagement
(2016)
Nicht im Elfenbeinturm
(2016)
Noncooperative Game Theory
(2016)
Mit den Themen Digitalisierung, Big Data, Industrie 4.0 und Cloud-Computing erfährt auch Geschäftsprozessmanagement immer mehr Aufmerksamkeit. Doch was sind die Treiber und Einflussfaktoren für erfolgreiches Business Process Management? Der BPM-Compass 2016 zeigt, dass Menschen auch während der digitalen Transformation entscheidend für erfolgreich umgesetzte Geschäftsprozesse sind.
Human beings spend much time under the influence of artificial lighting. Often, it is beneficial to adapt lighting to the task, as well as the user’s mental and physical constitution and well-being. This formulates new requirements for lighting - human-centric lighting - and drives a need for new light control methods in interior spaces. In this paper we present a holistic system that provides a novel approach to human-centric lighting by introducing simulation methods into interactive light control, to adapt the lighting based on the user's needs. We look at a simulation and evaluation platform that uses interactive stochastic spectral rendering methods to simulate light sources, allowing for their interactive adjustment and adaption.
This report summarises and integrates two different tracks of research for the purpose of envisioning and preparing a joint research project proposal. Soft- and hardware systems have become increasingly complex and act "concurrently", both with respect to memory access (i.e. information flow) and computational resources (i.e. "services"). The software development metaphor of cloud-storage, cloud-computing and service-oriented design has been anticipated by artificial intelligence (AI) research at least 30 years ago (parallel and distributed computation already dates back to the 1950’s and 1970s). What is known as a "service" today is what in AI is known as the capability of an agent; and the problem of information flow and consistency has been a headstone of information processing ever since. Based on a real-world robotics application we demonstrate how an increasingly abstract description of collaborating or competing agents correspond to a set of concurrent processes.
When navigating larger virtual environments and computer games, natural walking is often unfeasible. Here, we investigate how alternatives such as joystick- or leaning-based locomotion interfaces ("human joystick") can be enhanced by adding walking-related cues following a sensory substitution approach. Using a custom-designed foot haptics system and evaluating it in a multi-part study, we show that adding walking related auditory cues (footstep sounds), visual cues (simulating bobbing head-motions from walking), and vibrotactile cues (via vibrotactile transducers and bass-shakers under participants' feet) could all enhance participants' sensation of self-motion (vection) and involement/presence. These benefits occurred similarly for seated joystick and standing leaning locomotion. Footstep sounds and vibrotactile cues also enhanced participants' self-reported ability to judge self-motion velocities and distances traveled. Compared to seated joystick control, standing leaning enhanced self-motion sensations. Combining standing leaning with a minimal walking-in-place procedure showed no benefits and reduced usability, though. Together, results highlight the potential of incorporating walking-related auditory, visual, and vibrotactile cues for improving user experience and self-motion perception in applications such as virtual reality, gaming, and tele-presence.